diff --git a/databroker/experimental/server_ext.py b/databroker/experimental/server_ext.py
index f085bc5ba..f1e16b76a 100644
--- a/databroker/experimental/server_ext.py
+++ b/databroker/experimental/server_ext.py
@@ -19,6 +19,9 @@
     Comparison,
     Eq,
     FullText,
+    In,
+    NotEq,
+    NotIn,
     Operator,
     Regex,
 )
@@ -435,6 +438,10 @@ def eq(query, catalog):
     return catalog.apply_mongo_query({f"metadata.{query.key}": query.value})
 
 
+def noteq(query, catalog):
+    return catalog.apply_mongo_query({f"metadata.{query.key}": {"$ne": query.value}})
+
+
 def regex(query, catalog):
     options = "" if query.case_sensitive else "i"
     return catalog.apply_mongo_query(
@@ -442,6 +449,18 @@ def regex(query, catalog):
     )
 
 
+def _in(query, catalog):
+    if not isinstance(query.value, list):
+        query.value = [query.value]
+    return catalog.apply_mongo_query({f"metadata.{query.key}": {"$in": query.value}})
+
+
+def notin(query, catalog):
+    if not isinstance(query.value, list):
+        query.value = [query.value]
+    return catalog.apply_mongo_query({f"metadata.{query.key}": {"$nin": query.value}})
+
+
 def full_text_search(query, catalog):
     # First if this catalog is backed by mongomock, which does not support $text queries.
     # Avoid importing mongomock if it is not already imported.
@@ -463,5 +482,8 @@ def full_text_search(query, catalog):
 MongoAdapter.register_query(Contains, contains)
 MongoAdapter.register_query(Comparison, comparison)
 MongoAdapter.register_query(Eq, eq)
-MongoAdapter.register_query(FullText, full_text_search)
+MongoAdapter.register_query(NotEq, noteq)
 MongoAdapter.register_query(Regex, regex)
+MongoAdapter.register_query(In, _in)
+MongoAdapter.register_query(NotIn, notin)
+MongoAdapter.register_query(FullText, full_text_search)
diff --git a/databroker/tests/test_experimental.py b/databroker/tests/test_experimental.py
index e61e2a0f1..1fa21cd96 100644
--- a/databroker/tests/test_experimental.py
+++ b/databroker/tests/test_experimental.py
@@ -1,5 +1,15 @@
 from tiled.client import from_tree
-from tiled.queries import Contains, Comparison, Eq, FullText, Key, Regex
+from tiled.queries import (
+    Contains,
+    Comparison,
+    Eq,
+    FullText,
+    In,
+    Key,
+    NotEq,
+    NotIn,
+    Regex,
+)
 
 from ..experimental.server_ext import MongoAdapter
 
@@ -98,3 +108,18 @@ def test_queries(tmpdir):
     numpy.testing.assert_equal(
         test5.values()[0].read(), test5.values()[0].metadata["number"] * numpy.ones(10)
     )
+    test6 = client.search(NotEq("letter", "a"))
+    # The first result should not be "a"
+    assert test6.values()[0].metadata["letter"] != "a"
+
+    test7 = client.search(In("letter", ["a", "b"]))
+    numpy.testing.assert_equal(
+        test7.values()[0].read(), test7.values()[0].metadata["number"] * numpy.ones(10)
+    )
+    numpy.testing.assert_equal(
+        test7.values()[1].read(), test7.values()[1].metadata["number"] * numpy.ones(10)
+    )
+
+    test8 = client.search(NotIn("letter", ["a"]))
+    # The first result should not be "a"
+    assert test8.values()[0].metadata["letter"] != "a"