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transmem_proteins.swiss
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ID 140U_DROME Reviewed; 261 AA.
AC P81928; Q9VFM8;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 2.
DT 03-APR-2007, entry version 39.
DE RPII140-upstream gene protein.
GN Name=140up; ORFNames=CG9852;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC TISSUE=Embryo;
RX MEDLINE=91276237; PubMed=1905256; DOI=10.1016/0378-1119(91)90361-E;
RA Sitzler S., Oldenburg I., Petersen G., Bautz E.K.F.;
RT "Analysis of the promoter region of the housekeeping gene DmRP140 by
RT sequence comparison of Drosophila melanogaster and Drosophila
RT virilis.";
RL Gene 100:155-162(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX MEDLINE=22426066; PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Essential for viability.
CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein
CC (Potential).
DR EMBL; M62975; AAD40352.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF55023.1; -; Genomic_DNA.
DR EMBL; AY058577; AAL13806.1; -; mRNA.
DR PIR; JQ1024; JQ1024.
DR UniGene; Dm.10056; -.
DR Ensembl; CG9852; Drosophila melanogaster.
DR KEGG; dme:Dmel_CG9852; -.
DR FlyBase; FBgn0010340; 140up.
DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-011545-MONOMER; -.
DR GermOnline; CG9852; Drosophila melanogaster.
DR GO; GO:0007275; P:multicellular organismal development; IMP:UniProtKB.
DR InterPro; IPR003397; Tim17_Tim22.
DR Pfam; PF02466; Tim17; 1.
KW Complete proteome; Membrane; Transmembrane.
FT CHAIN 1 261 RPII140-upstream gene protein.
FT /FTId=PRO_0000064352.
FT TRANSMEM 67 87 Potential.
FT TRANSMEM 131 151 Potential.
FT TRANSMEM 183 203 Potential.
FT CONFLICT 64 64 S -> F (in Ref. 1).
SQ SEQUENCE 261 AA; 29182 MW; 5DB78CF6CFC4435A CRC64;
MNFLWKGRRF LIAGILPTFE GAADEIVDKE NKTYKAFLAS KPPEETGLER LKQMFTIDEF
GSISSELNSV YQAGFLGFLI GAIYGGVTQS RVAYMNFMEN NQATAFKSHF DAKKKLQDQF
TVNFAKGGFK WGWRVGLFTT SYFGIITCMS VYRGKSSIYE YLAAGSITGS LYKVSLGLRG
MAAGGIIGGF LGGVAGVTSL LLMKASGTSM EEVRYWQYKW RLDRDENIQQ AFKKLTEDEN
PELFKAHDEK TSEHVSLDTI K
//
ID 14KD_DAUCA Reviewed; 137 AA.
AC P14009;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 01-MAY-2007, entry version 43.
DE 14 kDa proline-rich protein DC2.15 precursor.
OS Daucus carota (Carrot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae;
OC Daucinae; Daucus.
OX NCBI_TaxID=4039;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Aleith F., Richter G.;
RT "Gene expression during induction of somatic embryogenesis in carrot
RT cell suspensions.";
RL Planta 183:17-24(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 1-8.
RA Kaldenhoff R., Holk A., Richter G.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be connected with the initiation of embryogenesis or
CC with the metabolic changes produced by the removal of auxins.
CC -!- DEVELOPMENTAL STAGE: Transiently expressed during early
CC embryogenesis.
CC -!- INDUCTION: By the removal of auxins.
DR EMBL; X15436; CAA33476.1; -; mRNA.
DR EMBL; X75806; CAA53441.1; -; Genomic_DNA.
DR EMBL; X75807; CAA53442.1; -; Genomic_DNA.
DR EMBL; X75808; CAA53443.1; -; Genomic_DNA.
DR EMBL; X75809; CAA53444.1; -; Genomic_DNA.
DR EMBL; X75810; CAA53445.1; -; Genomic_DNA.
DR PIR; S35714; S35714.
DR HSSP; P24337; 1HYP.
DR InterPro; IPR013770; LPT_helical.
DR InterPro; IPR003612; LTP/seed_store/tryp_amyl_inhib.
DR Gene3D; G3DSA:1.10.110.10; LPT_helical; 1.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR SMART; SM00499; AAI; 1.
KW Membrane; Signal; Transmembrane.
FT SIGNAL 1 25 Potential.
FT CHAIN 26 137 14 kDa proline-rich protein DC2.15.
FT /FTId=PRO_0000020572.
FT TRANSMEM 88 104 Potential.
FT COMPBIAS 30 49 Pro-rich.
SQ SEQUENCE 137 AA; 14392 MW; CAED1BDB3949F890 CRC64;
MGSKNSASVA LFFTLNILFF ALVSSTEKCP DPYKPKPKPT PKPTPTPYPS AGKCPRDALK
LGVCADVLNL VHNVVIGSPP TLPCCSLLEG LVNLEAAVCL CTAIKANILG KNLNLPIALS
LVLNNCGKQV PNGFECT
//
ID 14KD_RHOSH Reviewed; 124 AA.
AC P16536;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 31-OCT-2006, entry version 35.
DE 14 kDa peptide of ubiquinol-cytochrome c2 oxidoreductase complex.
OS Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=1063;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=91340695; PubMed=1651916;
RA Usui S., Yu L.;
RT "Subunit IV (Mr = 14,384) of the cytochrome b-c1 complex from
RT Rhodobacter sphaeroides. Cloning, DNA sequencing, and ubiquinone
RT binding domain.";
RL J. Biol. Chem. 266:15644-15649(1991).
RN [2]
RP PROTEIN SEQUENCE OF 61-108.
RX MEDLINE=90110107; PubMed=2153104;
RA Purvis D.J., Theiler R., Niederman R.A.;
RT "Chromatographic and protein chemical analysis of the ubiquinol-
RT cytochrome c2 oxidoreductase isolated from Rhodobacter sphaeroides.";
RL J. Biol. Chem. 265:1208-1215(1990).
CC -!- FUNCTION: Component of the ubiquinol-cytochrome c reductase
CC complex (complex III or cytochrome b-c1 complex), which is a
CC respiratory chain that generates an electrochemical potential
CC coupled to ATP synthesis.
DR EMBL; M68939; AAA26107.1; -; Genomic_DNA.
DR PIR; A40794; A40794.
KW Direct protein sequencing; Electron transport; Inner membrane;
KW Membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
FT CHAIN 1 124 14 kDa peptide of ubiquinol-cytochrome c2
FT oxidoreductase complex.
FT /FTId=PRO_0000064353.
FT TRANSMEM 85 102 Potential.
SQ SEQUENCE 124 AA; 14393 MW; E390C856C1D752F3 CRC64;
MFSFIDDIPS FEQIKARVRD DLRKHGWEKR WNDSRLVQKS RELLNDEELK IDPATWIWKR
MPSREEVAAR RQRDFETVWK YRYRLGGFAS GALLALALAG IFSTGNFGGS SDAGNRPSVV
YPIE
//
ID 1A01_GORGO Reviewed; 365 AA.
AC P30375;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 01-MAY-2007, entry version 49.
DE Class I histocompatibility antigen, GOGO-A0101 alpha chain precursor.
OS Gorilla gorilla gorilla (Lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA Lawlor D.A., Warren E., Taylor P., Parham P.;
RT "Gorilla class I major histocompatibility complex alleles: comparison
RT to human and chimpanzee class I.";
RL J. Exp. Med. 174:1491-1509(1991).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; X60258; CAA42810.1; -; mRNA.
DR PIR; JH0534; JH0534.
DR HSSP; P10315; 1HSB.
DR SMR; P30375; 25-299.
DR InterPro; IPR013151; Ig.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT SIGNAL 1 24 By similarity.
FT CHAIN 25 365 Class I histocompatibility antigen, GOGO-
FT A0101 alpha chain.
FT /FTId=PRO_0000018897.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 297 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
SQ SEQUENCE 365 AA; 40830 MW; FB1B14BCD4DF63A8 CRC64;
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ
RMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
RAYLEGTCVE WLRRHLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PEPLTLRWEP
SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
TACKV
//
ID 1A01_HUMAN Reviewed; 365 AA.
AC P30443; O77964; O78171; Q9MYA3; Q9TP25; Q9TQP5;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 01-MAY-2007, entry version 67.
DE HLA class I histocompatibility antigen, A-1 alpha chain precursor (MHC
DE class I antigen A*1).
GN Name=HLA-A; Synonyms=HLAA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RX MEDLINE=88234547; PubMed=3375250;
RA Parham P., Lomen C.E., Lawlor D.A., Ways J.P., Holmes N., Coppin H.L.,
RA Salter R.D., Wan A.M., Ennis P.D.;
RT "Nature of polymorphism in HLA-A, -B, and -C molecules.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:4005-4009(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RX MEDLINE=89235215; PubMed=2715640;
RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.;
RT "Diversity and diversification of HLA-A,B,C alleles.";
RL J. Immunol. 142:3937-3950(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RA Warren E.;
RL Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0101).
RX MEDLINE=91067475; PubMed=2251137; DOI=10.1093/nar/18.22.6701;
RA Girdlestone J.;
RT "Nucleotide sequence of an HLA-A1 gene.";
RL Nucleic Acids Res. 18:6701-6701(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0101).
RX MEDLINE=98007773; PubMed=9349617;
RA Laforet M., Froelich N., Parissiadis A., Pfeiffer B., Schell A.,
RA Faller B., Woehl-Jaegle M.L., Cazenave J.-P., Tongio M.M.;
RT "A nucleotide insertion in exon 4 is responsible for the absence of
RT expression of an HLA-A*01 allele.";
RL Tissue Antigens 50:347-350(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RA Waller M.J., Robinson J., Marsh S.G.E.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*0101).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0102).
RX MEDLINE=95282145; PubMed=7761977;
RA Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E.,
RA Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F.,
RA Parham P.;
RT "The HLA-A,B,C genotype of the class I negative cell line Daudi
RT reveals novel HLA-A and -B alleles.";
RL Tissue Antigens 45:177-187(1995).
RN [9]
RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0103).
RX MEDLINE=98101100; PubMed=9438203; DOI=10.1016/S0198-8859(97)00204-8;
RA Sitha S., Scheltinga S.A., Johnston-Dow L.A., White C.B.,
RA der van Zwan A.W., Bakema J.E., Rozemuller E.H., van der Tweel J.G.,
RA Kronink M.N., Tilanus M.G.J.;
RT "A generic sequencing based typing approach for the identification of
RT HLA-A diversity.";
RL Hum. Immunol. 57:120-128(1997).
RN [10]
RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0103).
RC TISSUE=Blood;
RX MEDLINE=21100775; PubMed=11182232; DOI=10.1016/S0198-8859(00)00238-X;
RA Poland G.A., Sohni Y., Domanico M., Kroning C.M., DeGoey S.R.,
RA Jimale M., Jacobson R.M., Moore S.B.;
RT "High frequency of HLA-A*0103 allele in a Somali population.";
RL Hum. Immunol. 62:197-200(2001).
RN [11]
RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0106).
RX MEDLINE=20309230; PubMed=10852390;
RX DOI=10.1034/j.1399-0039.2000.550412.x;
RA Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA Ng J., Hartzman R.J., Hurley C.K.;
RT "Seventeen more novel HLA-A locus alleles.";
RL Tissue Antigens 55:369-373(2000).
RN [12]
RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0107).
RA Tamouza R., Fortier C., Mahfoudh N., Schaeffer V., Poirier J.C.,
RA Marzais F., Gautreau C., Charron D.;
RT "A new HLA-A*01 allele.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [13]
RP SULFATION.
RX MEDLINE=88088800; PubMed=3121736;
RA Sant A.J., Zacheis M., Rumbarger T., Giacoletto K.S., Schwartz B.D.;
RT "Human Ia alpha- and beta-chains are sulfated.";
RL J. Immunol. 140:155-160(1988).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2-
CC microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- PTM: Sulfated. Polyubiquitinated in a post ER compartment through
CC interaction with human herpesvirus 8 MIR1 protein. This targets
CC the protein for rapid degradation via the ubiquitin system (By
CC similarity).
CC -!- POLYMORPHISM: The following alleles of A-1 are known: A*0101,
CC A*0102, A*0103, A*0106 and A*0107. The sequence shown is that of
CC A*0101.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; M24043; AAA59652.1; -; Genomic_DNA.
DR EMBL; X55710; CAA39243.1; -; Genomic_DNA.
DR EMBL; Z93949; CAB07989.1; -; Genomic_DNA.
DR EMBL; AJ278305; CAB93537.1; -; Genomic_DNA.
DR EMBL; BC003069; AAH03069.1; -; mRNA.
DR EMBL; U07161; AAA80569.1; -; mRNA.
DR EMBL; Y12469; CAA73072.1; -; Genomic_DNA.
DR EMBL; Y12470; CAA73073.1; -; Genomic_DNA.
DR EMBL; AF214112; AAF19525.1; -; Genomic_DNA.
DR EMBL; AF214111; AAF19525.1; JOINED; Genomic_DNA.
DR EMBL; AF143232; AAD33894.1; -; Genomic_DNA.
DR EMBL; AF143231; AAD33894.1; JOINED; Genomic_DNA.
DR EMBL; AF219633; AAF73862.1; -; Genomic_DNA.
DR EMBL; AF219632; AAF73862.1; JOINED; Genomic_DNA.
DR PIR; I38518; I38518.
DR PIR; I61856; I61856.
DR UniGene; Hs.181244; -.
DR PDB; 1W72; X-ray; A/D=25-298.
DR Ensembl; ENSG00000206441; Homo sapiens.
DR H-InvDB; HIX0005684; -.
DR HGNC; HGNC:4931; HLA-A.
DR MIM; 142800; gene.
DR LinkHub; P30443; -.
DR GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW 3D-structure; Glycoprotein; Host-virus interaction; Immune response;
KW Immunoglobulin domain; Membrane; MHC I; Polymorphism; Signal;
KW Sulfation; Transmembrane; Ubl conjugation.
FT SIGNAL 1 24
FT CHAIN 25 365 HLA class I histocompatibility antigen,
FT A-1 alpha chain.
FT /FTId=PRO_0000018813.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 295 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT MOD_RES 83 83 Sulfotyrosine (Potential).
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
FT VARIANT 33 33 F -> S (in allele A*0102).
FT /FTId=VAR_004332.
FT VARIANT 41 41 R -> S (in allele A*0102).
FT /FTId=VAR_004333.
FT VARIANT 80 80 G -> R (in allele A*0107).
FT /FTId=VAR_016719.
FT VARIANT 91 91 M -> V (in allele A*0107).
FT /FTId=VAR_016720.
FT VARIANT 100 100 A -> E (in allele A*0107).
FT /FTId=VAR_016721.
FT VARIANT 114 114 D -> A (in allele A*0107).
FT /FTId=VAR_016722.
FT VARIANT 121 121 I -> M (in allele A*0103).
FT /FTId=VAR_016723.
FT VARIANT 180 180 R -> L (in allele A*0106).
FT /FTId=VAR_016724.
FT VARIANT 182 182 V -> A (in allele A*0106).
FT /FTId=VAR_016725.
FT STRAND 27 38
FT TURN 39 41
FT STRAND 42 52
FT STRAND 55 61
FT STRAND 70 73
FT HELIX 74 78
FT HELIX 81 108
FT STRAND 113 115
FT STRAND 118 127
FT STRAND 133 142
FT STRAND 145 150
FT STRAND 157 161
FT HELIX 162 173
FT HELIX 176 185
FT HELIX 187 198
FT HELIX 200 203
FT STRAND 210 217
FT STRAND 219 235
FT STRAND 238 243
FT STRAND 250 254
FT STRAND 261 263
FT STRAND 265 274
FT HELIX 278 280
FT STRAND 281 286
FT STRAND 294 297
SQ SEQUENCE 365 AA; 40846 MW; 8667AFF3F06C4932 CRC64;
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ
IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR
RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
TACKV
//
ID 1A01_PANTR Reviewed; 365 AA.
AC P16209; Q549C1;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 01-MAY-2007, entry version 52.
DE CHLA class I histocompatibility antigen, A-2 alpha chain precursor.
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=90201944; PubMed=1690682;
RA Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT "Comparison of class I MHC alleles in humans and apes.";
RL Immunol. Rev. 113:147-185(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RX MEDLINE=20322475; PubMed=10866106; DOI=10.1007/s002510050638;
RA de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G.,
RA Madrigal J.A., Bontrop R.E.;
RT "Major histocompatibility complex class I diversity in a West African
RT chimpanzee population: implications for HIV research.";
RL Immunogenetics 51:398-409(2000).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; M30678; AAA87970.1; -; mRNA.
DR EMBL; AF168394; AAF72775.1; -; mRNA.
DR PIR; I36961; I36961.
DR HSSP; P10315; 1HSB.
DR SMR; P16209; 25-299.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT SIGNAL 1 24 By similarity.
FT CHAIN 25 365 CHLA class I histocompatibility antigen,
FT A-2 alpha chain.
FT /FTId=PRO_0000018910.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 295 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
SQ SEQUENCE 365 AA; 40849 MW; FC452786BD038D3E CRC64;
MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWIEQEG PEYWDEETRS AKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ
IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQR
RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
TACKV
//
ID 1A01_PONPY Reviewed; 365 AA.
AC P16211;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 01-MAY-2007, entry version 51.
DE Class I histocompatibility antigen, A-1 alpha chain precursor.
OS Pongo pygmaeus (Orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=90201944; PubMed=1690682;
RA Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT "Comparison of class I MHC alleles in humans and apes.";
RL Immunol. Rev. 113:147-185(1990).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; M30680; AAA88835.1; -; mRNA.
DR PIR; I84432; I84432.
DR HSSP; P10315; 1HSB.
DR SMR; P16211; 25-299.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT SIGNAL 1 24 By similarity.
FT CHAIN 25 365 Class I histocompatibility antigen, A-1
FT alpha chain.
FT /FTId=PRO_0000018918.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 297 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
SQ SEQUENCE 365 AA; 40658 MW; 11A5BC183009CF70 CRC64;
MAIMAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRTPWMEQEG PEYWDRETRS VKAHAQTNRV DLGTLRGYYN QSDGGSHTIQ
RMFGCDVGPD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAGAAEQD
RAYLEGLCVE SLRRYLENGK ETLQRTDAPK THMTHHPVSD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PEPLTLRWEL
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRRNSDRK GGSYSQAASN DSAQGSDVSL
TACKV
//
ID 1A01_SAGOE Reviewed; 365 AA.
AC P30515;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 01-MAY-2007, entry version 46.
DE Class I histocompatibility antigen, A alpha chain precursor.
OS Saguinus oedipus (Cotton-top tamarin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Platyrrhini; Cebidae; Callitrichinae; Saguinus.
OX NCBI_TaxID=9490;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=90111120; PubMed=2104912;
RA Watkins D.I., Letvin N.L., Hughes A.L., Tedder T.F.;
RT "Molecular cloning of cDNA that encode MHC class I molecules from a
RT New World primate (Saguinus oedipus). Natural selection acts at
RT positions that may affect peptide presentation to T cells.";
RL J. Immunol. 144:1136-1143(1990).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; M33475; AAA36951.1; -; mRNA.
DR PIR; I56053; I56053.
DR HSSP; Q29961; 1HSA.
DR SMR; P30515; 25-299.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT SIGNAL 1 24 By similarity.
FT CHAIN 25 365 Class I histocompatibility antigen, A
FT alpha chain.
FT /FTId=PRO_0000018920.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 297 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
SQ SEQUENCE 365 AA; 40973 MW; B34B24FB6848E373 CRC64;
MTVMAPRTLL LLLSGALVLT ETWAGSHSMR YFETSVSRPG RGEPRYISVG YVDDTQFVRF
DSDAASPRME PRAPWMEQEG PEYWEEETRK GKADAQTFRV DLQTLLGYYN QSEAGSHTIQ
WMYGCDLGPD GRLLRGYDQH AYDGKDYIAL NEDLRSWTAT DVAAQITQRK WEAANEAERT
RAYLEGTCVE WLHRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITVT
WQRDGEDQTQ DMELVETRPA GDGTFQKWAA VVVLSGEEQR YTCHVQHEGL PEPLTLRWEP
PSQPTIPIMG IVAILAILGV VVTGAVVAAV MWRKKSSDKK GGSYSQAARS DSAQGSDVSL
TACKV
//
ID 1A02_GORGO Reviewed; 365 AA.
AC P30376;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 01-MAY-2007, entry version 47.
DE Class I histocompatibility antigen, GOGO-A0201 alpha chain precursor.
OS Gorilla gorilla gorilla (Lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA Lawlor D.A., Warren E., Taylor P., Parham P.;
RT "Gorilla class I major histocompatibility complex alleles: comparison
RT to human and chimpanzee class I.";
RL J. Exp. Med. 174:1491-1509(1991).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC domain.
DR EMBL; X60259; CAA42811.1; -; mRNA.
DR PIR; JH0535; JH0535.
DR HSSP; P10315; 1HSB.
DR SMR; P30376; 25-300.
DR InterPro; IPR007110; Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003006; Ig_MHC.
DR InterPro; IPR001039; MHC_I_alpha_A1A2.
DR InterPro; IPR010579; MHC_I_alpha_C.
DR Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR ProDom; PD000050; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
KW Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT SIGNAL 1 24 By similarity.
FT CHAIN 25 365 Class I histocompatibility antigen, GOGO-
FT A0201 alpha chain.
FT /FTId=PRO_0000018898.
FT TOPO_DOM 25 308 Extracellular (Potential).
FT TRANSMEM 309 332 Potential.
FT TOPO_DOM 333 365 Cytoplasmic (Potential).
FT DOMAIN 209 295 Ig-like C1-type.
FT REGION 25 114 Alpha-1.
FT REGION 115 206 Alpha-2.
FT REGION 207 298 Alpha-3.
FT REGION 299 308 Connecting peptide.
FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
FT DISULFID 125 188 By similarity.
FT DISULFID 227 283 By similarity.
SQ SEQUENCE 365 AA; 40896 MW; 09E0E5FCD8E58507 CRC64;
MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWIEQEE PEYWDGETRK VKAHSQTDRV NLGTLRGYYN QSEAGSHTIQ
KMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
RAYLEGECVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHESL PKPLTLRWEP
SSQPTIPIVG IIAGLVLFGA VIAGAVIAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
TACKV
//
ID 1A02_HUMAN Reviewed; 365 AA.
AC P01892; O19619; P06338; P10313; P30444; P30445; P30446; P30514;
AC Q29680; Q29837; Q29899; Q95352; Q95380; Q9TPX8; Q9TPX9; Q9TPY0;
AC Q9TQH5; Q9TQI3;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 01-MAY-2007, entry version 87.
DE HLA class I histocompatibility antigen, A-2 alpha chain precursor (MHC
DE class I antigen A*2).
GN Name=HLA-A; Synonyms=HLAA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0201).
RX MEDLINE=85132727; PubMed=2982951;
RA Koller B.H., Orr H.T.;
RT "Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-
RT A alleles at the nucleotide level.";
RL J. Immunol. 134:2727-2733(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RX MEDLINE=89122144; PubMed=2914713;
RA Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G.,
RA Giannella G., Peschle C., Boncinelli E.;
RT "Three new class I HLA alleles: structure of mRNAs and alternative
RT mechanisms of processing.";
RL Immunogenetics 29:80-91(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RX MEDLINE=90207291; PubMed=2320591;
RA Ennis P.D., Zemmour J., Salter R.D., Parham P.;
RT "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction:
RT frequency and nature of errors produced in amplification.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 91-365.
RX MEDLINE=86033791; PubMed=3863816;
RA Davidson W.F., Kress M., Khoury G., Jay G.;
RT "Comparison of HLA class I gene sequences. Derivation of locus-
RT specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C
RT genes.";
RL J. Biol. Chem. 260:13414-13423(1985).
RN [5]
RP NUCLEOTIDE SEQUENCE (ALLELES A*0201; A*0211 AND A*0212).
RX MEDLINE=92269955; PubMed=1317015; DOI=10.1038/357326a0;
RA Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
RA Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
RT "Unusual HLA-B alleles in two tribes of Brazilian Indians.";
RL Nature 357:326-329(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 39-365 (ALLELE A*0201).
RX MEDLINE=85230571; PubMed=3874058;
RA Krangel M.S.;
RT "Unusual RNA splicing generates a secreted form of HLA-A2 in a
RT mutagenized B lymphoblastoid cell line.";
RL EMBO J. 4:1205-1210(1985).
RN [7]
RP PROTEIN SEQUENCE OF 25-295 (A*0201).
RX MEDLINE=80056745; PubMed=92029;
RA Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L.,
RA Strominger J.L.;
RT "Comparison of amino acid sequences of two human histocompatibility
RT antigens, HLA-A2 and HLA-B7: location of putative alloantigenic
RT sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979).
RN [8]
RP SEQUENCE REVISION (A*0201).
RX MEDLINE=82247941; PubMed=6179086;
RA Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.;
RT "Structure of crossreactive human histocompatibility antigens HLA-A28
RT and HLA-A2: possible implications for the generation of HLA
RT polymorphism.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0201).
RC TISSUE=Blood;
RX MEDLINE=95137784; PubMed=7836067; DOI=10.1016/0198-8859(94)90087-6;
RA Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.;
RT "HLA class I allele (HLA-A2) expression defect associated with a
RT mutation in its enhancer B inverted CAT box in two families.";
RL Hum. Immunol. 41:69-73(1994).
RN [10]
RP SEQUENCE REVISION.
RA Balas A.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RA Cox S.T.;
RT "Confirmation of HLA-A*0201.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELES A*0202 AND
RP A*0203).
RX MEDLINE=87306734; PubMed=3497874;
RA Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P.,
RA Biddison W.E.;
RT "DNA sequences of the genes that encode the CTL-defined HLA-A2
RT variants M7 and DK1.";
RL Immunogenetics 26:190-192(1987).
RN [13]
RP NUCLEOTIDE SEQUENCE (ALLELES A*0203 AND A*0205).
RX MEDLINE=87252273; PubMed=3496393;
RA Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.;
RT "Multiple genetic mechanisms have contributed to the generation of the
RT HLA-A2/A28 family of class I MHC molecules.";
RL J. Immunol. 139:936-941(1987).
RN [14]
RP NUCLEOTIDE SEQUENCE (ALLELES A*0203 AND A*0205).
RA Domena J.D.;
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN [15]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*0204).
RX MEDLINE=92039809; PubMed=1937577; DOI=10.1007/BF00211991;
RA Castano A.R., Lopez de Castro J.A.;
RT "Structure of the HLA-A*0204 antigen, found in South American Indians.
RT Spatial clustering of HLA-A2 subtype polymorphism.";
RL Immunogenetics 34:281-285(1991).
RN [16]
RP NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*0204).
RX MEDLINE=92269956; PubMed=1589035; DOI=10.1038/357329a0;
RA Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L.,
RA Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H.,
RA Troup G.M., Hughes A.L., Letvin N.L.;
RT "New recombinant HLA-B alleles in a tribe of South American
RT Amerindians indicate rapid evolution of MHC class I loci.";
RL Nature 357:329-333(1992).
RN [17]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0206).
RX MEDLINE=89235215; PubMed=2715640;
RA Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.;
RT "Diversity and diversification of HLA-A,B,C alleles.";
RL J. Immunol. 142:3937-3950(1989).
RN [18]
RP PARTIAL PROTEIN SEQUENCE (A*0206).
RX MEDLINE=86305811; PubMed=3489037;
RA Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A.,
RA Lopez de Castro J.A.;
RT "Molecular analysis of an HLA-A2 functional variant CLA defined by
RT cytolytic T lymphocytes.";
RL J. Immunol. 137:1642-1649(1986).
RN [19]
RP PARTIAL PROTEIN SEQUENCE (A*0207).
RX MEDLINE=88113844; PubMed=2448239;
RA Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A.;
RT "Structural analysis of HLA-A2.4 functional variant KNE. Implications
RT for the mapping of HLA-A2-specific T-cell epitopes.";
RL Immunogenetics 27:196-202(1988).
RN [20]
RP PARTIAL PROTEIN SEQUENCE (A*0208).
RX MEDLINE=88314183; PubMed=2457548;
RA Domenech N., Castano R., Goulmy E., Lopez de Castro J.A.;
RT "Molecular analysis of HLA-A2.4 functional variant KLO: close
RT structural and evolutionary relatedness to the HLA-A2.2 subtype.";
RL Immunogenetics 28:143-152(1988).
RN [21]
RP PARTIAL PROTEIN SEQUENCE (A*0209).
RX MEDLINE=88186100; PubMed=3258580;
RA Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A.;
RT "An HLA-A2 population variant with structural polymorphism in the
RT alpha 3 region.";
RL Immunogenetics 27:345-355(1988).
RN [22]
RP NUCLEOTIDE SEQUENCE (ALLELE A*0210).
RX MEDLINE=89122133; PubMed=2783680;
RA Epstein H., Kennedy L., Holmes N.;
RT "An Oriental HLA-A2 subtype is closely related to a subset of
RT Caucasoid HLA-A2 alleles.";
RL Immunogenetics 29:112-116(1989).
RN [23]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*0211).
RX MEDLINE=92218010; PubMed=1559719; DOI=10.1007/BF00189898;
RA Castano A.R., Lopez de Castro J.A.;
RT "Structure of the HLA-A*0211 (A2.5) subtype: further evidence for
RT selection-driven diversification of HLA-A2 antigens.";
RL Immunogenetics 35:344-346(1992).
RN [24]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0213).
RX MEDLINE=94222455; PubMed=8168863; DOI=10.1007/BF00189243;
RA Barber D.F., Fernandez J.M., Lopez de Castro J.A.;
RT "Primary structure of a new HLA-A2 subtype: HLA-A*0213.";
RL Immunogenetics 39:378-378(1994).
RN [25]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0216).
RX MEDLINE=95278976; PubMed=7759139;
RA Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J.;
RT "Identification of a novel HLA-A2 subtype, HLA-A*0216.";
RL Immunogenetics 41:388-388(1995).