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Unable to Look up TPMT recommendations with keys for 16/1 and 1/1 . #41

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davidyuyuan opened this issue Jul 23, 2024 · 2 comments

davidyuyuan commented Jul 23, 2024 •

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Similar to issue 40, https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={"TPMT": {"*16": 1, "*1": 1}}&drugname=in.(azathioprine,mercaptopurine,thioguanine)&order=drugname yields an empty Json response '[]'. So was with the key for *1/*1.

According to https://cpicpgx.org/guidelines/guideline-for-thiopurines-and-tpmt/, TPMT does have a TPMT diplotype-phenotype table. Both *1/*1 and *1/*16 have diplotype and phenotype mapping defined in the spreadsheet.

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davidyuyuan commented Oct 24, 2024

I was wondering if there is any update on this. https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={"TPMT": {"*1": 1, "*3C": 1}} returns an empty Json as well.

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davidyuyuan commented Oct 24, 2024

I also noticed https://api.cpicpgx.org/v1/rpc/recommendation_lookup?diplotypelookup={"NUDT15": {"*1": 1, "*3": 1}} returns an empty Json. Similarly, NUDT15 diplotype-phenotype table is in the guidelines of NUDT15.

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