Discrimination of similar TF motifs in SCENIC #331
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Dyrian525
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* General SCENIC questions
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One transcription factor that appears in my analysis is LHX3, however it has been documented that the protein shows high similarity for its sibling protein LHX4. I've been trying to discern from the motif database how similar the targets for each of these might be and whether misassignment of motifs to one gene over the other could be occurring.
Does anyone have further info on target motifs of highly similar proteins, whether SCENIC takes that into account in any way, or whether I need to err on the side of caution and allow that it could be both TFs contributing to this regulon as long as they both are present in similar gene expression patterns?
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