diff --git a/examples/fava.json b/examples/fava.json index f30206325..3704ea89e 100644 --- a/examples/fava.json +++ b/examples/fava.json @@ -1,9 +1,12 @@ { "title" : "Fava et al, 2002 BR", + "description": "Based on Fava et al. (2002), \"Acute Efficacy of Fluoxetine Versus Sertraline and Paroxetine in Major Depressive Disorder Including Effects of Baseline Insomnia\".", "criteria" : { "ham-d-responders" : { "title" : "HAM-D Responders", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", + "description": "Responders on the HAM-D rating scale", "pvf" : { "direction" : "increasing", "type" : "linear", @@ -13,6 +16,7 @@ "diarrhea" : { "title" : "Diarrhea", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -22,6 +26,7 @@ "dizziness" : { "title" : "Dizziness", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -31,6 +36,7 @@ "headache" : { "title" : "Headache", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -40,6 +46,7 @@ "insomnia" : { "title" : "Insomnia", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -49,6 +56,7 @@ "nausea" : { "title" : "Nausea", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -249,4 +257,4 @@ } } ], "preferences" : { } -} \ No newline at end of file +} diff --git a/examples/hansen.json b/examples/hansen.json index 7b8f5b483..9c9923bf7 100644 --- a/examples/hansen.json +++ b/examples/hansen.json @@ -1,9 +1,12 @@ { "title": "Hansen et al. 2005 with Placebo as baseline", + "description": "Based on Hansen et al. (2005), \"Efficacy and Safety of Second-Generation Antidepressants in the Treatment of Major Depressive Disorder\"", "criteria": { "HAM-D": { "title": "HAM-D", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", + "description": "Responders on the HAM-D rating scale", "pvf": { "direction": "increasing", "type": "linear", @@ -13,6 +16,7 @@ "Diarrhea": { "title": "Diarrhea", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "direction": "decreasing", "type": "linear", @@ -22,6 +26,7 @@ "Dizziness": { "title": "Dizziness", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "direction": "decreasing", "type": "linear", @@ -31,6 +36,7 @@ "Headache": { "title": "Headache", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "direction": "decreasing", "type": "linear", @@ -40,6 +46,7 @@ "Insomnia": { "title": "Insomnia", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "direction": "decreasing", "type": "linear", @@ -49,6 +56,7 @@ "Nausea": { "title": "Nausea", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "direction": "decreasing", "type": "linear", diff --git a/examples/hypertension.json b/examples/hypertension.json index 5e2edc211..020ae86b6 100644 --- a/examples/hypertension.json +++ b/examples/hypertension.json @@ -1,9 +1,12 @@ { - "title" : "Benefit-risk", + "title" : "EMA Edarbi EPAR (hypertension)", + "description": "Case study based on the EMA assessment report on Edarbi for the treatment of hypertension. The pivotal trials were pooled to obtain these results.", "criteria" : { "sbp-mean-trough-clinic-sitting" : { - "title" : "SBP mean trough (clinic, sitting)", + "title" : "Blood pressure", + "description": "Systolic blood pressure (mean trough, clinic, sitting)", "scale": [null, null], + "unitOfMeasurement": "mm Hg", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -12,7 +15,9 @@ }, "non-sae" : { "title" : "Non-SAE", + "description": "Non-serious adverse events", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -21,7 +26,9 @@ }, "sae" : { "title" : "SAE", + "description": "Serious adverse events", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf" : { "direction" : "decreasing", "type" : "linear", @@ -138,4 +145,4 @@ } } ], "preferences" : { } -} \ No newline at end of file +} diff --git a/examples/nemeroff-exact.json b/examples/nemeroff-exact.json index e0ae55df8..246cf6487 100644 --- a/examples/nemeroff-exact.json +++ b/examples/nemeroff-exact.json @@ -1,8 +1,11 @@ { "title": "Nemeroff and Thase anti-depressants Example", + "description": "Based on C.B. Nemeroff & M.E. Thase (2007), \"A double-blind, placebo-controlled comparison of venlafaxine and fluoxetine treatment in depressed outpatients\".", "criteria": { "response": { "title": "Treatment Responders", + "unitOfMeasurement": "Proportion", + "description": "Patients responding to treatment (50% or greater decrease on the HAM-D-21 rating scale)", "scale": [0.0, 1.0], "pvf": { "range": [0.28, 0.63], @@ -13,6 +16,7 @@ "nausea": { "title": "Nausea ADRs", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "range": [0.04, 0.50], "direction": "decreasing", @@ -22,6 +26,7 @@ "insomnia": { "title": "Insomnia ADRs", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "range": [0.08, 0.31], "direction": "decreasing", @@ -31,6 +36,7 @@ "anxiety": { "title": "Anxiety ADRs", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "range": [0.00, 0.17], "direction": "decreasing", diff --git a/examples/nemeroff.json b/examples/nemeroff.json index d266437fc..3b499d93c 100644 --- a/examples/nemeroff.json +++ b/examples/nemeroff.json @@ -1,9 +1,12 @@ { "title": "Nemeroff and Thase anti-depressants Example", + "description": "Based on C.B. Nemeroff & M.E. Thase (2007), \"A double-blind, placebo-controlled comparison of venlafaxine and fluoxetine treatment in depressed outpatients\".", "criteria": { "response": { "title": "Treatment Responders", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", + "description": "Patients responding to treatment (50% or greater decrease on the HAM-D-21 rating scale)", "pvf": { "range": [0.28, 0.63], "direction": "increasing", @@ -13,6 +16,7 @@ "nausea": { "title": "Nausea ADRs", "scale": [0.0, 1.0], + "unitOfMeasurement": "Proportion", "pvf": { "range": [0.04, 0.50], "direction": "decreasing", @@ -21,6 +25,7 @@ }, "insomnia": { "title": "Insomnia ADRs", + "unitOfMeasurement": "Proportion", "scale": [0.0, 1.0], "pvf": { "range": [0.08, 0.31], @@ -30,6 +35,7 @@ }, "anxiety": { "title": "Anxiety ADRs", + "unitOfMeasurement": "Proportion", "scale": [0.0, 1.0], "pvf": { "range": [0.00, 0.17], diff --git a/examples/rimonabant.json b/examples/rimonabant.json index dd974aac6..3b2b2d3a5 100644 --- a/examples/rimonabant.json +++ b/examples/rimonabant.json @@ -1,6 +1,6 @@ { "title": "Rimonabant in type 2 diabetes patients", - "description": "Indication: the use of rimonabant as an add-on therapy to an established first-line oral glucose control therapy.\nPatient population: overweight or obese patients with type 2 diabetes mellitus already on metforin or sulphonylurea monotherapy.\nDecision that needs to be taken: marketing authorization", + "description": "Indication: the use of rimonabant as an add-on therapy to an established first-line oral glucose control therapy.\nPatient population: overweight or obese patients with type 2 diabetes mellitus already on metforin or sulphonylurea monotherapy.\nDecision that needs to be taken: marketing authorization.", "criteria": { "Hypo": { "title": "Hypoglyceamia", @@ -17,7 +17,7 @@ "title": "Fasting glucose", "description": "Change in fasting glucose concentrations from baseline.", "unitOfMeasurement": "mmol/L", - "scale": [-5, 3], + "scale": [null, null], "pvf": { "range": [-2, 2], "type": "linear", @@ -28,7 +28,7 @@ "title": "SBP", "description": "Change in systolic blood pressure from baseline.", "unitOfMeasurement": "mm Hg", - "scale": [-30, 10], + "scale": [null, null], "pvf": { "range": [-10, 5], "type": "linear", @@ -39,7 +39,7 @@ "title": "HDL cholesterol", "description": "Change in HDL cholesterol from baseline.", "unitOfMeasurement": "mmol/L", - "scale": [-2, 2], + "scale": [null, null], "pvf": { "range": [0.0, 1.0], "type": "linear", @@ -61,7 +61,7 @@ "title": "Waist circumference", "description": "Change in waist circumference from baseline.", "unitOfMeasurement": "cm", - "scale": [-15, 5], + "scale": [null, null], "pvf": { "range": [-10, 0], "type": "linear",