diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 3046be99..0c10d0c8 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -7,6 +7,7 @@ TBD
 
 - Add support to change the Exchange Type for RabbitMQ. Default is 'topic', 
   but options like 'fanout' can now be supported
+- Better handling of Pika errors
 
 3.22.0
 ------
diff --git a/brewtils/pika.py b/brewtils/pika.py
index 2a6b6b7b..a8b59fad 100644
--- a/brewtils/pika.py
+++ b/brewtils/pika.py
@@ -14,7 +14,7 @@
     SSLOptions,
     URLParameters,
 )
-from pika.exceptions import AMQPError
+from pika.exceptions import AMQPError, ConnectionWrongStateError
 from pika.spec import PERSISTENT_DELIVERY_MODE
 
 from brewtils.errors import DiscardMessageException, RepublishRequestException
@@ -305,26 +305,29 @@ def run(self):
             None
         """
         while not self._panic_event.is_set():
-            self._connection = self.open_connection()
-            self._connection.ioloop.start()
-
-            if not self._panic_event.is_set():
-                if 0 <= self._max_reconnect_attempts <= self._reconnect_attempt:
-                    self.logger.warning("Max connection failures, shutting down")
-                    self._panic_event.set()
-                    return
-
-                self.logger.warning(
-                    "%s consumer has died, waiting %i seconds before reconnecting",
-                    self._queue_name,
-                    self._reconnect_timeout,
-                )
-                self._panic_event.wait(self._reconnect_timeout)
+            try:
+                self._connection = self.open_connection()
+                self._connection.ioloop.start()
+
+                if not self._panic_event.is_set():
+                    if 0 <= self._max_reconnect_attempts <= self._reconnect_attempt:
+                        self.logger.warning("Max connection failures, shutting down")
+                        self._panic_event.set()
+                        return
+
+                    self.logger.warning(
+                        "%s consumer has died, waiting %i seconds before reconnecting",
+                        self._queue_name,
+                        self._reconnect_timeout,
+                    )
+                    self._panic_event.wait(self._reconnect_timeout)
 
-                self._reconnect_attempt += 1
-                self._reconnect_timeout = min(
-                    self._reconnect_timeout * 2, self._max_reconnect_timeout
-                )
+                    self._reconnect_attempt += 1
+                    self._reconnect_timeout = min(
+                        self._reconnect_timeout * 2, self._max_reconnect_timeout
+                    )
+            except ConnectionWrongStateError as ex:
+                self.logger.error("Error running consumer IO-loop: %s", ex)
 
     def stop(self):
         """Cleanly shutdown
@@ -566,7 +569,10 @@ def on_connection_closed(self, connection, *args):
     def open_channel(self):
         """Open a channel"""
         self.logger.debug("Opening a new channel")
-        self._connection.channel(on_open_callback=self.on_channel_open)
+        try:
+            self._connection.channel(on_open_callback=self.on_channel_open)
+        except ConnectionWrongStateError as ex:
+            self.logger.error("Failure opening channel to consume messages: %s", ex)
 
     def on_channel_open(self, channel):
         """Channel open success callback