diff --git a/src/components/select/multi-select/components.test-pw.tsx b/src/components/select/multi-select/components.test-pw.tsx
index b161b6fc97..04a3cb0f55 100644
--- a/src/components/select/multi-select/components.test-pw.tsx
+++ b/src/components/select/multi-select/components.test-pw.tsx
@@ -194,6 +194,85 @@ export const MultiSelectLazyLoadTwiceComponent = (
   );
 };
 
+export const MultiSelectWithInfiniteScrollComponent = (
+  props: Partial<MultiSelectProps>,
+) => {
+  const preventLoading = useRef(false);
+  const preventLazyLoading = useRef(false);
+  const lazyLoadingCounter = useRef(0);
+  const [value, setValue] = useState<string[]>([]);
+  const [isLoading, setIsLoading] = useState(true);
+  const asyncList = [
+    <Option text="Amber" value="amber" key="Amber" />,
+    <Option text="Black" value="black" key="Black" />,
+    <Option text="Blue" value="blue" key="Blue" />,
+    <Option text="Brown" value="brown" key="Brown" />,
+    <Option text="Green" value="green" key="Green" />,
+  ];
+  const getLazyLoaded = () => {
+    const counter = lazyLoadingCounter.current;
+    return [
+      <Option
+        text={`Lazy Loaded A${counter}`}
+        value={`lazyA${counter}`}
+        key={`lazyA${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded B${counter}`}
+        value={`lazyB${counter}`}
+        key={`lazyB${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded C${counter}`}
+        value={`lazyC${counter}`}
+        key={`lazyC${counter}`}
+      />,
+    ];
+  };
+  const [optionList, setOptionList] = useState<React.ReactElement[]>([]);
+  function onChangeHandler(event: React.ChangeEvent<HTMLInputElement>) {
+    setValue(event.target.value as unknown as string[]);
+  }
+
+  function loadList() {
+    if (preventLoading.current) {
+      return;
+    }
+    preventLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      setIsLoading(false);
+      setOptionList(asyncList);
+    }, 2000);
+  }
+  function onLazyLoading() {
+    if (preventLazyLoading.current) {
+      return;
+    }
+    preventLazyLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      preventLazyLoading.current = false;
+      lazyLoadingCounter.current += 1;
+      setIsLoading(false);
+      setOptionList((prevList) => [...prevList, ...getLazyLoaded()]);
+    }, 2000);
+  }
+  return (
+    <MultiSelect
+      label="color"
+      value={value}
+      onChange={onChangeHandler}
+      onOpen={() => loadList()}
+      isLoading={isLoading}
+      onListScrollBottom={onLazyLoading}
+      {...props}
+    >
+      {optionList}
+    </MultiSelect>
+  );
+};
+
 export const MultiSelectObjectAsValueComponent = (
   props: Partial<MultiSelectProps>,
 ) => {
diff --git a/src/components/select/multi-select/multi-select-test.stories.tsx b/src/components/select/multi-select/multi-select-test.stories.tsx
index 10e04a2ed3..40eda37239 100644
--- a/src/components/select/multi-select/multi-select-test.stories.tsx
+++ b/src/components/select/multi-select/multi-select-test.stories.tsx
@@ -21,6 +21,7 @@ export default {
         "onChange",
         "onChangeDeferred",
         "onFilterChange",
+        "onListScrollBottom",
         "onOpen",
         "onBlur",
         "onClick",
@@ -300,6 +301,85 @@ export const MultiSelectLazyLoadTwiceComponent = (
   );
 };
 
+export const MultiSelectWithInfiniteScrollComponent = (
+  props: Partial<MultiSelectProps>,
+) => {
+  const preventLoading = useRef(false);
+  const preventLazyLoading = useRef(false);
+  const lazyLoadingCounter = useRef(0);
+  const [value, setValue] = useState<string[]>([]);
+  const [isLoading, setIsLoading] = useState(true);
+  const asyncList = [
+    <Option text="Amber" value="amber" key="Amber" />,
+    <Option text="Black" value="black" key="Black" />,
+    <Option text="Blue" value="blue" key="Blue" />,
+    <Option text="Brown" value="brown" key="Brown" />,
+    <Option text="Green" value="green" key="Green" />,
+  ];
+  const getLazyLoaded = () => {
+    const counter = lazyLoadingCounter.current;
+    return [
+      <Option
+        text={`Lazy Loaded A${counter}`}
+        value={`lazyA${counter}`}
+        key={`lazyA${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded B${counter}`}
+        value={`lazyB${counter}`}
+        key={`lazyB${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded C${counter}`}
+        value={`lazyC${counter}`}
+        key={`lazyC${counter}`}
+      />,
+    ];
+  };
+  const [optionList, setOptionList] = useState<React.ReactElement[]>([]);
+  function onChangeHandler(event: React.ChangeEvent<HTMLInputElement>) {
+    setValue(event.target.value as unknown as string[]);
+  }
+
+  function loadList() {
+    if (preventLoading.current) {
+      return;
+    }
+    preventLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      setIsLoading(false);
+      setOptionList(asyncList);
+    }, 2000);
+  }
+  function onLazyLoading() {
+    if (preventLazyLoading.current) {
+      return;
+    }
+    preventLazyLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      preventLazyLoading.current = false;
+      lazyLoadingCounter.current += 1;
+      setIsLoading(false);
+      setOptionList((prevList) => [...prevList, ...getLazyLoaded()]);
+    }, 2000);
+  }
+  return (
+    <MultiSelect
+      label="color"
+      value={value}
+      onChange={onChangeHandler}
+      onOpen={() => loadList()}
+      isLoading={isLoading}
+      onListScrollBottom={onLazyLoading}
+      {...props}
+    >
+      {optionList}
+    </MultiSelect>
+  );
+};
+
 export const MultiSelectObjectAsValueComponent = (
   props: Partial<MultiSelectProps>,
 ) => {
diff --git a/src/components/select/multi-select/multi-select.component.tsx b/src/components/select/multi-select/multi-select.component.tsx
index 8b2309f6f5..6d2266a305 100644
--- a/src/components/select/multi-select/multi-select.component.tsx
+++ b/src/components/select/multi-select/multi-select.component.tsx
@@ -65,6 +65,8 @@ export interface MultiSelectProps
   onFilterChange?: (filterText: string) => void;
   /** A custom callback for when the dropdown menu opens */
   onOpen?: () => void;
+  /** A callback that is triggered when a user scrolls to the bottom of the list */
+  onListScrollBottom?: () => void;
   /** If true the Component opens on focus */
   openOnFocus?: boolean;
   /** SelectList table header, should consist of multiple th elements.
@@ -124,6 +126,7 @@ export const MultiSelect = React.forwardRef<HTMLInputElement, MultiSelectProps>(
       noResultsMessage,
       placeholder,
       isLoading,
+      onListScrollBottom,
       tableHeader,
       multiColumn,
       tooltipPosition,
@@ -693,6 +696,7 @@ export const MultiSelect = React.forwardRef<HTMLInputElement, MultiSelectProps>(
         highlightedValue={highlightedValue}
         noResultsMessage={noResultsMessage}
         isLoading={isLoading}
+        onListScrollBottom={onListScrollBottom}
         tableHeader={tableHeader}
         multiColumn={multiColumn}
         listPlacement={listWidth !== undefined ? placement : listPlacement}
diff --git a/src/components/select/multi-select/multi-select.mdx b/src/components/select/multi-select/multi-select.mdx
index 7911e4b59c..b4cc952891 100644
--- a/src/components/select/multi-select/multi-select.mdx
+++ b/src/components/select/multi-select/multi-select.mdx
@@ -110,6 +110,13 @@ See [Colors](../?path=/docs/documentation-colors--docs) for more information on
 
 <Canvas of={MultiSelectStories.WithCustomColoredPills} />
 
+### Infinite scroll example
+
+The `isLoading` prop in combination with the `onListScrollBottom` prop can be used to implement infinite scroll.
+This prop will be called every time a user scrolls to the bottom of the list.
+
+<Canvas of={MultiSelectStories.WithInfiniteScroll} />
+
 ### With custom maxWidth
 
 In this example the `maxWidth` prop is 50%.
diff --git a/src/components/select/multi-select/multi-select.pw.tsx b/src/components/select/multi-select/multi-select.pw.tsx
index ecceca4e57..01a6f2d5bf 100644
--- a/src/components/select/multi-select/multi-select.pw.tsx
+++ b/src/components/select/multi-select/multi-select.pw.tsx
@@ -6,6 +6,7 @@ import {
   MultiSelectDefaultValueComponent,
   MultiSelectMaxOptionsComponent,
   MultiSelectWithLazyLoadingComponent,
+  MultiSelectWithInfiniteScrollComponent,
   MultiSelectLazyLoadTwiceComponent,
   MultiSelectObjectAsValueComponent,
   MultiSelectMultiColumnsComponent,
@@ -675,6 +676,58 @@ test.describe("MultiSelect component", () => {
     );
   });
 
+  test("should render a lazy loaded option when the infinite scroll prop is set", async ({
+    mount,
+    page,
+  }) => {
+    await mount(<MultiSelectWithInfiniteScrollComponent />);
+
+    const option = "Lazy Loaded A1";
+    const selectListWrapperElement = selectListWrapper(page);
+    await dropdownButton(page).click();
+    await expect(selectListWrapperElement).toBeVisible();
+    await Promise.all(
+      [0, 1, 2].map((i) => expect(loader(page, i)).toBeVisible()),
+    );
+    await expect(selectOptionByText(page, option)).toHaveCount(0);
+    await page.waitForTimeout(2000);
+    await selectListScrollableWrapper(page).evaluate((wrapper) => {
+      wrapper.scrollBy(0, 500);
+    });
+    await page.waitForTimeout(250);
+    await Promise.all(
+      [0, 1, 2].map((i) => expect(loader(page, i)).not.toBeVisible()),
+    );
+    await expect(await selectOptionByText(page, option)).toBeVisible();
+  });
+
+  test("the list should not change scroll position when the lazy-loaded options appear", async ({
+    mount,
+    page,
+  }) => {
+    await mount(<MultiSelectWithInfiniteScrollComponent />);
+
+    // open the select list and choose an option
+    const inputElement = commonDataElementInputPreview(page);
+    await inputElement.focus();
+    await inputElement.press("ArrowDown");
+    const firstOption = selectOptionByText(page, "Amber");
+    await firstOption.waitFor();
+    await firstOption.click();
+
+    const scrollableWrapper = selectListScrollableWrapper(page);
+    await scrollableWrapper.evaluate((wrapper) => wrapper.scrollBy(0, 500));
+    const scrollPositionBeforeLoad = await scrollableWrapper.evaluate(
+      (element) => element.scrollTop,
+    );
+
+    await selectOptionByText(page, "Lazy Loaded A1").waitFor();
+    const scrollPositionAfterLoad = await scrollableWrapper.evaluate(
+      (element) => element.scrollTop,
+    );
+    await expect(scrollPositionAfterLoad).toBe(scrollPositionBeforeLoad);
+  });
+
   test("should list options when value is set and select list is opened again", async ({
     mount,
     page,
@@ -1260,6 +1313,59 @@ test.describe("Check events for MultiSelect component", () => {
     await expect(callbackArguments.length).toBe(1);
     await expect(callbackArguments[0]).toBe(text);
   });
+
+  test("should call onListScrollBottom event when the list is scrolled to the bottom", async ({
+    mount,
+    page,
+  }) => {
+    let callbackCount = 0;
+    const callback = () => {
+      callbackCount += 1;
+    };
+    await mount(<MultiSelectComponent onListScrollBottom={callback} />);
+
+    await dropdownButton(page).click();
+    await selectListScrollableWrapper(page).evaluate((wrapper) =>
+      wrapper.scrollBy(0, 500),
+    );
+    await page.waitForTimeout(250);
+    await expect(callbackCount).toBe(1);
+  });
+
+  test("should not call onListScrollBottom callback when an option is clicked", async ({
+    mount,
+    page,
+  }) => {
+    let callbackCount = 0;
+    const callback = () => {
+      callbackCount += 1;
+    };
+    await mount(<MultiSelectComponent onListScrollBottom={callback} />);
+
+    await dropdownButton(page).click();
+    await selectOption(page, positionOfElement("first")).click();
+    expect(callbackCount).toBe(0);
+  });
+
+  test("should not be called when an option is clicked and list is re-opened", async ({
+    mount,
+    page,
+  }) => {
+    let callbackCount = 0;
+    const callback = () => {
+      callbackCount += 1;
+    };
+
+    await mount(<MultiSelectComponent onListScrollBottom={callback} />);
+
+    await dropdownButton(page).click();
+    await selectListScrollableWrapper(page).evaluate((wrapper) =>
+      wrapper.scrollBy(0, 500),
+    );
+    await selectOption(page, positionOfElement("first")).click();
+    await dropdownButton(page).click();
+    expect(callbackCount).toBe(1);
+  });
 });
 
 test.describe("Check virtual scrolling", () => {
@@ -1789,6 +1895,22 @@ test.describe("Accessibility tests for MultiSelect component", () => {
     await checkAccessibility(page);
   });
 
+  test("should pass accessibility tests with onListScrollBottom prop", async ({
+    mount,
+    page,
+  }) => {
+    await mount(<MultiSelectWithInfiniteScrollComponent />);
+
+    await dropdownButton(page).click();
+    await checkAccessibility(page);
+    // wait for content to finish loading before scrolling
+    await expect(selectOptionByText(page, "Amber")).toBeVisible();
+    await selectListScrollableWrapper(page).evaluate((wrapper) =>
+      wrapper.scrollBy(0, 500),
+    );
+    await checkAccessibility(page, undefined, "scrollable-region-focusable");
+  });
+
   test("should pass accessibility tests with openOnFocus prop", async ({
     mount,
     page,
diff --git a/src/components/select/multi-select/multi-select.stories.tsx b/src/components/select/multi-select/multi-select.stories.tsx
index b610c1994b..ddb368a757 100644
--- a/src/components/select/multi-select/multi-select.stories.tsx
+++ b/src/components/select/multi-select/multi-select.stories.tsx
@@ -433,6 +433,96 @@ export const WithCustomColoredPills: Story = () => {
 };
 WithCustomColoredPills.storyName = "With Custom Colored Pills";
 
+export const WithInfiniteScroll: Story = () => {
+  const preventLoading = useRef(false);
+  const preventLazyLoading = useRef(false);
+  const lazyLoadingCounter = useRef(0);
+
+  const [value, setValue] = useState<string[]>([]);
+  function onChangeHandler(event: React.ChangeEvent<HTMLInputElement>) {
+    setValue(event.target.value as unknown as string[]);
+  }
+  const [isLoading, setIsLoading] = useState(true);
+  const asyncList = [
+    <Option text="Amber" value="amber" key="Amber" />,
+    <Option text="Black" value="black" key="Black" />,
+    <Option text="Blue" value="blue" key="Blue" />,
+    <Option text="Brown" value="brown" key="Brown" />,
+    <Option text="Green" value="green" key="Green" />,
+  ];
+  const getLazyLoaded = () => {
+    const counter = lazyLoadingCounter.current;
+    return [
+      <Option
+        text={`Lazy Loaded A${counter}`}
+        value={`lazyA${counter}`}
+        key={`lazyA${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded B${counter}`}
+        value={`lazyB${counter}`}
+        key={`lazyB${counter}`}
+      />,
+      <Option
+        text={`Lazy Loaded C${counter}`}
+        value={`lazyC${counter}`}
+        key={`lazyC${counter}`}
+      />,
+    ];
+  };
+  const [optionList, setOptionList] = useState<React.ReactElement[]>([]);
+  function loadList() {
+    if (preventLoading.current) {
+      return;
+    }
+    preventLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      setOptionList(asyncList);
+      setIsLoading(false);
+    }, 2000);
+  }
+  function onLazyLoading() {
+    if (preventLazyLoading.current) {
+      return;
+    }
+    preventLazyLoading.current = true;
+    setIsLoading(true);
+    setTimeout(() => {
+      preventLazyLoading.current = false;
+      lazyLoadingCounter.current += 1;
+      setOptionList((prevList) => [...prevList, ...getLazyLoaded()]);
+      setIsLoading(false);
+    }, 2000);
+  }
+  function clearData() {
+    setOptionList([]);
+    setValue([]);
+    preventLoading.current = false;
+  }
+  return (
+    <Box height={300}>
+      <Button onClick={clearData} mb={2}>
+        reset
+      </Button>
+      <MultiSelect
+        name="infiniteScroll"
+        id="infiniteScroll"
+        label="color"
+        value={value}
+        onChange={onChangeHandler}
+        onOpen={() => loadList()}
+        isLoading={isLoading}
+        onListScrollBottom={onLazyLoading}
+      >
+        {optionList}
+      </MultiSelect>
+    </Box>
+  );
+};
+WithInfiniteScroll.storyName = "With infinite scroll";
+WithInfiniteScroll.parameters = { chromatic: { disableSnapshot: true } };
+
 export const WithCustomMaxWidth: Story = () => {
   return (
     <Box height={250}>
diff --git a/src/components/select/multi-select/multi-select.test.tsx b/src/components/select/multi-select/multi-select.test.tsx
index f3a9618178..546c9bc871 100644
--- a/src/components/select/multi-select/multi-select.test.tsx
+++ b/src/components/select/multi-select/multi-select.test.tsx
@@ -1127,6 +1127,25 @@ test("marks input as required when required prop is true", () => {
   expect(screen.getByRole("combobox")).toBeRequired();
 });
 
+test("should not be call `onListScrollBottom` callback when an option is clicked", async () => {
+  const onListScrollBottomFn = jest.fn();
+  const user = userEvent.setup();
+  render(
+    <MultiSelect
+      onListScrollBottom={onListScrollBottomFn}
+      openOnFocus
+      label="filterable-select"
+      onChange={() => {}}
+    >
+      <Option value="opt1" text="green" />
+    </MultiSelect>,
+  );
+  screen.getByRole("combobox").focus();
+  await user.click(await screen.findByRole("option", { name: "green" }));
+
+  expect(onListScrollBottomFn).not.toHaveBeenCalled();
+});
+
 test("does not call onOpen, when openOnFocus is true and the input is refocused while the dropdown list is already open", async () => {
   const onOpen = jest.fn();
   render(