diff --git a/src/josepy/json_util.py b/src/josepy/json_util.py
index ed4e4811..733ca0fc 100644
--- a/src/josepy/json_util.py
+++ b/src/josepy/json_util.py
@@ -10,6 +10,7 @@
 import abc
 import binascii
 import logging
+import warnings
 from typing import (
     Any,
     Callable,
@@ -20,8 +21,11 @@
     Optional,
     Type,
     TypeVar,
+    Union,
 )
 
+from cryptography import x509
+from cryptography.hazmat.primitives.serialization import Encoding
 from OpenSSL import crypto
 
 from josepy import b64, errors, interfaces, util
@@ -426,26 +430,41 @@ def decode_hex16(value: str, size: Optional[int] = None, minimum: bool = False)
         raise errors.DeserializationError(error)
 
 
-def encode_cert(cert: util.ComparableX509) -> str:
+def encode_cert(cert: Union[util.ComparableX509, x509.Certificate]) -> str:
     """Encode certificate as JOSE Base-64 DER.
 
-    :type cert: `OpenSSL.crypto.X509` wrapped in `.ComparableX509`
+    :type cert: `cryptography.x509.Certificate`
+        or `OpenSSL.crypto.X509` wrapped in `.ComparableX509`
     :rtype: unicode
-
     """
-    if isinstance(cert.wrapped, crypto.X509Req):
-        raise ValueError("Error input is actually a certificate request.")
-
-    return encode_b64jose(crypto.dump_certificate(crypto.FILETYPE_ASN1, cert.wrapped))
+    if isinstance(cert, util.ComparableX509):
+        # DEPRECATED; remove this in major release
+        warnings.warn(
+            "`josepy.json_util.encode_cert` has deprecated support for accepting "
+            "util.ComparableX509 objects, and support will be dropped in the next major release. "
+            "Please use `cryptography.x509.Certificate` objects instead.",
+            DeprecationWarning,
+        )
+        if isinstance(cert.wrapped, crypto.X509Req):
+            raise ValueError("Error input is actually a certificate request.")
+        return encode_b64jose(crypto.dump_certificate(crypto.FILETYPE_ASN1, cert.wrapped))
+    assert isinstance(cert, x509.Certificate)
+    return encode_b64jose(cert.public_bytes(Encoding.DER))
 
 
 def decode_cert(b64der: str) -> util.ComparableX509:
-    """Decode JOSE Base-64 DER-encoded certificate.
+    """Decode JOSE Base-64 DER-encoded certificate. Deprecated as of 1.15.0 and will be
+        removed in 2.0.0.
 
     :param unicode b64der:
     :rtype: `OpenSSL.crypto.X509` wrapped in `.ComparableX509`
 
     """
+    warnings.warn(
+        "`josepy.json_util.decode_cert` is deprecated, and will be removed in the next major "
+        "release. Please use `josepy.json_util.decode_cert_cryptography instead.",
+        DeprecationWarning,
+    )
     try:
         return util.ComparableX509(
             crypto.load_certificate(crypto.FILETYPE_ASN1, decode_b64jose(b64der))
@@ -454,10 +473,23 @@ def decode_cert(b64der: str) -> util.ComparableX509:
         raise errors.DeserializationError(error)
 
 
-def encode_csr(csr: util.ComparableX509) -> str:
+def decode_cert_cryptography(b64der: str) -> x509.Certificate:
+    """Decode JOSE Base-64 DER-encoded certificate.
+
+    :param unicode b64der:
+    :rtype: `cryptography.x509.Certificate`
+    """
+    try:
+        return x509.load_der_x509_certificate(decode_b64jose(b64der))
+    except Exception as error:
+        raise errors.DeserializationError(error)
+
+
+def encode_csr(csr: Union[util.ComparableX509, x509.CertificateSigningRequest]) -> str:
     """Encode CSR as JOSE Base-64 DER.
 
-    :type csr: `OpenSSL.crypto.X509Req` wrapped in `.ComparableX509`
+    :type csr: `cryptography.x509.CertificateSigningRequest`
+        or `OpenSSL.crypto.X509` wrapped in `.ComparableX509`
     :rtype: unicode
 
     """
@@ -466,14 +498,33 @@ def encode_csr(csr: util.ComparableX509) -> str:
 
     return encode_b64jose(crypto.dump_certificate_request(crypto.FILETYPE_ASN1, csr.wrapped))
 
+    if isinstance(csr, util.ComparableX509):
+        # DEPRECATED; remove this in major release
+        warnings.warn(
+            "`josepy.json_util.encode_csr` has deprecated support for accepting "
+            "util.ComparableX509 objects, and support will be dropped in the next major release. "
+            "Please use `cryptography.x509.CertificateSigningRequest` objects instead.",
+            DeprecationWarning,
+        )
+        if isinstance(csr.wrapped_new, x509.Certificate):
+            raise ValueError("Error input is actually a certificate.")
+        return encode_b64jose(crypto.dump_certificate_request(crypto.FILETYPE_ASN1, csr.wrapped))
+    assert isinstance(csr, x509.CertificateSigningRequest)
+    return encode_b64jose(csr.public_bytes(Encoding.DER))
+
 
 def decode_csr(b64der: str) -> util.ComparableX509:
-    """Decode JOSE Base-64 DER-encoded CSR.
+    """Decode JOSE Base-64 DER-encoded CSR. Deprecated as of 1.15.0 and will be removed in 2.0.0.
 
     :param unicode b64der:
     :rtype: `OpenSSL.crypto.X509Req` wrapped in `.ComparableX509`
 
     """
+    warnings.warn(
+        "`josepy.json_util.decode_csr` is deprecated, and will be removed in the next major "
+        "release. Please use `josepy.json_util.decode_csr_cryptography instead.",
+        DeprecationWarning,
+    )
     try:
         return util.ComparableX509(
             crypto.load_certificate_request(crypto.FILETYPE_ASN1, decode_b64jose(b64der))
@@ -482,6 +533,19 @@ def decode_csr(b64der: str) -> util.ComparableX509:
         raise errors.DeserializationError(error)
 
 
+def decode_csr_cryptography(b64der: str) -> x509.CertificateSigningRequest:
+    """Decode JOSE Base-64 DER-encoded CSR.
+
+    :param unicode b64der:
+    :rtype: `cryptography.x509.CertificateSigningRequest`
+
+    """
+    try:
+        return x509.load_der_x509_csr(decode_b64jose(b64der))
+    except Exception as error:
+        raise errors.DeserializationError(error)
+
+
 GenericTypedJSONObjectWithFields = TypeVar(
     "GenericTypedJSONObjectWithFields", bound="TypedJSONObjectWithFields"
 )