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  • Introduction

  • Methods

    • Study cohort
    • Primary outcome and secondary outcomes
    • Statistical methods
      • The doubly robust estimation
      • The gradient boosted model (GBM)
      • inverse probabilities weighting (IPW) model
    • Sensitivity analysis
    • Covariates
    • Comorbidities
    • Vital signs
    • Interventions
    • Laboratory results
  • Results

    • fig.1 流程图
    • table 1 Comparison of the basic demographics cohort and the adjusted (weighted) cohort
    • fig.2 The contributions of individual covariates to the final propensity score are illustrated in Fig. 2.
    • Doubly robust analysis
      • table 1 Comparison of the basic demographics cohort and the adjusted (weighted) cohort
    • Primary outcome and sensitivity studies
      • table 2 Primary outcome analysis with five different models
        • (1) doubly robust model with unbalanced covariates
        • (2) doubly robust model with all covariates,
        • (3) propensityscore IPW model
        • (4) propensity score matching model,
        • (5)multivariate logistic regression model
    • Secondary outcomes studies with propensity score
      • table 3 Secondary outcome analysis with propensity score matched cohorts matching
  • Discussion

  • Conclusions