diff --git a/docs/source/development-guide.rst b/docs/source/development-guide.rst
index d3e276fa..74628de8 100644
--- a/docs/source/development-guide.rst
+++ b/docs/source/development-guide.rst
@@ -45,6 +45,8 @@ Python Execution
     # `main()` creates an `E3SMtoCMIP` object and passes `args` to it, which sets the object parameters to execute a run.
     main(args)
 
+Note, a run script is provided at `/tests/run_script.py` to test changes at runtime.
+
 Example 2 (info mode)
 ~~~~~~~~~~~~~~~~~~~~~
 
diff --git a/tests/run_script.py b/tests/run_script.py
new file mode 100644
index 00000000..99d262f0
--- /dev/null
+++ b/tests/run_script.py
@@ -0,0 +1,43 @@
+"""A generic run script for testing changes to `e3sm_to_cmip` at runtime.
+
+This script is useful for testing code changes to `e3sm_to_cmip` without having
+to install the package. It imports the `main` function from the `__main__`
+module and passes a list of arguments to it. The arguments are the same as those
+passed to the command line interface (CLI) of `e3sm_to_cmip`.
+The script can be run from the command line or an IDE.
+
+NOTE: This script can only be executed on LCRC machines.
+"""
+
+import datetime
+
+from e3sm_to_cmip.__main__ import main
+
+# The list of variables to process. Update as needed.
+VAR_LIST = (
+    "pfull, phalf, tas, ts, psl, ps, sfcWind, huss, pr, prc, prsn, evspsbl, tauu, "
+    "tauv, hfls, clt, rlds, rlus, rsds, rsus, hfss, cl, clw, cli, clivi, clwvi, prw, "
+    "rldscs, rlut, rlutcs, rsdt, rsuscs, rsut, rsutcs, rtmt, abs550aer, od550aer "
+    "rsdscs, hur"
+)
+
+# The output path for CMORized datasets. Update as needed.
+OUTPUT_PATH = f"../qa/run_{datetime.datetime.now().strftime('%Y%m%d_%H%M%S')}"
+
+args = [
+    "--var-list",
+    f"{VAR_LIST}",
+    "--input",
+    "/lcrc/group/e3sm/e3sm_to_cmip/test-cases/atm-unified-eam/input-regridded",
+    "--output",
+    f"{OUTPUT_PATH}",
+    "--tables-path",
+    "/lcrc/group/e3sm/e3sm_to_cmip/cmip6-cmor-tables/Tables/",
+    "--user-metadata",
+    "/lcrc/group/e3sm/e3sm_to_cmip/CMIP6-Metadata/template.json",
+    "--serial",
+]
+
+# `main()` creates an `E3SMtoCMIP` object and passes `args` to it, which sets
+# the object parameters to execute a run.
+main(args)