From 30518ac9179b6c8bbf7dba2a183346fb5c0da92c Mon Sep 17 00:00:00 2001 From: Jim Balhoff Date: Tue, 3 Dec 2024 21:27:31 -0500 Subject: [PATCH] Add Reactome pathways xrefs to ontology (#29174) * Update committed version of Reactome reactions xrefs. * WIP Reactome pathways xrefs. * Add Reactome pathways xrefs to ontology. Update committed import file. --- src/ontology/Makefile | 7 +- .../imports/reactome_xrefs_import.owl | 8875 ++++++++++++++++- 2 files changed, 8679 insertions(+), 203 deletions(-) diff --git a/src/ontology/Makefile b/src/ontology/Makefile index a31821d53e..e3675599db 100644 --- a/src/ontology/Makefile +++ b/src/ontology/Makefile @@ -177,10 +177,15 @@ change-report.txt: $(SRC) $(PREVIOUS) imports/reactome_xrefs_import.owl: $(SRC) mkdir -p reactome-tmp wget -O reactome-tmp/Reactions2GoTerms_human.txt --no-check-certificate https://reactome.org/download/current/Reactions2GoTerms_human.txt + wget -O reactome-tmp/Pathways2GoTerms_human.txt --no-check-certificate https://github.com/user-attachments/files/17652333/Pathways2GoTerms_human.txt sed -i '1s/.*/Identifier\tName\tdefined_class/' reactome-tmp/Reactions2GoTerms_human.txt + sed -i '1d' reactome-tmp/Pathways2GoTerms_human.txt perl -i.bak -pe 's/[^[:ascii:]]//g' reactome-tmp/Reactions2GoTerms_human.txt + perl -i.bak -pe 's/[^[:ascii:]]//g' reactome-tmp/Pathways2GoTerms_human.txt + cat reactome-tmp/Reactions2GoTerms_human.txt reactome-tmp/Pathways2GoTerms_human.txt >reactome-tmp/combined.txt rm reactome-tmp/Reactions2GoTerms_human.txt.bak - $(DOSDP_TOOLS) generate --template=xref_dosdp_yaml/reactome_xref.yaml --infile=reactome-tmp/Reactions2GoTerms_human.txt --outfile=reactome-tmp/reactome_xrefs.ofn --obo-prefixes=true + rm reactome-tmp/Pathways2GoTerms_human.txt.bak + $(DOSDP_TOOLS) generate --template=xref_dosdp_yaml/reactome_xref.yaml --infile=reactome-tmp/combined.txt --outfile=reactome-tmp/reactome_xrefs.ofn --obo-prefixes=true $(ROBOT) convert --input reactome-tmp/reactome_xrefs.ofn --output imports/reactome_xrefs_import.owl annotate --ontology-iri $(BASE)/imports/reactome_xrefs_import.owl -V $(RELEASE_URIBASE)/$@ -o $@ # Remove reactome_xrefs_import.owl and go_taxon_constraints.owl from imports. These are merged in directly in enhanced.owl diff --git a/src/ontology/imports/reactome_xrefs_import.owl b/src/ontology/imports/reactome_xrefs_import.owl index 3403eb98a2..e7155f0ad0 100644 --- a/src/ontology/imports/reactome_xrefs_import.owl +++ b/src/ontology/imports/reactome_xrefs_import.owl @@ -8,7 +8,7 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + @@ -176,6 +176,15 @@ Reactome:R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA + + Reactome:R-HSA-70635 + + + + + Reactome:R-HSA-70635 + Urea cycle + Reactome:R-HSA-8848247 @@ -194,6 +203,60 @@ Reactome:R-HSA-70634 ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) + + Reactome:R-HSA-2500257 + + + + + Reactome:R-HSA-2500257 + Resolution of Sister Chromatid Cohesion + + + Reactome:R-HSA-69620 + + + + + Reactome:R-HSA-69620 + Cell Cycle Checkpoints + + + Reactome:R-HSA-69236 + + + + + Reactome:R-HSA-69236 + G1 Phase + + + Reactome:R-HSA-69206 + + + + + Reactome:R-HSA-69206 + G1/S Transition + + + Reactome:R-HSA-69275 + + + + + Reactome:R-HSA-69275 + G2/M Transition + + + Reactome:R-HSA-68886 + + + + + Reactome:R-HSA-68886 + M Phase + Reactome:R-HSA-8855062 @@ -203,6 +266,40 @@ Reactome:R-HSA-8855062 SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy + + Reactome:R-HSA-1614635 + + + + + Reactome:R-HSA-1614635 + Sulfur amino acid metabolism + + + Reactome:R-HSA-1614558 + + + + + Reactome:R-HSA-1614558 + Degradation of cysteine and homocysteine + + + Reactome:R-HSA-2173795 + Reactome:R-HSA-8866904 + + + + + Reactome:R-HSA-2173795 + Downregulation of SMAD2/3:SMAD4 transcriptional activity + + + + + Reactome:R-HSA-8866904 + Negative regulation of activity of TFAP2 (AP-2) family transcription factors + Reactome:R-HSA-75883 @@ -365,6 +462,38 @@ Reactome:R-HSA-912458 Formation of meiotic heteroduplex + + Reactome:R-HSA-6790901 + Reactome:R-HSA-6793080 + + + + + Reactome:R-HSA-6790901 + rRNA modification in the nucleus and cytosol + + + + + Reactome:R-HSA-6793080 + rRNA modification in the mitochondrion + + + Reactome:R-HSA-169893 + Reactome:R-HSA-5673001 + + + + + Reactome:R-HSA-169893 + Prolonged ERK activation events + + + + + Reactome:R-HSA-5673001 + RAF/MAP kinase cascade + Reactome:R-HSA-428260 @@ -448,6 +577,40 @@ Reactome:R-HSA-6793066 TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 + + Reactome:R-HSA-427359 + Reactome:R-HSA-427413 + + + + + Reactome:R-HSA-427359 + SIRT1 negatively regulates rRNA expression + + + + + Reactome:R-HSA-427413 + NoRC negatively regulates rRNA expression + + + Reactome:R-HSA-927802 + + + + + Reactome:R-HSA-927802 + Nonsense-Mediated Decay (NMD) + + + Reactome:R-HSA-983168 + + + + + Reactome:R-HSA-983168 + Antigen processing: Ubiquitination & Proteasome degradation + Reactome:R-HSA-8850594 @@ -466,6 +629,15 @@ Reactome:R-HSA-162857 N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate + + Reactome:R-HSA-68877 + + + + + Reactome:R-HSA-68877 + Mitotic Prometaphase + Reactome:R-HSA-195664 Reactome:R-HSA-6807053 @@ -539,6 +711,24 @@ Reactome:R-HSA-194669 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol + + Reactome:R-HSA-69278 + + + + + Reactome:R-HSA-69278 + Cell Cycle, Mitotic + + + Reactome:R-HSA-68884 + + + + + Reactome:R-HSA-68884 + Mitotic Telophase/Cytokinesis + Reactome:R-HSA-1675910 Reactome:R-HSA-1675921 @@ -569,6 +759,24 @@ Reactome:R-HSA-1676168 PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane + + Reactome:R-HSA-429914 + + + + + Reactome:R-HSA-429914 + Deadenylation-dependent mRNA decay + + + Reactome:R-HSA-429947 + + + + + Reactome:R-HSA-429947 + Deadenylation of mRNA + Reactome:R-HSA-389652 @@ -605,6 +813,49 @@ Reactome:R-HSA-9770236 Formation of the Spliceosomal P complex and exon ligation + + Reactome:R-HSA-191859 + + + + + Reactome:R-HSA-191859 + snRNP Assembly + + + Reactome:R-HSA-72163 + Reactome:R-HSA-72165 + + + + + Reactome:R-HSA-72165 + mRNA Splicing - Minor Pathway + + + + + Reactome:R-HSA-72163 + mRNA Splicing - Major Pathway + + + Reactome:R-HSA-5205647 + + + + + Reactome:R-HSA-5205647 + Mitophagy + + + Reactome:R-HSA-9664873 + + + + + Reactome:R-HSA-9664873 + Pexophagy + Reactome:R-HSA-110224 Reactome:R-HSA-110226 @@ -628,6 +879,33 @@ Reactome:R-HSA-110227 Cleavage of dihydrouracil by NTHL1 glycosylase + + Reactome:R-HSA-5696394 + + + + + Reactome:R-HSA-5696394 + DNA Damage Recognition in GG-NER + + + Reactome:R-HSA-157579 + + + + + Reactome:R-HSA-157579 + Telomere Maintenance + + + Reactome:R-HSA-5693538 + + + + + Reactome:R-HSA-5693538 + Homology Directed Repair + Reactome:R-HSA-5252079 @@ -726,6 +1004,15 @@ Reactome:R-HSA-5690886 ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs + + Reactome:R-HSA-9836573 + + + + + Reactome:R-HSA-9836573 + Mitochondrial RNA degradation + Reactome:R-HSA-6814549 Reactome:R-HSA-6814559 @@ -795,6 +1082,15 @@ Reactome:R-HSA-9856604 MLXIPL:MLX binds AGPAT1 gene promoter + + Reactome:R-HSA-112313 + + + + + Reactome:R-HSA-112313 + Neurotransmitter uptake and metabolism In glial cells + Reactome:R-HSA-8936519 @@ -809,6 +1105,12 @@ Reactome:R-HSA-3656269 Reactome:R-HSA-6786012 + + + + Reactome:R-HSA-2046222 + CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG + @@ -821,11 +1123,28 @@ Reactome:R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins + + Reactome:R-HSA-2187335 + Reactome:R-HSA-2453902 + Reactome:R-HSA-975634 + - + - Reactome:R-HSA-2046222 - CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG + Reactome:R-HSA-2187335 + The retinoid cycle in cones (daylight vision) + + + + + Reactome:R-HSA-2453902 + The canonical retinoid cycle in rods (twilight vision) + + + + + Reactome:R-HSA-975634 + Retinoid metabolism and transport Reactome:R-HSA-2022063 @@ -850,6 +1169,15 @@ Reactome:R-HSA-6786034 CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin + + Reactome:R-HSA-389599 + + + + + Reactome:R-HSA-389599 + Alpha-oxidation of phytanate + Reactome:R-HSA-500717 @@ -898,6 +1226,15 @@ Reactome:R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol + + Reactome:R-HSA-9823730 + + + + + Reactome:R-HSA-9823730 + Formation of definitive endoderm + Reactome:R-HSA-2160492 @@ -973,6 +1310,15 @@ Reactome:R-HSA-72095 Internal Methylation of mRNA + + Reactome:R-HSA-9824272 + + + + + Reactome:R-HSA-9824272 + Somitogenesis + Reactome:R-HSA-5362522 Reactome:R-HSA-5696101 @@ -989,6 +1335,97 @@ Reactome:R-HSA-5696101 ALDH8A1 oxidises 9cRAL to 9cRA + + Reactome:R-HSA-9830369 + + + + + Reactome:R-HSA-9830369 + Kidney development + + + Reactome:R-HSA-9758919 + + + + + Reactome:R-HSA-9758919 + Epithelial-Mesenchymal Transition (EMT) during gastrulation + + + Reactome:R-HSA-166662 + + + + + Reactome:R-HSA-166662 + Lectin pathway of complement activation + + + Reactome:R-HSA-2408499 + Reactome:R-HSA-2408508 + Reactome:R-HSA-2408550 + Reactome:R-HSA-2408552 + Reactome:R-HSA-5263617 + + + + + Reactome:R-HSA-2408499 + Formation of selenosugars for excretion + + + + + Reactome:R-HSA-2408508 + Metabolism of ingested SeMet, Sec, MeSec into H2Se + + + + + Reactome:R-HSA-2408550 + Metabolism of ingested H2SeO4 and H2SeO3 into H2Se + + + + + Reactome:R-HSA-2408552 + Methylation of MeSeH for excretion + + + + + Reactome:R-HSA-5263617 + Metabolism of ingested MeSeO2H into MeSeH + + + Reactome:R-HSA-9637698 + + + + + Reactome:R-HSA-9637698 + Phagocyte cell death caused by cytosolic Mtb + + + Reactome:R-HSA-8939247 + + + + + Reactome:R-HSA-8939247 + RUNX1 regulates transcription of genes involved in interleukin signaling + + + Reactome:R-HSA-2022377 + + + + + Reactome:R-HSA-2022377 + Metabolism of Angiotensinogen to Angiotensins + Reactome:R-HSA-1297354 @@ -1016,6 +1453,154 @@ Reactome:R-HSA-9836998 GRSF1 unwinds quadruplex G regions in RNA + + Reactome:R-HSA-5621481 + + + + + Reactome:R-HSA-5621481 + C-type lectin receptors (CLRs) + + + Reactome:R-HSA-168898 + + + + + Reactome:R-HSA-168898 + Toll-like Receptor Cascades + + + Reactome:R-HSA-1280218 + + + + + Reactome:R-HSA-1280218 + Adaptive Immune System + + + Reactome:R-HSA-983169 + + + + + Reactome:R-HSA-983169 + Class I MHC mediated antigen processing & presentation + + + Reactome:R-HSA-1236973 + Reactome:R-HSA-1236974 + Reactome:R-HSA-1236978 + + + + + Reactome:R-HSA-1236973 + Cross-presentation of particulate exogenous antigens (phagosomes) + + + + + Reactome:R-HSA-1236974 + ER-Phagosome pathway + + + + + Reactome:R-HSA-1236978 + Cross-presentation of soluble exogenous antigens (endosomes) + + + Reactome:R-HSA-1236977 + + + + + Reactome:R-HSA-1236977 + Endosomal/Vacuolar pathway + + + Reactome:R-HSA-114608 + + + + + Reactome:R-HSA-114608 + Platelet degranulation + + + Reactome:R-HSA-9645460 + + + + + Reactome:R-HSA-9645460 + Alpha-protein kinase 1 signaling pathway + + + Reactome:R-HSA-166058 + Reactome:R-HSA-975871 + + + + + Reactome:R-HSA-166058 + MyD88:MAL(TIRAP) cascade initiated on plasma membrane + + + + + Reactome:R-HSA-975871 + MyD88 cascade initiated on plasma membrane + + + Reactome:R-HSA-166166 + Reactome:R-HSA-168927 + + + + + Reactome:R-HSA-166166 + MyD88-independent TLR4 cascade + + + + + Reactome:R-HSA-168927 + TICAM1, RIP1-mediated IKK complex recruitment + + + Reactome:R-HSA-9660821 + Reactome:R-HSA-9662834 + Reactome:R-HSA-9664323 + Reactome:R-HSA-9664535 + + + + + Reactome:R-HSA-9660821 + ADORA2B mediated anti-inflammatory cytokines production + + + + + Reactome:R-HSA-9662834 + CD163 mediating an anti-inflammatory response + + + + + Reactome:R-HSA-9664323 + FCGR3A-mediated IL10 synthesis + + + + + Reactome:R-HSA-9664535 + LTC4-CYSLTR mediated IL4 production + Reactome:R-HSA-8959462 @@ -1025,6 +1610,24 @@ Reactome:R-HSA-8959462 SAMD8 transfers phosphatidyl from PE onto C16DH CER + + Reactome:R-HSA-432040 + + + + + Reactome:R-HSA-432040 + Vasopressin regulates renal water homeostasis via Aquaporins + + + Reactome:R-HSA-9725554 + + + + + Reactome:R-HSA-9725554 + Differentiation of keratinocytes in interfollicular epidermis in mammalian skin + Reactome:R-HSA-5693589 @@ -6975,180 +7578,6 @@ Reactome:R-HSA-9840564 Reactome:R-HSA-9844241 - - - - Reactome:R-HSA-8949668 - YME1L1 proteolyzes unassembled proSMDT1 - - - - - Reactome:R-HSA-9624272 - MMPs cleave HB-EGF - - - - - Reactome:R-HSA-9822532 - ADAMTS13 cleaves VWF multimer - - - - - Reactome:R-HSA-9824402 - ADAMTS13 variant does not cleave VWF multimer - - - - - Reactome:R-HSA-9840408 - OMA1 cleaves DELE1 - - - - - Reactome:R-HSA-9840532 - OMA1 self-cleaves - - - - - Reactome:R-HSA-9840564 - OMA1 hydrolyzes YME1L1 - - - - - Reactome:R-HSA-9844241 - ADAMTS13 cleaves VWF variant multimer - - - - - Reactome:R-HSA-1168777 - Metalloprotease cleavage of GHR - - - - - Reactome:R-HSA-1251992 - Cleavage of P-ERBB4jmA isoforms by ADAM17 - - - - - Reactome:R-HSA-1299476 - MPP cleaves targeting peptide (presequence) of inner membrane precursors - - - - - Reactome:R-HSA-1299478 - MPP cleaves targeting peptide (presequence) of matrix precursors - - - - - Reactome:R-HSA-1454757 - Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - - - - - Reactome:R-HSA-1454822 - Collagen type I degradation by MMP1,2,8,13, PRSS2 - - - - - Reactome:R-HSA-1458433 - Collagen type I degradation by MMP14 - - - - - Reactome:R-HSA-1474196 - Collagen type II degradation by MMP14 - - - - - Reactome:R-HSA-1474210 - Collagen type III degradation by MMP14 - - - - - Reactome:R-HSA-1474213 - Collagen type III degradation by MMP1,8,9,13 - - - - - Reactome:R-HSA-1564112 - Collagen type VI degradation by MMP2,9,11 - - - - - Reactome:R-HSA-1564117 - Collagen type XIV degradation by MMP9,13 - - - - - Reactome:R-HSA-1564120 - Collagen type VII degradation by MMP1,2,3 - - - - - Reactome:R-HSA-1564142 - Collagen type IV degradation by MMP2,3,4,9,10,12 - - - - - Reactome:R-HSA-1564143 - Collagen type X degradation by MMP1,2 - - - - - Reactome:R-HSA-1564164 - Collagen type V degradation by MMP2,9,10 - - - - - Reactome:R-HSA-1564169 - Collagen type VIII degradation by MMP1 - - - - - Reactome:R-HSA-1564179 - Collagen type XI degradation by MMP1,2,3,9 - - - - - Reactome:R-HSA-1564184 - Collagen type IX degradation by MMP3,13 - - - - - Reactome:R-HSA-1592310 - Aggrecan degradation by ADAMTSs - - - - - Reactome:R-HSA-1655851 - S2P hydrolyzes SREBP1A,1C,2 - @@ -7575,6 +8004,180 @@ Reactome:R-HSA-8949659 AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU + + + + Reactome:R-HSA-8949668 + YME1L1 proteolyzes unassembled proSMDT1 + + + + + Reactome:R-HSA-9624272 + MMPs cleave HB-EGF + + + + + Reactome:R-HSA-9822532 + ADAMTS13 cleaves VWF multimer + + + + + Reactome:R-HSA-9824402 + ADAMTS13 variant does not cleave VWF multimer + + + + + Reactome:R-HSA-9840408 + OMA1 cleaves DELE1 + + + + + Reactome:R-HSA-9840532 + OMA1 self-cleaves + + + + + Reactome:R-HSA-9840564 + OMA1 hydrolyzes YME1L1 + + + + + Reactome:R-HSA-9844241 + ADAMTS13 cleaves VWF variant multimer + + + + + Reactome:R-HSA-1168777 + Metalloprotease cleavage of GHR + + + + + Reactome:R-HSA-1251992 + Cleavage of P-ERBB4jmA isoforms by ADAM17 + + + + + Reactome:R-HSA-1299476 + MPP cleaves targeting peptide (presequence) of inner membrane precursors + + + + + Reactome:R-HSA-1299478 + MPP cleaves targeting peptide (presequence) of matrix precursors + + + + + Reactome:R-HSA-1454757 + Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 + + + + + Reactome:R-HSA-1454822 + Collagen type I degradation by MMP1,2,8,13, PRSS2 + + + + + Reactome:R-HSA-1458433 + Collagen type I degradation by MMP14 + + + + + Reactome:R-HSA-1474196 + Collagen type II degradation by MMP14 + + + + + Reactome:R-HSA-1474210 + Collagen type III degradation by MMP14 + + + + + Reactome:R-HSA-1474213 + Collagen type III degradation by MMP1,8,9,13 + + + + + Reactome:R-HSA-1564112 + Collagen type VI degradation by MMP2,9,11 + + + + + Reactome:R-HSA-1564117 + Collagen type XIV degradation by MMP9,13 + + + + + Reactome:R-HSA-1564120 + Collagen type VII degradation by MMP1,2,3 + + + + + Reactome:R-HSA-1564142 + Collagen type IV degradation by MMP2,3,4,9,10,12 + + + + + Reactome:R-HSA-1564143 + Collagen type X degradation by MMP1,2 + + + + + Reactome:R-HSA-1564164 + Collagen type V degradation by MMP2,9,10 + + + + + Reactome:R-HSA-1564169 + Collagen type VIII degradation by MMP1 + + + + + Reactome:R-HSA-1564179 + Collagen type XI degradation by MMP1,2,3,9 + + + + + Reactome:R-HSA-1564184 + Collagen type IX degradation by MMP3,13 + + + + + Reactome:R-HSA-1592310 + Aggrecan degradation by ADAMTSs + + + + + Reactome:R-HSA-1655851 + S2P hydrolyzes SREBP1A,1C,2 + Reactome:R-HSA-114697 Reactome:R-HSA-1181152 @@ -28855,6 +29458,2129 @@ Reactome:R-HSA-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane + + Reactome:R-HSA-71387 + + + + + Reactome:R-HSA-71387 + Metabolism of carbohydrates + + + Reactome:R-HSA-8982491 + + + + + Reactome:R-HSA-8982491 + Glycogen metabolism + + + Reactome:R-HSA-3322077 + + + + + Reactome:R-HSA-3322077 + Glycogen synthesis + + + Reactome:R-HSA-70221 + + + + + Reactome:R-HSA-70221 + Glycogen breakdown (glycogenolysis) + + + Reactome:R-HSA-5653890 + + + + + Reactome:R-HSA-5653890 + Lactose synthesis + + + Reactome:R-HSA-163754 + + + + + Reactome:R-HSA-163754 + Insulin effects increased synthesis of Xylulose-5-Phosphate + + + Reactome:R-HSA-5652084 + + + + + Reactome:R-HSA-5652084 + Fructose metabolism + + + Reactome:R-HSA-70326 + + + + + Reactome:R-HSA-70326 + Glucose metabolism + + + Reactome:R-HSA-73843 + + + + + Reactome:R-HSA-73843 + 5-Phosphoribose 1-diphosphate biosynthesis + + + Reactome:R-HSA-2024101 + + + + + Reactome:R-HSA-2024101 + CS/DS degradation + + + Reactome:R-HSA-446210 + + + + + Reactome:R-HSA-446210 + Synthesis of UDP-N-acetyl-glucosamine + + + Reactome:R-HSA-71384 + + + + + Reactome:R-HSA-71384 + Ethanol oxidation + + + Reactome:R-HSA-9861559 + + + + + Reactome:R-HSA-9861559 + PDH complex synthesizes acetyl-CoA from PYR + + + Reactome:R-HSA-70268 + + + + + Reactome:R-HSA-70268 + Pyruvate metabolism + + + Reactome:R-HSA-70263 + + + + + Reactome:R-HSA-70263 + Gluconeogenesis + + + Reactome:R-HSA-71336 + + + + + Reactome:R-HSA-71336 + Pentose phosphate pathway + + + Reactome:R-HSA-71403 + + + + + Reactome:R-HSA-71403 + Citric acid cycle (TCA cycle) + + + Reactome:R-HSA-2978092 + Reactome:R-HSA-880009 + + + + + Reactome:R-HSA-2978092 + Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate + + + + + Reactome:R-HSA-880009 + Interconversion of 2-oxoglutarate and 2-hydroxyglutarate + + + Reactome:R-HSA-170822 + + + + + Reactome:R-HSA-170822 + Regulation of Glucokinase by Glucokinase Regulatory Protein + + + Reactome:R-HSA-2395516 + + + + + Reactome:R-HSA-2395516 + Electron transport from NADPH to Ferredoxin + + + Reactome:R-HSA-74259 + + + + + Reactome:R-HSA-74259 + Purine catabolism + + + Reactome:R-HSA-176187 + Reactome:R-HSA-69239 + + + + + Reactome:R-HSA-176187 + Activation of ATR in response to replication stress + + + + + Reactome:R-HSA-69239 + Synthesis of DNA + + + Reactome:R-HSA-69306 + + + + + Reactome:R-HSA-69306 + DNA Replication + + + Reactome:R-HSA-68952 + Reactome:R-HSA-68962 + + + + + Reactome:R-HSA-68952 + DNA replication initiation + + + + + Reactome:R-HSA-68962 + Activation of the pre-replicative complex + + + Reactome:R-HSA-69190 + + + + + Reactome:R-HSA-69190 + DNA strand elongation + + + Reactome:R-HSA-162589 + + + + + Reactome:R-HSA-162589 + Reverse Transcription of HIV RNA + + + Reactome:R-HSA-73894 + + + + + Reactome:R-HSA-73894 + DNA Repair + + + Reactome:R-HSA-6781827 + + + + + Reactome:R-HSA-6781827 + Transcription-Coupled Nucleotide Excision Repair (TC-NER) + + + Reactome:R-HSA-73884 + Reactome:R-HSA-73930 + + + + + Reactome:R-HSA-73884 + Base Excision Repair + + + + + Reactome:R-HSA-73930 + Abasic sugar-phosphate removal via the single-nucleotide replacement pathway + + + Reactome:R-HSA-73929 + + + + + Reactome:R-HSA-73929 + Base-Excision Repair, AP Site Formation + + + Reactome:R-HSA-73933 + + + + + Reactome:R-HSA-73933 + Resolution of Abasic Sites (AP sites) + + + Reactome:R-HSA-5696398 + Reactome:R-HSA-5696400 + + + + + Reactome:R-HSA-5696398 + Nucleotide Excision Repair + + + + + Reactome:R-HSA-5696400 + Dual Incision in GG-NER + + + Reactome:R-HSA-5696397 + + + + + Reactome:R-HSA-5696397 + Gap-filling DNA repair synthesis and ligation in GG-NER + + + Reactome:R-HSA-5358508 + + + + + Reactome:R-HSA-5358508 + Mismatch Repair + + + Reactome:R-HSA-5693532 + + + + + Reactome:R-HSA-5693532 + DNA Double-Strand Break Repair + + + Reactome:R-HSA-5693571 + + + + + Reactome:R-HSA-5693571 + Nonhomologous End-Joining (NHEJ) + + + Reactome:R-HSA-5657655 + Reactome:R-HSA-73943 + + + + + Reactome:R-HSA-5657655 + MGMT-mediated DNA damage reversal + + + + + Reactome:R-HSA-73943 + Reversal of alkylation damage by DNA dioxygenases + + + Reactome:R-HSA-140342 + + + + + Reactome:R-HSA-140342 + Apoptosis induced DNA fragmentation + + + Reactome:R-HSA-4839726 + + + + + Reactome:R-HSA-4839726 + Chromatin organization + + + Reactome:R-HSA-774815 + + + + + Reactome:R-HSA-774815 + Nucleosome assembly + + + Reactome:R-HSA-2173793 + Reactome:R-HSA-74160 + + + + + Reactome:R-HSA-2173793 + Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer + + + + + Reactome:R-HSA-74160 + Gene expression (Transcription) + + + Reactome:R-HSA-9013695 + Reactome:R-HSA-9762293 + + + + + Reactome:R-HSA-9013695 + NOTCH4 Intracellular Domain Regulates Transcription + + + + + Reactome:R-HSA-9762293 + Regulation of CDH11 gene transcription + + + Reactome:R-HSA-8864260 + + + + + Reactome:R-HSA-8864260 + Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors + + + Reactome:R-HSA-73864 + + + + + Reactome:R-HSA-73864 + RNA Polymerase I Transcription + + + Reactome:R-HSA-73854 + + + + + Reactome:R-HSA-73854 + RNA Polymerase I Promoter Clearance + + + Reactome:R-HSA-73863 + + + + + Reactome:R-HSA-73863 + RNA Polymerase I Transcription Termination + + + Reactome:R-HSA-72312 + + + + + Reactome:R-HSA-72312 + rRNA processing + + + Reactome:R-HSA-73857 + + + + + Reactome:R-HSA-73857 + RNA Polymerase II Transcription + + + Reactome:R-HSA-167161 + Reactome:R-HSA-2032785 + Reactome:R-HSA-350054 + Reactome:R-HSA-383280 + Reactome:R-HSA-73779 + Reactome:R-HSA-75953 + + + + + Reactome:R-HSA-167161 + HIV Transcription Initiation + + + + + Reactome:R-HSA-2032785 + YAP1- and WWTR1 (TAZ)-stimulated gene expression + + + + + Reactome:R-HSA-350054 + Notch-HLH transcription pathway + + + + + Reactome:R-HSA-383280 + Nuclear Receptor transcription pathway + + + + + Reactome:R-HSA-73779 + RNA Polymerase II Transcription Pre-Initiation And Promoter Opening + + + + + Reactome:R-HSA-75953 + RNA Polymerase II Transcription Initiation + + + Reactome:R-HSA-167169 + Reactome:R-HSA-73776 + Reactome:R-HSA-75955 + + + + + Reactome:R-HSA-167169 + HIV Transcription Elongation + + + + + Reactome:R-HSA-73776 + RNA Polymerase II Promoter Escape + + + + + Reactome:R-HSA-75955 + RNA Polymerase II Transcription Elongation + + + Reactome:R-HSA-73856 + + + + + Reactome:R-HSA-73856 + RNA Polymerase II Transcription Termination + + + Reactome:R-HSA-72086 + + + + + Reactome:R-HSA-72086 + mRNA Capping + + + Reactome:R-HSA-75064 + + + + + Reactome:R-HSA-75064 + mRNA Editing: A to I Conversion + + + Reactome:R-HSA-74158 + + + + + Reactome:R-HSA-74158 + RNA Polymerase III Transcription + + + Reactome:R-HSA-73780 + + + + + Reactome:R-HSA-73780 + RNA Polymerase III Chain Elongation + + + Reactome:R-HSA-73980 + + + + + Reactome:R-HSA-73980 + RNA Polymerase III Transcription Termination + + + Reactome:R-HSA-75944 + + + + + Reactome:R-HSA-75944 + Transcription from mitochondrial promoters + + + Reactome:R-HSA-163282 + + + + + Reactome:R-HSA-163282 + Mitochondrial transcription initiation + + + Reactome:R-HSA-163316 + + + + + Reactome:R-HSA-163316 + Mitochondrial transcription termination + + + Reactome:R-HSA-77588 + + + + + Reactome:R-HSA-77588 + SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs + + + Reactome:R-HSA-6782315 + + + + + Reactome:R-HSA-6782315 + tRNA modification in the nucleus and cytosol + + + Reactome:R-HSA-72202 + + + + + Reactome:R-HSA-72202 + Transport of Mature Transcript to Cytoplasm + + + Reactome:R-HSA-72766 + + + + + Reactome:R-HSA-72766 + Translation + + + Reactome:R-HSA-72613 + + + + + Reactome:R-HSA-72613 + Eukaryotic Translation Initiation + + + Reactome:R-HSA-156842 + + + + + Reactome:R-HSA-156842 + Eukaryotic Translation Elongation + + + Reactome:R-HSA-72764 + + + + + Reactome:R-HSA-72764 + Eukaryotic Translation Termination + + + Reactome:R-HSA-379724 + + + + + Reactome:R-HSA-379724 + tRNA Aminoacylation + + + Reactome:R-HSA-389960 + Reactome:R-HSA-390466 + Reactome:R-HSA-532668 + + + + + Reactome:R-HSA-389960 + Formation of tubulin folding intermediates by CCT/TriC + + + + + Reactome:R-HSA-390466 + Chaperonin-mediated protein folding + + + + + Reactome:R-HSA-532668 + N-glycan trimming in the ER and Calnexin/Calreticulin cycle + + + Reactome:R-HSA-159782 + + + + + Reactome:R-HSA-159782 + Removal of aminoterminal propeptides from gamma-carboxylated proteins + + + Reactome:R-HSA-8876725 + + + + + Reactome:R-HSA-8876725 + Protein methylation + + + Reactome:R-HSA-446193 + + + + + Reactome:R-HSA-446193 + Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein + + + Reactome:R-HSA-446199 + + + + + Reactome:R-HSA-446199 + Synthesis of Dolichyl-phosphate + + + Reactome:R-HSA-5173105 + + + + + Reactome:R-HSA-5173105 + O-linked glycosylation + + + Reactome:R-HSA-163125 + + + + + Reactome:R-HSA-163125 + Post-translational modification: synthesis of GPI-anchored proteins + + + Reactome:R-HSA-162710 + + + + + Reactome:R-HSA-162710 + Synthesis of glycosylphosphatidylinositol (GPI) + + + Reactome:R-HSA-2980736 + + + + + Reactome:R-HSA-2980736 + Peptide hormone metabolism + + + Reactome:R-HSA-350562 + + + + + Reactome:R-HSA-350562 + Regulation of ornithine decarboxylase (ODC) + + + Reactome:R-HSA-6783984 + + + + + Reactome:R-HSA-6783984 + Glycine degradation + + + Reactome:R-HSA-70921 + + + + + Reactome:R-HSA-70921 + Histidine catabolism + + + Reactome:R-HSA-71064 + + + + + Reactome:R-HSA-71064 + Lysine catabolism + + + Reactome:R-HSA-8964208 + + + + + Reactome:R-HSA-8964208 + Phenylalanine metabolism + + + Reactome:R-HSA-70688 + + + + + Reactome:R-HSA-70688 + Proline catabolism + + + Reactome:R-HSA-977347 + + + + + Reactome:R-HSA-977347 + Serine biosynthesis + + + Reactome:R-HSA-71240 + + + + + Reactome:R-HSA-71240 + Tryptophan catabolism + + + Reactome:R-HSA-8963684 + + + + + Reactome:R-HSA-8963684 + Tyrosine catabolism + + + Reactome:R-HSA-209968 + + + + + Reactome:R-HSA-209968 + Thyroxine biosynthesis + + + Reactome:R-HSA-351202 + + + + + Reactome:R-HSA-351202 + Metabolism of polyamines + + + Reactome:R-HSA-351200 + + + + + Reactome:R-HSA-351200 + Interconversion of polyamines + + + Reactome:R-HSA-71288 + + + + + Reactome:R-HSA-71288 + Creatine metabolism + + + Reactome:R-HSA-1799339 + + + + + Reactome:R-HSA-1799339 + SRP-dependent cotranslational protein targeting to membrane + + + Reactome:R-HSA-1268020 + + + + + Reactome:R-HSA-1268020 + Mitochondrial protein import + + + Reactome:R-HSA-556833 + + + + + Reactome:R-HSA-556833 + Metabolism of lipids + + + Reactome:R-HSA-211935 + Reactome:R-HSA-434313 + Reactome:R-HSA-8978868 + + + + + Reactome:R-HSA-211935 + Fatty acids + + + + + Reactome:R-HSA-434313 + Intracellular metabolism of fatty acids regulates insulin secretion + + + + + Reactome:R-HSA-8978868 + Fatty acid metabolism + + + Reactome:R-HSA-77289 + + + + + Reactome:R-HSA-77289 + Mitochondrial Fatty Acid Beta-Oxidation + + + Reactome:R-HSA-8979227 + + + + + Reactome:R-HSA-8979227 + Triglyceride metabolism + + + Reactome:R-HSA-1483115 + Reactome:R-HSA-1483152 + Reactome:R-HSA-1483257 + + + + + Reactome:R-HSA-1483115 + Hydrolysis of LPC + + + + + Reactome:R-HSA-1483152 + Hydrolysis of LPE + + + + + Reactome:R-HSA-1483257 + Phospholipid metabolism + + + Reactome:R-HSA-1483213 + + + + + Reactome:R-HSA-1483213 + Synthesis of PE + + + Reactome:R-HSA-1483166 + + + + + Reactome:R-HSA-1483166 + Synthesis of PA + + + Reactome:R-HSA-1483148 + + + + + Reactome:R-HSA-1483148 + Synthesis of PG + + + Reactome:R-HSA-1483191 + + + + + Reactome:R-HSA-1483191 + Synthesis of PC + + + Reactome:R-HSA-1483101 + + + + + Reactome:R-HSA-1483101 + Synthesis of PS + + + Reactome:R-HSA-1483226 + Reactome:R-HSA-1483248 + Reactome:R-HSA-1660499 + Reactome:R-HSA-1660514 + Reactome:R-HSA-1660516 + Reactome:R-HSA-1660517 + + + + + Reactome:R-HSA-1483226 + Synthesis of PI + + + + + Reactome:R-HSA-1483248 + Synthesis of PIPs at the ER membrane + + + + + Reactome:R-HSA-1660499 + Synthesis of PIPs at the plasma membrane + + + + + Reactome:R-HSA-1660514 + Synthesis of PIPs at the Golgi membrane + + + + + Reactome:R-HSA-1660516 + Synthesis of PIPs at the early endosome membrane + + + + + Reactome:R-HSA-1660517 + Synthesis of PIPs at the late endosome membrane + + + Reactome:R-HSA-428157 + + + + + Reactome:R-HSA-428157 + Sphingolipid metabolism + + + Reactome:R-HSA-1660662 + + + + + Reactome:R-HSA-1660662 + Glycosphingolipid metabolism + + + Reactome:R-HSA-9840309 + + + + + Reactome:R-HSA-9840309 + Glycosphingolipid biosynthesis + + + Reactome:R-HSA-211979 + + + + + Reactome:R-HSA-211979 + Eicosanoids + + + Reactome:R-HSA-2142691 + + + + + Reactome:R-HSA-2142691 + Synthesis of Leukotrienes (LT) and Eoxins (EX) + + + Reactome:R-HSA-140180 + + + + + Reactome:R-HSA-140180 + COX reactions + + + Reactome:R-HSA-191273 + + + + + Reactome:R-HSA-191273 + Cholesterol biosynthesis + + + Reactome:R-HSA-192105 + + + + + Reactome:R-HSA-192105 + Synthesis of bile acids and bile salts + + + Reactome:R-HSA-196108 + + + + + Reactome:R-HSA-196108 + Pregnenolone biosynthesis + + + Reactome:R-HSA-193048 + + + + + Reactome:R-HSA-193048 + Androgen biosynthesis + + + Reactome:R-HSA-193144 + + + + + Reactome:R-HSA-193144 + Estrogen biosynthesis + + + Reactome:R-HSA-194002 + + + + + Reactome:R-HSA-194002 + Glucocorticoid biosynthesis + + + Reactome:R-HSA-193993 + + + + + Reactome:R-HSA-193993 + Mineralocorticoid biosynthesis + + + Reactome:R-HSA-389542 + + + + + Reactome:R-HSA-389542 + NADPH regeneration + + + Reactome:R-HSA-2142789 + + + + + Reactome:R-HSA-2142789 + Ubiquinol biosynthesis + + + Reactome:R-HSA-174403 + + + + + Reactome:R-HSA-174403 + Glutathione synthesis and recycling + + + Reactome:R-HSA-211916 + + + + + Reactome:R-HSA-211916 + Vitamins + + + Reactome:R-HSA-196849 + + + + + Reactome:R-HSA-196849 + Metabolism of water-soluble vitamins and cofactors + + + Reactome:R-HSA-196780 + + + + + Reactome:R-HSA-196780 + Biotin transport and metabolism + + + Reactome:R-HSA-196843 + + + + + Reactome:R-HSA-196843 + Vitamin B2 (riboflavin) metabolism + + + Reactome:R-HSA-6806667 + + + + + Reactome:R-HSA-6806667 + Metabolism of fat-soluble vitamins + + + Reactome:R-HSA-189445 + + + + + Reactome:R-HSA-189445 + Metabolism of porphyrins + + + Reactome:R-HSA-189451 + + + + + Reactome:R-HSA-189451 + Heme biosynthesis + + + Reactome:R-HSA-211859 + Reactome:R-HSA-211981 + Reactome:R-HSA-2161541 + Reactome:R-HSA-9748784 + + + + + Reactome:R-HSA-211859 + Biological oxidations + + + + + Reactome:R-HSA-211981 + Xenobiotics + + + + + Reactome:R-HSA-2161541 + Abacavir metabolism + + + + + Reactome:R-HSA-9748784 + Drug ADME + + + Reactome:R-HSA-382551 + + + + + Reactome:R-HSA-382551 + Transport of small molecules + + + Reactome:R-HSA-425393 + + + + + Reactome:R-HSA-425393 + Transport of inorganic cations/anions and amino acids/oligopeptides + + + Reactome:R-HSA-445717 + + + + + Reactome:R-HSA-445717 + Aquaporin-mediated transport + + + Reactome:R-HSA-181429 + Reactome:R-HSA-181430 + Reactome:R-HSA-210500 + Reactome:R-HSA-212676 + Reactome:R-HSA-264642 + + + + + Reactome:R-HSA-181429 + Serotonin Neurotransmitter Release Cycle + + + + + Reactome:R-HSA-181430 + Norepinephrine Neurotransmitter Release Cycle + + + + + Reactome:R-HSA-210500 + Glutamate Neurotransmitter Release Cycle + + + + + Reactome:R-HSA-212676 + Dopamine Neurotransmitter Release Cycle + + + + + Reactome:R-HSA-264642 + Acetylcholine Neurotransmitter Release Cycle + + + Reactome:R-HSA-8949215 + + + + + Reactome:R-HSA-8949215 + Mitochondrial calcium ion transport + + + Reactome:R-HSA-200425 + + + + + Reactome:R-HSA-200425 + Carnitine shuttle + + + Reactome:R-HSA-352230 + + + + + Reactome:R-HSA-352230 + Amino acid transport across the plasma membrane + + + Reactome:R-HSA-1369062 + + + + + Reactome:R-HSA-1369062 + ABC transporters in lipid homeostasis + + + Reactome:R-HSA-917937 + + + + + Reactome:R-HSA-917937 + Iron uptake and transport + + + Reactome:R-HSA-159763 + Reactome:R-HSA-199977 + + + + + Reactome:R-HSA-159763 + Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus + + + + + Reactome:R-HSA-199977 + ER to Golgi Anterograde Transport + + + Reactome:R-HSA-6811434 + + + + + Reactome:R-HSA-6811434 + COPI-dependent Golgi-to-ER retrograde traffic + + + Reactome:R-HSA-199992 + + + + + Reactome:R-HSA-199992 + trans-Golgi Network Vesicle Budding + + + Reactome:R-HSA-2173782 + + + + + Reactome:R-HSA-2173782 + Binding and Uptake of Ligands by Scavenger Receptors + + + Reactome:R-HSA-9664417 + + + + + Reactome:R-HSA-9664417 + Leishmania phagocytosis + + + Reactome:R-HSA-9612973 + + + + + Reactome:R-HSA-9612973 + Autophagy + + + Reactome:R-HSA-109581 + + + + + Reactome:R-HSA-109581 + Apoptosis + + + Reactome:R-HSA-69416 + + + + + Reactome:R-HSA-69416 + Dimerization of procaspase-8 + + + Reactome:R-HSA-168277 + + + + + Reactome:R-HSA-168277 + Influenza Virus Induced Apoptosis + + + Reactome:R-HSA-445355 + + + + + Reactome:R-HSA-445355 + Smooth Muscle Contraction + + + Reactome:R-HSA-9733458 + + + + + Reactome:R-HSA-9733458 + Induction of Cell-Cell Fusion + + + Reactome:R-HSA-166658 + + + + + Reactome:R-HSA-166658 + Complement cascade + + + Reactome:R-HSA-173736 + + + + + Reactome:R-HSA-173736 + Alternative complement activation + + + Reactome:R-HSA-173623 + + + + + Reactome:R-HSA-173623 + Classical antibody-mediated complement activation + + + Reactome:R-HSA-6791312 + Reactome:R-HSA-69563 + + + + + Reactome:R-HSA-6791312 + TP53 Regulates Transcription of Cell Cycle Genes + + + + + Reactome:R-HSA-69563 + p53-Dependent G1 DNA Damage Response + + + Reactome:R-HSA-1852241 + + + + + Reactome:R-HSA-1852241 + Organelle biogenesis and maintenance + + + Reactome:R-HSA-171319 + + + + + Reactome:R-HSA-171319 + Telomere Extension By Telomerase + + + Reactome:R-HSA-1592230 + + + + + Reactome:R-HSA-1592230 + Mitochondrial biogenesis + + + Reactome:R-HSA-983189 + + + + + Reactome:R-HSA-983189 + Kinesins + + + Reactome:R-HSA-389977 + + + + + Reactome:R-HSA-389977 + Post-chaperonin tubulin folding pathway + + + Reactome:R-HSA-1640170 + + + + + Reactome:R-HSA-1640170 + Cell Cycle + + + Reactome:R-HSA-9648025 + + + + + Reactome:R-HSA-9648025 + EML4 and NUDC in mitotic spindle formation + + + Reactome:R-HSA-2468052 + + + + + Reactome:R-HSA-2468052 + Establishment of Sister Chromatid Cohesion + + + Reactome:R-HSA-2299718 + Reactome:R-HSA-2514853 + + + + + Reactome:R-HSA-2299718 + Condensation of Prophase Chromosomes + + + + + Reactome:R-HSA-2514853 + Condensation of Prometaphase Chromosomes + + + Reactome:R-HSA-2980766 + + + + + Reactome:R-HSA-2980766 + Nuclear Envelope Breakdown + + + Reactome:R-HSA-2995410 + + + + + Reactome:R-HSA-2995410 + Nuclear Envelope (NE) Reassembly + + + Reactome:R-HSA-68881 + + + + + Reactome:R-HSA-68881 + Mitotic Metaphase/Anaphase Transition + + + Reactome:R-HSA-69618 + + + + + Reactome:R-HSA-69618 + Mitotic Spindle Checkpoint + + + Reactome:R-HSA-176409 + + + + + Reactome:R-HSA-176409 + APC/C:Cdc20 mediated degradation of mitotic proteins + + + Reactome:R-HSA-212718 + + + + + Reactome:R-HSA-212718 + EGFR interacts with phospholipase C-gamma + + + Reactome:R-HSA-73887 + + + + + Reactome:R-HSA-73887 + Death Receptor Signaling + + + Reactome:R-HSA-187015 + + + + + Reactome:R-HSA-187015 + Activation of TRKA receptors + + + Reactome:R-HSA-177929 + + + + + Reactome:R-HSA-177929 + Signaling by EGFR + + + Reactome:R-HSA-170834 + + + + + Reactome:R-HSA-170834 + Signaling by TGF-beta Receptor Complex + + + Reactome:R-HSA-373076 + Reactome:R-HSA-388396 + + + + + Reactome:R-HSA-373076 + Class A/1 (Rhodopsin-like receptors) + + + + + Reactome:R-HSA-388396 + GPCR downstream signalling + + + Reactome:R-HSA-170660 + + + + + Reactome:R-HSA-170660 + Adenylate cyclase activating pathway + + + Reactome:R-HSA-187024 + + + + + Reactome:R-HSA-187024 + NGF-independant TRKA activation + + + Reactome:R-HSA-170670 + + + + + Reactome:R-HSA-170670 + Adenylate cyclase inhibitory pathway + + + Reactome:R-HSA-157118 + + + + + Reactome:R-HSA-157118 + Signaling by NOTCH + + + Reactome:R-HSA-9013508 + + + + + Reactome:R-HSA-9013508 + NOTCH3 Intracellular Domain Regulates Transcription + + + Reactome:R-HSA-4086398 + + + + + Reactome:R-HSA-4086398 + Ca2+ pathway + + + Reactome:R-HSA-5357956 + Reactome:R-HSA-9014325 + Reactome:R-HSA-937072 + + + + + Reactome:R-HSA-5357956 + TNFR1-induced NF-kappa-B signaling pathway + + + + + Reactome:R-HSA-9014325 + TICAM1,TRAF6-dependent induction of TAK1 complex + + + + + Reactome:R-HSA-937072 + TRAF6-mediated induction of TAK1 complex within TLR4 complex + + + Reactome:R-HSA-450321 + + + + + Reactome:R-HSA-450321 + JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 + + + Reactome:R-HSA-187706 + Reactome:R-HSA-194315 + + + + + Reactome:R-HSA-187706 + Signalling to p38 via RIT and RIN + + + + + Reactome:R-HSA-194315 + Signaling by Rho GTPases + + + Reactome:R-HSA-1169092 + Reactome:R-HSA-167044 + + + + + Reactome:R-HSA-1169092 + Activation of RAS in B cells + + + + + Reactome:R-HSA-167044 + Signalling to RAS + + + Reactome:R-HSA-112316 + Reactome:R-HSA-442720 + Reactome:R-HSA-442729 + Reactome:R-HSA-442742 + Reactome:R-HSA-451307 + Reactome:R-HSA-451308 + Reactome:R-HSA-9619229 + Reactome:R-HSA-9619483 + Reactome:R-HSA-9620244 + + + + + Reactome:R-HSA-112316 + Neuronal System + + + + + Reactome:R-HSA-442720 + CREB1 phosphorylation through the activation of Adenylate Cyclase + + + + + Reactome:R-HSA-442729 + CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde + + + + + Reactome:R-HSA-442742 + CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling + + + + + Reactome:R-HSA-451307 + Activation of Na-permeable kainate receptors + + + + + Reactome:R-HSA-451308 + Activation of Ca-permeable Kainate Receptor + + + + + Reactome:R-HSA-9619229 + Activation of RAC1 downstream of NMDARs + + + + + Reactome:R-HSA-9619483 + Activation of AMPK downstream of NMDARs + + + + + Reactome:R-HSA-9620244 + Long-term potentiation + + + Reactome:R-HSA-112310 + + + + + Reactome:R-HSA-112310 + Neurotransmitter release cycle + + + Reactome:R-HSA-9827857 + + + + + Reactome:R-HSA-9827857 + Specification of primordial germ cells + + + Reactome:R-HSA-1187000 + + + + + Reactome:R-HSA-1187000 + Fertilization + + + Reactome:R-HSA-1300645 + + + + + Reactome:R-HSA-1300645 + Acrosome Reaction and Sperm:Oocyte Membrane Binding + + + Reactome:R-HSA-2465910 + Reactome:R-HSA-68911 + + + + + Reactome:R-HSA-2465910 + MASTL Facilitates Mitotic Progression + + + + + Reactome:R-HSA-68911 + G2 Phase + + + Reactome:R-HSA-9758941 + + + + + Reactome:R-HSA-9758941 + Gastrulation + + + Reactome:R-HSA-9675108 + + + + + Reactome:R-HSA-9675108 + Nervous system development + + + Reactome:R-HSA-422475 + + + + + Reactome:R-HSA-422475 + Axon guidance + + + Reactome:R-HSA-8935690 + + + + + Reactome:R-HSA-8935690 + Digestion + + + Reactome:R-HSA-109582 + + + + + Reactome:R-HSA-109582 + Hemostasis + + + Reactome:R-HSA-140837 + + + + + Reactome:R-HSA-140837 + Intrinsic Pathway of Fibrin Clot Formation + + + Reactome:R-HSA-140834 + + + + + Reactome:R-HSA-140834 + Extrinsic Pathway of Fibrin Clot Formation + + + Reactome:R-HSA-9709957 + + + + + Reactome:R-HSA-9709957 + Sensory Perception + + + Reactome:R-HSA-2187338 + + + + + Reactome:R-HSA-2187338 + Visual phototransduction + + + Reactome:R-HSA-9659379 + + + + + Reactome:R-HSA-9659379 + Sensory processing of sound + + + Reactome:R-HSA-400253 + + + + + Reactome:R-HSA-400253 + Circadian Clock + Reactome:R-HSA-9614343 @@ -28894,6 +31620,15 @@ Reactome:R-HSA-9645220 SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol + + Reactome:R-HSA-72306 + + + + + Reactome:R-HSA-72306 + tRNA processing + Reactome:R-HSA-2468039 Reactome:R-HSA-2473152 @@ -28933,6 +31668,15 @@ Reactome:R-HSA-5693578 TDP1 and TDP2 process unligatable DSB ends + + Reactome:R-HSA-9609507 + + + + + Reactome:R-HSA-9609507 + Protein localization + Reactome:R-HSA-9036987 Reactome:R-HSA-9603982 @@ -29261,6 +32005,15 @@ Reactome:R-HSA-9753277 SULT dimers sulfate APAP to APAP-SO3 + + Reactome:R-HSA-1430728 + + + + + Reactome:R-HSA-1430728 + Metabolism + Reactome:R-HSA-212269 Reactome:R-HSA-379387 @@ -29551,6 +32304,24 @@ Reactome:R-HSA-75899 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate + + Reactome:R-HSA-8957322 + + + + + Reactome:R-HSA-8957322 + Metabolism of steroids + + + Reactome:R-HSA-194068 + + + + + Reactome:R-HSA-194068 + Bile acid and bile salt metabolism + Reactome:R-HSA-205112 Reactome:R-HSA-3000243 @@ -30075,6 +32846,15 @@ Reactome:R-HSA-9632182 PRMT1 methylates ESRs + + Reactome:R-HSA-74752 + + + + + Reactome:R-HSA-74752 + Signaling by Insulin receptor + Reactome:R-HSA-111930 Reactome:R-HSA-442715 @@ -30507,6 +33287,15 @@ Reactome:R-HSA-3697894 PRDX5 reduces peroxynitrite to nitrite using TXN2 + + Reactome:R-HSA-72172 + + + + + Reactome:R-HSA-72172 + mRNA Splicing + Reactome:R-HSA-5684267 Reactome:R-HSA-5684275 @@ -31720,6 +34509,15 @@ Reactome:R-HSA-110244 Excision of FapyG by OGG1 glycosylase + + Reactome:R-HSA-190236 + + + + + Reactome:R-HSA-190236 + Signaling by FGFR + Reactome:R-HSA-168162 @@ -31747,6 +34545,15 @@ Reactome:R-HSA-9668419 SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites + + Reactome:R-HSA-9690406 + + + + + Reactome:R-HSA-9690406 + Transcriptional regulation of testis differentiation + Reactome:R-HSA-139906 @@ -31765,6 +34572,42 @@ Reactome:R-HSA-390427 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate + + Reactome:R-HSA-75896 + + + + + Reactome:R-HSA-75896 + Plasmalogen biosynthesis + + + Reactome:R-HSA-204626 + + + + + Reactome:R-HSA-204626 + Hypusine synthesis from eIF5A-lysine + + + Reactome:R-HSA-111459 + + + + + Reactome:R-HSA-111459 + Activation of caspases through apoptosome-mediated cleavage + + + Reactome:R-HSA-189200 + + + + + Reactome:R-HSA-189200 + Cellular hexose transport + Reactome:R-HSA-6793127 @@ -32197,6 +35040,132 @@ Reactome:R-HSA-2564826 4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold + + Reactome:R-HSA-390918 + + + + + Reactome:R-HSA-390918 + Peroxisomal lipid metabolism + + + Reactome:R-HSA-8964539 + + + + + Reactome:R-HSA-8964539 + Glutamate and glutamine metabolism + + + Reactome:R-HSA-8963693 + + + + + Reactome:R-HSA-8963693 + Aspartate and asparagine metabolism + + + Reactome:R-HSA-8963691 + + + + + Reactome:R-HSA-8963691 + Phenylalanine and tyrosine metabolism + + + Reactome:R-HSA-8964540 + + + + + Reactome:R-HSA-8964540 + Alanine metabolism + + + Reactome:R-HSA-70895 + + + + + Reactome:R-HSA-70895 + Branched-chain amino acid catabolism + + + Reactome:R-HSA-73817 + + + + + Reactome:R-HSA-73817 + Purine ribonucleoside monophosphate biosynthesis + + + Reactome:R-HSA-173599 + + + + + Reactome:R-HSA-173599 + Formation of the active cofactor, UDP-glucuronate + + + Reactome:R-HSA-9759218 + + + + + Reactome:R-HSA-9759218 + Cobalamin (Cbl) metabolism + + + Reactome:R-HSA-9857492 + + + + + Reactome:R-HSA-9857492 + Protein lipoylation + + + Reactome:R-HSA-9711097 + + + + + Reactome:R-HSA-9711097 + Cellular response to starvation + + + Reactome:R-HSA-446205 + + + + + Reactome:R-HSA-446205 + Synthesis of GDP-mannose + + + Reactome:R-HSA-9033658 + + + + + Reactome:R-HSA-9033658 + Blood group systems biosynthesis + + + Reactome:R-HSA-8853383 + + + + + Reactome:R-HSA-8853383 + Lysosomal oligosaccharide catabolism + Reactome:R-HSA-6790944 Reactome:R-HSA-6793057 @@ -32229,6 +35198,51 @@ Reactome:R-HSA-4088322 Defective GNE does not phosphorylate ManNAc to ManNAc-6-P + + Reactome:R-HSA-888568 + + + + + Reactome:R-HSA-888568 + GABA synthesis + + + Reactome:R-HSA-916853 + + + + + Reactome:R-HSA-916853 + Degradation of GABA + + + Reactome:R-HSA-9824446 + + + + + Reactome:R-HSA-9824446 + Viral Infection Pathways + + + Reactome:R-HSA-9824439 + + + + + Reactome:R-HSA-9824439 + Bacterial Infection Pathways + + + Reactome:R-HSA-5619507 + + + + + Reactome:R-HSA-5619507 + Activation of HOX genes during differentiation + Reactome:R-HSA-2046083 Reactome:R-HSA-2046088 @@ -32301,6 +35315,15 @@ Reactome:R-HSA-548830 ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA + + Reactome:R-HSA-8849472 + + + + + Reactome:R-HSA-8849472 + PTK6 Down-Regulation + Reactome:R-HSA-6782381 Reactome:R-HSA-6786583 @@ -32338,6 +35361,24 @@ Reactome:R-HSA-8870289 PUS3 transforms uridine-39 to pseudouridine-39 in tRNA + + Reactome:R-HSA-9640463 + + + + + Reactome:R-HSA-9640463 + Wax biosynthesis + + + Reactome:R-HSA-5660526 + + + + + Reactome:R-HSA-5660526 + Response to metal ions + Reactome:R-HSA-1237119 @@ -32347,6 +35388,15 @@ Reactome:R-HSA-1237119 Acireductone is oxidized to MOB + + Reactome:R-HSA-8854518 + + + + + Reactome:R-HSA-8854518 + AURKA Activation by TPX2 + Reactome:R-HSA-2162193 @@ -32356,6 +35406,58 @@ Reactome:R-HSA-2162193 COQ3 methylates DHDB + + Reactome:R-HSA-163767 + Reactome:R-HSA-9752946 + + + + + Reactome:R-HSA-163767 + PP2A-mediated dephosphorylation of key metabolic factors + + + + + Reactome:R-HSA-9752946 + Expression and translocation of olfactory receptors + + + Reactome:R-HSA-204174 + + + + + Reactome:R-HSA-204174 + Regulation of pyruvate dehydrogenase (PDH) complex + + + Reactome:R-HSA-203927 + + + + + Reactome:R-HSA-203927 + MicroRNA (miRNA) biogenesis + + + Reactome:R-HSA-163358 + + + + + Reactome:R-HSA-163358 + PKA-mediated phosphorylation of key metabolic factors + + + Reactome:R-HSA-5357905 + + + + + Reactome:R-HSA-5357905 + Regulation of TNFR1 signaling + Reactome:R-HSA-400097 @@ -32404,6 +35506,33 @@ Reactome:R-HSA-9837354 NUDT8 hydrolyzes CoA-SH to PPANT + + Reactome:R-HSA-9648895 + + + + + Reactome:R-HSA-9648895 + Response of EIF2AK1 (HRI) to heme deficiency + + + Reactome:R-HSA-5357801 + + + + + Reactome:R-HSA-5357801 + Programmed Cell Death + + + Reactome:R-HSA-2022928 + + + + + Reactome:R-HSA-2022928 + HS-GAG biosynthesis + Reactome:R-HSA-2022860 @@ -34430,6 +37559,126 @@ Reactome:R-HSA-9672770 SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix + + Reactome:R-HSA-8981607 + + + + + Reactome:R-HSA-8981607 + Intracellular oxygen transport + + + Reactome:R-HSA-1475029 + Reactome:R-HSA-1480926 + Reactome:R-HSA-425381 + + + + + Reactome:R-HSA-1475029 + Reversible hydration of carbon dioxide + + + + + Reactome:R-HSA-1480926 + O2/CO2 exchange in erythrocytes + + + + + Reactome:R-HSA-425381 + Bicarbonate transporters + + + Reactome:R-HSA-159418 + + + + + Reactome:R-HSA-159418 + Recycling of bile acids and salts + + + Reactome:R-HSA-432030 + + + + + Reactome:R-HSA-432030 + Transport of glycerol from adipocytes to the liver by Aquaporins + + + Reactome:R-HSA-429593 + + + + + Reactome:R-HSA-429593 + Inositol transporters + + + Reactome:R-HSA-9758881 + Reactome:R-HSA-9758890 + + + + + Reactome:R-HSA-9758881 + Uptake of dietary cobalamins into enterocytes + + + + + Reactome:R-HSA-9758890 + Transport of RCbl within the body + + + Reactome:R-HSA-804914 + + + + + Reactome:R-HSA-804914 + Transport of fatty acids + + + Reactome:R-HSA-1483196 + + + + + Reactome:R-HSA-1483196 + PI and PC transport between ER and Golgi membranes + + + Reactome:R-HSA-196783 + + + + + Reactome:R-HSA-196783 + Coenzyme A biosynthesis + + + Reactome:R-HSA-199220 + + + + + Reactome:R-HSA-199220 + Vitamin B5 (pantothenate) metabolism + + + Reactome:R-HSA-499943 + + + + + Reactome:R-HSA-499943 + Interconversion of nucleotide di- and triphosphates + Reactome:R-HSA-400023 @@ -34439,6 +37688,15 @@ Reactome:R-HSA-400023 Gq alpha activates Phospholipase C beta + + Reactome:R-HSA-162906 + + + + + Reactome:R-HSA-162906 + HIV Infection + Reactome:R-HSA-71173 @@ -34448,6 +37706,60 @@ Reactome:R-HSA-71173 GSTZ1 isomerizes 4-MAA + + Reactome:R-HSA-195721 + + + + + Reactome:R-HSA-195721 + Signaling by WNT + + + Reactome:R-HSA-2514856 + + + + + Reactome:R-HSA-2514856 + The phototransduction cascade + + + Reactome:R-HSA-8953854 + + + + + Reactome:R-HSA-8953854 + Metabolism of RNA + + + Reactome:R-HSA-111367 + + + + + Reactome:R-HSA-111367 + SLBP independent Processing of Histone Pre-mRNAs + + + Reactome:R-HSA-9708296 + + + + + Reactome:R-HSA-9708296 + tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis + + + Reactome:R-HSA-211976 + + + + + Reactome:R-HSA-211976 + Endogenous sterols + Reactome:R-HSA-70903 @@ -34545,6 +37857,15 @@ Reactome:R-HSA-9673797 NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen + + Reactome:R-HSA-917729 + + + + + Reactome:R-HSA-917729 + Endosomal Sorting Complex Required For Transport (ESCRT) + Reactome:R-HSA-175983 Reactome:R-HSA-8955010 @@ -34632,6 +37953,22 @@ Reactome:R-HSA-909776 beta-alanine + pyruvate => 3-oxopropanoate + alanine + + Reactome:R-HSA-1362409 + Reactome:R-HSA-2564830 + + + + + Reactome:R-HSA-1362409 + Mitochondrial iron-sulfur cluster biogenesis + + + + + Reactome:R-HSA-2564830 + Cytosolic iron-sulfur cluster assembly + Reactome:R-HSA-6786048 @@ -34641,6 +37978,29 @@ Reactome:R-HSA-6786048 CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 + + Reactome:R-HSA-1632852 + Reactome:R-HSA-5205685 + Reactome:R-HSA-8934903 + + + + + Reactome:R-HSA-1632852 + Macroautophagy + + + + + Reactome:R-HSA-5205685 + PINK1-PRKN Mediated Mitophagy + + + + + Reactome:R-HSA-8934903 + Receptor Mediated Mitophagy + Reactome:R-HSA-1678708 Reactome:R-HSA-2090043 @@ -34671,6 +38031,24 @@ Reactome:R-HSA-9036050 Defective SGSH does not hydrolyse Heparan sulfate chain(2) + + Reactome:R-HSA-162791 + + + + + Reactome:R-HSA-162791 + Attachment of GPI anchor to uPAR + + + Reactome:R-HSA-2408522 + + + + + Reactome:R-HSA-2408522 + Selenoamino acid metabolism + Reactome:R-HSA-1964505 Reactome:R-HSA-6785524 @@ -34687,6 +38065,24 @@ Reactome:R-HSA-6785524 Defective C1GALT1C1 does not bind C1GALT1 + + Reactome:R-HSA-190861 + + + + + Reactome:R-HSA-190861 + Gap junction assembly + + + Reactome:R-HSA-913709 + + + + + Reactome:R-HSA-913709 + O-linked glycosylation of mucins + Reactome:R-HSA-191790 Reactome:R-HSA-5205798 @@ -35383,6 +38779,38 @@ Reactome:R-HSA-6810472 NUDT13 hydrolyses AP6A to AP4 and ADP + + Reactome:R-HSA-9033500 + + + + + Reactome:R-HSA-9033500 + TYSND1 cleaves peroxisomal proteins + + + Reactome:R-HSA-209952 + Reactome:R-HSA-400508 + Reactome:R-HSA-422085 + + + + + Reactome:R-HSA-209952 + Peptide hormone biosynthesis + + + + + Reactome:R-HSA-400508 + Incretin synthesis, secretion, and inactivation + + + + + Reactome:R-HSA-422085 + Synthesis, secretion, and deacylation of Ghrelin + Reactome:R-HSA-1614362 Reactome:R-HSA-209921 @@ -35573,6 +39001,51 @@ Reactome:R-HSA-3215385 CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 + + Reactome:R-HSA-72200 + + + + + Reactome:R-HSA-72200 + mRNA Editing: C to U Conversion + + + Reactome:R-HSA-75072 + + + + + Reactome:R-HSA-75072 + mRNA Editing + + + Reactome:R-HSA-8852135 + + + + + Reactome:R-HSA-8852135 + Protein ubiquitination + + + Reactome:R-HSA-5688426 + + + + + Reactome:R-HSA-5688426 + Deubiquitination + + + Reactome:R-HSA-428540 + + + + + Reactome:R-HSA-428540 + Activation of RAC1 + Reactome:R-HSA-1500781 @@ -36853,6 +40326,15 @@ Reactome:R-HSA-400012 Acetylcholine binds Muscarinic Acetylcholine Receptor M3 + + Reactome:R-HSA-2990846 + + + + + Reactome:R-HSA-2990846 + SUMOylation + Reactome:R-HSA-975389 @@ -37343,6 +40825,24 @@ Reactome:R-HSA-5358475 DPH6 ligates ammonium to diphthine-EEF2 + + Reactome:R-HSA-5358493 + + + + + Reactome:R-HSA-5358493 + Synthesis of diphthamide-EEF2 + + + Reactome:R-HSA-159854 + + + + + Reactome:R-HSA-159854 + Gamma-carboxylation, transport, and amino-terminal cleavage of proteins + Reactome:R-HSA-8954468 @@ -37361,6 +40861,24 @@ Reactome:R-HSA-6786205 KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 + + Reactome:R-HSA-9629569 + + + + + Reactome:R-HSA-9629569 + Protein hydroxylation + + + Reactome:R-HSA-2022854 + + + + + Reactome:R-HSA-2022854 + Keratan sulfate biosynthesis + Reactome:R-HSA-2993447 Reactome:R-HSA-2993799 @@ -37426,6 +40944,29 @@ Reactome:R-HSA-9035990 Defective HLCS does not biotinylate 6x(PCCA:PCCB) + + Reactome:R-HSA-162699 + Reactome:R-HSA-446203 + Reactome:R-HSA-480985 + + + + + Reactome:R-HSA-162699 + Synthesis of dolichyl-phosphate mannose + + + + + Reactome:R-HSA-446203 + Asparagine N-linked glycosylation + + + + + Reactome:R-HSA-480985 + Synthesis of dolichyl-phosphate-glucose + Reactome:R-HSA-8856945 @@ -37531,6 +41072,279 @@ Reactome:R-HSA-156909 eEF1A complexes with GTP + + Reactome:R-HSA-164938 + Reactome:R-HSA-164944 + Reactome:R-HSA-168305 + Reactome:R-HSA-169131 + + + + + Reactome:R-HSA-164938 + Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters + + + + + Reactome:R-HSA-164944 + Nef and signal transduction + + + + + Reactome:R-HSA-168305 + Inhibition of Interferon Synthesis + + + + + Reactome:R-HSA-169131 + Inhibition of PKR + + + Reactome:R-HSA-168276 + Reactome:R-HSA-9833110 + + + + + Reactome:R-HSA-168276 + NS1 Mediated Effects on Host Pathways + + + + + Reactome:R-HSA-9833110 + RSV-host interactions + + + Reactome:R-HSA-162588 + Reactome:R-HSA-168255 + Reactome:R-HSA-9609646 + + + + + Reactome:R-HSA-162588 + Budding and maturation of HIV virion + + + + + Reactome:R-HSA-168255 + Influenza Infection + + + + + Reactome:R-HSA-9609646 + HCMV Infection + + + Reactome:R-HSA-168874 + + + + + Reactome:R-HSA-168874 + Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus + + + Reactome:R-HSA-162585 + Reactome:R-HSA-168336 + + + + + Reactome:R-HSA-162585 + Uncoating of the HIV Virion + + + + + Reactome:R-HSA-168336 + Uncoating of the Influenza Virion + + + Reactome:R-HSA-168288 + + + + + Reactome:R-HSA-168288 + Fusion of the Influenza Virion to the Host Cell Endosome + + + Reactome:R-HSA-168275 + + + + + Reactome:R-HSA-168275 + Entry of Influenza Virion into Host Cell via Endocytosis + + + Reactome:R-HSA-168302 + Reactome:R-HSA-168316 + Reactome:R-HSA-175474 + + + + + Reactome:R-HSA-168302 + Budding + + + + + Reactome:R-HSA-168316 + Assembly of Viral Components at the Budding Site + + + + + Reactome:R-HSA-175474 + Assembly Of The HIV Virion + + + Reactome:R-HSA-168330 + + + + + Reactome:R-HSA-168330 + Viral RNP Complexes in the Host Cell Nucleus + + + Reactome:R-HSA-168303 + + + + + Reactome:R-HSA-168303 + Packaging of Eight RNA Segments + + + Reactome:R-HSA-168298 + + + + + Reactome:R-HSA-168298 + Release + + + Reactome:R-HSA-9683701 + Reactome:R-HSA-9694635 + Reactome:R-HSA-9727281 + + + + + Reactome:R-HSA-9683701 + Translation of Structural Proteins + + + + + Reactome:R-HSA-9694635 + Translation of Structural Proteins + + + + + Reactome:R-HSA-9727281 + Translation of Accessory Proteins + + + Reactome:R-HSA-171286 + Reactome:R-HSA-174495 + Reactome:R-HSA-9683610 + Reactome:R-HSA-9683612 + Reactome:R-HSA-9683673 + Reactome:R-HSA-9683686 + Reactome:R-HSA-9694548 + Reactome:R-HSA-9694594 + Reactome:R-HSA-9694631 + Reactome:R-HSA-9694719 + + + + + Reactome:R-HSA-171286 + Synthesis and processing of ENV and VPU + + + + + Reactome:R-HSA-174495 + Synthesis And Processing Of GAG, GAGPOL Polyproteins + + + + + Reactome:R-HSA-9683610 + Maturation of nucleoprotein + + + + + Reactome:R-HSA-9683612 + Maturation of protein M + + + + + Reactome:R-HSA-9683673 + Maturation of protein 3a + + + + + Reactome:R-HSA-9683686 + Maturation of spike protein + + + + + Reactome:R-HSA-9694548 + Maturation of spike protein + + + + + Reactome:R-HSA-9694594 + Maturation of protein M + + + + + Reactome:R-HSA-9694631 + Maturation of nucleoprotein + + + + + Reactome:R-HSA-9694719 + Maturation of protein 3a + + + Reactome:R-HSA-167172 + Reactome:R-HSA-168273 + + + + + Reactome:R-HSA-167172 + Transcription of the HIV genome + + + + + Reactome:R-HSA-168273 + Influenza Viral RNA Transcription and Replication + Reactome:R-HSA-110218 Reactome:R-HSA-110219 @@ -37882,6 +41696,68 @@ Reactome:R-HSA-5689000 AADAC deacetylates PHEN + + Reactome:R-HSA-2426168 + Reactome:R-HSA-400206 + + + + + Reactome:R-HSA-2426168 + Activation of gene expression by SREBF (SREBP) + + + + + Reactome:R-HSA-400206 + Regulation of lipid metabolism by PPARalpha + + + Reactome:R-HSA-449147 + Reactome:R-HSA-913531 + Reactome:R-HSA-9607240 + Reactome:R-HSA-9674555 + Reactome:R-HSA-9680350 + + + + + Reactome:R-HSA-449147 + Signaling by Interleukins + + + + + Reactome:R-HSA-913531 + Interferon Signaling + + + + + Reactome:R-HSA-9607240 + FLT3 Signaling + + + + + Reactome:R-HSA-9674555 + Signaling by CSF3 (G-CSF) + + + + + Reactome:R-HSA-9680350 + Signaling by CSF1 (M-CSF) in myeloid cells + + + Reactome:R-HSA-1989781 + + + + + Reactome:R-HSA-1989781 + PPARA activates gene expression + Reactome:R-HSA-74241 Reactome:R-HSA-9014641 @@ -37912,6 +41788,142 @@ Reactome:R-HSA-9754964 ADA deamidates RBV + + Reactome:R-HSA-1614603 + + + + + Reactome:R-HSA-1614603 + Cysteine formation from homocysteine + + + Reactome:R-HSA-2142753 + Reactome:R-HSA-426048 + + + + + Reactome:R-HSA-2142753 + Arachidonate metabolism + + + + + Reactome:R-HSA-426048 + Arachidonate production from DAG + + + Reactome:R-HSA-2142688 + Reactome:R-HSA-2142712 + Reactome:R-HSA-2142770 + Reactome:R-HSA-9025094 + + + + + Reactome:R-HSA-2142688 + Synthesis of 5-eicosatetraenoic acids + + + + + Reactome:R-HSA-2142712 + Synthesis of 12-eicosatetraenoic acid derivatives + + + + + Reactome:R-HSA-2142770 + Synthesis of 15-eicosatetraenoic acid derivatives + + + + + Reactome:R-HSA-9025094 + Biosynthesis of DPAn-3 SPMs + + + Reactome:R-HSA-2142670 + + + + + Reactome:R-HSA-2142670 + Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) + + + Reactome:R-HSA-75109 + + + + + Reactome:R-HSA-75109 + Triglyceride biosynthesis + + + Reactome:R-HSA-163560 + + + + + Reactome:R-HSA-163560 + Triglyceride catabolism + + + Reactome:R-HSA-1237112 + + + + + Reactome:R-HSA-1237112 + Methionine salvage pathway + + + Reactome:R-HSA-8849175 + + + + + Reactome:R-HSA-8849175 + Threonine catabolism + + + Reactome:R-HSA-392499 + + + + + Reactome:R-HSA-392499 + Metabolism of proteins + + + Reactome:R-HSA-71032 + + + + + Reactome:R-HSA-71032 + Propionyl-CoA catabolism + + + Reactome:R-HSA-5661270 + + + + + Reactome:R-HSA-5661270 + Formation of xylulose-5-phosphate + + + Reactome:R-HSA-196807 + + + + + Reactome:R-HSA-196807 + Nicotinate metabolism + Reactome:R-HSA-203567 Reactome:R-HSA-5682084 @@ -37963,6 +41975,24 @@ Reactome:R-HSA-9830875 G is palmitoylated + + Reactome:R-HSA-6803157 + + + + + Reactome:R-HSA-6803157 + Antimicrobial peptides + + + Reactome:R-HSA-389661 + + + + + Reactome:R-HSA-389661 + Glyoxylate metabolism and glycine degradation + Reactome:R-HSA-5681981 @@ -39096,6 +43126,24 @@ Reactome:R-HSA-5692480 ATP13A2 transports cations from cytosol to lysosomal lumen + + Reactome:R-HSA-196836 + + + + + Reactome:R-HSA-196836 + Vitamin C (ascorbate) metabolism + + + Reactome:R-HSA-2132295 + + + + + Reactome:R-HSA-2132295 + MHC class II antigen presentation + Reactome:R-HSA-180038 @@ -39128,6 +43176,15 @@ Reactome:R-HSA-2993784 Conjugation of SUMO2 to UBA2:SAE1 + + Reactome:R-HSA-73893 + + + + + Reactome:R-HSA-73893 + DNA Damage Bypass + Reactome:R-HSA-400015 @@ -39137,6 +43194,24 @@ Reactome:R-HSA-400015 Diacylgycerol activates Protein kinase C, alpha type + + Reactome:R-HSA-2514859 + + + + + Reactome:R-HSA-2514859 + Inactivation, recovery and regulation of the phototransduction cascade + + + Reactome:R-HSA-1474228 + + + + + Reactome:R-HSA-1474228 + Degradation of the extracellular matrix + Reactome:R-HSA-2534378 Reactome:R-HSA-6788999 @@ -39220,6 +43295,24 @@ Reactome:R-HSA-6784436 An unknown carrier transports mitochondrial glyoxylate to the cytosol + + Reactome:R-HSA-611105 + + + + + Reactome:R-HSA-611105 + Respiratory electron transport + + + Reactome:R-HSA-390522 + + + + + Reactome:R-HSA-390522 + Striated Muscle Contraction + Reactome:R-HSA-70979 Reactome:R-HSA-9856871 @@ -39236,6 +43329,33 @@ Reactome:R-HSA-9856871 MDH1 reduces OA + + Reactome:R-HSA-264876 + + + + + Reactome:R-HSA-264876 + Insulin processing + + + Reactome:R-HSA-5676934 + + + + + Reactome:R-HSA-5676934 + Protein repair + + + Reactome:R-HSA-8939256 + + + + + Reactome:R-HSA-8939256 + RUNX1 regulates transcription of genes involved in WNT signaling + Reactome:R-HSA-9696980 Reactome:R-HSA-975916 @@ -39252,6 +43372,24 @@ Reactome:R-HSA-975916 Addition of GlcNAc to position 5 by MGAT5 + + Reactome:R-HSA-1660661 + + + + + Reactome:R-HSA-1660661 + Sphingolipid de novo biosynthesis + + + Reactome:R-HSA-9845614 + + + + + Reactome:R-HSA-9845614 + Sphingolipid catabolism + Reactome:R-HSA-1878002 @@ -39261,6 +43399,140 @@ Reactome:R-HSA-1878002 XYLTs transfer Xyl to core protein + + Reactome:R-HSA-392023 + Reactome:R-HSA-392170 + Reactome:R-HSA-418592 + Reactome:R-HSA-76002 + + + + + Reactome:R-HSA-392023 + Adrenaline signalling through Alpha-2 adrenergic receptor + + + + + Reactome:R-HSA-392170 + ADP signalling through P2Y purinoceptor 12 + + + + + Reactome:R-HSA-418592 + ADP signalling through P2Y purinoceptor 1 + + + + + Reactome:R-HSA-76002 + Platelet activation, signaling and aggregation + + + Reactome:R-HSA-1474244 + + + + + Reactome:R-HSA-1474244 + Extracellular matrix organization + + + Reactome:R-HSA-1474290 + Reactome:R-HSA-2214320 + Reactome:R-HSA-2243919 + + + + + Reactome:R-HSA-1474290 + Collagen formation + + + + + Reactome:R-HSA-2214320 + Anchoring fibril formation + + + + + Reactome:R-HSA-2243919 + Crosslinking of collagen fibrils + + + Reactome:R-HSA-2024096 + + + + + Reactome:R-HSA-2024096 + HS-GAG degradation + + + Reactome:R-HSA-1630316 + + + + + Reactome:R-HSA-1630316 + Glycosaminoglycan metabolism + + + Reactome:R-HSA-1793185 + + + + + Reactome:R-HSA-1793185 + Chondroitin sulfate/dermatan sulfate metabolism + + + Reactome:R-HSA-2022870 + + + + + Reactome:R-HSA-2022870 + Chondroitin sulfate biosynthesis + + + Reactome:R-HSA-2022923 + + + + + Reactome:R-HSA-2022923 + Dermatan sulfate biosynthesis + + + Reactome:R-HSA-2142845 + + + + + Reactome:R-HSA-2142845 + Hyaluronan metabolism + + + Reactome:R-HSA-2142850 + + + + + Reactome:R-HSA-2142850 + Hyaluronan biosynthesis and export + + + Reactome:R-HSA-2160916 + + + + + Reactome:R-HSA-2160916 + Hyaluronan uptake and degradation + Reactome:R-HSA-202129 Reactome:R-HSA-202144 @@ -39404,6 +43676,15 @@ Reactome:R-HSA-70920 N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate + + Reactome:R-HSA-426486 + + + + + Reactome:R-HSA-426486 + Small interfering RNA (siRNA) biogenesis + Reactome:R-HSA-71217 @@ -39413,6 +43694,15 @@ Reactome:R-HSA-71217 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + + Reactome:R-HSA-977606 + + + + + Reactome:R-HSA-977606 + Regulation of Complement cascade + Reactome:R-HSA-5226964 @@ -39422,6 +43712,33 @@ Reactome:R-HSA-5226964 ANKH transports PPi from cytosol to extracellular region + + Reactome:R-HSA-201451 + + + + + Reactome:R-HSA-201451 + Signaling by BMP + + + Reactome:R-HSA-2173788 + + + + + Reactome:R-HSA-2173788 + Downregulation of TGF-beta receptor signaling + + + Reactome:R-HSA-9024446 + + + + + Reactome:R-HSA-9024446 + NR1H2 and NR1H3-mediated signaling + Reactome:R-HSA-111925 Reactome:R-HSA-381608 @@ -39452,6 +43769,15 @@ Reactome:R-HSA-381707 PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP + + Reactome:R-HSA-1442490 + + + + + Reactome:R-HSA-1442490 + Collagen degradation + Reactome:R-HSA-3149518 @@ -39504,6 +43830,42 @@ Reactome:R-HSA-5696220 AS3MT transfers CH3 from AdoMet to arsenite(3-) + + Reactome:R-HSA-9616222 + + + + + Reactome:R-HSA-9616222 + Transcriptional regulation of granulopoiesis + + + Reactome:R-HSA-381119 + + + + + Reactome:R-HSA-381119 + Unfolded Protein Response (UPR) + + + Reactome:R-HSA-186712 + + + + + Reactome:R-HSA-186712 + Regulation of beta-cell development + + + Reactome:R-HSA-211000 + + + + + Reactome:R-HSA-211000 + Gene Silencing by RNA + Reactome:R-HSA-1362408 Reactome:R-HSA-947514 @@ -39520,6 +43882,115 @@ Reactome:R-HSA-947514 PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 + + Reactome:R-HSA-72187 + Reactome:R-HSA-75067 + + + + + Reactome:R-HSA-72187 + mRNA 3'-end processing + + + + + Reactome:R-HSA-75067 + Processing of Capped Intronless Pre-mRNA + + + Reactome:R-HSA-174048 + Reactome:R-HSA-174143 + Reactome:R-HSA-174154 + Reactome:R-HSA-174184 + + + + + Reactome:R-HSA-174048 + APC/C:Cdc20 mediated degradation of Cyclin B + + + + + Reactome:R-HSA-174143 + APC/C-mediated degradation of cell cycle proteins + + + + + Reactome:R-HSA-174154 + APC/C:Cdc20 mediated degradation of Securin + + + + + Reactome:R-HSA-174184 + Cdc20:Phospho-APC/C mediated degradation of Cyclin A + + + Reactome:R-HSA-193692 + + + + + Reactome:R-HSA-193692 + Regulated proteolysis of p75NTR + + + Reactome:R-HSA-388841 + + + + + Reactome:R-HSA-388841 + Costimulation by the CD28 family + + + Reactome:R-HSA-163765 + + + + + Reactome:R-HSA-163765 + ChREBP activates metabolic gene expression + + + Reactome:R-HSA-9664433 + + + + + Reactome:R-HSA-9664433 + Leishmania parasite growth and survival + + + Reactome:R-HSA-9664420 + + + + + Reactome:R-HSA-9664420 + Killing mechanisms + + + Reactome:R-HSA-6805567 + + + + + Reactome:R-HSA-6805567 + Keratinization + + + Reactome:R-HSA-5334118 + + + + + Reactome:R-HSA-5334118 + DNA methylation + Reactome:R-HSA-9630769 @@ -39573,6 +44044,15 @@ Reactome:R-HSA-1234181 Nuclear PHD1,3 hydroxylates proline residues on HIF1A + + Reactome:R-HSA-446107 + + + + + Reactome:R-HSA-446107 + Type I hemidesmosome assembly + Reactome:R-HSA-8875013 @@ -39612,6 +44092,33 @@ Reactome:R-HSA-9914143 SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH + + Reactome:R-HSA-399997 + + + + + Reactome:R-HSA-399997 + Acetylcholine regulates insulin secretion + + + Reactome:R-HSA-1483076 + + + + + Reactome:R-HSA-1483076 + Synthesis of CL + + + Reactome:R-HSA-174417 + + + + + Reactome:R-HSA-174417 + Telomere C-strand (Lagging Strand) Synthesis + Reactome:R-HSA-3165230 @@ -39621,6 +44128,24 @@ Reactome:R-HSA-3165230 SLC52A1,2,3 transport RIB from extracellular region to cytosol + + Reactome:R-HSA-156581 + + + + + Reactome:R-HSA-156581 + Methylation + + + Reactome:R-HSA-947581 + + + + + Reactome:R-HSA-947581 + Molybdenum cofactor biosynthesis + Reactome:R-HSA-3214912 Reactome:R-HSA-4722133 @@ -39802,6 +44327,42 @@ Reactome:R-HSA-997263 JMJD1C demethylates H3K9 mono- and di-methylation + + Reactome:R-HSA-167060 + + + + + Reactome:R-HSA-167060 + NGF processing + + + Reactome:R-HSA-3134975 + + + + + Reactome:R-HSA-3134975 + Regulation of innate immune responses to cytosolic DNA + + + Reactome:R-HSA-936440 + + + + + Reactome:R-HSA-936440 + Negative regulators of DDX58/IFIH1 signaling + + + Reactome:R-HSA-1834949 + + + + + Reactome:R-HSA-1834949 + Cytosolic sensors of pathogen-associated DNA + Reactome:R-HSA-9760094 @@ -39811,6 +44372,15 @@ Reactome:R-HSA-9760094 SRXN1 reduces hyperoxidized PRDX1 dimer + + Reactome:R-HSA-5368287 + + + + + Reactome:R-HSA-5368287 + Mitochondrial translation + Reactome:R-HSA-9682695 Reactome:R-HSA-9694265 @@ -39827,6 +44397,15 @@ Reactome:R-HSA-9694265 nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template + + Reactome:R-HSA-8866427 + + + + + Reactome:R-HSA-8866427 + VLDLR internalisation and degradation + Reactome:R-HSA-1268025 Reactome:R-HSA-1299482 @@ -39864,6 +44443,24 @@ Reactome:R-HSA-9906955 MT-ND4 is translated + + Reactome:R-HSA-6799198 + + + + + Reactome:R-HSA-6799198 + Complex I biogenesis + + + Reactome:R-HSA-8931987 + + + + + Reactome:R-HSA-8931987 + RUNX1 regulates estrogen receptor mediated transcription + Reactome:R-HSA-429786 Reactome:R-HSA-429798 @@ -39896,6 +44493,82 @@ Reactome:R-HSA-4551451 Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling + + Reactome:R-HSA-5668541 + Reactome:R-HSA-75893 + + + + + Reactome:R-HSA-5668541 + TNFR2 non-canonical NF-kB pathway + + + + + Reactome:R-HSA-75893 + TNF signaling + + + Reactome:R-HSA-1222449 + + + + + Reactome:R-HSA-1222449 + Mtb iron assimilation by chelation + + + Reactome:R-HSA-1855156 + Reactome:R-HSA-1855170 + Reactome:R-HSA-1855184 + Reactome:R-HSA-1855192 + Reactome:R-HSA-1855196 + Reactome:R-HSA-1855215 + Reactome:R-HSA-1855229 + + + + + Reactome:R-HSA-1855156 + IPs transport between ER lumen and nucleus + + + + + Reactome:R-HSA-1855170 + IPs transport between nucleus and cytosol + + + + + Reactome:R-HSA-1855184 + IPs transport between cytosol and ER lumen + + + + + Reactome:R-HSA-1855192 + IPs transport between nucleus and ER lumen + + + + + Reactome:R-HSA-1855196 + IP3 and IP4 transport between cytosol and nucleus + + + + + Reactome:R-HSA-1855215 + IPs transport between ER lumen and cytosol + + + + + Reactome:R-HSA-1855229 + IP6 and IP7 transport between cytosol and nucleus + Reactome:R-HSA-198818 @@ -39905,6 +44578,58 @@ Reactome:R-HSA-198818 SLC2A1,3 transports DeHA from extracellular region to cytosol + + Reactome:R-HSA-6807047 + + + + + Reactome:R-HSA-6807047 + Cholesterol biosynthesis via desmosterol + + + Reactome:R-HSA-6807062 + + + + + Reactome:R-HSA-6807062 + Cholesterol biosynthesis via lathosterol + + + Reactome:R-HSA-70370 + + + + + Reactome:R-HSA-70370 + Galactose catabolism + + + Reactome:R-HSA-389887 + Reactome:R-HSA-390247 + + + + + Reactome:R-HSA-389887 + Beta-oxidation of pristanoyl-CoA + + + + + Reactome:R-HSA-390247 + Beta-oxidation of very long chain fatty acids + + + Reactome:R-HSA-2262752 + + + + + Reactome:R-HSA-2262752 + Cellular responses to stress + Reactome:R-HSA-5693092 Reactome:R-HSA-8952069 @@ -39949,6 +44674,15 @@ Reactome:R-HSA-9841847 SIRT3 deacetylates Ac-K272,K290-FOXO3 + + Reactome:R-HSA-2046104 + + + + + Reactome:R-HSA-2046104 + alpha-linolenic (omega3) and linoleic (omega6) acid metabolism + Reactome:R-HSA-197963 Reactome:R-HSA-197972 @@ -39972,6 +44706,33 @@ Reactome:R-HSA-9709098 DHFR dimer reduces FOLA to DHF + + Reactome:R-HSA-917977 + + + + + Reactome:R-HSA-917977 + Transferrin endocytosis and recycling + + + Reactome:R-HSA-9864848 + + + + + Reactome:R-HSA-9864848 + Complex IV assembly + + + Reactome:R-HSA-9635465 + + + + + Reactome:R-HSA-9635465 + Suppression of apoptosis + Reactome:R-HSA-163120 @@ -40177,6 +44938,15 @@ Reactome:R-HSA-5679145 Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region + + Reactome:R-HSA-9636569 + + + + + Reactome:R-HSA-9636569 + Suppression of autophagy + Reactome:R-HSA-5696807 Reactome:R-HSA-6786881 @@ -40193,6 +44963,121 @@ Reactome:R-HSA-6786881 TRNT1 polymerizes CCA at the 3' end of pre-tRNA + + Reactome:R-HSA-606279 + + + + + Reactome:R-HSA-606279 + Deposition of new CENPA-containing nucleosomes at the centromere + + + Reactome:R-HSA-9645135 + + + + + Reactome:R-HSA-9645135 + STAT5 Activation + + + Reactome:R-HSA-9759476 + + + + + Reactome:R-HSA-9759476 + Regulation of Homotypic Cell-Cell Adhesion + + + Reactome:R-HSA-9860276 + + + + + Reactome:R-HSA-9860276 + SLC15A4:TASL-dependent IRF5 activation + + + Reactome:R-HSA-181438 + + + + + Reactome:R-HSA-181438 + Toll Like Receptor 2 (TLR2) Cascade + + + Reactome:R-HSA-168164 + + + + + Reactome:R-HSA-168164 + Toll Like Receptor 3 (TLR3) Cascade + + + Reactome:R-HSA-166016 + + + + + Reactome:R-HSA-166016 + Toll Like Receptor 4 (TLR4) Cascade + + + Reactome:R-HSA-168176 + + + + + Reactome:R-HSA-168176 + Toll Like Receptor 5 (TLR5) Cascade + + + Reactome:R-HSA-168138 + + + + + Reactome:R-HSA-168138 + Toll Like Receptor 9 (TLR9) Cascade + + + Reactome:R-HSA-168142 + + + + + Reactome:R-HSA-168142 + Toll Like Receptor 10 (TLR10) Cascade + + + Reactome:R-HSA-9633012 + Reactome:R-HSA-9639288 + + + + + Reactome:R-HSA-9633012 + Response of EIF2AK4 (GCN2) to amino acid deficiency + + + + + Reactome:R-HSA-9639288 + Amino acids regulate mTORC1 + + + Reactome:R-HSA-163615 + + + + + Reactome:R-HSA-163615 + PKA activation + Reactome:R-HSA-446212 Reactome:R-HSA-4570573 @@ -40225,6 +45110,177 @@ Reactome:R-HSA-9760081 CREBBP, EP300 acetylates NFE2L2 + + Reactome:R-HSA-983712 + + + + + Reactome:R-HSA-983712 + Ion channel transport + + + Reactome:R-HSA-446728 + + + + + Reactome:R-HSA-446728 + Cell junction organization + + + Reactome:R-HSA-418990 + + + + + Reactome:R-HSA-418990 + Adherens junctions interactions + + + Reactome:R-HSA-197264 + + + + + Reactome:R-HSA-197264 + Nicotinamide salvaging + + + Reactome:R-HSA-8963899 + + + + + Reactome:R-HSA-8963899 + Plasma lipoprotein remodeling + + + Reactome:R-HSA-8963901 + + + + + Reactome:R-HSA-8963901 + Chylomicron remodeling + + + Reactome:R-HSA-8964041 + + + + + Reactome:R-HSA-8964041 + LDL remodeling + + + Reactome:R-HSA-8964058 + + + + + Reactome:R-HSA-8964058 + HDL remodeling + + + Reactome:R-HSA-8963898 + + + + + Reactome:R-HSA-8963898 + Plasma lipoprotein assembly + + + Reactome:R-HSA-8963888 + + + + + Reactome:R-HSA-8963888 + Chylomicron assembly + + + Reactome:R-HSA-8866423 + + + + + Reactome:R-HSA-8866423 + VLDL assembly + + + Reactome:R-HSA-8963896 + + + + + Reactome:R-HSA-8963896 + HDL assembly + + + Reactome:R-HSA-8964043 + + + + + Reactome:R-HSA-8964043 + Plasma lipoprotein clearance + + + Reactome:R-HSA-8964026 + + + + + Reactome:R-HSA-8964026 + Chylomicron clearance + + + Reactome:R-HSA-8964038 + + + + + Reactome:R-HSA-8964038 + LDL clearance + + + Reactome:R-HSA-8964011 + + + + + Reactome:R-HSA-8964011 + HDL clearance + + + Reactome:R-HSA-8964572 + + + + + Reactome:R-HSA-8964572 + Lipid particle organization + + + Reactome:R-HSA-8956320 + + + + + Reactome:R-HSA-8956320 + Nucleotide biosynthesis + + + Reactome:R-HSA-8964046 + + + + + Reactome:R-HSA-8964046 + VLDL clearance + Reactome:R-HSA-937050 Reactome:R-HSA-975122 @@ -40268,6 +45324,24 @@ Reactome:R-HSA-1675949 PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane + + Reactome:R-HSA-9865881 + + + + + Reactome:R-HSA-9865881 + Complex III assembly + + + Reactome:R-HSA-5601884 + + + + + Reactome:R-HSA-5601884 + PIWI-interacting RNA (piRNA) biogenesis + Reactome:R-HSA-6784213 @@ -40316,6 +45390,31 @@ Reactome:R-HSA-6810410 PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus + + Reactome:R-HSA-3299685 + Reactome:R-HSA-9707564 + + + + + Reactome:R-HSA-3299685 + Detoxification of Reactive Oxygen Species + + + + + Reactome:R-HSA-9707564 + Cytoprotection by HMOX1 + + + Reactome:R-HSA-3371556 + + + + + Reactome:R-HSA-3371556 + Cellular response to heat stress + Reactome:R-HSA-9009950 Reactome:R-HSA-9615042 @@ -40364,6 +45463,15 @@ Reactome:R-HSA-2466802 Defective ABCA4 does not transport NRPE from disc membranes + + Reactome:R-HSA-8956319 + + + + + Reactome:R-HSA-8956319 + Nucleotide catabolism + Reactome:R-HSA-8876696 @@ -40484,6 +45592,49 @@ Reactome:R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 + + Reactome:R-HSA-452723 + + + + + Reactome:R-HSA-452723 + Transcriptional regulation of pluripotent stem cells + + + Reactome:R-HSA-1300642 + Reactome:R-HSA-2534343 + + + + + Reactome:R-HSA-1300642 + Sperm Motility And Taxes + + + + + Reactome:R-HSA-2534343 + Interaction With Cumulus Cells And The Zona Pellucida + + + Reactome:R-HSA-426496 + + + + + Reactome:R-HSA-426496 + Post-transcriptional silencing by small RNAs + + + Reactome:R-HSA-9759811 + + + + + Reactome:R-HSA-9759811 + Regulation of CDH11 mRNA translation by microRNAs + Reactome:R-HSA-9729283 @@ -40550,6 +45701,24 @@ Reactome:R-HSA-1855179 I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol + + Reactome:R-HSA-2028269 + + + + + Reactome:R-HSA-2028269 + Signaling by Hippo + + + Reactome:R-HSA-75876 + + + + + Reactome:R-HSA-75876 + Synthesis of very long-chain fatty acyl-CoAs + Reactome:R-HSA-1237042 Reactome:R-HSA-1237069 @@ -40637,6 +45806,15 @@ Reactome:R-HSA-9750555 NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP + + Reactome:R-HSA-3858494 + + + + + Reactome:R-HSA-3858494 + Beta-catenin independent WNT signaling + Reactome:R-HSA-2172678 @@ -40646,6 +45824,15 @@ Reactome:R-HSA-2172678 PHF8 demethylates histone H4K20me1 + + Reactome:R-HSA-9660826 + + + + + Reactome:R-HSA-9660826 + Purinergic signaling in leishmaniasis infection + Reactome:R-HSA-6786571 @@ -40655,6 +45842,76 @@ Reactome:R-HSA-6786571 CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 + + Reactome:R-HSA-9845576 + + + + + Reactome:R-HSA-9845576 + Glycosphingolipid transport + + + Reactome:R-HSA-9012546 + + + + + Reactome:R-HSA-9012546 + Interleukin-18 signaling + + + Reactome:R-HSA-9013973 + Reactome:R-HSA-937061 + + + + + Reactome:R-HSA-9013973 + TICAM1-dependent activation of IRF3/IRF7 + + + + + Reactome:R-HSA-937061 + TRIF (TICAM1)-mediated TLR4 signaling + + + Reactome:R-HSA-9837999 + + + + + Reactome:R-HSA-9837999 + Mitochondrial protein degradation + + + Reactome:R-HSA-447115 + + + + + Reactome:R-HSA-447115 + Interleukin-12 family signaling + + + Reactome:R-HSA-8983432 + + + + + Reactome:R-HSA-8983432 + Interleukin-15 signaling + + + Reactome:R-HSA-5620924 + + + + + Reactome:R-HSA-5620924 + Intraflagellar transport + Reactome:R-HSA-8954398 @@ -40673,6 +45930,33 @@ Reactome:R-HSA-2509838 ITPA hydrolyses dITP to dIMP + + Reactome:R-HSA-168643 + + + + + Reactome:R-HSA-168643 + Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways + + + Reactome:R-HSA-1482798 + + + + + Reactome:R-HSA-1482798 + Acyl chain remodeling of CL + + + Reactome:R-HSA-9646399 + + + + + Reactome:R-HSA-9646399 + Aggrephagy + Reactome:R-HSA-6800138 @@ -40682,6 +45966,24 @@ Reactome:R-HSA-6800138 N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer + + Reactome:R-HSA-5173214 + + + + + Reactome:R-HSA-5173214 + O-glycosylation of TSR domain-containing proteins + + + Reactome:R-HSA-2046106 + + + + + Reactome:R-HSA-2046106 + alpha-linolenic acid (ALA) metabolism + Reactome:R-HSA-2161549 @@ -40734,6 +46036,60 @@ Reactome:R-HSA-9630993 RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 + + Reactome:R-HSA-1482925 + + + + + Reactome:R-HSA-1482925 + Acyl chain remodelling of PG + + + Reactome:R-HSA-1482922 + + + + + Reactome:R-HSA-1482922 + Acyl chain remodelling of PI + + + Reactome:R-HSA-1482801 + + + + + Reactome:R-HSA-1482801 + Acyl chain remodelling of PS + + + Reactome:R-HSA-1482788 + + + + + Reactome:R-HSA-1482788 + Acyl chain remodelling of PC + + + Reactome:R-HSA-1482839 + + + + + Reactome:R-HSA-1482839 + Acyl chain remodelling of PE + + + Reactome:R-HSA-1482883 + + + + + Reactome:R-HSA-1482883 + Acyl chain remodeling of DAG and TAG + Reactome:R-HSA-2162195 @@ -40786,6 +46142,15 @@ Reactome:R-HSA-2509831 ITPA hydrolyses XTP to XMP + + Reactome:R-HSA-6783310 + + + + + Reactome:R-HSA-6783310 + Fanconi Anemia Pathway + Reactome:R-HSA-1222712 Reactome:R-HSA-266046 @@ -40872,6 +46237,15 @@ Reactome:R-HSA-9753634 GGT dimers hydrolyse APAP-SG + + Reactome:R-HSA-68867 + + + + + Reactome:R-HSA-68867 + Assembly of the pre-replicative complex + Reactome:R-HSA-977324 @@ -40908,6 +46282,42 @@ Reactome:R-HSA-203712 eNOS associates with Caveolin-1 + + Reactome:R-HSA-381070 + + + + + Reactome:R-HSA-381070 + IRE1alpha activates chaperones + + + Reactome:R-HSA-381042 + + + + + Reactome:R-HSA-381042 + PERK regulates gene expression + + + Reactome:R-HSA-381033 + + + + + Reactome:R-HSA-381033 + ATF6 (ATF6-alpha) activates chaperones + + + Reactome:R-HSA-77387 + + + + + Reactome:R-HSA-77387 + Insulin receptor recycling + Reactome:R-HSA-203716 Reactome:R-HSA-3000103 @@ -40919,52 +46329,185 @@ Reactome:R-HSA-9759209 - + + + Reactome:R-HSA-203716 + eNOS:Caveolin-1 complex binds to Nostrin + + + + + Reactome:R-HSA-3000103 + CUBN:AMN binds CBLIF:RCbl + + + + + Reactome:R-HSA-3000112 + CD320-mediated TCN2:RCbl uptake and delivery to lysosome + + + + + Reactome:R-HSA-3000122 + CD320 binds extracellular TCN2:RCbl + + + + + Reactome:R-HSA-3000137 + CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome + + + + + Reactome:R-HSA-350168 + LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D + + + + + Reactome:R-HSA-9759202 + LRP2-mediated TCN2:RCbl uptake and delivery to lysosome + + + + + Reactome:R-HSA-9759209 + LRP2 binds extracellular TCN2:RCbl + + + Reactome:R-HSA-5676590 + + + + + Reactome:R-HSA-5676590 + NIK-->noncanonical NF-kB signaling + + + Reactome:R-HSA-450302 + + + + + Reactome:R-HSA-450302 + activated TAK1 mediates p38 MAPK activation + + + Reactome:R-HSA-2454202 + + + + + Reactome:R-HSA-2454202 + Fc epsilon receptor (FCERI) signaling + + + Reactome:R-HSA-2029480 + Reactome:R-HSA-9664422 + + + + + Reactome:R-HSA-2029480 + Fcgamma receptor (FCGR) dependent phagocytosis + + + + + Reactome:R-HSA-9664422 + FCGR3A-mediated phagocytosis + + + Reactome:R-HSA-9020558 + + + + + Reactome:R-HSA-9020558 + Interleukin-2 signaling + + + Reactome:R-HSA-1266695 + + + - Reactome:R-HSA-203716 - eNOS:Caveolin-1 complex binds to Nostrin + Reactome:R-HSA-1266695 + Interleukin-7 signaling + + Reactome:R-HSA-8985947 + - + - Reactome:R-HSA-3000103 - CUBN:AMN binds CBLIF:RCbl + Reactome:R-HSA-8985947 + Interleukin-9 signaling + + Reactome:R-HSA-9020958 + - + - Reactome:R-HSA-3000112 - CD320-mediated TCN2:RCbl uptake and delivery to lysosome + Reactome:R-HSA-9020958 + Interleukin-21 signaling + + Reactome:R-HSA-168179 + - + - Reactome:R-HSA-3000122 - CD320 binds extracellular TCN2:RCbl + Reactome:R-HSA-168179 + Toll Like Receptor TLR1:TLR2 Cascade + + Reactome:R-HSA-168188 + - + - Reactome:R-HSA-3000137 - CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome + Reactome:R-HSA-168188 + Toll Like Receptor TLR6:TLR2 Cascade + + Reactome:R-HSA-1227986 + - + - Reactome:R-HSA-350168 - LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D + Reactome:R-HSA-1227986 + Signaling by ERBB2 + + Reactome:R-HSA-9020933 + - + - Reactome:R-HSA-9759202 - LRP2-mediated TCN2:RCbl uptake and delivery to lysosome + Reactome:R-HSA-9020933 + Interleukin-23 signaling + + Reactome:R-HSA-9006335 + - + - Reactome:R-HSA-9759209 - LRP2 binds extracellular TCN2:RCbl + Reactome:R-HSA-9006335 + Signaling by Erythropoietin + + + Reactome:R-HSA-9014843 + + + + + Reactome:R-HSA-9014843 + Interleukin-33 signaling Reactome:R-HSA-5340195 @@ -40975,6 +46518,40 @@ Reactome:R-HSA-5340195 NR1H4 binds DCA, CDCA, LCHA + + Reactome:R-HSA-168315 + + + + + Reactome:R-HSA-168315 + Inhibition of Host mRNA Processing and RNA Silencing + + + Reactome:R-HSA-9833482 + + + + + Reactome:R-HSA-9833482 + PKR-mediated signaling + + + Reactome:R-HSA-212165 + Reactome:R-HSA-8986944 + + + + + Reactome:R-HSA-212165 + Epigenetic regulation of gene expression + + + + + Reactome:R-HSA-8986944 + Transcriptional Regulation by MECP2 + Reactome:R-HSA-5205861 Reactome:R-HSA-5216234 @@ -40998,6 +46575,15 @@ Reactome:R-HSA-9822583 METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) + + Reactome:R-HSA-182971 + + + + + Reactome:R-HSA-182971 + EGFR downregulation + Reactome:R-HSA-70479 @@ -41007,6 +46593,47 @@ Reactome:R-HSA-70479 FBP tetramers hydrolyze F1,6PP to Fru(6)P + + Reactome:R-HSA-189483 + + + + + Reactome:R-HSA-189483 + Heme degradation + + + Reactome:R-HSA-9707616 + + + + + Reactome:R-HSA-9707616 + Heme signaling + + + Reactome:R-HSA-110312 + Reactome:R-HSA-5655862 + Reactome:R-HSA-5656121 + + + + + Reactome:R-HSA-110312 + Translesion synthesis by REV1 + + + + + Reactome:R-HSA-5655862 + Translesion synthesis by POLK + + + + + Reactome:R-HSA-5656121 + Translesion synthesis by POLI + Reactome:R-HSA-428259 @@ -41025,6 +46652,69 @@ Reactome:R-HSA-5653754 UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA + + Reactome:R-HSA-163680 + + + + + Reactome:R-HSA-163680 + AMPK inhibits chREBP transcriptional activation activity + + + Reactome:R-HSA-1638074 + + + + + Reactome:R-HSA-1638074 + Keratan sulfate/keratin metabolism + + + Reactome:R-HSA-2022857 + + + + + Reactome:R-HSA-2022857 + Keratan sulfate degradation + + + Reactome:R-HSA-6787639 + + + + + Reactome:R-HSA-6787639 + GDP-fucose biosynthesis + + + Reactome:R-HSA-196791 + + + + + Reactome:R-HSA-196791 + Vitamin D (calciferol) metabolism + + + Reactome:R-HSA-8877627 + + + + + Reactome:R-HSA-8877627 + Vitamin E + + + Reactome:R-HSA-6806664 + + + + + Reactome:R-HSA-6806664 + Metabolism of vitamin K + Reactome:R-HSA-428664 Reactome:R-HSA-428690 @@ -41048,6 +46738,76 @@ Reactome:R-HSA-428696 PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate + + Reactome:R-HSA-350864 + + + + + Reactome:R-HSA-350864 + Regulation of thyroid hormone activity + + + Reactome:R-HSA-8949613 + + + + + Reactome:R-HSA-8949613 + Cristae formation + + + Reactome:R-HSA-379397 + Reactome:R-HSA-379398 + + + + + Reactome:R-HSA-379397 + Enzymatic degradation of dopamine by COMT + + + + + Reactome:R-HSA-379398 + Enzymatic degradation of Dopamine by monoamine oxidase + + + Reactome:R-HSA-209905 + + + + + Reactome:R-HSA-209905 + Catecholamine biosynthesis + + + Reactome:R-HSA-6798163 + + + + + Reactome:R-HSA-6798163 + Choline catabolism + + + Reactome:R-HSA-380612 + + + + + Reactome:R-HSA-380612 + Metabolism of serotonin + + + Reactome:R-HSA-5662702 + + + + + Reactome:R-HSA-5662702 + Melanin biosynthesis + Reactome:R-HSA-8863101 Reactome:R-HSA-9708457 @@ -41064,6 +46824,15 @@ Reactome:R-HSA-9708457 HM13 cleaves HMOX1 dimer + + Reactome:R-HSA-1236975 + + + + + Reactome:R-HSA-1236975 + Antigen processing-Cross presentation + Reactome:R-HSA-1467457 Reactome:R-HSA-2161506 @@ -41178,6 +46947,79 @@ Reactome:R-HSA-9794572 ABCG2 transports Cipro from hepatic cell to extracellular space + + Reactome:R-HSA-196819 + + + + + Reactome:R-HSA-196819 + Vitamin B1 (thiamin) metabolism + + + Reactome:R-HSA-75205 + + + + + Reactome:R-HSA-75205 + Dissolution of Fibrin Clot + + + Reactome:R-HSA-9018677 + Reactome:R-HSA-9018679 + Reactome:R-HSA-9018683 + Reactome:R-HSA-9026403 + Reactome:R-HSA-9027604 + + + + + Reactome:R-HSA-9018677 + Biosynthesis of DHA-derived SPMs + + + + + Reactome:R-HSA-9018679 + Biosynthesis of EPA-derived SPMs + + + + + Reactome:R-HSA-9018683 + Biosynthesis of DPA-derived SPMs + + + + + Reactome:R-HSA-9026403 + Biosynthesis of DPAn-3-derived 13-series resolvins + + + + + Reactome:R-HSA-9027604 + Biosynthesis of electrophilic -3 PUFA oxo-derivatives + + + Reactome:R-HSA-163210 + + + + + Reactome:R-HSA-163210 + Formation of ATP by chemiosmotic coupling + + + Reactome:R-HSA-6807505 + + + + + Reactome:R-HSA-6807505 + RNA polymerase II transcribes snRNA genes + Reactome:R-HSA-2301205 Reactome:R-HSA-5682965 @@ -41252,6 +47094,15 @@ Reactome:R-HSA-9843121 KMT2D,(KMT2C) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers + + Reactome:R-HSA-964975 + + + + + Reactome:R-HSA-964975 + Vitamin B6 activation to pyridoxal phosphate + Reactome:R-HSA-5618331 @@ -41277,6 +47128,97 @@ Reactome:R-HSA-597628 SLC22A18 exchanges extracellular organic cations for cytosolic H+ + + Reactome:R-HSA-169911 + Reactome:R-HSA-5633008 + + + + + Reactome:R-HSA-169911 + Regulation of Apoptosis + + + + + Reactome:R-HSA-5633008 + TP53 Regulates Transcription of Cell Death Genes + + + Reactome:R-HSA-9037628 + + + + + Reactome:R-HSA-9037628 + Rhesus blood group biosynthesis + + + Reactome:R-HSA-193648 + Reactome:R-HSA-205043 + + + + + Reactome:R-HSA-193648 + NRAGE signals death through JNK + + + + + Reactome:R-HSA-205043 + NRIF signals cell death from the nucleus + + + Reactome:R-HSA-193639 + Reactome:R-HSA-211728 + Reactome:R-HSA-211733 + + + + + Reactome:R-HSA-193639 + p75NTR signals via NF-kB + + + + + Reactome:R-HSA-211728 + Regulation of PAK-2p34 activity by PS-GAP/RHG10 + + + + + Reactome:R-HSA-211733 + Regulation of activated PAK-2p34 by proteasome mediated degradation + + + Reactome:R-HSA-73614 + + + + + Reactome:R-HSA-73614 + Pyrimidine salvage + + + Reactome:R-HSA-74217 + + + + + Reactome:R-HSA-74217 + Purine salvage + + + Reactome:R-HSA-937039 + + + + + Reactome:R-HSA-937039 + IRAK1 recruits IKK complex + Reactome:R-HSA-1169404 Reactome:R-HSA-205008 @@ -41376,6 +47318,33 @@ Reactome:R-HSA-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER + + Reactome:R-HSA-5218900 + + + + + Reactome:R-HSA-5218900 + CASP8 activity is inhibited + + + Reactome:R-HSA-75815 + + + + + Reactome:R-HSA-75815 + Ubiquitin-dependent degradation of Cyclin D + + + Reactome:R-HSA-8956321 + + + + + Reactome:R-HSA-8956321 + Nucleotide salvage + Reactome:R-HSA-1454916 Reactome:R-HSA-5690340 @@ -41392,6 +47361,42 @@ Reactome:R-HSA-5690340 Defective ABCC6 does not transport organic anion from cytosol to extracellular region + + Reactome:R-HSA-9907900 + + + + + Reactome:R-HSA-9907900 + Proteasome assembly + + + Reactome:R-HSA-879518 + + + + + Reactome:R-HSA-879518 + Transport of organic anions + + + Reactome:R-HSA-205025 + + + + + Reactome:R-HSA-205025 + NADE modulates death signalling + + + Reactome:R-HSA-6798695 + + + + + Reactome:R-HSA-6798695 + Neutrophil degranulation + Reactome:R-HSA-1483063 @@ -41401,6 +47406,81 @@ Reactome:R-HSA-1483063 PG and CDP-DAG are converted to CL by CRLS1 + + Reactome:R-HSA-163685 + + + + + Reactome:R-HSA-163685 + Integration of energy metabolism + + + Reactome:R-HSA-428359 + Reactome:R-HSA-450531 + + + + + Reactome:R-HSA-428359 + Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA + + + + + Reactome:R-HSA-450531 + Regulation of mRNA stability by proteins that bind AU-rich elements + + + Reactome:R-HSA-9856872 + + + + + Reactome:R-HSA-9856872 + Malate-aspartate shuttle + + + Reactome:R-HSA-198203 + Reactome:R-HSA-198323 + Reactome:R-HSA-198693 + + + + + Reactome:R-HSA-198203 + PI3K/AKT activation + + + + + Reactome:R-HSA-198323 + AKT phosphorylates targets in the cytosol + + + + + Reactome:R-HSA-198693 + AKT phosphorylates targets in the nucleus + + + Reactome:R-HSA-1483249 + + + + + Reactome:R-HSA-1483249 + Inositol phosphate metabolism + + + Reactome:R-HSA-2046105 + + + + + Reactome:R-HSA-2046105 + Linoleic acid (LA) metabolism + Reactome:R-HSA-3697838 Reactome:R-HSA-6803545 @@ -41431,6 +47511,15 @@ Reactome:R-HSA-936895 ATP7B transports cytosolic Cu2+ to Golgi lumen + + Reactome:R-HSA-597592 + + + + + Reactome:R-HSA-597592 + Post-translational protein modification + Reactome:R-HSA-1675836 Reactome:R-HSA-1676005 @@ -41495,6 +47584,22 @@ Reactome:R-HSA-2263490 Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate + + Reactome:R-HSA-9635644 + Reactome:R-HSA-9636667 + + + + + Reactome:R-HSA-9635644 + Inhibition of membrane repair + + + + + Reactome:R-HSA-9636667 + Manipulation of host energy metabolism + Reactome:R-HSA-9018785 Reactome:R-HSA-9855212 @@ -41525,6 +47630,60 @@ Reactome:R-HSA-9866253 apo-UQCRFS1 binds LYRM7 + + Reactome:R-HSA-1428517 + + + + + Reactome:R-HSA-1428517 + Aerobic respiration and respiratory electron transport + + + Reactome:R-HSA-192456 + + + + + Reactome:R-HSA-192456 + Digestion of dietary lipid + + + Reactome:R-HSA-189085 + + + + + Reactome:R-HSA-189085 + Digestion of dietary carbohydrate + + + Reactome:R-HSA-173107 + + + + + Reactome:R-HSA-173107 + Binding and entry of HIV virion + + + Reactome:R-HSA-9824443 + + + + + Reactome:R-HSA-9824443 + Parasitic Infection Pathways + + + Reactome:R-HSA-9837092 + + + + + Reactome:R-HSA-9837092 + FASTK family proteins regulate processing and stability of mitochondrial RNAs + Reactome:R-HSA-9765952 @@ -41568,6 +47727,76 @@ Reactome:R-HSA-2395965 NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP + + Reactome:R-HSA-9821002 + Reactome:R-HSA-9821993 + + + + + Reactome:R-HSA-9821002 + Chromatin modifications during the maternal to zygotic transition (MZT) + + + + + Reactome:R-HSA-9821993 + Replacement of protamines by nucleosomes in the male pronucleus + + + Reactome:R-HSA-5693554 + + + + + Reactome:R-HSA-5693554 + Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) + + + Reactome:R-HSA-73927 + + + + + Reactome:R-HSA-73927 + Depurination + + + Reactome:R-HSA-73928 + + + + + Reactome:R-HSA-73928 + Depyrimidination + + + Reactome:R-HSA-9603798 + + + + + Reactome:R-HSA-9603798 + Class I peroxisomal membrane protein import + + + Reactome:R-HSA-9609523 + + + + + Reactome:R-HSA-9609523 + Insertion of tail-anchored proteins into the endoplasmic reticulum membrane + + + Reactome:R-HSA-168249 + + + + + Reactome:R-HSA-168249 + Innate Immune System + Reactome:R-HSA-6803771 @@ -41595,6 +47824,77 @@ Reactome:R-HSA-198813 GSTO dimers reduce DeHA to AscH- + + Reactome:R-HSA-421270 + + + + + Reactome:R-HSA-421270 + Cell-cell junction organization + + + Reactome:R-HSA-71262 + + + + + Reactome:R-HSA-71262 + Carnitine synthesis + + + Reactome:R-HSA-1660502 + Reactome:R-HSA-1660508 + Reactome:R-HSA-1660510 + Reactome:R-HSA-1660524 + Reactome:R-HSA-1660537 + + + + + Reactome:R-HSA-1660502 + PIPs transport between early and late endosome membranes + + + + + Reactome:R-HSA-1660508 + PIPs transport between late endosome and Golgi membranes + + + + + Reactome:R-HSA-1660510 + PIPs transport between Golgi and plasma membranes + + + + + Reactome:R-HSA-1660524 + PIPs transport between plasma and early endosome membranes + + + + + Reactome:R-HSA-1660537 + PIPs transport between early endosome and Golgi membranes + + + Reactome:R-HSA-1222541 + Reactome:R-HSA-1222556 + + + + + Reactome:R-HSA-1222541 + Cell redox homeostasis + + + + + Reactome:R-HSA-1222556 + ROS and RNS production in phagocytes + Reactome:R-HSA-2046089 Reactome:R-HSA-2046092 @@ -41611,6 +47911,216 @@ Reactome:R-HSA-2046092 Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA + + Reactome:R-HSA-1655829 + + + + + Reactome:R-HSA-1655829 + Regulation of cholesterol biosynthesis by SREBP (SREBF) + + + Reactome:R-HSA-8877330 + + + + + Reactome:R-HSA-8877330 + RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) + + + Reactome:R-HSA-8939242 + + + + + Reactome:R-HSA-8939242 + RUNX1 regulates transcription of genes involved in differentiation of keratinocytes + + + Reactome:R-HSA-8939246 + + + + + Reactome:R-HSA-8939246 + RUNX1 regulates transcription of genes involved in differentiation of myeloid cells + + + Reactome:R-HSA-8936459 + + + + + Reactome:R-HSA-8936459 + RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function + + + Reactome:R-HSA-69656 + + + + + Reactome:R-HSA-69656 + Cyclin A:Cdk2-associated events at S phase entry + + + Reactome:R-HSA-8849469 + + + + + Reactome:R-HSA-8849469 + PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 + + + Reactome:R-HSA-9604323 + + + + + Reactome:R-HSA-9604323 + Negative regulation of NOTCH4 signaling + + + Reactome:R-HSA-193670 + + + + + Reactome:R-HSA-193670 + p75NTR negatively regulates cell cycle via SC1 + + + Reactome:R-HSA-8849470 + + + + + Reactome:R-HSA-8849470 + PTK6 Regulates Cell Cycle + + + Reactome:R-HSA-212300 + Reactome:R-HSA-5250941 + + + + + Reactome:R-HSA-212300 + PRC2 methylates histones and DNA + + + + + Reactome:R-HSA-5250941 + Negative epigenetic regulation of rRNA expression + + + Reactome:R-HSA-5250913 + + + + + Reactome:R-HSA-5250913 + Positive epigenetic regulation of rRNA expression + + + Reactome:R-HSA-8854050 + + + + + Reactome:R-HSA-8854050 + FBXL7 down-regulates AURKA during mitotic entry and in early mitosis + + + Reactome:R-HSA-2173796 + Reactome:R-HSA-8866906 + Reactome:R-HSA-8866907 + + + + + Reactome:R-HSA-2173796 + SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription + + + + + Reactome:R-HSA-8866906 + TFAP2 (AP-2) family regulates transcription of other transcription factors + + + + + Reactome:R-HSA-8866907 + Activation of the TFAP2 (AP-2) family of transcription factors + + + Reactome:R-HSA-500753 + + + + + Reactome:R-HSA-500753 + Pyrimidine biosynthesis + + + Reactome:R-HSA-73621 + + + + + Reactome:R-HSA-73621 + Pyrimidine catabolism + + + Reactome:R-HSA-1474151 + + + + + Reactome:R-HSA-1474151 + Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation + + + Reactome:R-HSA-202131 + + + + + Reactome:R-HSA-202131 + Metabolism of nitric oxide: NOS3 activation and regulation + + + Reactome:R-HSA-209931 + + + + + Reactome:R-HSA-209931 + Serotonin and melatonin biosynthesis + + + Reactome:R-HSA-5423646 + + + + + Reactome:R-HSA-5423646 + Aflatoxin activation and detoxification + + + Reactome:R-HSA-5652227 + + + + + Reactome:R-HSA-5652227 + Fructose biosynthesis + Reactome:R-HSA-5649705 @@ -41620,6 +48130,51 @@ Reactome:R-HSA-5649705 PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) + + Reactome:R-HSA-8849474 + + + + + Reactome:R-HSA-8849474 + PTK6 Activates STAT3 + + + Reactome:R-HSA-2162123 + + + + + Reactome:R-HSA-2162123 + Synthesis of Prostaglandins (PG) and Thromboxanes (TX) + + + Reactome:R-HSA-1483206 + + + + + Reactome:R-HSA-1483206 + Glycerophospholipid biosynthesis + + + Reactome:R-HSA-6814848 + + + + + Reactome:R-HSA-6814848 + Glycerophospholipid catabolism + + + Reactome:R-HSA-9840310 + + + + + Reactome:R-HSA-9840310 + Glycosphingolipid catabolism + Reactome:R-HSA-1237096 Reactome:R-HSA-1299507 @@ -41679,6 +48234,29 @@ Reactome:R-HSA-1237140 Dehydration of methylthio-ribulose-P + + Reactome:R-HSA-9026519 + Reactome:R-HSA-9027284 + Reactome:R-HSA-9034864 + + + + + Reactome:R-HSA-9026519 + Activated NTRK2 signals through RAS + + + + + Reactome:R-HSA-9027284 + Erythropoietin activates RAS + + + + + Reactome:R-HSA-9034864 + Activated NTRK3 signals through RAS + Reactome:R-HSA-9695890 Reactome:R-HSA-9843721 @@ -41695,6 +48273,49 @@ Reactome:R-HSA-9843721 ABCC1,ABCG2 transport C18-S1P to extracellular region + + Reactome:R-HSA-196757 + + + + + Reactome:R-HSA-196757 + Metabolism of folate and pterines + + + Reactome:R-HSA-400042 + + + + + Reactome:R-HSA-400042 + Adrenaline,noradrenaline inhibits insulin secretion + + + Reactome:R-HSA-9639775 + + + + + Reactome:R-HSA-9639775 + Antimicrobial action and antimicrobial resistance in Mtb + + + Reactome:R-HSA-168270 + Reactome:R-HSA-8876384 + + + + + Reactome:R-HSA-168270 + Fusion and Uncoating of the Influenza Virion + + + + + Reactome:R-HSA-8876384 + Listeria monocytogenes entry into host cells + Reactome:R-HSA-1008248 @@ -42099,6 +48720,42 @@ Reactome:R-HSA-390347 Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane + + Reactome:R-HSA-75105 + + + + + Reactome:R-HSA-75105 + Fatty acyl-CoA biosynthesis + + + Reactome:R-HSA-74182 + + + + + Reactome:R-HSA-74182 + Ketone body metabolism + + + Reactome:R-HSA-77111 + + + + + Reactome:R-HSA-77111 + Synthesis of Ketone Bodies + + + Reactome:R-HSA-77108 + + + + + Reactome:R-HSA-77108 + Utilization of Ketone Bodies + Reactome:R-HSA-741449 @@ -43116,6 +49773,72 @@ Reactome:R-HSA-6788611 HYKK phosphorylates 5HLYS + + Reactome:R-HSA-2404192 + + + + + Reactome:R-HSA-2404192 + Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) + + + Reactome:R-HSA-194138 + + + + + Reactome:R-HSA-194138 + Signaling by VEGF + + + Reactome:R-HSA-166520 + Reactome:R-HSA-167021 + Reactome:R-HSA-187042 + Reactome:R-HSA-193704 + + + + + Reactome:R-HSA-166520 + Signaling by NTRKs + + + + + Reactome:R-HSA-167021 + PLC-gamma1 signalling + + + + + Reactome:R-HSA-187042 + TRKA activation by NGF + + + + + Reactome:R-HSA-193704 + p75 NTR receptor-mediated signalling + + + Reactome:R-HSA-8852405 + + + + + Reactome:R-HSA-8852405 + Signaling by MST1 + + + Reactome:R-HSA-2682334 + + + + + Reactome:R-HSA-2682334 + EPH-Ephrin signaling + Reactome:R-HSA-163625 Reactome:R-HSA-381612 @@ -43141,6 +49864,24 @@ Reactome:R-HSA-8863761 UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose + + Reactome:R-HSA-204005 + + + + + Reactome:R-HSA-204005 + COPII-mediated vesicle transport + + + Reactome:R-HSA-9670095 + + + + + Reactome:R-HSA-9670095 + Inhibition of DNA recombination at telomere + Reactome:R-HSA-389639 @@ -43150,6 +49891,60 @@ Reactome:R-HSA-389639 phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 + + Reactome:R-HSA-162658 + + + + + Reactome:R-HSA-162658 + Golgi Cisternae Pericentriolar Stack Reorganization + + + Reactome:R-HSA-9796292 + + + + + Reactome:R-HSA-9796292 + Formation of axial mesoderm + + + Reactome:R-HSA-9793380 + + + + + Reactome:R-HSA-9793380 + Formation of paraxial mesoderm + + + Reactome:R-HSA-9758920 + + + + + Reactome:R-HSA-9758920 + Formation of lateral plate mesoderm + + + Reactome:R-HSA-9761174 + + + + + Reactome:R-HSA-9761174 + Formation of intermediate mesoderm + + + Reactome:R-HSA-1474165 + + + + + Reactome:R-HSA-1474165 + Reproduction + Reactome:R-HSA-2855020 @@ -43573,6 +50368,24 @@ Reactome:R-HSA-70349 DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate + + Reactome:R-HSA-156584 + + + + + Reactome:R-HSA-156584 + Cytosolic sulfonation of small molecules + + + Reactome:R-HSA-167246 + + + + + Reactome:R-HSA-167246 + Tat-mediated elongation of the HIV-1 transcript + Reactome:R-HSA-5696415 @@ -43890,6 +50703,60 @@ Reactome:R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 + + Reactome:R-HSA-9018678 + + + + + Reactome:R-HSA-9018678 + Biosynthesis of specialized proresolving mediators (SPMs) + + + Reactome:R-HSA-193697 + + + + + Reactome:R-HSA-193697 + p75NTR regulates axonogenesis + + + Reactome:R-HSA-193634 + + + + + Reactome:R-HSA-193634 + Axonal growth inhibition (RHOA activation) + + + Reactome:R-HSA-209563 + + + + + Reactome:R-HSA-209563 + Axonal growth stimulation + + + Reactome:R-HSA-198933 + + + + + Reactome:R-HSA-198933 + Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell + + + Reactome:R-HSA-422356 + + + + + Reactome:R-HSA-422356 + Regulation of insulin secretion + Reactome:R-HSA-372342 @@ -43899,6 +50766,60 @@ Reactome:R-HSA-372342 MPC1:MPC2 imports PYR, H+ to mitochondrial matrix + + Reactome:R-HSA-202403 + + + + + Reactome:R-HSA-202403 + TCR signaling + + + Reactome:R-HSA-8939245 + + + + + Reactome:R-HSA-8939245 + RUNX1 regulates transcription of genes involved in BCR signaling + + + Reactome:R-HSA-381340 + + + + + Reactome:R-HSA-381340 + Transcriptional regulation of white adipocyte differentiation + + + Reactome:R-HSA-8963676 + + + + + Reactome:R-HSA-8963676 + Intestinal absorption + + + Reactome:R-HSA-202733 + + + + + Reactome:R-HSA-202733 + Cell surface interactions at the vascular wall + + + Reactome:R-HSA-9717189 + + + + + Reactome:R-HSA-9717189 + Sensory perception of taste + Reactome:R-HSA-203906 @@ -43908,6 +50829,15 @@ Reactome:R-HSA-203906 Exportin complex translocates pre-miRNA to cytosol + + Reactome:R-HSA-9012999 + + + + + Reactome:R-HSA-9012999 + RHO GTPase cycle + Reactome:R-HSA-9683772 Reactome:R-HSA-9694337 @@ -43924,6 +50854,33 @@ Reactome:R-HSA-9694337 Trimmed spike protein binds to calnexin + + Reactome:R-HSA-391251 + + + + + Reactome:R-HSA-391251 + Protein folding + + + Reactome:R-HSA-390450 + + + + + Reactome:R-HSA-390450 + Folding of actin by CCT/TriC + + + Reactome:R-HSA-9708530 + + + + + Reactome:R-HSA-9708530 + Regulation of BACH1 activity + Reactome:R-HSA-428779 Reactome:R-HSA-8875902 @@ -43963,6 +50920,15 @@ Reactome:R-HSA-8942208 ALOXE3 isomerises 12R-HpETE to HXA3 + + Reactome:R-HSA-2142696 + + + + + Reactome:R-HSA-2142696 + Synthesis of Hepoxilins (HX) and Trioxilins (TrX) + Reactome:R-HSA-435171 @@ -43972,6 +50938,15 @@ Reactome:R-HSA-435171 NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages + + Reactome:R-HSA-525793 + + + + + Reactome:R-HSA-525793 + Myogenesis + Reactome:R-HSA-112120 Reactome:R-HSA-112121 @@ -44002,6 +50977,15 @@ Reactome:R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3 + + Reactome:R-HSA-2467813 + + + + + Reactome:R-HSA-2467813 + Separation of Sister Chromatids + Reactome:R-HSA-162798 @@ -44011,6 +50995,52 @@ Reactome:R-HSA-162798 mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol + + Reactome:R-HSA-9024909 + Reactome:R-HSA-9025046 + Reactome:R-HSA-9026357 + Reactome:R-HSA-9034013 + Reactome:R-HSA-9034793 + + + + + Reactome:R-HSA-9024909 + BDNF activates NTRK2 (TRKB) signaling + + + + + Reactome:R-HSA-9025046 + NTF3 activates NTRK2 (TRKB) signaling + + + + + Reactome:R-HSA-9026357 + NTF4 activates NTRK2 (TRKB) signaling + + + + + Reactome:R-HSA-9034013 + NTF3 activates NTRK3 signaling + + + + + Reactome:R-HSA-9034793 + Activated NTRK3 signals through PLCG1 + + + Reactome:R-HSA-450294 + + + + + Reactome:R-HSA-450294 + MAP kinase activation + Reactome:R-HSA-5690873 @@ -44020,6 +51050,49 @@ Reactome:R-HSA-5690873 ACO1 binds 4Fe-4S + + Reactome:R-HSA-8983711 + + + + + Reactome:R-HSA-8983711 + OAS antiviral response + + + Reactome:R-HSA-9635486 + Reactome:R-HSA-9658195 + + + + + Reactome:R-HSA-9635486 + Infection with Mycobacterium tuberculosis + + + + + Reactome:R-HSA-9658195 + Leishmania infection + + + Reactome:R-HSA-9662851 + + + + + Reactome:R-HSA-9662851 + Anti-inflammatory response favouring Leishmania parasite infection + + + Reactome:R-HSA-8953897 + + + + + Reactome:R-HSA-8953897 + Cellular responses to stimuli + Reactome:R-HSA-1855200 Reactome:R-HSA-1855205 @@ -44086,6 +51159,22 @@ Reactome:R-HSA-5367022 DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 + + Reactome:R-HSA-156711 + Reactome:R-HSA-380972 + + + + + Reactome:R-HSA-156711 + Polo-like kinase mediated events + + + + + Reactome:R-HSA-380972 + Energy dependent regulation of mTOR by LKB1-AMPK + Reactome:R-HSA-8956427 @@ -44120,6 +51209,61 @@ Reactome:R-HSA-1676204 PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane + + Reactome:R-HSA-6811558 + + + + + Reactome:R-HSA-6811558 + PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling + + + Reactome:R-HSA-1257604 + Reactome:R-HSA-165158 + Reactome:R-HSA-9027276 + Reactome:R-HSA-9028335 + Reactome:R-HSA-9603381 + + + + + Reactome:R-HSA-1257604 + PIP3 activates AKT signaling + + + + + Reactome:R-HSA-165158 + Activation of AKT2 + + + + + Reactome:R-HSA-9027276 + Erythropoietin activates Phosphoinositide-3-kinase (PI3K) + + + + + Reactome:R-HSA-9028335 + Activated NTRK2 signals through PI3K + + + + + Reactome:R-HSA-9603381 + Activated NTRK3 signals through PI3K + + + Reactome:R-HSA-112308 + + + + + Reactome:R-HSA-112308 + Presynaptic depolarization and calcium channel opening + Reactome:R-HSA-5692237 @@ -44152,6 +51296,15 @@ Reactome:R-HSA-1500804 Peroxynitrite is reduced by AhpE + + Reactome:R-HSA-888593 + + + + + Reactome:R-HSA-888593 + Reuptake of GABA + Reactome:R-HSA-880007 Reactome:R-HSA-880053 @@ -44168,6 +51321,40 @@ Reactome:R-HSA-880053 2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] + + Reactome:R-HSA-9637628 + Reactome:R-HSA-9637690 + + + + + Reactome:R-HSA-9637628 + Modulation by Mtb of host immune system + + + + + Reactome:R-HSA-9637690 + Response of Mtb to phagocytosis + + + Reactome:R-HSA-1222387 + + + + + Reactome:R-HSA-1222387 + Tolerance of reactive oxygen produced by macrophages + + + Reactome:R-HSA-9637687 + + + + + Reactome:R-HSA-9637687 + Suppression of phagosomal maturation + Reactome:R-HSA-6784462 Reactome:R-HSA-6787567 @@ -44184,6 +51371,15 @@ Reactome:R-HSA-6787567 TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) + + Reactome:R-HSA-1222499 + + + + + Reactome:R-HSA-1222499 + Latent infection - Other responses of Mtb to phagocytosis + Reactome:R-HSA-5696131 @@ -44366,6 +51562,15 @@ Reactome:R-HSA-9749792 CES1,CES2 hydrolyze ASA- to ST + + Reactome:R-HSA-156588 + + + + + Reactome:R-HSA-156588 + Glucuronidation + Reactome:R-HSA-1855197 Reactome:R-HSA-2267372 @@ -44764,6 +51969,216 @@ Reactome:R-HSA-8981574 GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol + + Reactome:R-HSA-382556 + Reactome:R-HSA-425407 + Reactome:R-HSA-5223345 + + + + + Reactome:R-HSA-382556 + ABC-family proteins mediated transport + + + + + Reactome:R-HSA-425407 + SLC-mediated transmembrane transport + + + + + Reactome:R-HSA-5223345 + Miscellaneous transport and binding events + + + Reactome:R-HSA-15869 + Reactome:R-HSA-2393930 + + + + + Reactome:R-HSA-15869 + Metabolism of nucleotides + + + + + Reactome:R-HSA-2393930 + Phosphate bond hydrolysis by NUDT proteins + + + Reactome:R-HSA-4641262 + + + + + Reactome:R-HSA-4641262 + Disassembly of the destruction complex and recruitment of AXIN to the membrane + + + Reactome:R-HSA-4086400 + + + + + Reactome:R-HSA-4086400 + PCP/CE pathway + + + Reactome:R-HSA-380320 + + + + + Reactome:R-HSA-380320 + Recruitment of NuMA to mitotic centrosomes + + + Reactome:R-HSA-212436 + + + + + Reactome:R-HSA-212436 + Generic Transcription Pathway + + + Reactome:R-HSA-5617833 + + + + + Reactome:R-HSA-5617833 + Cilium Assembly + + + Reactome:R-HSA-9664424 + + + + + Reactome:R-HSA-9664424 + Cell recruitment (pro-inflammatory response) + + + Reactome:R-HSA-877300 + + + + + Reactome:R-HSA-877300 + Interferon gamma signaling + + + Reactome:R-HSA-877312 + + + + + Reactome:R-HSA-877312 + Regulation of IFNG signaling + + + Reactome:R-HSA-909733 + + + + + Reactome:R-HSA-909733 + Interferon alpha/beta signaling + + + Reactome:R-HSA-912694 + + + + + Reactome:R-HSA-912694 + Regulation of IFNA/IFNB signaling + + + Reactome:R-HSA-982772 + + + + + Reactome:R-HSA-982772 + Growth hormone receptor signaling + + + Reactome:R-HSA-5675482 + + + + + Reactome:R-HSA-5675482 + Regulation of necroptotic cell death + + + Reactome:R-HSA-9830674 + + + + + Reactome:R-HSA-9830674 + Formation of the ureteric bud + + + Reactome:R-HSA-5625886 + + + + + Reactome:R-HSA-5625886 + Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 + + + Reactome:R-HSA-9834899 + + + + + Reactome:R-HSA-9834899 + Specification of the neural plate border + + + Reactome:R-HSA-9733709 + + + + + Reactome:R-HSA-9733709 + Cardiogenesis + + + Reactome:R-HSA-5578749 + + + + + Reactome:R-HSA-5578749 + Transcriptional regulation by small RNAs + + + Reactome:R-HSA-199991 + + + + + Reactome:R-HSA-199991 + Membrane Trafficking + + + Reactome:R-HSA-5576891 + + + + + Reactome:R-HSA-5576891 + Cardiac conduction + Reactome:R-HSA-3244614 @@ -44953,6 +52368,24 @@ Reactome:R-HSA-70342 ALDOB tetramer cleaves Fru-1-P to GA and DHAP + + Reactome:R-HSA-70171 + + + + + Reactome:R-HSA-70171 + Glycolysis + + + Reactome:R-HSA-70350 + + + + + Reactome:R-HSA-70350 + Fructose catabolism + Reactome:R-HSA-5696838 @@ -45631,6 +53064,15 @@ Reactome:R-HSA-9842868 TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 + + Reactome:R-HSA-9613829 + + + + + Reactome:R-HSA-9613829 + Chaperone Mediated Autophagy + Reactome:R-HSA-9861626 @@ -45658,6 +53100,15 @@ Reactome:R-HSA-6784494 EKC complex threonylcarbamoylates A37 of tRNAs + + Reactome:R-HSA-9613354 + + + + + Reactome:R-HSA-9613354 + Lipophagy + Reactome:R-HSA-6811508 Reactome:R-HSA-8951966 @@ -45716,6 +53167,15 @@ Reactome:R-HSA-9825747 CREBBP acetylates HINT1 dimer + + Reactome:R-HSA-9615710 + + + + + Reactome:R-HSA-9615710 + Late endosomal microautophagy + Reactome:R-HSA-8869606 Reactome:R-HSA-8869607 @@ -45773,6 +53233,15 @@ Reactome:R-HSA-9822115 NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA + + Reactome:R-HSA-9861718 + + + + + Reactome:R-HSA-9861718 + Regulation of pyruvate metabolism + Reactome:R-HSA-9631355 @@ -45805,6 +53274,15 @@ Reactome:R-HSA-9731661 ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine + + Reactome:R-HSA-9711123 + + + + + Reactome:R-HSA-9711123 + Cellular response to chemical stress + Reactome:R-HSA-6790906 @@ -45839,6 +53317,51 @@ Reactome:R-HSA-6790982 WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 + + Reactome:R-HSA-1059683 + + + + + Reactome:R-HSA-1059683 + Interleukin-6 signaling + + + Reactome:R-HSA-9020956 + + + + + Reactome:R-HSA-9020956 + Interleukin-27 signaling + + + Reactome:R-HSA-5368286 + + + + + Reactome:R-HSA-5368286 + Mitochondrial translation initiation + + + Reactome:R-HSA-5389840 + + + + + Reactome:R-HSA-5389840 + Mitochondrial translation elongation + + + Reactome:R-HSA-5419276 + + + + + Reactome:R-HSA-5419276 + Mitochondrial translation termination + Reactome:R-HSA-2990840 Reactome:R-HSA-2990842 @@ -45862,6 +53385,15 @@ Reactome:R-HSA-2993763 SENP1,2,5 proteolytically process SUMO3 + + Reactome:R-HSA-1614517 + + + + + Reactome:R-HSA-1614517 + Sulfide oxidation to sulfate + Reactome:R-HSA-1614665 @@ -45880,6 +53412,33 @@ Reactome:R-HSA-389632 pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate + + Reactome:R-HSA-5213460 + + + + + Reactome:R-HSA-5213460 + RIPK1-mediated regulated necrosis + + + Reactome:R-HSA-6809371 + + + + + Reactome:R-HSA-6809371 + Formation of the cornified envelope + + + Reactome:R-HSA-5620971 + + + + + Reactome:R-HSA-5620971 + Pyroptosis + Reactome:R-HSA-2466831 @@ -45889,6 +53448,33 @@ Reactome:R-HSA-2466831 A2PE hydrolyses to A2E + + Reactome:R-HSA-8953750 + + + + + Reactome:R-HSA-8953750 + Transcriptional Regulation by E2F6 + + + Reactome:R-HSA-112409 + + + + + Reactome:R-HSA-112409 + RAF-independent MAPK1/3 activation + + + Reactome:R-HSA-9020702 + + + + + Reactome:R-HSA-9020702 + Interleukin-1 signaling + Reactome:R-HSA-9757706 Reactome:R-HSA-9759259 @@ -45967,6 +53553,15 @@ Reactome:R-HSA-9817458 TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 + + Reactome:R-HSA-3295583 + + + + + Reactome:R-HSA-3295583 + TRP channels + Reactome:R-HSA-73800 Reactome:R-HSA-73828 @@ -46035,6 +53630,15 @@ Reactome:R-HSA-8955869 Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin + + Reactome:R-HSA-8984722 + + + + + Reactome:R-HSA-8984722 + Interleukin-35 Signalling + Reactome:R-HSA-428262 @@ -46053,6 +53657,121 @@ Reactome:R-HSA-9630022 JMJD6 dimer hydroxylates lysine residues of U2AF2 + + Reactome:R-HSA-420029 + + + + + Reactome:R-HSA-420029 + Tight junction interactions + + + Reactome:R-HSA-6787450 + + + + + Reactome:R-HSA-6787450 + tRNA modification in the mitochondrion + + + Reactome:R-HSA-5696399 + + + + + Reactome:R-HSA-5696399 + Global Genome Nucleotide Excision Repair (GG-NER) + + + Reactome:R-HSA-110320 + + + + + Reactome:R-HSA-110320 + Translesion Synthesis by POLH + + + Reactome:R-HSA-9855142 + + + + + Reactome:R-HSA-9855142 + Cellular responses to mechanical stimuli + + + Reactome:R-HSA-71737 + + + + + Reactome:R-HSA-71737 + Pyrophosphate hydrolysis + + + Reactome:R-HSA-9007892 + Reactome:R-HSA-9008059 + + + + + Reactome:R-HSA-9007892 + Interleukin-38 signaling + + + + + Reactome:R-HSA-9008059 + Interleukin-37 signaling + + + Reactome:R-HSA-163359 + + + + + Reactome:R-HSA-163359 + Glucagon signaling in metabolic regulation + + + Reactome:R-HSA-3371497 + + + + + Reactome:R-HSA-3371497 + HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand + + + Reactome:R-HSA-1234174 + + + + + Reactome:R-HSA-1234174 + Cellular response to hypoxia + + + Reactome:R-HSA-9860931 + + + + + Reactome:R-HSA-9860931 + Response of endothelial cells to shear stress + + + Reactome:R-HSA-5357786 + + + + + Reactome:R-HSA-5357786 + TNFR1-induced proapoptotic signaling + Reactome:R-HSA-3222593 Reactome:R-HSA-5617431 @@ -46090,6 +53809,15 @@ Reactome:R-HSA-9822985 KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) + + Reactome:R-HSA-435354 + + + + + Reactome:R-HSA-435354 + Zinc transporters + Reactome:R-HSA-428990 @@ -46099,6 +53827,42 @@ Reactome:R-HSA-428990 SLC27A1 transports arachidonate across the ER membrane + + Reactome:R-HSA-1296071 + + + + + Reactome:R-HSA-1296071 + Potassium Channels + + + Reactome:R-HSA-174824 + + + + + Reactome:R-HSA-174824 + Plasma lipoprotein assembly, remodeling, and clearance + + + Reactome:R-HSA-9830364 + + + + + Reactome:R-HSA-9830364 + Formation of the nephric duct + + + Reactome:R-HSA-9831926 + + + + + Reactome:R-HSA-9831926 + Nephron development + Reactome:R-HSA-2685505 @@ -46108,6 +53872,15 @@ Reactome:R-HSA-2685505 TPCN1/2 transport lysosomal Ca2+ to cytosol + + Reactome:R-HSA-2161517 + + + + + Reactome:R-HSA-2161517 + Abacavir transmembrane transport + Reactome:R-HSA-8942575 @@ -46117,6 +53890,47 @@ Reactome:R-HSA-8942575 N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG + + Reactome:R-HSA-9664407 + + + + + Reactome:R-HSA-9664407 + Parasite infection + + + Reactome:R-HSA-162592 + + + + + Reactome:R-HSA-162592 + Integration of provirus + + + Reactome:R-HSA-168271 + Reactome:R-HSA-168274 + Reactome:R-HSA-174490 + + + + + Reactome:R-HSA-168271 + Transport of Ribonucleoproteins into the Host Nucleus + + + + + Reactome:R-HSA-168274 + Export of Viral Ribonucleoproteins from Nucleus + + + + + Reactome:R-HSA-174490 + Membrane binding and targetting of GAG proteins + Reactome:R-HSA-5693761 @@ -46142,6 +53956,76 @@ Reactome:R-HSA-1614614 Cysteine is degraded to serine and H2S + + Reactome:R-HSA-9754189 + + + + + Reactome:R-HSA-9754189 + Germ layer formation at gastrulation + + + Reactome:R-HSA-9823739 + + + + + Reactome:R-HSA-9823739 + Formation of the anterior neural plate + + + Reactome:R-HSA-9832991 + + + + + Reactome:R-HSA-9832991 + Formation of the posterior neural plate + + + Reactome:R-HSA-3772470 + Reactome:R-HSA-4641258 + + + + + Reactome:R-HSA-3772470 + Negative regulation of TCF-dependent signaling by WNT ligand antagonists + + + + + Reactome:R-HSA-4641258 + Degradation of DVL + + + Reactome:R-HSA-4641257 + + + + + Reactome:R-HSA-4641257 + Degradation of AXIN + + + Reactome:R-HSA-9843743 + + + + + Reactome:R-HSA-9843743 + Transcriptional regulation of brown and beige adipocyte differentiation + + + Reactome:R-HSA-2559583 + + + + + Reactome:R-HSA-2559583 + Cellular Senescence + Reactome:R-HSA-8869603 @@ -46194,6 +54078,24 @@ Reactome:R-HSA-9036729 Defective GAA does not hydrolyze lysosomal glycogen + + Reactome:R-HSA-6785470 + + + + + Reactome:R-HSA-6785470 + tRNA processing in the mitochondrion + + + Reactome:R-HSA-351143 + + + + + Reactome:R-HSA-351143 + Agmatine biosynthesis + Reactome:R-HSA-6800797 @@ -46212,6 +54114,65 @@ Reactome:R-HSA-1497796 BH2 binding can lead to eNOS uncoupling + + Reactome:R-HSA-193681 + Reactome:R-HSA-204998 + Reactome:R-HSA-75157 + + + + + Reactome:R-HSA-193681 + Ceramide signalling + + + + + Reactome:R-HSA-204998 + Cell death signalling via NRAGE, NRIF and NADE + + + + + Reactome:R-HSA-75157 + FasL/ CD95L signaling + + + Reactome:R-HSA-5357769 + + + + + Reactome:R-HSA-5357769 + Caspase activation via extrinsic apoptotic signalling pathway + + + Reactome:R-HSA-418889 + + + + + Reactome:R-HSA-418889 + Caspase activation via Dependence Receptors in the absence of ligand + + + Reactome:R-HSA-109606 + + + + + Reactome:R-HSA-109606 + Intrinsic Pathway for Apoptosis + + + Reactome:R-HSA-75153 + + + + + Reactome:R-HSA-75153 + Apoptotic execution phase + Reactome:R-HSA-2161567 @@ -46291,6 +54252,15 @@ Reactome:R-HSA-2161776 5S-HETE is oxidised to 5-oxoETE by 5-HEDH + + Reactome:R-HSA-2142816 + + + + + Reactome:R-HSA-2142816 + Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) + Reactome:R-HSA-2162253 @@ -46300,6 +54270,24 @@ Reactome:R-HSA-2162253 PDSS1,2 ligates FPP to IPPP + + Reactome:R-HSA-140534 + + + + + Reactome:R-HSA-140534 + Caspase activation via Death Receptors in the presence of ligand + + + Reactome:R-HSA-5218859 + + + + + Reactome:R-HSA-5218859 + Regulated Necrosis + Reactome:R-HSA-9687828 @@ -46318,6 +54306,42 @@ Reactome:R-HSA-2509793 NUDT16 hydrolyses dIDP to dIMP + + Reactome:R-HSA-448424 + + + + + Reactome:R-HSA-448424 + Interleukin-17 signaling + + + Reactome:R-HSA-9856530 + + + + + Reactome:R-HSA-9856530 + High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells + + + Reactome:R-HSA-9860927 + + + + + Reactome:R-HSA-9860927 + Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells + + + Reactome:R-HSA-5620912 + + + + + Reactome:R-HSA-5620912 + Anchoring of the basal body to the plasma membrane + Reactome:R-HSA-5690046 Reactome:R-HSA-9027670 @@ -46532,6 +54556,24 @@ Reactome:R-HSA-5263616 MeSeO2H is reduced to MeSeOH by TXNRD1 + + Reactome:R-HSA-9840373 + + + + + Reactome:R-HSA-9840373 + Cellular response to mitochondrial stress + + + Reactome:R-HSA-8963678 + + + + + Reactome:R-HSA-8963678 + Intestinal lipid absorption + Reactome:R-HSA-9659515 @@ -46589,6 +54631,15 @@ Reactome:R-HSA-1222526 AhpC reduces peroxidated lipids + + Reactome:R-HSA-8981373 + + + + + Reactome:R-HSA-8981373 + Intestinal hexose absorption + Reactome:R-HSA-6788668 Reactome:R-HSA-6788684 @@ -46917,6 +54968,15 @@ Reactome:R-HSA-8951850 TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane + + Reactome:R-HSA-381771 + + + + + Reactome:R-HSA-381771 + Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) + Reactome:R-HSA-1449687 Reactome:R-HSA-3149494 @@ -47370,6 +55430,24 @@ Reactome:R-HSA-5651657 SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) + + Reactome:R-HSA-9842860 + + + + + Reactome:R-HSA-9842860 + Regulation of endogenous retroelements + + + Reactome:R-HSA-9845323 + + + + + Reactome:R-HSA-9845323 + Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) + Reactome:R-HSA-548818 @@ -47379,6 +55457,15 @@ Reactome:R-HSA-548818 HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA + + Reactome:R-HSA-1222538 + + + + + Reactome:R-HSA-1222538 + Tolerance by Mtb to nitric oxide produced by macrophages + Reactome:R-HSA-6788707 @@ -47397,6 +55484,15 @@ Reactome:R-HSA-5358484 DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 + + Reactome:R-HSA-5221030 + + + + + Reactome:R-HSA-5221030 + TET1,2,3 and TDG demethylate DNA + Reactome:R-HSA-9825790 @@ -47406,6 +55502,15 @@ Reactome:R-HSA-9825790 p-S207 KARS1 dimer synthesizes A(5')p4(5')A + + Reactome:R-HSA-9816359 + + + + + Reactome:R-HSA-9816359 + Maternal to zygotic transition (MZT) + Reactome:R-HSA-429767 @@ -47467,6 +55572,124 @@ Reactome:R-HSA-2671885 ASIC trimers:H+ transport extracellular Na+ to cytosol + + Reactome:R-HSA-3371453 + Reactome:R-HSA-3371571 + + + + + Reactome:R-HSA-3371453 + Regulation of HSF1-mediated heat shock response + + + + + Reactome:R-HSA-3371571 + HSF1-dependent transactivation + + + Reactome:R-HSA-111452 + Reactome:R-HSA-114294 + + + + + Reactome:R-HSA-111452 + Activation and oligomerization of BAK protein + + + + + Reactome:R-HSA-114294 + Activation, translocation and oligomerization of BAX + + + Reactome:R-HSA-9853506 + + + + + Reactome:R-HSA-9853506 + OGDH complex synthesizes succinyl-CoA from 2-OG + + + Reactome:R-HSA-1296041 + Reactome:R-HSA-1296052 + + + + + Reactome:R-HSA-1296041 + Activation of G protein gated Potassium channels + + + + + Reactome:R-HSA-1296052 + Ca2+ activated K+ channels + + + Reactome:R-HSA-71291 + + + + + Reactome:R-HSA-71291 + Metabolism of amino acids and derivatives + + + Reactome:R-HSA-156590 + + + + + Reactome:R-HSA-156590 + Glutathione conjugation + + + Reactome:R-HSA-5633007 + + + + + Reactome:R-HSA-5633007 + Regulation of TP53 Activity + + + Reactome:R-HSA-174113 + Reactome:R-HSA-176412 + + + + + Reactome:R-HSA-174113 + SCF-beta-TrCP mediated degradation of Emi1 + + + + + Reactome:R-HSA-176412 + Phosphorylation of the APC/C + + + Reactome:R-HSA-8939236 + + + + + Reactome:R-HSA-8939236 + RUNX1 regulates transcription of genes involved in differentiation of HSCs + + + Reactome:R-HSA-3371378 + + + + + Reactome:R-HSA-3371378 + Regulation by c-FLIP + Reactome:R-HSA-5339535 @@ -47476,6 +55699,24 @@ Reactome:R-HSA-5339535 CPTP transports C1P from plasma membrane to Golgi membrane + + Reactome:R-HSA-167826 + + + + + Reactome:R-HSA-167826 + The fatty acid cycling model + + + Reactome:R-HSA-8852276 + + + + + Reactome:R-HSA-8852276 + The role of GTSE1 in G2/M progression after G2 checkpoint + Reactome:R-HSA-9010034 @@ -47485,6 +55726,56 @@ Reactome:R-HSA-9010034 ADAM10:Zn2+:TSPANs cleaves APP(18-770) + + Reactome:R-HSA-9032845 + + + + + Reactome:R-HSA-9032845 + Activated NTRK2 signals through CDK5 + + + Reactome:R-HSA-211958 + + + + + Reactome:R-HSA-211958 + Miscellaneous substrates + + + Reactome:R-HSA-114452 + Reactome:R-HSA-75108 + + + + + Reactome:R-HSA-114452 + Activation of BH3-only proteins + + + + + Reactome:R-HSA-75108 + Activation, myristolyation of BID and translocation to mitochondria + + + Reactome:R-HSA-5578768 + Reactome:R-HSA-5578775 + + + + + Reactome:R-HSA-5578768 + Physiological factors + + + + + Reactome:R-HSA-5578775 + Ion homeostasis + Reactome:R-HSA-947535 @@ -47494,6 +55785,51 @@ Reactome:R-HSA-947535 Cyclisation of GTP to precursor Z + + Reactome:R-HSA-9843745 + + + + + Reactome:R-HSA-9843745 + Adipogenesis + + + Reactome:R-HSA-110314 + + + + + Reactome:R-HSA-110314 + Recognition of DNA damage by PCNA-containing replication complex + + + Reactome:R-HSA-901032 + + + + + Reactome:R-HSA-901032 + ER Quality Control Compartment (ERQC) + + + Reactome:R-HSA-964827 + + + + + Reactome:R-HSA-964827 + Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 + + + Reactome:R-HSA-9634600 + + + + + Reactome:R-HSA-9634600 + Regulation of glycolysis by fructose 2,6-bisphosphate metabolism + Reactome:R-HSA-1500817 @@ -47503,6 +55839,42 @@ Reactome:R-HSA-1500817 Glutathione is taken up by the bacterium + + Reactome:R-HSA-201722 + + + + + Reactome:R-HSA-201722 + Formation of the beta-catenin:TCF transactivating complex + + + Reactome:R-HSA-9027283 + + + + + Reactome:R-HSA-9027283 + Erythropoietin activates STAT5 + + + Reactome:R-HSA-176408 + + + + + Reactome:R-HSA-176408 + Regulation of APC/C activators between G1/S and early anaphase + + + Reactome:R-HSA-977225 + + + + + Reactome:R-HSA-977225 + Amyloid fiber formation + Reactome:R-HSA-2509816 @@ -47544,6 +55916,105 @@ Reactome:R-HSA-9833031 Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs + + Reactome:R-HSA-166187 + + + + + Reactome:R-HSA-166187 + Mitochondrial Uncoupling + + + Reactome:R-HSA-9764260 + + + + + Reactome:R-HSA-9764260 + Regulation of Expression and Function of Type II Classical Cadherins + + + Reactome:R-HSA-211163 + + + + + Reactome:R-HSA-211163 + AKT-mediated inactivation of FOXO1A + + + Reactome:R-HSA-6785631 + + + + + Reactome:R-HSA-6785631 + ERBB2 Regulates Cell Motility + + + Reactome:R-HSA-5626978 + + + + + Reactome:R-HSA-5626978 + TNFR1-mediated ceramide production + + + Reactome:R-HSA-438066 + + + + + Reactome:R-HSA-438066 + Unblocking of NMDA receptors, glutamate binding and activation + + + Reactome:R-HSA-8935964 + + + + + Reactome:R-HSA-8935964 + RUNX1 regulates expression of components of tight junctions + + + Reactome:R-HSA-9603505 + + + + + Reactome:R-HSA-9603505 + NTRK3 as a dependence receptor + + + Reactome:R-HSA-111453 + + + + + Reactome:R-HSA-111453 + BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members + + + Reactome:R-HSA-2142700 + + + + + Reactome:R-HSA-2142700 + Biosynthesis of Lipoxins (LX) + + + Reactome:R-HSA-1483171 + + + + + Reactome:R-HSA-1483171 + Synthesis of BMP +