diff --git a/CHANGELOG b/CHANGELOG index 928f26c2..d55ffc64 100644 --- a/CHANGELOG +++ b/CHANGELOG @@ -1,3 +1,16 @@ +v1.4.5: + * Fieldbioinformatics now supports rapid barcoded (fragmented) primer trimming and normalisation + * Nanopolish has been removed completely due to several compatibility issues + * Medaka has also been removed completely due to kicking out long indels in a way that cannot be changed. + * Clair3 is now the default variant caller, by default only the r9.4.1 models are available but a artic_get_models command has been added which will fetch the ONT created r10.4.1 models listed in the rerio repository. + * The pipeline will also attempt to pick an appropriate model based on the basecall_model_version_id field that is added to read headers by default by ONT sequencers. + * Removed longshot entirely, it also kicks out long variants and is now unnecessary due to clair3 being a much better variant caller. + * Primer scheme fetcher has been updated to pull from the quick-lab primal hub schemes repository. For schemes not available in this repository you may provide them directly with the arguments --bed and --ref. + * Automated docker builds pushing to quay.io for use in nextflow pipelines etc. + * Remove some old functionality which is no longer relevant (basecalling, gather, etc) + * Re-implement CI as a gh action. + * Fix the overlapping variants issue by normalising variants against the pre-consensus using bcftools norm. + v1.1.0-rc1: * Support for read groups: * Support ‘pool’ read groups taken from BED file, e.g.: diff --git a/README.md b/README.md index a2d5cf9a..bb72296d 100644 --- a/README.md +++ b/README.md @@ -25,8 +25,6 @@ Features include: - variant calling - consensus building -There are **2 workflows** baked into this pipeline, one which uses signal data (via [nanopolish](https://github.com/jts/nanopolish)) and one that does not (via [medaka](https://github.com/nanoporetech/medaka)). -