diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
new file mode 100644
index 00000000..2f687ec8
--- /dev/null
+++ b/.github/workflows/main.yml
@@ -0,0 +1,44 @@
+name: "Xanthos Tests"
+
+on:
+  push:
+    branches:
+      - '**'
+  pull_request:
+    branches:
+      - '**'
+
+jobs:
+  tests:
+    runs-on: ubuntu-latest
+    strategy:
+      matrix:
+        python-version: [3.7, 3.8, 3.9, 3.10, 3.11]
+
+    steps:
+    - name: Checkout repository
+      uses: actions/checkout@v4
+
+    - name: Set up Python ${{ matrix.python-version }}
+      uses: actions/setup-python@v4
+      with:
+        python-version: ${{ matrix.python-version }}
+
+    - name: Upgrade pip
+      run: python -m pip install --upgrade pip
+
+    - name: Install Xanthos
+      run: pip install git+https://github.com/JGCRI/xanthos@dev-testing
+
+    - name: Install test dependencies
+      run: pip install pytest pytest-cov
+
+    - name: Run tests
+      run: pytest --cov=xanthos --cov-report=xml
+
+    - name: Upload coverage to Codecov
+      uses: codecov/codecov-action@v3
+      with:
+        token: ${{ secrets.CODECOV_TOKEN }}
+        file: ./coverage.xml
+        fail_ci_if_error: true