Imesao_Dados-Aula_04_ITALO.ipynb

{"nbformat":4,"nbformat_minor":0,"metadata":{"colab":{"name":"Imesao_Dados-Aula_04_ITALO.ipynb","provenance":[],"collapsed_sections":["rxQ-aufPp6pS","rYgDJU8Q8iS4","bF3tDCYd99ui","xVA3LTDODapH","tC0kNerFGT06","w4WzpX4OM2Th","JT4xq15492fT","oe0okI4JAF1M"],"toc_visible":true},"kernelspec":{"name":"python3","display_name":"Python 3"},"language_info":{"name":"python"}},"cells":[{"cell_type":"code","metadata":{"id":"Vw8sW4p1sUUn","executionInfo":{"status":"ok","timestamp":1620339235088,"user_tz":180,"elapsed":7583,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["import pandas as pd\n","\n","url_dados = 'https://github.com/alura-cursos/imersaodados3/blob/main/dados/dados_experimentos.zip?raw=true'\n","\n","dados = pd.read_csv(url_dados, compression = 'zip')"],"execution_count":1,"outputs":[]},{"cell_type":"code","metadata":{"id":"cbF_jlGksVfY","executionInfo":{"status":"ok","timestamp":1620339235089,"user_tz":180,"elapsed":7579,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["mapa = {'droga': 'composto'}\n","dados.rename(columns=mapa, inplace=True)"],"execution_count":2,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"hg2Lz3uoYUPx"},"source":["#Aula 4"]},{"cell_type":"markdown","metadata":{"id":"at6B8esQVKnu"},"source":["Olá cientista!\n","\n","Seja bem vindo e bem vinda à aula 04!\n","\n","Na aula passada, exploramos a relação e a correlação entre nossas variáveis. \n","Estudamos a função ```crosstab```, gráfico de dispersão, linha de tendência, correlação entre variáveis e mapa de calor. Puxa, foi muita coisa!\n","\n","Você conseguiur resolver os desafios que o Guilherme, o Thiago e a Vanessa deixaram pra vocês? Esperamos que sim porque hoje, vamos mergulhar na nossa penúltima aula!\n","\n","A primeira coisa que vamos fazer para essa aula é abrir a nossa outra base de dados. Para baixá-la vamos acessar o github para copiarmos o link do arquivo. No repositório nós temos dois arquivos: os dados_experimentos.zip e o dados_arquivos.csv. Nós vamos agora trabalhar com os dados_arquivos.csv.\n","\n","Vamos clicar com o botão esquerdo; assim que ele abrir, vamos clicar na opção \"View raw\" com o botão direito, e selecionar a opção \"copiar endereço do link\".\n","\n","Vamos importar o pandas(caso você não tenha importado ainda) para nos ajudar a ler essa base de dados, através do seguinte código:"]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":436},"id":"CEHxcFL_YTuv","executionInfo":{"status":"ok","timestamp":1620339236753,"user_tz":180,"elapsed":9178,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"ee46985f-ea10-4699-ba4f-0427be38f42a"},"source":["dados_resultados = pd.read_csv('https://github.com/alura-cursos/imersao-dados-desafio-final/blob/main/Dados/dados_resultados.csv?raw=true')\n","dados_resultados"],"execution_count":3,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>5-alpha_reductase_inhibitor</th>\n","      <th>11-beta-hsd1_inhibitor</th>\n","      <th>acat_inhibitor</th>\n","      <th>acetylcholine_receptor_agonist</th>\n","      <th>acetylcholine_receptor_antagonist</th>\n","      <th>acetylcholinesterase_inhibitor</th>\n","      <th>adenosine_receptor_agonist</th>\n","      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<td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>...</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","    </tr>\n","    <tr>\n","      <th>23813</th>\n","      <td>id_ffffdd77b</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>...</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>23814 rows × 207 columns</p>\n","</div>"],"text/plain":["                 id  ...  wnt_inhibitor\n","0      id_000644bb2  ...              0\n","1      id_000779bfc  ...              0\n","2      id_000a6266a  ...              0\n","3      id_0015fd391  ...              0\n","4      id_001626bd3  ...              0\n","...             ...  ...            ...\n","23809  id_fffb1ceed  ...              0\n","23810  id_fffb70c0c  ...              0\n","23811  id_fffc1c3f4  ...              0\n","23812  id_fffcb9e7c  ...              0\n","23813  id_ffffdd77b  ...              0\n","\n","[23814 rows x 207 columns]"]},"metadata":{"tags":[]},"execution_count":3}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"HRuyvnIj9wJB","executionInfo":{"status":"ok","timestamp":1620339236755,"user_tz":180,"elapsed":9166,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"3c4380ff-761a-4d4d-a54a-63dc2f3746ee"},"source":["dados_resultados.shape"],"execution_count":4,"outputs":[{"output_type":"execute_result","data":{"text/plain":["(23814, 207)"]},"metadata":{"tags":[]},"execution_count":4}]},{"cell_type":"markdown","metadata":{"id":"Wv7yFk6bVddQ"},"source":["Repare que ele já mostra pra gente o número de colunas: 207. Ou seja, é um dataset bem extenso.\n","\n","Vamos começar a analisar as colunas. A primeria coluna tem o nome de \"id\", o que nos remete a um identificador. Além disso, as seguintes colunas possuem nomes bem complexos. Não são nomes muito descritivos para quem não é da área.\n","\n","Com a ajuda da Vanessa, descobrimos que esses nomes remetem aos mecanismos de ação das drogas. Ou seja, esses dados nos trazem a relação do mecanismo de ação do alvo (enzima, proteína, etc) com a droga utilizada. Ela também explicou sobre os termos \"agonista\" e \"antiagonista\", que ativam o receptor e o bloqueiam, respectivamente.\n","\n","Nesse ponto a Vanessa nos explica numa apresentação como funciona a ligação do spike com o receptor e todo o procedimento de infecção nas nossas células.\n","\n","Agora já sabemos que cada coluna do nosso dataframe representa um mecanismo de ação. Olhando para nosso cabeçalho percebemos que temos praticamente todos os dados com o valor 0. Será que todos os dados da tabela tem esse valor? Vamos investigar!"]},{"cell_type":"code","metadata":{"id":"SAXgKy4QbjDn","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339236756,"user_tz":180,"elapsed":9154,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"2969a366-bc27-4249-bffb-f0dd7537bc58"},"source":["dados_resultados['acetylcholine_receptor_agonist'].unique()"],"execution_count":5,"outputs":[{"output_type":"execute_result","data":{"text/plain":["array([0, 1])"]},"metadata":{"tags":[]},"execution_count":5}]},{"cell_type":"markdown","metadata":{"id":"ZjPedtNHKH7D"},"source":["Olha só! Nosso resultado foi um array entre 0 e 1. Se você quiser fazer um teste com todos os outros mecanismos de ação também encontrará o resultado entre 0 e 1. Mas por que isso acontece?\n","\n","Cada linha é o resultado do experimento da outra base de dados dos experimentos que trabalhamos. Quando um determinado mecanismo de ação é ativado ele é indicado como 1. Quando esse mecanismo de ação não é ativado ele é detectado como 0.\n","\n","Portanto, todo resultado que obtivermos o número 1, saberemos que ele foi ativado.\n","\n","Vamos fazer uma investigação agora que pode ser muito interessante para o cientista que está trabalhando nesse projeto: qual foi o mecanismo de ação que foi mais ativado?\n","\n","Vamos então fazer a soma das colunas, para saber qual vai ser o que apresenta mais o número 1. Mas antes vamos verificar se todas as minhas colunas possuem somente números ou se possuem strings também nelas, através desse código:"]},{"cell_type":"code","metadata":{"id":"WV3a0L6zdXXf","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339236758,"user_tz":180,"elapsed":9140,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"0db40309-c97b-4c94-cca1-1edf9effa64c"},"source":["dados_resultados.info()"],"execution_count":6,"outputs":[{"output_type":"stream","text":["<class 'pandas.core.frame.DataFrame'>\n","RangeIndex: 23814 entries, 0 to 23813\n","Columns: 207 entries, id to wnt_inhibitor\n","dtypes: int64(206), object(1)\n","memory usage: 37.6+ MB\n"],"name":"stdout"}]},{"cell_type":"markdown","metadata":{"id":"VVS__zNtM4sC"},"source":["Vimos que uma delas apresenta como resultado 1 objeto. Ou seja, não conseguiremos aplicar a função soma de forma direta.\n","\n","Vamos então fazer essa soma excluindo a coluna id, que possui dados diferentes de números em sua composição, da seguinte maneira:"]},{"cell_type":"code","metadata":{"id":"wBa8ABGrcc1t","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339236759,"user_tz":180,"elapsed":9127,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"487a2082-a977-4522-90be-5fab5b1c13c6"},"source":["#contagem_moa = dados_resultados.select_dtypes('int64').sum().sort_values(ascending=False)\n","contagem_moa = dados_resultados.drop('id', axis=1).sum().sort_values(ascending=False)\n","contagem_moa"],"execution_count":7,"outputs":[{"output_type":"execute_result","data":{"text/plain":["nfkb_inhibitor                                832\n","proteasome_inhibitor                          726\n","cyclooxygenase_inhibitor                      435\n","dopamine_receptor_antagonist                  424\n","serotonin_receptor_antagonist                 404\n","                                             ... \n","protein_phosphatase_inhibitor                   6\n","autotaxin_inhibitor                             6\n","diuretic                                        6\n","erbb2_inhibitor                                 1\n","atp-sensitive_potassium_channel_antagonist      1\n","Length: 206, dtype: int64"]},"metadata":{"tags":[]},"execution_count":7}]},{"cell_type":"markdown","metadata":{"id":"fF8c4vBFNYHJ"},"source":["Legal. No resultado há uma informação que nos chama a atenção: os inibidores, no topo do nosso resultado, são os que possuem maior quantidade de resultados positivos. Seria um ponto a se investigar.\n","\n","Então aqui vamos ter o nosso primeiro desafio da aula 4. Lembrando que todos os desafios estão no final desse notebook da aula.\n","\n"]},{"cell_type":"markdown","metadata":{"id":"iBFkVtI0VB5o"},"source":["Nós fizemos uma contagem para saber onde o mecanismo de ação obteve mais respostas; agora vamos fazer outros testes.\n","\n","Vamos verificar se a linha específica que vamos escolher foi ativada em algum momento. E, se ela foi ativada, quantas vezes isso ocorreu?\n","\n","Utilizaremos o seguinte código:"]},{"cell_type":"code","metadata":{"id":"9B5ZPzLbezz9","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339237714,"user_tz":180,"elapsed":10071,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"832655b9-2b0e-4078-8135-0cf0f06a998a"},"source":["dados_resultados.drop('id', axis=1).sum(axis=1)"],"execution_count":8,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0        1\n","1        0\n","2        3\n","3        0\n","4        1\n","        ..\n","23809    1\n","23810    1\n","23811    0\n","23812    1\n","23813    0\n","Length: 23814, dtype: int64"]},"metadata":{"tags":[]},"execution_count":8}]},{"cell_type":"markdown","metadata":{"id":"HPH4fhrNXiHY"},"source":["E aqui temos o nosso resultado. Na primeira linha tivemos uma única ativação. Já na segunda não obtivemos nenhuma. Na terceira tivemos 3, e assim por diante. Nesse que tivemos a resposta como 0, precisaríamos saber se foi um controle, ou se realmente a droga não ativou nenhuma resposta.\n","\n","Aqui embaixo temos os nossos dados dos resultados:\n"]},{"cell_type":"code","metadata":{"id":"w2bhDXghgnQM","colab":{"base_uri":"https://localhost:8080/","height":260},"executionInfo":{"status":"ok","timestamp":1620339237715,"user_tz":180,"elapsed":10058,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"2e2ca2f8-7ed3-457b-a58c-b4ecb7bee439"},"source":["dados_resultados.head()"],"execution_count":9,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>5-alpha_reductase_inhibitor</th>\n","      <th>11-beta-hsd1_inhibitor</th>\n","      <th>acat_inhibitor</th>\n","      <th>acetylcholine_receptor_agonist</th>\n","      <th>acetylcholine_receptor_antagonist</th>\n","      <th>acetylcholinesterase_inhibitor</th>\n","      <th>adenosine_receptor_agonist</th>\n","      <th>adenosine_receptor_antagonist</th>\n","      <th>adenylyl_cyclase_activator</th>\n","      <th>adrenergic_receptor_agonist</th>\n","      <th>adrenergic_receptor_antagonist</th>\n","      <th>akt_inhibitor</th>\n","      <th>aldehyde_dehydrogenase_inhibitor</th>\n","      <th>alk_inhibitor</th>\n","      <th>ampk_activator</th>\n","      <th>analgesic</th>\n","      <th>androgen_receptor_agonist</th>\n","      <th>androgen_receptor_antagonist</th>\n","      <th>anesthetic_-_local</th>\n","      <th>angiogenesis_inhibitor</th>\n","      <th>angiotensin_receptor_antagonist</th>\n","      <th>anti-inflammatory</th>\n","      <th>antiarrhythmic</th>\n","      <th>antibiotic</th>\n","      <th>anticonvulsant</th>\n","      <th>antifungal</th>\n","      <th>antihistamine</th>\n","      <th>antimalarial</th>\n","      <th>antioxidant</th>\n","      <th>antiprotozoal</th>\n","      <th>antiviral</th>\n","      <th>apoptosis_stimulant</th>\n","      <th>aromatase_inhibitor</th>\n","      <th>atm_kinase_inhibitor</th>\n","      <th>atp-sensitive_potassium_channel_antagonist</th>\n","      <th>atp_synthase_inhibitor</th>\n","      <th>atpase_inhibitor</th>\n","      <th>atr_kinase_inhibitor</th>\n","      <th>aurora_kinase_inhibitor</th>\n","      <th>...</th>\n","      <th>protein_synthesis_inhibitor</th>\n","      <th>protein_tyrosine_kinase_inhibitor</th>\n","      <th>radiopaque_medium</th>\n","      <th>raf_inhibitor</th>\n","      <th>ras_gtpase_inhibitor</th>\n","      <th>retinoid_receptor_agonist</th>\n","      <th>retinoid_receptor_antagonist</th>\n","      <th>rho_associated_kinase_inhibitor</th>\n","      <th>ribonucleoside_reductase_inhibitor</th>\n","      <th>rna_polymerase_inhibitor</th>\n","      <th>serotonin_receptor_agonist</th>\n","      <th>serotonin_receptor_antagonist</th>\n","      <th>serotonin_reuptake_inhibitor</th>\n","      <th>sigma_receptor_agonist</th>\n","      <th>sigma_receptor_antagonist</th>\n","      <th>smoothened_receptor_antagonist</th>\n","      <th>sodium_channel_inhibitor</th>\n","      <th>sphingosine_receptor_agonist</th>\n","      <th>src_inhibitor</th>\n","      <th>steroid</th>\n","      <th>syk_inhibitor</th>\n","      <th>tachykinin_antagonist</th>\n","      <th>tgf-beta_receptor_inhibitor</th>\n","      <th>thrombin_inhibitor</th>\n","      <th>thymidylate_synthase_inhibitor</th>\n","      <th>tlr_agonist</th>\n","      <th>tlr_antagonist</th>\n","      <th>tnf_inhibitor</th>\n","      <th>topoisomerase_inhibitor</th>\n","      <th>transient_receptor_potential_channel_antagonist</th>\n","      <th>tropomyosin_receptor_kinase_inhibitor</th>\n","      <th>trpv_agonist</th>\n","      <th>trpv_antagonist</th>\n","      <th>tubulin_inhibitor</th>\n","      <th>tyrosine_kinase_inhibitor</th>\n","      <th>ubiquitin_specific_protease_inhibitor</th>\n","      <th>vegfr_inhibitor</th>\n","      <th>vitamin_b</th>\n","      <th>vitamin_d_receptor_agonist</th>\n","      <th>wnt_inhibitor</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>0</th>\n","      <td>id_000644bb2</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      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<td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>...</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      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   <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>...</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>5 rows × 207 columns</p>\n","</div>"],"text/plain":["             id  ...  wnt_inhibitor\n","0  id_000644bb2  ...              0\n","1  id_000779bfc  ...              0\n","2  id_000a6266a  ...              0\n","3  id_0015fd391  ...              0\n","4  id_001626bd3  ...              0\n","\n","[5 rows x 207 columns]"]},"metadata":{"tags":[]},"execution_count":9}]},{"cell_type":"markdown","metadata":{"id":"c9nJ-o1-itEW"},"source":["E aqui temos a nossa base de dados:"]},{"cell_type":"code","metadata":{"id":"bPHy80Lqfc3T","colab":{"base_uri":"https://localhost:8080/","height":243},"executionInfo":{"status":"ok","timestamp":1620339237716,"user_tz":180,"elapsed":10044,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"be868ab2-6deb-418d-e30e-875f4a6afd37"},"source":["dados.head()"],"execution_count":10,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-60</th>\n","      <th>c-61</th>\n","      <th>c-62</th>\n","      <th>c-63</th>\n","      <th>c-64</th>\n","      <th>c-65</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>0</th>\n","      <td>id_000644bb2</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>b68db1d53</td>\n","      <td>1.0620</td>\n","      <td>0.5577</td>\n","      <td>-0.2479</td>\n","      <td>-0.6208</td>\n","      <td>-0.1944</td>\n","      <td>-1.0120</td>\n","      <td>-1.0220</td>\n","      <td>-0.0326</td>\n","      <td>0.5548</td>\n","      <td>-0.0921</td>\n","      <td>1.1830</td>\n","      <td>0.1530</td>\n","      <td>0.5574</td>\n","      <td>-0.4015</td>\n","      <td>0.1789</td>\n","      <td>-0.6528</td>\n","      <td>-0.7969</td>\n","      <td>0.6342</td>\n","      <td>0.1778</td>\n","      <td>-0.3694</td>\n","      <td>-0.5688</td>\n","      <td>-1.1360</td>\n","      <td>-1.1880</td>\n","      <td>0.6940</td>\n","      <td>0.4393</td>\n","      <td>0.2664</td>\n","      <td>0.1907</td>\n","      <td>0.1628</td>\n","      <td>-0.2853</td>\n","      <td>0.5819</td>\n","      <td>0.2934</td>\n","      <td>-0.5584</td>\n","      <td>-0.0916</td>\n","      <td>-0.3010</td>\n","      <td>-0.1537</td>\n","      <td>...</td>\n","      <td>0.4805</td>\n","      <td>0.4965</td>\n","      <td>0.3680</td>\n","      <td>0.8427</td>\n","      <td>0.1042</td>\n","      <td>0.1403</td>\n","      <td>0.1758</td>\n","      <td>1.2570</td>\n","      <td>-0.5979</td>\n","      <td>1.2250</td>\n","      <td>-0.0553</td>\n","      <td>0.7351</td>\n","      <td>0.5810</td>\n","      <td>0.9590</td>\n","      <td>0.2427</td>\n","      <td>0.0495</td>\n","      <td>0.4141</td>\n","      <td>0.8432</td>\n","      <td>0.6162</td>\n","      <td>-0.7318</td>\n","      <td>1.2120</td>\n","      <td>0.6362</td>\n","      <td>-0.4427</td>\n","      <td>0.1288</td>\n","      <td>1.4840</td>\n","      <td>0.1799</td>\n","      <td>0.5367</td>\n","      <td>-0.1111</td>\n","      <td>-1.0120</td>\n","      <td>0.6685</td>\n","      <td>0.2862</td>\n","      <td>0.2584</td>\n","      <td>0.8076</td>\n","      <td>0.5523</td>\n","      <td>-0.1912</td>\n","      <td>0.6584</td>\n","      <td>-0.3981</td>\n","      <td>0.2139</td>\n","      <td>0.3801</td>\n","      <td>0.4176</td>\n","    </tr>\n","    <tr>\n","      <th>1</th>\n","      <td>id_000779bfc</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>df89a8e5a</td>\n","      <td>0.0743</td>\n","      <td>0.4087</td>\n","      <td>0.2991</td>\n","      <td>0.0604</td>\n","      <td>1.0190</td>\n","      <td>0.5207</td>\n","      <td>0.2341</td>\n","      <td>0.3372</td>\n","      <td>-0.4047</td>\n","      <td>0.8507</td>\n","      <td>-1.1520</td>\n","      <td>-0.4201</td>\n","      <td>-0.0958</td>\n","      <td>0.4590</td>\n","      <td>0.0803</td>\n","      <td>0.2250</td>\n","      <td>0.5293</td>\n","      <td>0.2839</td>\n","      <td>-0.3494</td>\n","      <td>0.2883</td>\n","      <td>0.9449</td>\n","      <td>-0.1646</td>\n","      <td>-0.2657</td>\n","      <td>-0.3372</td>\n","      <td>0.3135</td>\n","      <td>-0.4316</td>\n","      <td>0.4773</td>\n","      <td>0.2075</td>\n","      <td>-0.4216</td>\n","      <td>-0.1161</td>\n","      <td>-0.0499</td>\n","      <td>-0.2627</td>\n","      <td>0.9959</td>\n","      <td>-0.2483</td>\n","      <td>0.2655</td>\n","      <td>...</td>\n","      <td>0.4083</td>\n","      <td>0.0319</td>\n","      <td>0.3905</td>\n","      <td>0.7099</td>\n","      <td>0.2912</td>\n","      <td>0.4151</td>\n","      <td>-0.2840</td>\n","      <td>-0.3104</td>\n","      <td>-0.6373</td>\n","      <td>0.2887</td>\n","      <td>-0.0765</td>\n","      <td>0.2539</td>\n","      <td>0.4443</td>\n","      <td>0.5932</td>\n","      <td>0.2031</td>\n","      <td>0.7639</td>\n","      <td>0.5499</td>\n","      <td>-0.3322</td>\n","      <td>-0.0977</td>\n","      <td>0.4329</td>\n","      <td>-0.2782</td>\n","      <td>0.7827</td>\n","      <td>0.5934</td>\n","      <td>0.3402</td>\n","      <td>0.1499</td>\n","      <td>0.4420</td>\n","      <td>0.9366</td>\n","      <td>0.8193</td>\n","      <td>-0.4236</td>\n","      <td>0.3192</td>\n","      <td>-0.4265</td>\n","      <td>0.7543</td>\n","      <td>0.4708</td>\n","      <td>0.0230</td>\n","      <td>0.2957</td>\n","      <td>0.4899</td>\n","      <td>0.1522</td>\n","      <td>0.1241</td>\n","      <td>0.6077</td>\n","      <td>0.7371</td>\n","    </tr>\n","    <tr>\n","      <th>2</th>\n","      <td>id_000a6266a</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>18bb41b2c</td>\n","      <td>0.6280</td>\n","      <td>0.5817</td>\n","      <td>1.5540</td>\n","      <td>-0.0764</td>\n","      <td>-0.0323</td>\n","      <td>1.2390</td>\n","      <td>0.1715</td>\n","      <td>0.2155</td>\n","      <td>0.0065</td>\n","      <td>1.2300</td>\n","      <td>-0.4797</td>\n","      <td>-0.5631</td>\n","      <td>-0.0366</td>\n","      <td>-1.8300</td>\n","      <td>0.6057</td>\n","      <td>-0.3278</td>\n","      <td>0.6042</td>\n","      <td>-0.3075</td>\n","      <td>-0.1147</td>\n","      <td>-0.0570</td>\n","      <td>-0.0799</td>\n","      <td>-0.8181</td>\n","      <td>-1.5320</td>\n","      <td>0.2307</td>\n","      <td>0.4901</td>\n","      <td>0.4780</td>\n","      <td>-1.3970</td>\n","      <td>4.6240</td>\n","      <td>-0.0437</td>\n","      <td>1.2870</td>\n","      <td>-1.8530</td>\n","      <td>0.6069</td>\n","      <td>0.4290</td>\n","      <td>0.1783</td>\n","      <td>0.0018</td>\n","      <td>...</td>\n","      <td>-0.5477</td>\n","      <td>-0.7576</td>\n","      <td>-0.0444</td>\n","      <td>0.1894</td>\n","      <td>-0.0014</td>\n","      <td>-2.3640</td>\n","      <td>-0.4682</td>\n","      <td>0.1210</td>\n","      <td>-0.5177</td>\n","      <td>-0.0604</td>\n","      <td>0.1682</td>\n","      <td>-0.4436</td>\n","      <td>0.4963</td>\n","      <td>0.1363</td>\n","      <td>0.3335</td>\n","      <td>0.9760</td>\n","      <td>-0.0427</td>\n","      <td>-0.1235</td>\n","      <td>0.0959</td>\n","      <td>0.0690</td>\n","      <td>-0.9416</td>\n","      <td>-0.7548</td>\n","      <td>-0.1109</td>\n","      <td>-0.6272</td>\n","      <td>0.3019</td>\n","      <td>0.1172</td>\n","      <td>0.1093</td>\n","      <td>-0.3113</td>\n","      <td>0.3019</td>\n","      <td>-0.0873</td>\n","      <td>-0.7250</td>\n","      <td>-0.6297</td>\n","      <td>0.6103</td>\n","      <td>0.0223</td>\n","      <td>-1.3240</td>\n","      <td>-0.3174</td>\n","      <td>-0.6417</td>\n","      <td>-0.2187</td>\n","      <td>-1.4080</td>\n","      <td>0.6931</td>\n","    </tr>\n","    <tr>\n","      <th>3</th>\n","      <td>id_0015fd391</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>8c7f86626</td>\n","      <td>-0.5138</td>\n","      <td>-0.2491</td>\n","      <td>-0.2656</td>\n","      <td>0.5288</td>\n","      <td>4.0620</td>\n","      <td>-0.8095</td>\n","      <td>-1.9590</td>\n","      <td>0.1792</td>\n","      <td>-0.1321</td>\n","      <td>-1.0600</td>\n","      <td>-0.8269</td>\n","      <td>-0.3584</td>\n","      <td>-0.8511</td>\n","      <td>-0.5844</td>\n","      <td>-2.5690</td>\n","      <td>0.8183</td>\n","      <td>-0.0532</td>\n","      <td>-0.8554</td>\n","      <td>0.1160</td>\n","      <td>-2.3520</td>\n","      <td>2.1200</td>\n","      <td>-1.1580</td>\n","      <td>-0.7191</td>\n","      <td>-0.8004</td>\n","      <td>-1.4670</td>\n","      <td>-0.0107</td>\n","      <td>-0.8995</td>\n","      <td>0.2406</td>\n","      <td>-0.2479</td>\n","      <td>-1.0890</td>\n","      <td>-0.7575</td>\n","      <td>0.0881</td>\n","      <td>-2.7370</td>\n","      <td>0.8745</td>\n","      <td>0.5787</td>\n","      <td>...</td>\n","      <td>-2.1220</td>\n","      <td>-0.3752</td>\n","      <td>-2.3820</td>\n","      <td>-3.7350</td>\n","      <td>-2.9740</td>\n","      <td>-1.4930</td>\n","      <td>-1.6600</td>\n","      <td>-3.1660</td>\n","      <td>0.2816</td>\n","      <td>-0.2990</td>\n","      <td>-1.1870</td>\n","      <td>-0.5044</td>\n","      <td>-1.7750</td>\n","      <td>-1.6120</td>\n","      <td>-0.9215</td>\n","      <td>-1.0810</td>\n","      <td>-3.0520</td>\n","      <td>-3.4470</td>\n","      <td>-2.7740</td>\n","      <td>-1.8460</td>\n","      <td>-0.5568</td>\n","      <td>-3.3960</td>\n","      <td>-2.9510</td>\n","      <td>-1.1550</td>\n","      <td>-3.2620</td>\n","      <td>-1.5390</td>\n","      <td>-2.4600</td>\n","      <td>-0.9417</td>\n","      <td>-1.5550</td>\n","      <td>0.2431</td>\n","      <td>-2.0990</td>\n","      <td>-0.6441</td>\n","      <td>-5.6300</td>\n","      <td>-1.3780</td>\n","      <td>-0.8632</td>\n","      <td>-1.2880</td>\n","      <td>-1.6210</td>\n","      <td>-0.8784</td>\n","      <td>-0.3876</td>\n","      <td>-0.8154</td>\n","    </tr>\n","    <tr>\n","      <th>4</th>\n","      <td>id_001626bd3</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>7cbed3131</td>\n","      <td>-0.3254</td>\n","      <td>-0.4009</td>\n","      <td>0.9700</td>\n","      <td>0.6919</td>\n","      <td>1.4180</td>\n","      <td>-0.8244</td>\n","      <td>-0.2800</td>\n","      <td>-0.1498</td>\n","      <td>-0.8789</td>\n","      <td>0.8630</td>\n","      <td>-0.2219</td>\n","      <td>-0.5121</td>\n","      <td>-0.9577</td>\n","      <td>1.1750</td>\n","      <td>0.2042</td>\n","      <td>0.1970</td>\n","      <td>0.1244</td>\n","      <td>-1.7090</td>\n","      <td>-0.3543</td>\n","      <td>-0.5160</td>\n","      <td>-0.3330</td>\n","      <td>-0.2685</td>\n","      <td>0.7649</td>\n","      <td>0.2057</td>\n","      <td>1.3720</td>\n","      <td>0.6835</td>\n","      <td>0.8056</td>\n","      <td>-0.3754</td>\n","      <td>-1.2090</td>\n","      <td>0.2965</td>\n","      <td>-0.0712</td>\n","      <td>0.6389</td>\n","      <td>0.6674</td>\n","      <td>-0.0783</td>\n","      <td>1.1740</td>\n","      <td>...</td>\n","      <td>-0.2274</td>\n","      <td>0.3215</td>\n","      <td>0.1535</td>\n","      <td>-0.4640</td>\n","      <td>-0.5943</td>\n","      <td>0.3973</td>\n","      <td>0.1500</td>\n","      <td>0.5178</td>\n","      <td>0.5159</td>\n","      <td>0.6091</td>\n","      <td>0.1813</td>\n","      <td>-0.4249</td>\n","      <td>0.7832</td>\n","      <td>0.6529</td>\n","      <td>0.5648</td>\n","      <td>0.4817</td>\n","      <td>0.0587</td>\n","      <td>0.5303</td>\n","      <td>0.6376</td>\n","      <td>-0.3966</td>\n","      <td>-1.4950</td>\n","      <td>-0.9625</td>\n","      <td>-0.0541</td>\n","      <td>0.6273</td>\n","      <td>0.4563</td>\n","      <td>0.0698</td>\n","      <td>0.8134</td>\n","      <td>0.1924</td>\n","      <td>0.6054</td>\n","      <td>-0.1824</td>\n","      <td>0.0042</td>\n","      <td>0.0048</td>\n","      <td>0.6670</td>\n","      <td>1.0690</td>\n","      <td>0.5523</td>\n","      <td>-0.3031</td>\n","      <td>0.1094</td>\n","      <td>0.2885</td>\n","      <td>-0.3786</td>\n","      <td>0.7125</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>5 rows × 877 columns</p>\n","</div>"],"text/plain":["             id tratamento  tempo dose  ...    c-96    c-97    c-98    c-99\n","0  id_000644bb2  com_droga     24   D1  ... -0.3981  0.2139  0.3801  0.4176\n","1  id_000779bfc  com_droga     72   D1  ...  0.1522  0.1241  0.6077  0.7371\n","2  id_000a6266a  com_droga     48   D1  ... -0.6417 -0.2187 -1.4080  0.6931\n","3  id_0015fd391  com_droga     48   D1  ... -1.6210 -0.8784 -0.3876 -0.8154\n","4  id_001626bd3  com_droga     72   D2  ...  0.1094  0.2885 -0.3786  0.7125\n","\n","[5 rows x 877 columns]"]},"metadata":{"tags":[]},"execution_count":10}]},{"cell_type":"markdown","metadata":{"id":"ailRL013iv5G"},"source":["Na base de dados resultados não temos a informação que queremos, referente ao tratamento. Nós só temos a coluna tratamento na base de dados inteira.\n","\n","No tratamento só temos a coluna id, e os mecanismos de ação que foram ativados por aquela coluna. Então, agora, precisamos de alguma maneira, mesclar essas informações.\n","\n","Antes de fazer esse passo, de mesclar, vamos criar duas novas colunas na base de dados resultado. Vamos criar uma primeira coluna que vamos chamar de n_moa(número de moas ativos), que é justamente o que havíamos calculado anteriormente, dessa maneira:"]},{"cell_type":"code","metadata":{"id":"HS0ZHSeTjFrr","executionInfo":{"status":"ok","timestamp":1620339237717,"user_tz":180,"elapsed":10042,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["dados_resultados['n_moa'] = dados_resultados.drop('id', axis=1).sum(axis=1)"],"execution_count":11,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"g4fz70-SkKrK"},"source":[" Vamos então verificar se a coluna apresenta resultados diferentes de 0; se for diferente de 0 ela retorna a mensagem 'true'; se for igual a 0 retorna 'false':"]},{"cell_type":"code","metadata":{"id":"MNMsak-ih9PQ","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339237718,"user_tz":180,"elapsed":10024,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"fefcbbf4-1c2a-4a51-8f9c-b9b34f6e6c0b"},"source":["dados_resultados['n_moa'] != 0"],"execution_count":12,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0         True\n","1        False\n","2         True\n","3        False\n","4         True\n","         ...  \n","23809     True\n","23810     True\n","23811    False\n","23812     True\n","23813    False\n","Name: n_moa, Length: 23814, dtype: bool"]},"metadata":{"tags":[]},"execution_count":12}]},{"cell_type":"markdown","metadata":{"id":"rZCppZQ-la6x"},"source":["Ok, então o código para criarmos e visualizarmos as duas colunas é esse:"]},{"cell_type":"code","metadata":{"id":"bba-i1D8hcu8","colab":{"base_uri":"https://localhost:8080/","height":260},"executionInfo":{"status":"ok","timestamp":1620339237719,"user_tz":180,"elapsed":10013,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"aea727f9-a8be-4eda-ffa1-672aded8f9b8"},"source":["dados_resultados['ativo_moa'] = (dados_resultados['n_moa'] != 0)\n","dados_resultados.head()"],"execution_count":13,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: 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<th>anti-inflammatory</th>\n","      <th>antiarrhythmic</th>\n","      <th>antibiotic</th>\n","      <th>anticonvulsant</th>\n","      <th>antifungal</th>\n","      <th>antihistamine</th>\n","      <th>antimalarial</th>\n","      <th>antioxidant</th>\n","      <th>antiprotozoal</th>\n","      <th>antiviral</th>\n","      <th>apoptosis_stimulant</th>\n","      <th>aromatase_inhibitor</th>\n","      <th>atm_kinase_inhibitor</th>\n","      <th>atp-sensitive_potassium_channel_antagonist</th>\n","      <th>atp_synthase_inhibitor</th>\n","      <th>atpase_inhibitor</th>\n","      <th>atr_kinase_inhibitor</th>\n","      <th>aurora_kinase_inhibitor</th>\n","      <th>...</th>\n","      <th>radiopaque_medium</th>\n","      <th>raf_inhibitor</th>\n","      <th>ras_gtpase_inhibitor</th>\n","      <th>retinoid_receptor_agonist</th>\n","      <th>retinoid_receptor_antagonist</th>\n","      <th>rho_associated_kinase_inhibitor</th>\n","      <th>ribonucleoside_reductase_inhibitor</th>\n","      <th>rna_polymerase_inhibitor</th>\n","      <th>serotonin_receptor_agonist</th>\n","      <th>serotonin_receptor_antagonist</th>\n","      <th>serotonin_reuptake_inhibitor</th>\n","      <th>sigma_receptor_agonist</th>\n","      <th>sigma_receptor_antagonist</th>\n","      <th>smoothened_receptor_antagonist</th>\n","      <th>sodium_channel_inhibitor</th>\n","      <th>sphingosine_receptor_agonist</th>\n","      <th>src_inhibitor</th>\n","      <th>steroid</th>\n","      <th>syk_inhibitor</th>\n","      <th>tachykinin_antagonist</th>\n","      <th>tgf-beta_receptor_inhibitor</th>\n","      <th>thrombin_inhibitor</th>\n","      <th>thymidylate_synthase_inhibitor</th>\n","      <th>tlr_agonist</th>\n","      <th>tlr_antagonist</th>\n","      <th>tnf_inhibitor</th>\n","      <th>topoisomerase_inhibitor</th>\n","      <th>transient_receptor_potential_channel_antagonist</th>\n","      <th>tropomyosin_receptor_kinase_inhibitor</th>\n","      <th>trpv_agonist</th>\n","      <th>trpv_antagonist</th>\n","      <th>tubulin_inhibitor</th>\n","      <th>tyrosine_kinase_inhibitor</th>\n","      <th>ubiquitin_specific_protease_inhibitor</th>\n","      <th>vegfr_inhibitor</th>\n","      <th>vitamin_b</th>\n","      <th>vitamin_d_receptor_agonist</th>\n","      <th>wnt_inhibitor</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>0</th>\n","      <td>id_000644bb2</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","  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<td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>...</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>0</td>\n","      <td>1</td>\n","      <td>True</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>5 rows × 209 columns</p>\n","</div>"],"text/plain":["             id  5-alpha_reductase_inhibitor  ...  n_moa  ativo_moa\n","0  id_000644bb2                            0  ...      1       True\n","1  id_000779bfc                            0  ...      0      False\n","2  id_000a6266a                            0  ...      3       True\n","3  id_0015fd391                            0  ...      0      False\n","4  id_001626bd3                            0  ...      1       True\n","\n","[5 rows x 209 columns]"]},"metadata":{"tags":[]},"execution_count":13}]},{"cell_type":"markdown","metadata":{"id":"oOA4vQ6glg5l"},"source":["Para visualizarmos basta ir até as duas últimas colunas que elas estarão lá."]},{"cell_type":"markdown","metadata":{"id":"4w-2eB_gm0o5"},"source":["Agora que temos as duas colunas que queremos, vamos mesclar, ou então \"mergear\", as informações que queremos.\n","\n","Para isso vamos utilizar o merge do pandas, através desse código:"]},{"cell_type":"code","metadata":{"id":"0r4V83bujiao","colab":{"base_uri":"https://localhost:8080/","height":243},"executionInfo":{"status":"ok","timestamp":1620339237720,"user_tz":180,"elapsed":9995,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"61e67dfa-4a8c-419e-b963-bcf948f812ea"},"source":[" dados_combinados = pd.merge(dados, dados_resultados[['id','n_moa', 'ativo_moa']], on='id')\n"," dados_combinados.head()"],"execution_count":14,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-62</th>\n","      <th>c-63</th>\n","      <th>c-64</th>\n","      <th>c-65</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>0</th>\n","      <td>id_000644bb2</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>b68db1d53</td>\n","      <td>1.0620</td>\n","      <td>0.5577</td>\n","      <td>-0.2479</td>\n","      <td>-0.6208</td>\n","      <td>-0.1944</td>\n","      <td>-1.0120</td>\n","      <td>-1.0220</td>\n","      <td>-0.0326</td>\n","      <td>0.5548</td>\n","      <td>-0.0921</td>\n","      <td>1.1830</td>\n","      <td>0.1530</td>\n","      <td>0.5574</td>\n","      <td>-0.4015</td>\n","      <td>0.1789</td>\n","      <td>-0.6528</td>\n","      <td>-0.7969</td>\n","      <td>0.6342</td>\n","      <td>0.1778</td>\n","      <td>-0.3694</td>\n","      <td>-0.5688</td>\n","      <td>-1.1360</td>\n","      <td>-1.1880</td>\n","      <td>0.6940</td>\n","      <td>0.4393</td>\n","      <td>0.2664</td>\n","      <td>0.1907</td>\n","      <td>0.1628</td>\n","      <td>-0.2853</td>\n","      <td>0.5819</td>\n","      <td>0.2934</td>\n","      <td>-0.5584</td>\n","      <td>-0.0916</td>\n","      <td>-0.3010</td>\n","      <td>-0.1537</td>\n","      <td>...</td>\n","      <td>0.3680</td>\n","      <td>0.8427</td>\n","      <td>0.1042</td>\n","      <td>0.1403</td>\n","      <td>0.1758</td>\n","      <td>1.2570</td>\n","      <td>-0.5979</td>\n","      <td>1.2250</td>\n","      <td>-0.0553</td>\n","      <td>0.7351</td>\n","      <td>0.5810</td>\n","      <td>0.9590</td>\n","      <td>0.2427</td>\n","      <td>0.0495</td>\n","      <td>0.4141</td>\n","      <td>0.8432</td>\n","      <td>0.6162</td>\n","      <td>-0.7318</td>\n","      <td>1.2120</td>\n","      <td>0.6362</td>\n","      <td>-0.4427</td>\n","      <td>0.1288</td>\n","      <td>1.4840</td>\n","      <td>0.1799</td>\n","      <td>0.5367</td>\n","      <td>-0.1111</td>\n","      <td>-1.0120</td>\n","      <td>0.6685</td>\n","      <td>0.2862</td>\n","      <td>0.2584</td>\n","      <td>0.8076</td>\n","      <td>0.5523</td>\n","      <td>-0.1912</td>\n","      <td>0.6584</td>\n","      <td>-0.3981</td>\n","      <td>0.2139</td>\n","      <td>0.3801</td>\n","      <td>0.4176</td>\n","      <td>1</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>1</th>\n","      <td>id_000779bfc</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>df89a8e5a</td>\n","      <td>0.0743</td>\n","      <td>0.4087</td>\n","      <td>0.2991</td>\n","      <td>0.0604</td>\n","      <td>1.0190</td>\n","      <td>0.5207</td>\n","      <td>0.2341</td>\n","      <td>0.3372</td>\n","      <td>-0.4047</td>\n","      <td>0.8507</td>\n","      <td>-1.1520</td>\n","      <td>-0.4201</td>\n","      <td>-0.0958</td>\n","      <td>0.4590</td>\n","      <td>0.0803</td>\n","      <td>0.2250</td>\n","      <td>0.5293</td>\n","      <td>0.2839</td>\n","      <td>-0.3494</td>\n","      <td>0.2883</td>\n","      <td>0.9449</td>\n","      <td>-0.1646</td>\n","      <td>-0.2657</td>\n","      <td>-0.3372</td>\n","      <td>0.3135</td>\n","      <td>-0.4316</td>\n","      <td>0.4773</td>\n","      <td>0.2075</td>\n","      <td>-0.4216</td>\n","      <td>-0.1161</td>\n","      <td>-0.0499</td>\n","      <td>-0.2627</td>\n","      <td>0.9959</td>\n","      <td>-0.2483</td>\n","      <td>0.2655</td>\n","      <td>...</td>\n","      <td>0.3905</td>\n","      <td>0.7099</td>\n","      <td>0.2912</td>\n","      <td>0.4151</td>\n","      <td>-0.2840</td>\n","      <td>-0.3104</td>\n","      <td>-0.6373</td>\n","      <td>0.2887</td>\n","      <td>-0.0765</td>\n","      <td>0.2539</td>\n","      <td>0.4443</td>\n","      <td>0.5932</td>\n","      <td>0.2031</td>\n","      <td>0.7639</td>\n","      <td>0.5499</td>\n","      <td>-0.3322</td>\n","      <td>-0.0977</td>\n","      <td>0.4329</td>\n","      <td>-0.2782</td>\n","      <td>0.7827</td>\n","      <td>0.5934</td>\n","      <td>0.3402</td>\n","      <td>0.1499</td>\n","      <td>0.4420</td>\n","      <td>0.9366</td>\n","      <td>0.8193</td>\n","      <td>-0.4236</td>\n","      <td>0.3192</td>\n","      <td>-0.4265</td>\n","      <td>0.7543</td>\n","      <td>0.4708</td>\n","      <td>0.0230</td>\n","      <td>0.2957</td>\n","      <td>0.4899</td>\n","      <td>0.1522</td>\n","      <td>0.1241</td>\n","      <td>0.6077</td>\n","      <td>0.7371</td>\n","      <td>0</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>2</th>\n","      <td>id_000a6266a</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>18bb41b2c</td>\n","      <td>0.6280</td>\n","      <td>0.5817</td>\n","      <td>1.5540</td>\n","      <td>-0.0764</td>\n","      <td>-0.0323</td>\n","      <td>1.2390</td>\n","      <td>0.1715</td>\n","      <td>0.2155</td>\n","      <td>0.0065</td>\n","      <td>1.2300</td>\n","      <td>-0.4797</td>\n","      <td>-0.5631</td>\n","      <td>-0.0366</td>\n","      <td>-1.8300</td>\n","      <td>0.6057</td>\n","      <td>-0.3278</td>\n","      <td>0.6042</td>\n","      <td>-0.3075</td>\n","      <td>-0.1147</td>\n","      <td>-0.0570</td>\n","      <td>-0.0799</td>\n","      <td>-0.8181</td>\n","      <td>-1.5320</td>\n","      <td>0.2307</td>\n","      <td>0.4901</td>\n","      <td>0.4780</td>\n","      <td>-1.3970</td>\n","      <td>4.6240</td>\n","      <td>-0.0437</td>\n","      <td>1.2870</td>\n","      <td>-1.8530</td>\n","      <td>0.6069</td>\n","      <td>0.4290</td>\n","      <td>0.1783</td>\n","      <td>0.0018</td>\n","      <td>...</td>\n","      <td>-0.0444</td>\n","      <td>0.1894</td>\n","      <td>-0.0014</td>\n","      <td>-2.3640</td>\n","      <td>-0.4682</td>\n","      <td>0.1210</td>\n","      <td>-0.5177</td>\n","      <td>-0.0604</td>\n","      <td>0.1682</td>\n","      <td>-0.4436</td>\n","      <td>0.4963</td>\n","      <td>0.1363</td>\n","      <td>0.3335</td>\n","      <td>0.9760</td>\n","      <td>-0.0427</td>\n","      <td>-0.1235</td>\n","      <td>0.0959</td>\n","      <td>0.0690</td>\n","      <td>-0.9416</td>\n","      <td>-0.7548</td>\n","      <td>-0.1109</td>\n","      <td>-0.6272</td>\n","      <td>0.3019</td>\n","      <td>0.1172</td>\n","      <td>0.1093</td>\n","      <td>-0.3113</td>\n","      <td>0.3019</td>\n","      <td>-0.0873</td>\n","      <td>-0.7250</td>\n","      <td>-0.6297</td>\n","      <td>0.6103</td>\n","      <td>0.0223</td>\n","      <td>-1.3240</td>\n","      <td>-0.3174</td>\n","      <td>-0.6417</td>\n","      <td>-0.2187</td>\n","      <td>-1.4080</td>\n","      <td>0.6931</td>\n","      <td>3</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>3</th>\n","      <td>id_0015fd391</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>8c7f86626</td>\n","      <td>-0.5138</td>\n","      <td>-0.2491</td>\n","      <td>-0.2656</td>\n","      <td>0.5288</td>\n","      <td>4.0620</td>\n","      <td>-0.8095</td>\n","      <td>-1.9590</td>\n","      <td>0.1792</td>\n","      <td>-0.1321</td>\n","      <td>-1.0600</td>\n","      <td>-0.8269</td>\n","      <td>-0.3584</td>\n","      <td>-0.8511</td>\n","      <td>-0.5844</td>\n","      <td>-2.5690</td>\n","      <td>0.8183</td>\n","      <td>-0.0532</td>\n","      <td>-0.8554</td>\n","      <td>0.1160</td>\n","      <td>-2.3520</td>\n","      <td>2.1200</td>\n","      <td>-1.1580</td>\n","      <td>-0.7191</td>\n","      <td>-0.8004</td>\n","      <td>-1.4670</td>\n","      <td>-0.0107</td>\n","      <td>-0.8995</td>\n","      <td>0.2406</td>\n","      <td>-0.2479</td>\n","      <td>-1.0890</td>\n","      <td>-0.7575</td>\n","      <td>0.0881</td>\n","      <td>-2.7370</td>\n","      <td>0.8745</td>\n","      <td>0.5787</td>\n","      <td>...</td>\n","      <td>-2.3820</td>\n","      <td>-3.7350</td>\n","      <td>-2.9740</td>\n","      <td>-1.4930</td>\n","      <td>-1.6600</td>\n","      <td>-3.1660</td>\n","      <td>0.2816</td>\n","      <td>-0.2990</td>\n","      <td>-1.1870</td>\n","      <td>-0.5044</td>\n","      <td>-1.7750</td>\n","      <td>-1.6120</td>\n","      <td>-0.9215</td>\n","      <td>-1.0810</td>\n","      <td>-3.0520</td>\n","      <td>-3.4470</td>\n","      <td>-2.7740</td>\n","      <td>-1.8460</td>\n","      <td>-0.5568</td>\n","      <td>-3.3960</td>\n","      <td>-2.9510</td>\n","      <td>-1.1550</td>\n","      <td>-3.2620</td>\n","      <td>-1.5390</td>\n","      <td>-2.4600</td>\n","      <td>-0.9417</td>\n","      <td>-1.5550</td>\n","      <td>0.2431</td>\n","      <td>-2.0990</td>\n","      <td>-0.6441</td>\n","      <td>-5.6300</td>\n","      <td>-1.3780</td>\n","      <td>-0.8632</td>\n","      <td>-1.2880</td>\n","      <td>-1.6210</td>\n","      <td>-0.8784</td>\n","      <td>-0.3876</td>\n","      <td>-0.8154</td>\n","      <td>0</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>4</th>\n","      <td>id_001626bd3</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>7cbed3131</td>\n","      <td>-0.3254</td>\n","      <td>-0.4009</td>\n","      <td>0.9700</td>\n","      <td>0.6919</td>\n","      <td>1.4180</td>\n","      <td>-0.8244</td>\n","      <td>-0.2800</td>\n","      <td>-0.1498</td>\n","      <td>-0.8789</td>\n","      <td>0.8630</td>\n","      <td>-0.2219</td>\n","      <td>-0.5121</td>\n","      <td>-0.9577</td>\n","      <td>1.1750</td>\n","      <td>0.2042</td>\n","      <td>0.1970</td>\n","      <td>0.1244</td>\n","      <td>-1.7090</td>\n","      <td>-0.3543</td>\n","      <td>-0.5160</td>\n","      <td>-0.3330</td>\n","      <td>-0.2685</td>\n","      <td>0.7649</td>\n","      <td>0.2057</td>\n","      <td>1.3720</td>\n","      <td>0.6835</td>\n","      <td>0.8056</td>\n","      <td>-0.3754</td>\n","      <td>-1.2090</td>\n","      <td>0.2965</td>\n","      <td>-0.0712</td>\n","      <td>0.6389</td>\n","      <td>0.6674</td>\n","      <td>-0.0783</td>\n","      <td>1.1740</td>\n","      <td>...</td>\n","      <td>0.1535</td>\n","      <td>-0.4640</td>\n","      <td>-0.5943</td>\n","      <td>0.3973</td>\n","      <td>0.1500</td>\n","      <td>0.5178</td>\n","      <td>0.5159</td>\n","      <td>0.6091</td>\n","      <td>0.1813</td>\n","      <td>-0.4249</td>\n","      <td>0.7832</td>\n","      <td>0.6529</td>\n","      <td>0.5648</td>\n","      <td>0.4817</td>\n","      <td>0.0587</td>\n","      <td>0.5303</td>\n","      <td>0.6376</td>\n","      <td>-0.3966</td>\n","      <td>-1.4950</td>\n","      <td>-0.9625</td>\n","      <td>-0.0541</td>\n","      <td>0.6273</td>\n","      <td>0.4563</td>\n","      <td>0.0698</td>\n","      <td>0.8134</td>\n","      <td>0.1924</td>\n","      <td>0.6054</td>\n","      <td>-0.1824</td>\n","      <td>0.0042</td>\n","      <td>0.0048</td>\n","      <td>0.6670</td>\n","      <td>1.0690</td>\n","      <td>0.5523</td>\n","      <td>-0.3031</td>\n","      <td>0.1094</td>\n","      <td>0.2885</td>\n","      <td>-0.3786</td>\n","      <td>0.7125</td>\n","      <td>1</td>\n","      <td>True</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>5 rows × 879 columns</p>\n","</div>"],"text/plain":["             id tratamento  tempo dose  ...    c-98    c-99  n_moa  ativo_moa\n","0  id_000644bb2  com_droga     24   D1  ...  0.3801  0.4176      1       True\n","1  id_000779bfc  com_droga     72   D1  ...  0.6077  0.7371      0      False\n","2  id_000a6266a  com_droga     48   D1  ... -1.4080  0.6931      3       True\n","3  id_0015fd391  com_droga     48   D1  ... -0.3876 -0.8154      0      False\n","4  id_001626bd3  com_droga     72   D2  ... -0.3786  0.7125      1       True\n","\n","[5 rows x 879 columns]"]},"metadata":{"tags":[]},"execution_count":14}]},{"cell_type":"markdown","metadata":{"id":"reBfjtcrpvw8"},"source":["Maravilha! Conseguimos agora a junção dos nossos dados de resultados com os dados de experimentos. Agora conseguimos responder a pergunta que fizemos anteriormente. No tratamento eu ativei algum moa?"]},{"cell_type":"markdown","metadata":{"id":"KnP6B84IqHaE"},"source":["Para fazer isso vamos utilizar o método:\n","\n","> Bloco com recuo\n","\n"]},{"cell_type":"code","metadata":{"id":"rcU4LnVnkch6","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339237721,"user_tz":180,"elapsed":9979,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"6f570d1e-a70b-4d01-e2e5-0bd14ac34927"},"source":["dados_combinados.query('tratamento == \"com_controle\"' )['ativo_moa'].value_counts()"],"execution_count":15,"outputs":[{"output_type":"execute_result","data":{"text/plain":["False    1866\n","Name: ativo_moa, dtype: int64"]},"metadata":{"tags":[]},"execution_count":15}]},{"cell_type":"markdown","metadata":{"id":"s4YOtp4bqfFt"},"source":["E obtivemos todas as respostas com o 'false'. Isso quer dizer que com controle não tivemos nenhuma resposta de algum mecanismo de ação."]},{"cell_type":"markdown","metadata":{"id":"nMfh6CUruZTg"},"source":["Agora, será que algum tratamento que o paciente recebeu (com_droga, nesse caso) teve alguma substância que não ativou o mecanismo de ação? Vamos responder isso com a seguinte alteração no código anterior:"]},{"cell_type":"code","metadata":{"id":"eyBpIF8pmBrJ","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620339237981,"user_tz":180,"elapsed":10221,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"8ed553c3-f558-4e84-9057-217baf44e6f2"},"source":["dados_combinados.query('tratamento == \"com_droga\"' )['ativo_moa'].value_counts()"],"execution_count":16,"outputs":[{"output_type":"execute_result","data":{"text/plain":["True     14447\n","False     7501\n","Name: ativo_moa, dtype: int64"]},"metadata":{"tags":[]},"execution_count":16}]},{"cell_type":"markdown","metadata":{"id":"RcJO5IuAuycz"},"source":["Olha só, tivemos um resultado interessante. Vemos que 14447 tiveram mecanismos de ação, e aproximadamente 7500 não foram ativados. "]},{"cell_type":"markdown","metadata":{"id":"RT7fCu0eb3F0"},"source":["Vamos fazer uma análise utilizando agora o boxplot, que gera uma imagem onde podemos identificar a mediana(linha central) e os quartis, entendendo assim como está a distribuição dos dados; dessa maneira vamos identificar, de forma visual, a comparação de categoria dos dados. Para isso vamos utilizar os seguintes códigos:"]},{"cell_type":"code","metadata":{"id":"qSPy0nsImdIO","colab":{"base_uri":"https://localhost:8080/","height":515},"executionInfo":{"status":"ok","timestamp":1620339239881,"user_tz":180,"elapsed":12103,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"dbb710cf-9557-4525-b1f3-9636a80a396f"},"source":["import seaborn as sns\n","import matplotlib.pyplot as plt\n","composto_principal = dados_combinados['composto'].value_counts().index[:5]\n","plt.figure(figsize=(12,8))\n","sns.boxplot(data = dados_combinados.query('composto in @composto_principal'), y= 'g-0', x='composto', hue='ativo_moa')\n"],"execution_count":17,"outputs":[{"output_type":"execute_result","data":{"text/plain":["<matplotlib.axes._subplots.AxesSubplot at 0x7fb124a7de50>"]},"metadata":{"tags":[]},"execution_count":17},{"output_type":"display_data","data":{"image/png":"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\n","text/plain":["<Figure size 864x576 with 1 Axes>"]},"metadata":{"tags":[],"needs_background":"light"}}]},{"cell_type":"markdown","metadata":{"id":"vz5Sggy4d0AE"},"source":["Analisando os boxplots, percebemos que temos algumas categorias com a mediana próxima de 0; temos outra com a mediana próxima de 5 e a outra próxima de 2.\n","\n","É curioso observarmos também que o 3º boxplot, da esquerda para a direita, está bem concentrado; esse composto específico é na verdade o composto que nos indica que foi \"com tratamento\".\n","\n","Outro ponto interessante é que o último boxplot tem um comportamento muito semelhante ao 3º; provavelmente a droga não modificou tanto assim o gene 0.\n","\n","Agora é com você! Faça os desafios e nos encontramos na próxima aula."]},{"cell_type":"markdown","metadata":{"id":"X_Lg2XTu20ND"},"source":["##Aula 04\n","\n","###Desafio 01: Encontrar o top 10, das ações do MOA (inibidor, agonista...)\n","\n","###Desafio 02: Criar a coluna eh_controle para quando na linha tratamento == com_controle\n","\n","###Desafio 03: Criar três colunas para indicar o tempo 24, 48, 72\n","\n","###Desafio 04: Estudar sobre combinações de DF https://pandas.pydata.org/pandas-docs/stable/user_guide/merging.html\n","\n","\n","###Desafio 05: Fazer análise mais detalhada considerando tempo e dose, para comparar as distribuições (Escolher uma droga e comparar com controle)\n","\n","###Desafio 06: Descobrir se tem algum composto que dependendo da configuração do experimento, ativa ou não ativa algum MOA \n","\n","###Desafio 07: Descobrir se tem algum composto que dependendo da configuração do experimento, ativa MOAs diferentes\n","\n","\n","###Desafio 08: Resumo do que você aprendeu com os dados\n"]},{"cell_type":"markdown","metadata":{"id":"rxQ-aufPp6pS"},"source":["# Desafio 1:"]},{"cell_type":"markdown","metadata":{"id":"mU10lr-Rq-8h"},"source":[""]},{"cell_type":"markdown","metadata":{"id":"CfIoOJQcqKrh"},"source":["A primeira ideia que me surgiu foi renomear as colunas eliminando tudo que vem antes do \"_\". Porém acho que não funciona. A segundo ideia que tive foi usar a serie \"contage_moa\" e passar uma operação logia para saber se um trecho do nome pertence ao str. será que funciona? "]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"jYvXE5wtrO2T","executionInfo":{"status":"ok","timestamp":1620339239882,"user_tz":180,"elapsed":12091,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"6eba7b55-d645-4be8-9e27-ed80172a1137"},"source":["type(contagem_moa)"],"execution_count":18,"outputs":[{"output_type":"execute_result","data":{"text/plain":["pandas.core.series.Series"]},"metadata":{"tags":[]},"execution_count":18}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":194},"id":"klfgWnVmp9lC","executionInfo":{"status":"ok","timestamp":1620339239883,"user_tz":180,"elapsed":12081,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"17111cb9-edf7-472b-8eb6-5cba7d1a46f4"},"source":["contagem_moa_d = pd.DataFrame(data = contagem_moa)\n","contagem_moa_d.head()"],"execution_count":19,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>0</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>nfkb_inhibitor</th>\n","      <td>832</td>\n","    </tr>\n","    <tr>\n","      <th>proteasome_inhibitor</th>\n","      <td>726</td>\n","    </tr>\n","    <tr>\n","      <th>cyclooxygenase_inhibitor</th>\n","      <td>435</td>\n","    </tr>\n","    <tr>\n","      <th>dopamine_receptor_antagonist</th>\n","      <td>424</td>\n","    </tr>\n","    <tr>\n","      <th>serotonin_receptor_antagonist</th>\n","      <td>404</td>\n","    </tr>\n","  </tbody>\n","</table>\n","</div>"],"text/plain":["                                 0\n","nfkb_inhibitor                 832\n","proteasome_inhibitor           726\n","cyclooxygenase_inhibitor       435\n","dopamine_receptor_antagonist   424\n","serotonin_receptor_antagonist  404"]},"metadata":{"tags":[]},"execution_count":19}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"XtKAFFyJx0XT","executionInfo":{"status":"ok","timestamp":1620339239884,"user_tz":180,"elapsed":12069,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"dc48d8ec-37e5-4238-dde6-23e74978d469"},"source":["contagem_moa_d.index"],"execution_count":20,"outputs":[{"output_type":"execute_result","data":{"text/plain":["Index(['nfkb_inhibitor', 'proteasome_inhibitor', 'cyclooxygenase_inhibitor',\n","       'dopamine_receptor_antagonist', 'serotonin_receptor_antagonist',\n","       'dna_inhibitor', 'glutamate_receptor_antagonist',\n","       'adrenergic_receptor_antagonist', 'cdk_inhibitor', 'egfr_inhibitor',\n","       ...\n","       'calcineurin_inhibitor', 'atm_kinase_inhibitor',\n","       'nicotinic_receptor_agonist', 'retinoid_receptor_antagonist',\n","       'antiarrhythmic', 'protein_phosphatase_inhibitor',\n","       'autotaxin_inhibitor', 'diuretic', 'erbb2_inhibitor',\n","       'atp-sensitive_potassium_channel_antagonist'],\n","      dtype='object', length=206)"]},"metadata":{"tags":[]},"execution_count":20}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"QE2I-k31sev7","executionInfo":{"status":"ok","timestamp":1620339239884,"user_tz":180,"elapsed":12061,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"edbc27e3-47a7-4d7d-e1e8-d0ba2d718ded"},"source":["contagem_moa_d[contagem_moa_d.index.str.contains(\"inhibitor\")].sum()[0]"],"execution_count":21,"outputs":[{"output_type":"execute_result","data":{"text/plain":["9693"]},"metadata":{"tags":[]},"execution_count":21}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"m8sDJlGXxELe","executionInfo":{"status":"ok","timestamp":1620339239885,"user_tz":180,"elapsed":12054,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"462d8ff3-0e7d-4e45-f203-3aa725382375"},"source":["contagem_moa_d[contagem_moa_d.index.str.contains(\"antagonist\")].sum()"],"execution_count":22,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0    3449\n","dtype: int64"]},"metadata":{"tags":[]},"execution_count":22}]},{"cell_type":"markdown","metadata":{"id":"ljcq5WbHzVqT"},"source":["O problema dessa forma é que eu não sei quais são todos os tipos. Só conheço o inhibitor, antagonist e agonist.\n","\n","\n","Uma forma que vi no discord talvez funcione melhor que foi usar um for para "]},{"cell_type":"code","metadata":{"id":"KUrzIuKtymkf","executionInfo":{"status":"ok","timestamp":1620339239886,"user_tz":180,"elapsed":12053,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["import numpy as np"],"execution_count":23,"outputs":[]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"cXbXB5rp0Rax","executionInfo":{"status":"ok","timestamp":1620339239887,"user_tz":180,"elapsed":12043,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"88df3771-dd4f-4636-88a5-4c14efbaf10f"},"source":["# Pegar todos os tipos que temos (uma informação que eu não tinha só de olhar)\n","unique_moa_types = np.unique([col.split('_')[-1] for col in dados_resultados.drop(['id', 'n_moa', 'ativo_moa'],axis=1).columns])\n","unique_moa_types"],"execution_count":24,"outputs":[{"output_type":"execute_result","data":{"text/plain":["array(['activator', 'agent', 'agonist', 'analgesic', 'antagonist',\n","       'anti-inflammatory', 'antiarrhythmic', 'antibiotic',\n","       'anticonvulsant', 'antifolate', 'antifungal', 'antihistamine',\n","       'antimalarial', 'antioxidant', 'antiprotozoal', 'antiviral', 'b',\n","       'blocker', 'diuretic', 'donor', 'immunosuppressant', 'inhibitor',\n","       'laxative', 'local', 'medium', 'scavenger', 'secretagogue',\n","       'sensitizer', 'steroid', 'stimulant'], dtype='<U17')"]},"metadata":{"tags":[]},"execution_count":24}]},{"cell_type":"markdown","metadata":{"id":"20fE4Ntf01FR"},"source":["Desse ponto eu posso fazer manualmente de um por um com a ideia anterior. Mas provavelmente existe uma forta de fazer automaticamente."]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"OYIu6Ara0Wku","executionInfo":{"status":"ok","timestamp":1620339239888,"user_tz":180,"elapsed":12033,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"2c2ba6c5-0dd7-43dd-842f-6a689c613960"},"source":["frequencia = []\n"," #for tipo in unique_moa_types:\n","suporte  = contagem_moa_d[contagem_moa_d.index.str.contains(\"inhibitor\")].sum()[0]\n","frequencia.append({'inhibitor' : suporte})\n","suporte  = contagem_moa_d[contagem_moa_d.index.str.contains(\"antagonist\")].sum()[0]\n","frequencia.append({'antagonist' : suporte})\n","frequencia"],"execution_count":25,"outputs":[{"output_type":"execute_result","data":{"text/plain":["[{'inhibitor': 9693}, {'antagonist': 3449}]"]},"metadata":{"tags":[]},"execution_count":25}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"iuA_DVh22PK7","executionInfo":{"status":"ok","timestamp":1620339239895,"user_tz":180,"elapsed":12028,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"77b7c1f7-be53-4dcb-ce64-c68fcf8dbe22"},"source":["import operator\n","frequencia = {}\n","for tipo in unique_moa_types:\n","  suporte  = contagem_moa_d[contagem_moa_d.index.str.contains(tipo)].sum()[0]\n","  frequencia.update({tipo : suporte})\n","\n","x = sorted(frequencia.items(), key=operator.itemgetter(1), reverse=True)\n","x[1:11]"],"execution_count":26,"outputs":[{"output_type":"execute_result","data":{"text/plain":["[('inhibitor', 9693),\n"," ('agonist', 5779),\n"," ('antagonist', 3449),\n"," ('blocker', 323),\n"," ('agent', 150),\n"," ('activator', 115),\n"," ('local', 80),\n"," ('anti-inflammatory', 73),\n"," ('antioxidant', 73),\n"," ('immunosuppressant', 73)]"]},"metadata":{"tags":[]},"execution_count":26}]},{"cell_type":"markdown","metadata":{"id":"rYgDJU8Q8iS4"},"source":["#Desafio 2:"]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"e9AEH5CB8ouP","executionInfo":{"status":"ok","timestamp":1620339239896,"user_tz":180,"elapsed":12017,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"11c9abf3-f12d-492c-b22d-a3d122d82a22"},"source":["# Primeito vamos testar a logica pra ver se tá okey.\n","(dados_combinados['tratamento'] == 'com_controle')"],"execution_count":27,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0        False\n","1        False\n","2        False\n","3        False\n","4        False\n","         ...  \n","23809    False\n","23810    False\n","23811     True\n","23812    False\n","23813    False\n","Name: tratamento, Length: 23814, dtype: bool"]},"metadata":{"tags":[]},"execution_count":27}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":0},"id":"Nwu_LTjN9b-V","executionInfo":{"status":"ok","timestamp":1620339239897,"user_tz":180,"elapsed":12006,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"934887bf-12b9-47dd-a155-7c1ffd16ed83"},"source":["dados_combinados['tratamento_controle'] = (dados_combinados['tratamento'] == 'com_controle')\n","dados_combinados.tail(10)"],"execution_count":28,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-63</th>\n","      <th>c-64</th>\n","      <th>c-65</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","      <th>tratamento_controle</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>23804</th>\n","      <td>id_fff506720</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>74515bfd2</td>\n","      <td>-1.0140</td>\n","      <td>0.1709</td>\n","      <td>-0.4291</td>\n","      <td>1.8750</td>\n","      <td>0.9859</td>\n","      <td>0.3009</td>\n","      <td>0.0650</td>\n","      <td>-1.3920</td>\n","      <td>-1.0410</td>\n","      <td>1.4790</td>\n","      <td>-0.4459</td>\n","      <td>0.7377</td>\n","      <td>-0.0037</td>\n","      <td>-0.0995</td>\n","      <td>-0.2393</td>\n","      <td>-1.1670</td>\n","      <td>-0.9359</td>\n","      <td>1.1260</td>\n","      <td>0.3450</td>\n","      <td>-1.0780</td>\n","      <td>2.7230</td>\n","      <td>0.5255</td>\n","      <td>0.6368</td>\n","      <td>0.0000</td>\n","      <td>-0.1172</td>\n","      <td>0.8256</td>\n","      <td>0.2120</td>\n","      <td>2.1500</td>\n","      <td>0.5925</td>\n","      <td>-0.7637</td>\n","      <td>0.1157</td>\n","      <td>0.0919</td>\n","      <td>-0.5855</td>\n","      <td>-0.6233</td>\n","      <td>-0.7982</td>\n","      <td>...</td>\n","      <td>-2.6910</td>\n","      <td>-0.6001</td>\n","      <td>-1.3260</td>\n","      <td>-1.5960</td>\n","      <td>-0.3137</td>\n","      <td>-0.4209</td>\n","      <td>-0.9542</td>\n","      <td>-1.4760</td>\n","      <td>-1.0180</td>\n","      <td>-1.1360</td>\n","      <td>0.1523</td>\n","      <td>-1.0130</td>\n","      <td>-0.4065</td>\n","      <td>0.8502</td>\n","      <td>-0.0978</td>\n","      <td>-0.7339</td>\n","      <td>-0.5680</td>\n","      <td>-0.5700</td>\n","      <td>0.7834</td>\n","      <td>-2.5930</td>\n","      <td>-2.1570</td>\n","      <td>-0.7917</td>\n","      <td>-0.9154</td>\n","      <td>1.5140</td>\n","      <td>-3.1070</td>\n","      <td>-0.2346</td>\n","      <td>-0.2662</td>\n","      <td>-0.6730</td>\n","      <td>0.3175</td>\n","      <td>-1.5510</td>\n","      <td>-1.2800</td>\n","      <td>-0.7632</td>\n","      <td>-0.6736</td>\n","      <td>-0.4097</td>\n","      <td>0.2282</td>\n","      <td>-0.3213</td>\n","      <td>-0.0836</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23805</th>\n","      <td>id_fff6df1c5</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>5628cb3ee</td>\n","      <td>1.7380</td>\n","      <td>-1.2900</td>\n","      <td>-0.4533</td>\n","      <td>-1.1640</td>\n","      <td>-0.4841</td>\n","      <td>-0.2392</td>\n","      <td>-0.1774</td>\n","      <td>-1.3980</td>\n","      <td>-0.4059</td>\n","      <td>0.1553</td>\n","      <td>0.1083</td>\n","      <td>-0.8020</td>\n","      <td>-0.5039</td>\n","      <td>-0.7167</td>\n","      <td>-0.5016</td>\n","      <td>-0.9369</td>\n","      <td>-0.5864</td>\n","      <td>-0.1009</td>\n","      <td>0.8987</td>\n","      <td>0.3389</td>\n","      <td>-1.3460</td>\n","      <td>-0.5087</td>\n","      <td>-0.0892</td>\n","      <td>-0.6559</td>\n","      <td>0.0864</td>\n","      <td>-0.6251</td>\n","      <td>0.2471</td>\n","      <td>-0.4523</td>\n","      <td>-0.0389</td>\n","      <td>1.0340</td>\n","      <td>0.0796</td>\n","      <td>-0.2560</td>\n","      <td>-0.7851</td>\n","      <td>-0.1687</td>\n","      <td>-1.2890</td>\n","      <td>...</td>\n","      <td>0.2883</td>\n","      <td>0.5843</td>\n","      <td>0.0907</td>\n","      <td>-0.9303</td>\n","      <td>0.1981</td>\n","      <td>0.6515</td>\n","      <td>0.2877</td>\n","      <td>0.4389</td>\n","      <td>-0.3859</td>\n","      <td>0.5203</td>\n","      <td>-1.1070</td>\n","      <td>2.3870</td>\n","      <td>0.1820</td>\n","      <td>-0.6434</td>\n","      <td>-0.9722</td>\n","      <td>-0.4200</td>\n","      <td>-0.5693</td>\n","      <td>1.0700</td>\n","      <td>1.1110</td>\n","      <td>-0.5117</td>\n","      <td>-1.2130</td>\n","      <td>0.3769</td>\n","      <td>0.5296</td>\n","      <td>1.0400</td>\n","      <td>0.0587</td>\n","      <td>1.0150</td>\n","      <td>-0.7669</td>\n","      <td>0.2865</td>\n","      <td>0.5974</td>\n","      <td>-0.2727</td>\n","      <td>0.1188</td>\n","      <td>1.0770</td>\n","      <td>-1.0250</td>\n","      <td>0.1516</td>\n","      <td>0.4503</td>\n","      <td>-0.6312</td>\n","      <td>-0.8302</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23806</th>\n","      <td>id_fff790a17</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>47dd8f190</td>\n","      <td>-0.1150</td>\n","      <td>-0.8037</td>\n","      <td>0.0988</td>\n","      <td>-0.1301</td>\n","      <td>0.2013</td>\n","      <td>0.9126</td>\n","      <td>0.2234</td>\n","      <td>0.8321</td>\n","      <td>0.0486</td>\n","      <td>-0.4505</td>\n","      <td>0.3666</td>\n","      <td>-0.0418</td>\n","      <td>0.5645</td>\n","      <td>0.4406</td>\n","      <td>0.5708</td>\n","      <td>-0.0984</td>\n","      <td>1.2150</td>\n","      <td>-0.0770</td>\n","      <td>0.4057</td>\n","      <td>0.7522</td>\n","      <td>-0.3141</td>\n","      <td>-0.2469</td>\n","      <td>-0.5490</td>\n","      <td>-0.1521</td>\n","      <td>0.5957</td>\n","      <td>-0.0912</td>\n","      <td>0.4107</td>\n","      <td>-0.0944</td>\n","      <td>-0.1861</td>\n","      <td>0.5627</td>\n","      <td>-0.0437</td>\n","      <td>-0.5673</td>\n","      <td>0.2384</td>\n","      <td>0.5478</td>\n","      <td>0.3555</td>\n","      <td>...</td>\n","      <td>-0.5505</td>\n","      <td>0.5671</td>\n","      <td>0.2905</td>\n","      <td>0.8563</td>\n","      <td>-0.4375</td>\n","      <td>0.3678</td>\n","      <td>0.3119</td>\n","      <td>0.4316</td>\n","      <td>-0.6997</td>\n","      <td>0.5957</td>\n","      <td>0.1860</td>\n","      <td>0.3508</td>\n","      <td>0.2853</td>\n","      <td>1.0110</td>\n","      <td>0.0014</td>\n","      <td>-0.2718</td>\n","      <td>-0.1950</td>\n","      <td>1.0390</td>\n","      <td>-0.3072</td>\n","      <td>0.8025</td>\n","      <td>-0.1202</td>\n","      <td>-1.0380</td>\n","      <td>0.9099</td>\n","      <td>0.2493</td>\n","      <td>-0.7423</td>\n","      <td>0.3864</td>\n","      <td>1.2630</td>\n","      <td>0.2358</td>\n","      <td>0.1086</td>\n","      <td>-0.1686</td>\n","      <td>-0.3482</td>\n","      <td>0.4121</td>\n","      <td>0.5728</td>\n","      <td>1.2630</td>\n","      <td>0.7823</td>\n","      <td>-0.6947</td>\n","      <td>0.7277</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23807</th>\n","      <td>id_fff7e6992</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>a28556d51</td>\n","      <td>0.1420</td>\n","      <td>-0.3696</td>\n","      <td>-0.0093</td>\n","      <td>-0.2495</td>\n","      <td>-0.0175</td>\n","      <td>0.0959</td>\n","      <td>-0.2201</td>\n","      <td>0.2443</td>\n","      <td>0.4879</td>\n","      <td>0.3432</td>\n","      <td>0.4151</td>\n","      <td>0.9056</td>\n","      <td>0.3538</td>\n","      <td>0.5246</td>\n","      <td>-0.4441</td>\n","      <td>-0.1605</td>\n","      <td>-0.3720</td>\n","      <td>-0.5619</td>\n","      <td>-0.1409</td>\n","      <td>0.1255</td>\n","      <td>0.1214</td>\n","      <td>-0.1975</td>\n","      <td>-0.4367</td>\n","      <td>0.0000</td>\n","      <td>0.4301</td>\n","      <td>-0.7606</td>\n","      <td>-0.0248</td>\n","      <td>0.0270</td>\n","      <td>-0.0367</td>\n","      <td>-1.2480</td>\n","      <td>0.0559</td>\n","      <td>-0.0984</td>\n","      <td>0.5537</td>\n","      <td>0.1063</td>\n","      <td>0.3893</td>\n","      <td>...</td>\n","      <td>0.9227</td>\n","      <td>-0.0460</td>\n","      <td>0.3756</td>\n","      <td>1.0730</td>\n","      <td>-0.6904</td>\n","      <td>0.9298</td>\n","      <td>1.0500</td>\n","      <td>0.4646</td>\n","      <td>0.4481</td>\n","      <td>0.9771</td>\n","      <td>0.7187</td>\n","      <td>0.5299</td>\n","      <td>0.1079</td>\n","      <td>1.2010</td>\n","      <td>0.2529</td>\n","      <td>-0.4546</td>\n","      <td>0.7998</td>\n","      <td>0.6401</td>\n","      <td>-1.3370</td>\n","      <td>0.6542</td>\n","      <td>0.8561</td>\n","      <td>0.4829</td>\n","      <td>0.3213</td>\n","      <td>-0.0177</td>\n","      <td>-0.2656</td>\n","      <td>0.4626</td>\n","      <td>0.0030</td>\n","      <td>0.8775</td>\n","      <td>0.5230</td>\n","      <td>0.1589</td>\n","      <td>0.7715</td>\n","      <td>0.5497</td>\n","      <td>0.6929</td>\n","      <td>0.3738</td>\n","      <td>0.8636</td>\n","      <td>0.4494</td>\n","      <td>0.1218</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23808</th>\n","      <td>id_fff8c2444</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>6c3a459be</td>\n","      <td>0.1608</td>\n","      <td>-1.0500</td>\n","      <td>0.2551</td>\n","      <td>-0.2239</td>\n","      <td>-0.2431</td>\n","      <td>0.4256</td>\n","      <td>-0.1166</td>\n","      <td>-0.1777</td>\n","      <td>-0.7480</td>\n","      <td>0.1368</td>\n","      <td>0.5493</td>\n","      <td>-0.5083</td>\n","      <td>0.4112</td>\n","      <td>0.1181</td>\n","      <td>0.7861</td>\n","      <td>-0.1877</td>\n","      <td>0.2476</td>\n","      <td>0.1956</td>\n","      <td>0.0273</td>\n","      <td>0.1182</td>\n","      <td>-0.5037</td>\n","      <td>-0.5939</td>\n","      <td>0.4825</td>\n","      <td>-0.5187</td>\n","      <td>0.1618</td>\n","      <td>-0.2253</td>\n","      <td>0.3153</td>\n","      <td>0.4839</td>\n","      <td>0.0520</td>\n","      <td>1.3850</td>\n","      <td>0.6502</td>\n","      <td>-0.4198</td>\n","      <td>0.2723</td>\n","      <td>-0.3629</td>\n","      <td>1.0820</td>\n","      <td>...</td>\n","      <td>0.6607</td>\n","      <td>-0.1849</td>\n","      <td>-0.6546</td>\n","      <td>-0.5798</td>\n","      <td>0.3449</td>\n","      <td>-0.6208</td>\n","      <td>0.2949</td>\n","      <td>0.4158</td>\n","      <td>0.8586</td>\n","      <td>0.3868</td>\n","      <td>1.0030</td>\n","      <td>-0.4593</td>\n","      <td>0.6498</td>\n","      <td>0.8293</td>\n","      <td>-0.7645</td>\n","      <td>0.5379</td>\n","      <td>0.5610</td>\n","      <td>0.2577</td>\n","      <td>-0.5493</td>\n","      <td>0.2690</td>\n","      <td>0.6392</td>\n","      <td>-0.5774</td>\n","      <td>-0.3393</td>\n","      <td>0.5068</td>\n","      <td>-0.2005</td>\n","      <td>-0.4559</td>\n","      <td>0.3734</td>\n","      <td>0.0789</td>\n","      <td>0.3538</td>\n","      <td>0.0558</td>\n","      <td>0.3377</td>\n","      <td>-0.4753</td>\n","      <td>-0.2504</td>\n","      <td>-0.7415</td>\n","      <td>0.8413</td>\n","      <td>-0.4259</td>\n","      <td>0.2434</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23809</th>\n","      <td>id_fffb1ceed</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>df1d0a5a1</td>\n","      <td>0.1394</td>\n","      <td>-0.0636</td>\n","      <td>-0.1112</td>\n","      <td>-0.5080</td>\n","      <td>-0.4713</td>\n","      <td>0.7201</td>\n","      <td>0.5773</td>\n","      <td>0.3055</td>\n","      <td>-0.4726</td>\n","      <td>0.1269</td>\n","      <td>0.2531</td>\n","      <td>0.1730</td>\n","      <td>-0.4532</td>\n","      <td>-1.0790</td>\n","      <td>0.2474</td>\n","      <td>-0.4550</td>\n","      <td>0.3588</td>\n","      <td>0.1600</td>\n","      <td>-0.7362</td>\n","      <td>-0.1103</td>\n","      <td>0.8550</td>\n","      <td>-0.4139</td>\n","      <td>0.5541</td>\n","      <td>0.2310</td>\n","      <td>-0.5573</td>\n","      <td>-0.4397</td>\n","      <td>-0.9260</td>\n","      <td>-0.2424</td>\n","      <td>-0.6686</td>\n","      <td>0.2326</td>\n","      <td>0.6456</td>\n","      <td>0.0136</td>\n","      <td>-0.5141</td>\n","      <td>-0.6320</td>\n","      <td>0.7166</td>\n","      <td>...</td>\n","      <td>0.4420</td>\n","      <td>0.9641</td>\n","      <td>-0.1846</td>\n","      <td>-0.0014</td>\n","      <td>0.3154</td>\n","      <td>-0.2071</td>\n","      <td>-0.6158</td>\n","      <td>-0.2977</td>\n","      <td>0.0992</td>\n","      <td>0.6838</td>\n","      <td>0.5259</td>\n","      <td>0.7882</td>\n","      <td>0.3119</td>\n","      <td>-0.7697</td>\n","      <td>0.2203</td>\n","      <td>-1.0710</td>\n","      <td>0.5979</td>\n","      <td>0.0848</td>\n","      <td>-0.2555</td>\n","      <td>0.6293</td>\n","      <td>1.1660</td>\n","      <td>0.3329</td>\n","      <td>0.2754</td>\n","      <td>0.4108</td>\n","      <td>-0.1252</td>\n","      <td>-0.2340</td>\n","      <td>0.2267</td>\n","      <td>0.1969</td>\n","      <td>0.0262</td>\n","      <td>-0.8121</td>\n","      <td>0.3434</td>\n","      <td>0.5372</td>\n","      <td>-0.3246</td>\n","      <td>0.0631</td>\n","      <td>0.9171</td>\n","      <td>0.5258</td>\n","      <td>0.4680</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23810</th>\n","      <td>id_fffb70c0c</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>ecf3b6b74</td>\n","      <td>-1.3260</td>\n","      <td>0.3478</td>\n","      <td>-0.3743</td>\n","      <td>0.9905</td>\n","      <td>-0.7178</td>\n","      <td>0.6621</td>\n","      <td>-0.2252</td>\n","      <td>-0.5565</td>\n","      <td>0.5112</td>\n","      <td>0.6727</td>\n","      <td>-0.1851</td>\n","      <td>2.8650</td>\n","      <td>-0.2140</td>\n","      <td>-0.6153</td>\n","      <td>0.8362</td>\n","      <td>0.5584</td>\n","      <td>-0.2589</td>\n","      <td>0.1292</td>\n","      <td>0.0148</td>\n","      <td>0.0949</td>\n","      <td>-0.2182</td>\n","      <td>-0.9235</td>\n","      <td>0.0749</td>\n","      <td>-1.5910</td>\n","      <td>-0.8359</td>\n","      <td>-0.9217</td>\n","      <td>0.3013</td>\n","      <td>0.1716</td>\n","      <td>0.0880</td>\n","      <td>0.1842</td>\n","      <td>0.1835</td>\n","      <td>0.5436</td>\n","      <td>-0.0533</td>\n","      <td>-0.0491</td>\n","      <td>0.9543</td>\n","      <td>...</td>\n","      <td>0.8129</td>\n","      <td>-0.1514</td>\n","      <td>-0.4652</td>\n","      <td>-0.7390</td>\n","      <td>-1.3270</td>\n","      <td>0.9925</td>\n","      <td>1.0570</td>\n","      <td>-0.3355</td>\n","      <td>-0.2555</td>\n","      <td>0.8219</td>\n","      <td>0.6995</td>\n","      <td>-0.2942</td>\n","      <td>0.2408</td>\n","      <td>-0.7781</td>\n","      <td>-0.0929</td>\n","      <td>-0.0329</td>\n","      <td>0.0781</td>\n","      <td>-1.4440</td>\n","      <td>-0.0921</td>\n","      <td>0.3188</td>\n","      <td>-1.1080</td>\n","      <td>0.4895</td>\n","      <td>-0.2144</td>\n","      <td>1.0960</td>\n","      <td>0.3335</td>\n","      <td>0.4444</td>\n","      <td>-1.1130</td>\n","      <td>0.4286</td>\n","      <td>0.4426</td>\n","      <td>0.0423</td>\n","      <td>-0.3195</td>\n","      <td>-0.8086</td>\n","      <td>-0.9798</td>\n","      <td>-0.2084</td>\n","      <td>-0.1224</td>\n","      <td>-0.2715</td>\n","      <td>0.3689</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23811</th>\n","      <td>id_fffc1c3f4</td>\n","      <td>com_controle</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>cacb2b860</td>\n","      <td>0.3942</td>\n","      <td>0.3756</td>\n","      <td>0.3109</td>\n","      <td>-0.7389</td>\n","      <td>0.5505</td>\n","      <td>-0.0159</td>\n","      <td>-0.2541</td>\n","      <td>0.1745</td>\n","      <td>-0.0340</td>\n","      <td>0.4865</td>\n","      <td>-0.1854</td>\n","      <td>0.0716</td>\n","      <td>0.1729</td>\n","      <td>-0.0434</td>\n","      <td>0.1542</td>\n","      <td>-0.2192</td>\n","      <td>-0.0302</td>\n","      <td>-0.4218</td>\n","      <td>0.4057</td>\n","      <td>-0.5372</td>\n","      <td>0.1521</td>\n","      <td>-0.2651</td>\n","      <td>0.2310</td>\n","      <td>-0.8101</td>\n","      <td>0.4943</td>\n","      <td>0.6905</td>\n","      <td>-0.3720</td>\n","      <td>-1.4110</td>\n","      <td>0.4516</td>\n","      <td>1.2300</td>\n","      <td>-0.1949</td>\n","      <td>-1.3280</td>\n","      <td>-0.4276</td>\n","      <td>-0.0040</td>\n","      <td>-0.3086</td>\n","      <td>...</td>\n","      <td>0.4718</td>\n","      <td>-0.2020</td>\n","      <td>0.2783</td>\n","      <td>0.4934</td>\n","      <td>0.4144</td>\n","      <td>0.5449</td>\n","      <td>1.4690</td>\n","      <td>-0.6142</td>\n","      <td>0.6068</td>\n","      <td>0.3434</td>\n","      <td>0.9880</td>\n","      <td>-0.0468</td>\n","      <td>-0.1882</td>\n","      <td>-0.0087</td>\n","      <td>-0.0356</td>\n","      <td>0.5718</td>\n","      <td>0.4971</td>\n","      <td>0.1057</td>\n","      <td>0.2111</td>\n","      <td>0.6992</td>\n","      <td>0.0708</td>\n","      <td>0.6169</td>\n","      <td>0.2248</td>\n","      <td>0.5994</td>\n","      <td>0.2689</td>\n","      <td>0.0305</td>\n","      <td>1.2320</td>\n","      <td>0.5409</td>\n","      <td>0.3755</td>\n","      <td>0.7343</td>\n","      <td>0.2807</td>\n","      <td>0.4116</td>\n","      <td>0.6422</td>\n","      <td>0.2256</td>\n","      <td>0.7592</td>\n","      <td>0.6656</td>\n","      <td>0.3808</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>23812</th>\n","      <td>id_fffcb9e7c</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>8b87a7a83</td>\n","      <td>0.6660</td>\n","      <td>0.2324</td>\n","      <td>0.4392</td>\n","      <td>0.2044</td>\n","      <td>0.8531</td>\n","      <td>-0.0343</td>\n","      <td>0.0323</td>\n","      <td>0.0463</td>\n","      <td>0.4299</td>\n","      <td>-0.7985</td>\n","      <td>0.5742</td>\n","      <td>0.1421</td>\n","      <td>2.2700</td>\n","      <td>0.2046</td>\n","      <td>0.5363</td>\n","      <td>-1.7330</td>\n","      <td>0.1450</td>\n","      <td>0.6097</td>\n","      <td>0.2024</td>\n","      <td>0.9865</td>\n","      <td>-0.7805</td>\n","      <td>0.9608</td>\n","      <td>0.3440</td>\n","      <td>2.7650</td>\n","      <td>0.4925</td>\n","      <td>0.6698</td>\n","      <td>0.2374</td>\n","      <td>-0.3372</td>\n","      <td>0.8771</td>\n","      <td>-2.6560</td>\n","      <td>-0.2000</td>\n","      <td>-0.2043</td>\n","      <td>0.6797</td>\n","      <td>-0.0248</td>\n","      <td>-0.0927</td>\n","      <td>...</td>\n","      <td>0.9261</td>\n","      <td>0.4419</td>\n","      <td>0.0295</td>\n","      <td>0.4220</td>\n","      <td>0.4677</td>\n","      <td>-0.1184</td>\n","      <td>0.4524</td>\n","      <td>0.4135</td>\n","      <td>0.1356</td>\n","      <td>-0.5801</td>\n","      <td>0.0411</td>\n","      <td>1.0240</td>\n","      <td>1.0340</td>\n","      <td>-0.0270</td>\n","      <td>-0.4194</td>\n","      <td>0.7403</td>\n","      <td>-0.6793</td>\n","      <td>-0.1423</td>\n","      <td>0.7307</td>\n","      <td>0.7946</td>\n","      <td>-0.0650</td>\n","      <td>0.9038</td>\n","      <td>0.2324</td>\n","      <td>0.9676</td>\n","      <td>1.0940</td>\n","      <td>0.4290</td>\n","      <td>0.5187</td>\n","      <td>-0.1105</td>\n","      <td>0.4258</td>\n","      <td>-0.2012</td>\n","      <td>0.1506</td>\n","      <td>1.5230</td>\n","      <td>0.7101</td>\n","      <td>0.1732</td>\n","      <td>0.7015</td>\n","      <td>-0.6290</td>\n","      <td>0.0740</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23813</th>\n","      <td>id_ffffdd77b</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>972f41291</td>\n","      <td>-0.8598</td>\n","      <td>1.0240</td>\n","      <td>-0.1361</td>\n","      <td>0.7952</td>\n","      <td>-0.3611</td>\n","      <td>-3.6750</td>\n","      <td>-1.2420</td>\n","      <td>0.9146</td>\n","      <td>3.0790</td>\n","      <td>1.2460</td>\n","      <td>1.9460</td>\n","      <td>1.4370</td>\n","      <td>2.9780</td>\n","      <td>2.2370</td>\n","      <td>-0.6818</td>\n","      <td>0.6870</td>\n","      <td>-1.1060</td>\n","      <td>0.0182</td>\n","      <td>-0.9247</td>\n","      <td>-0.0738</td>\n","      <td>-0.1919</td>\n","      <td>-0.7722</td>\n","      <td>-1.4050</td>\n","      <td>-1.0050</td>\n","      <td>-1.1170</td>\n","      <td>-0.5293</td>\n","      <td>-1.1720</td>\n","      <td>-0.2885</td>\n","      <td>0.1599</td>\n","      <td>-0.4250</td>\n","      <td>0.3591</td>\n","      <td>-0.1420</td>\n","      <td>-0.9530</td>\n","      <td>-0.2005</td>\n","      <td>-1.8340</td>\n","      <td>...</td>\n","      <td>-4.7130</td>\n","      <td>-1.7250</td>\n","      <td>-3.8650</td>\n","      <td>-3.0800</td>\n","      <td>-4.1530</td>\n","      <td>-1.2030</td>\n","      <td>-1.1690</td>\n","      <td>-4.1460</td>\n","      <td>-1.2670</td>\n","      <td>-1.1300</td>\n","      <td>-2.4390</td>\n","      <td>0.1591</td>\n","      <td>-2.2490</td>\n","      <td>-2.5860</td>\n","      <td>-1.9520</td>\n","      <td>-2.1810</td>\n","      <td>-4.6690</td>\n","      <td>-3.9450</td>\n","      <td>-2.9560</td>\n","      <td>-2.7930</td>\n","      <td>-2.1560</td>\n","      <td>-2.4100</td>\n","      <td>-1.8190</td>\n","      <td>-3.3480</td>\n","      <td>-0.1414</td>\n","      <td>-2.6430</td>\n","      <td>-2.5810</td>\n","      <td>-3.3890</td>\n","      <td>-1.7450</td>\n","      <td>-6.6300</td>\n","      <td>-4.0950</td>\n","      <td>-7.3860</td>\n","      <td>-1.4160</td>\n","      <td>-3.5770</td>\n","      <td>-0.4775</td>\n","      <td>-2.1500</td>\n","      <td>-4.2520</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>10 rows × 880 columns</p>\n","</div>"],"text/plain":["                 id    tratamento  tempo  ... n_moa ativo_moa  tratamento_controle\n","23804  id_fff506720     com_droga     24  ...     0     False                False\n","23805  id_fff6df1c5     com_droga     48  ...     1      True                False\n","23806  id_fff790a17     com_droga     48  ...     0     False                False\n","23807  id_fff7e6992     com_droga     48  ...     1      True                False\n","23808  id_fff8c2444     com_droga     72  ...     1      True                False\n","23809  id_fffb1ceed     com_droga     24  ...     1      True                False\n","23810  id_fffb70c0c     com_droga     24  ...     1      True                False\n","23811  id_fffc1c3f4  com_controle     48  ...     0     False                 True\n","23812  id_fffcb9e7c     com_droga     24  ...     1      True                False\n","23813  id_ffffdd77b     com_droga     72  ...     0     False                False\n","\n","[10 rows x 880 columns]"]},"metadata":{"tags":[]},"execution_count":28}]},{"cell_type":"markdown","metadata":{"id":"bF3tDCYd99ui"},"source":["# Desafio 3:"]},{"cell_type":"markdown","metadata":{"id":"k_YKPpiq-GKc"},"source":["Usar a mesma Logia do desafio anterior"]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"tU4Ugrdy-Ae1","executionInfo":{"status":"ok","timestamp":1620339239898,"user_tz":180,"elapsed":11989,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"b8b87c30-610e-4d0a-8940-d0a06ade1711"},"source":["(dados_combinados['tempo'] == 24)"],"execution_count":29,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0         True\n","1        False\n","2        False\n","3        False\n","4        False\n","         ...  \n","23809     True\n","23810     True\n","23811    False\n","23812     True\n","23813    False\n","Name: tempo, Length: 23814, dtype: bool"]},"metadata":{"tags":[]},"execution_count":29}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"eDxsX-CE-Oo9","executionInfo":{"status":"ok","timestamp":1620339239899,"user_tz":180,"elapsed":11977,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"01b45ed3-3d90-4acb-9b75-15eccc82719d"},"source":["(dados_combinados['tempo'] == 48)"],"execution_count":30,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0        False\n","1        False\n","2         True\n","3         True\n","4        False\n","         ...  \n","23809    False\n","23810    False\n","23811     True\n","23812    False\n","23813    False\n","Name: tempo, Length: 23814, dtype: bool"]},"metadata":{"tags":[]},"execution_count":30}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"GZdbXn13-RBP","executionInfo":{"status":"ok","timestamp":1620339239900,"user_tz":180,"elapsed":11967,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"6795dd75-8b07-49f4-8a25-f6db31b8e937"},"source":["(dados_combinados['tempo'] == 72)"],"execution_count":31,"outputs":[{"output_type":"execute_result","data":{"text/plain":["0        False\n","1         True\n","2        False\n","3        False\n","4         True\n","         ...  \n","23809    False\n","23810    False\n","23811    False\n","23812    False\n","23813     True\n","Name: tempo, Length: 23814, dtype: bool"]},"metadata":{"tags":[]},"execution_count":31}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":0},"id":"nH5Ieo4j_Lx6","executionInfo":{"status":"ok","timestamp":1620339239900,"user_tz":180,"elapsed":11943,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"7af84c79-5e5a-4c00-e35f-27c3b1d88926"},"source":["dados_combinados['tempo_24'] = (dados_combinados['tempo'] == 24)\n","dados_combinados['tempo_48'] = (dados_combinados['tempo'] == 48)\n","dados_combinados['tempo_72'] = (dados_combinados['tempo'] == 72)\n","dados_combinados.head(10)"],"execution_count":32,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","      <th>tratamento_controle</th>\n","      <th>tempo_24</th>\n","      <th>tempo_48</th>\n","      <th>tempo_72</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>0</th>\n","      <td>id_000644bb2</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>b68db1d53</td>\n","      <td>1.0620</td>\n","      <td>0.5577</td>\n","      <td>-0.2479</td>\n","      <td>-0.6208</td>\n","      <td>-0.1944</td>\n","      <td>-1.0120</td>\n","      <td>-1.0220</td>\n","      <td>-0.0326</td>\n","      <td>0.5548</td>\n","      <td>-0.0921</td>\n","      <td>1.1830</td>\n","      <td>0.1530</td>\n","      <td>0.5574</td>\n","      <td>-0.4015</td>\n","      <td>0.1789</td>\n","      <td>-0.6528</td>\n","      <td>-0.7969</td>\n","      <td>0.6342</td>\n","      <td>0.1778</td>\n","      <td>-0.3694</td>\n","      <td>-0.5688</td>\n","      <td>-1.1360</td>\n","      <td>-1.1880</td>\n","      <td>0.6940</td>\n","      <td>0.4393</td>\n","      <td>0.2664</td>\n","      <td>0.1907</td>\n","      <td>0.1628</td>\n","      <td>-0.2853</td>\n","      <td>0.5819</td>\n","      <td>0.2934</td>\n","      <td>-0.5584</td>\n","      <td>-0.0916</td>\n","      <td>-0.3010</td>\n","      <td>-0.1537</td>\n","      <td>...</td>\n","      <td>0.1758</td>\n","      <td>1.2570</td>\n","      <td>-0.5979</td>\n","      <td>1.2250</td>\n","      <td>-0.0553</td>\n","      <td>0.7351</td>\n","      <td>0.5810</td>\n","      <td>0.9590</td>\n","      <td>0.2427</td>\n","      <td>0.0495</td>\n","      <td>0.4141</td>\n","      <td>0.8432</td>\n","      <td>0.6162</td>\n","      <td>-0.7318</td>\n","      <td>1.2120</td>\n","      <td>0.6362</td>\n","      <td>-0.4427</td>\n","      <td>0.1288</td>\n","      <td>1.4840</td>\n","      <td>0.1799</td>\n","      <td>0.5367</td>\n","      <td>-0.1111</td>\n","      <td>-1.0120</td>\n","      <td>0.6685</td>\n","      <td>0.2862</td>\n","      <td>0.2584</td>\n","      <td>0.8076</td>\n","      <td>0.5523</td>\n","      <td>-0.1912</td>\n","      <td>0.6584</td>\n","      <td>-0.3981</td>\n","      <td>0.2139</td>\n","      <td>0.3801</td>\n","      <td>0.4176</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>1</th>\n","      <td>id_000779bfc</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>df89a8e5a</td>\n","      <td>0.0743</td>\n","      <td>0.4087</td>\n","      <td>0.2991</td>\n","      <td>0.0604</td>\n","      <td>1.0190</td>\n","      <td>0.5207</td>\n","      <td>0.2341</td>\n","      <td>0.3372</td>\n","      <td>-0.4047</td>\n","      <td>0.8507</td>\n","      <td>-1.1520</td>\n","      <td>-0.4201</td>\n","      <td>-0.0958</td>\n","      <td>0.4590</td>\n","      <td>0.0803</td>\n","      <td>0.2250</td>\n","      <td>0.5293</td>\n","      <td>0.2839</td>\n","      <td>-0.3494</td>\n","      <td>0.2883</td>\n","      <td>0.9449</td>\n","      <td>-0.1646</td>\n","      <td>-0.2657</td>\n","      <td>-0.3372</td>\n","      <td>0.3135</td>\n","      <td>-0.4316</td>\n","      <td>0.4773</td>\n","      <td>0.2075</td>\n","      <td>-0.4216</td>\n","      <td>-0.1161</td>\n","      <td>-0.0499</td>\n","      <td>-0.2627</td>\n","      <td>0.9959</td>\n","      <td>-0.2483</td>\n","      <td>0.2655</td>\n","      <td>...</td>\n","      <td>-0.2840</td>\n","      <td>-0.3104</td>\n","      <td>-0.6373</td>\n","      <td>0.2887</td>\n","      <td>-0.0765</td>\n","      <td>0.2539</td>\n","      <td>0.4443</td>\n","      <td>0.5932</td>\n","      <td>0.2031</td>\n","      <td>0.7639</td>\n","      <td>0.5499</td>\n","      <td>-0.3322</td>\n","      <td>-0.0977</td>\n","      <td>0.4329</td>\n","      <td>-0.2782</td>\n","      <td>0.7827</td>\n","      <td>0.5934</td>\n","      <td>0.3402</td>\n","      <td>0.1499</td>\n","      <td>0.4420</td>\n","      <td>0.9366</td>\n","      <td>0.8193</td>\n","      <td>-0.4236</td>\n","      <td>0.3192</td>\n","      <td>-0.4265</td>\n","      <td>0.7543</td>\n","      <td>0.4708</td>\n","      <td>0.0230</td>\n","      <td>0.2957</td>\n","      <td>0.4899</td>\n","      <td>0.1522</td>\n","      <td>0.1241</td>\n","      <td>0.6077</td>\n","      <td>0.7371</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>2</th>\n","      <td>id_000a6266a</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>18bb41b2c</td>\n","      <td>0.6280</td>\n","      <td>0.5817</td>\n","      <td>1.5540</td>\n","      <td>-0.0764</td>\n","      <td>-0.0323</td>\n","      <td>1.2390</td>\n","      <td>0.1715</td>\n","      <td>0.2155</td>\n","      <td>0.0065</td>\n","      <td>1.2300</td>\n","      <td>-0.4797</td>\n","      <td>-0.5631</td>\n","      <td>-0.0366</td>\n","      <td>-1.8300</td>\n","      <td>0.6057</td>\n","      <td>-0.3278</td>\n","      <td>0.6042</td>\n","      <td>-0.3075</td>\n","      <td>-0.1147</td>\n","      <td>-0.0570</td>\n","      <td>-0.0799</td>\n","      <td>-0.8181</td>\n","      <td>-1.5320</td>\n","      <td>0.2307</td>\n","      <td>0.4901</td>\n","      <td>0.4780</td>\n","      <td>-1.3970</td>\n","      <td>4.6240</td>\n","      <td>-0.0437</td>\n","      <td>1.2870</td>\n","      <td>-1.8530</td>\n","      <td>0.6069</td>\n","      <td>0.4290</td>\n","      <td>0.1783</td>\n","      <td>0.0018</td>\n","      <td>...</td>\n","      <td>-0.4682</td>\n","      <td>0.1210</td>\n","      <td>-0.5177</td>\n","      <td>-0.0604</td>\n","      <td>0.1682</td>\n","      <td>-0.4436</td>\n","      <td>0.4963</td>\n","      <td>0.1363</td>\n","      <td>0.3335</td>\n","      <td>0.9760</td>\n","      <td>-0.0427</td>\n","      <td>-0.1235</td>\n","      <td>0.0959</td>\n","      <td>0.0690</td>\n","      <td>-0.9416</td>\n","      <td>-0.7548</td>\n","      <td>-0.1109</td>\n","      <td>-0.6272</td>\n","      <td>0.3019</td>\n","      <td>0.1172</td>\n","      <td>0.1093</td>\n","      <td>-0.3113</td>\n","      <td>0.3019</td>\n","      <td>-0.0873</td>\n","      <td>-0.7250</td>\n","      <td>-0.6297</td>\n","      <td>0.6103</td>\n","      <td>0.0223</td>\n","      <td>-1.3240</td>\n","      <td>-0.3174</td>\n","      <td>-0.6417</td>\n","      <td>-0.2187</td>\n","      <td>-1.4080</td>\n","      <td>0.6931</td>\n","      <td>3</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>3</th>\n","      <td>id_0015fd391</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>8c7f86626</td>\n","      <td>-0.5138</td>\n","      <td>-0.2491</td>\n","      <td>-0.2656</td>\n","      <td>0.5288</td>\n","      <td>4.0620</td>\n","      <td>-0.8095</td>\n","      <td>-1.9590</td>\n","      <td>0.1792</td>\n","      <td>-0.1321</td>\n","      <td>-1.0600</td>\n","      <td>-0.8269</td>\n","      <td>-0.3584</td>\n","      <td>-0.8511</td>\n","      <td>-0.5844</td>\n","      <td>-2.5690</td>\n","      <td>0.8183</td>\n","      <td>-0.0532</td>\n","      <td>-0.8554</td>\n","      <td>0.1160</td>\n","      <td>-2.3520</td>\n","      <td>2.1200</td>\n","      <td>-1.1580</td>\n","      <td>-0.7191</td>\n","      <td>-0.8004</td>\n","      <td>-1.4670</td>\n","      <td>-0.0107</td>\n","      <td>-0.8995</td>\n","      <td>0.2406</td>\n","      <td>-0.2479</td>\n","      <td>-1.0890</td>\n","      <td>-0.7575</td>\n","      <td>0.0881</td>\n","      <td>-2.7370</td>\n","      <td>0.8745</td>\n","      <td>0.5787</td>\n","      <td>...</td>\n","      <td>-1.6600</td>\n","      <td>-3.1660</td>\n","      <td>0.2816</td>\n","      <td>-0.2990</td>\n","      <td>-1.1870</td>\n","      <td>-0.5044</td>\n","      <td>-1.7750</td>\n","      <td>-1.6120</td>\n","      <td>-0.9215</td>\n","      <td>-1.0810</td>\n","      <td>-3.0520</td>\n","      <td>-3.4470</td>\n","      <td>-2.7740</td>\n","      <td>-1.8460</td>\n","      <td>-0.5568</td>\n","      <td>-3.3960</td>\n","      <td>-2.9510</td>\n","      <td>-1.1550</td>\n","      <td>-3.2620</td>\n","      <td>-1.5390</td>\n","      <td>-2.4600</td>\n","      <td>-0.9417</td>\n","      <td>-1.5550</td>\n","      <td>0.2431</td>\n","      <td>-2.0990</td>\n","      <td>-0.6441</td>\n","      <td>-5.6300</td>\n","      <td>-1.3780</td>\n","      <td>-0.8632</td>\n","      <td>-1.2880</td>\n","      <td>-1.6210</td>\n","      <td>-0.8784</td>\n","      <td>-0.3876</td>\n","      <td>-0.8154</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>4</th>\n","      <td>id_001626bd3</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>7cbed3131</td>\n","      <td>-0.3254</td>\n","      <td>-0.4009</td>\n","      <td>0.9700</td>\n","      <td>0.6919</td>\n","      <td>1.4180</td>\n","      <td>-0.8244</td>\n","      <td>-0.2800</td>\n","      <td>-0.1498</td>\n","      <td>-0.8789</td>\n","      <td>0.8630</td>\n","      <td>-0.2219</td>\n","      <td>-0.5121</td>\n","      <td>-0.9577</td>\n","      <td>1.1750</td>\n","      <td>0.2042</td>\n","      <td>0.1970</td>\n","      <td>0.1244</td>\n","      <td>-1.7090</td>\n","      <td>-0.3543</td>\n","      <td>-0.5160</td>\n","      <td>-0.3330</td>\n","      <td>-0.2685</td>\n","      <td>0.7649</td>\n","      <td>0.2057</td>\n","      <td>1.3720</td>\n","      <td>0.6835</td>\n","      <td>0.8056</td>\n","      <td>-0.3754</td>\n","      <td>-1.2090</td>\n","      <td>0.2965</td>\n","      <td>-0.0712</td>\n","      <td>0.6389</td>\n","      <td>0.6674</td>\n","      <td>-0.0783</td>\n","      <td>1.1740</td>\n","      <td>...</td>\n","      <td>0.1500</td>\n","      <td>0.5178</td>\n","      <td>0.5159</td>\n","      <td>0.6091</td>\n","      <td>0.1813</td>\n","      <td>-0.4249</td>\n","      <td>0.7832</td>\n","      <td>0.6529</td>\n","      <td>0.5648</td>\n","      <td>0.4817</td>\n","      <td>0.0587</td>\n","      <td>0.5303</td>\n","      <td>0.6376</td>\n","      <td>-0.3966</td>\n","      <td>-1.4950</td>\n","      <td>-0.9625</td>\n","      <td>-0.0541</td>\n","      <td>0.6273</td>\n","      <td>0.4563</td>\n","      <td>0.0698</td>\n","      <td>0.8134</td>\n","      <td>0.1924</td>\n","      <td>0.6054</td>\n","      <td>-0.1824</td>\n","      <td>0.0042</td>\n","      <td>0.0048</td>\n","      <td>0.6670</td>\n","      <td>1.0690</td>\n","      <td>0.5523</td>\n","      <td>-0.3031</td>\n","      <td>0.1094</td>\n","      <td>0.2885</td>\n","      <td>-0.3786</td>\n","      <td>0.7125</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>5</th>\n","      <td>id_001762a82</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>e06749542</td>\n","      <td>-0.6111</td>\n","      <td>0.2941</td>\n","      <td>-0.9901</td>\n","      <td>0.2277</td>\n","      <td>1.2810</td>\n","      <td>0.5203</td>\n","      <td>0.0543</td>\n","      <td>-0.2225</td>\n","      <td>-0.1586</td>\n","      <td>0.4289</td>\n","      <td>0.0361</td>\n","      <td>0.3543</td>\n","      <td>0.8310</td>\n","      <td>-0.9129</td>\n","      <td>0.7677</td>\n","      <td>-0.2512</td>\n","      <td>0.7087</td>\n","      <td>0.0481</td>\n","      <td>-0.4486</td>\n","      <td>1.2570</td>\n","      <td>1.2550</td>\n","      <td>0.3359</td>\n","      <td>-0.5103</td>\n","      <td>-0.2993</td>\n","      <td>-1.1950</td>\n","      <td>-0.3208</td>\n","      <td>-0.1187</td>\n","      <td>1.0030</td>\n","      <td>0.9133</td>\n","      <td>0.0376</td>\n","      <td>0.3015</td>\n","      <td>-0.9578</td>\n","      <td>0.5354</td>\n","      <td>1.1360</td>\n","      <td>1.1310</td>\n","      <td>...</td>\n","      <td>0.8918</td>\n","      <td>0.4290</td>\n","      <td>0.0716</td>\n","      <td>0.8465</td>\n","      <td>0.6596</td>\n","      <td>1.3710</td>\n","      <td>1.0580</td>\n","      <td>1.7570</td>\n","      <td>1.0030</td>\n","      <td>0.2152</td>\n","      <td>1.6920</td>\n","      <td>-0.2930</td>\n","      <td>1.4590</td>\n","      <td>1.0950</td>\n","      <td>0.5854</td>\n","      <td>1.7270</td>\n","      <td>0.5580</td>\n","      <td>1.3090</td>\n","      <td>1.0100</td>\n","      <td>0.6980</td>\n","      <td>0.5455</td>\n","      <td>1.0170</td>\n","      <td>1.2910</td>\n","      <td>1.5430</td>\n","      <td>1.8390</td>\n","      <td>1.1570</td>\n","      <td>-1.0120</td>\n","      <td>1.9010</td>\n","      <td>1.4270</td>\n","      <td>0.4519</td>\n","      <td>1.2120</td>\n","      <td>0.3765</td>\n","      <td>0.7848</td>\n","      <td>1.3990</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>6</th>\n","      <td>id_001bd861f</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>746ca1f5a</td>\n","      <td>2.0440</td>\n","      <td>1.7000</td>\n","      <td>-1.5390</td>\n","      <td>5.9440</td>\n","      <td>-2.1670</td>\n","      <td>-4.0360</td>\n","      <td>3.6950</td>\n","      <td>1.4530</td>\n","      <td>0.9724</td>\n","      <td>-2.4380</td>\n","      <td>5.1340</td>\n","      <td>-4.6600</td>\n","      <td>5.7960</td>\n","      <td>4.9700</td>\n","      <td>1.5540</td>\n","      <td>2.4790</td>\n","      <td>-3.8010</td>\n","      <td>-1.0230</td>\n","      <td>5.3110</td>\n","      <td>-0.5660</td>\n","      <td>-4.4450</td>\n","      <td>1.2210</td>\n","      <td>1.3750</td>\n","      <td>0.3932</td>\n","      <td>0.3392</td>\n","      <td>4.3510</td>\n","      <td>5.7540</td>\n","      <td>-1.6590</td>\n","      <td>5.3000</td>\n","      <td>5.6050</td>\n","      <td>5.5320</td>\n","      <td>3.7860</td>\n","      <td>0.9197</td>\n","      <td>1.9310</td>\n","      <td>2.4870</td>\n","      <td>...</td>\n","      <td>0.6507</td>\n","      <td>0.9838</td>\n","      <td>0.4532</td>\n","      <td>-0.3212</td>\n","      <td>0.2662</td>\n","      <td>0.6864</td>\n","      <td>1.6300</td>\n","      <td>1.3810</td>\n","      <td>0.0061</td>\n","      <td>0.2908</td>\n","      <td>0.2598</td>\n","      <td>0.1266</td>\n","      <td>-0.3526</td>\n","      <td>1.1750</td>\n","      <td>-1.1030</td>\n","      <td>1.3650</td>\n","      <td>1.0610</td>\n","      <td>0.4034</td>\n","      <td>1.0880</td>\n","      <td>-0.4230</td>\n","      <td>0.4013</td>\n","      <td>0.1726</td>\n","      <td>0.7464</td>\n","      <td>0.9418</td>\n","      <td>0.1855</td>\n","      <td>1.1720</td>\n","      <td>0.8325</td>\n","      <td>0.6486</td>\n","      <td>0.8090</td>\n","      <td>1.5880</td>\n","      <td>2.4670</td>\n","      <td>0.0357</td>\n","      <td>0.1351</td>\n","      <td>-0.3179</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>7</th>\n","      <td>id_0020d0484</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>8b87a7a83</td>\n","      <td>0.2711</td>\n","      <td>0.5133</td>\n","      <td>-0.1327</td>\n","      <td>2.5950</td>\n","      <td>0.6980</td>\n","      <td>0.5846</td>\n","      <td>-0.2633</td>\n","      <td>-2.1490</td>\n","      <td>0.4881</td>\n","      <td>1.4750</td>\n","      <td>-0.0488</td>\n","      <td>-0.0561</td>\n","      <td>0.1641</td>\n","      <td>0.1749</td>\n","      <td>-0.3464</td>\n","      <td>-0.1811</td>\n","      <td>0.5685</td>\n","      <td>1.2970</td>\n","      <td>1.0510</td>\n","      <td>-0.9585</td>\n","      <td>0.7911</td>\n","      <td>-0.2991</td>\n","      <td>2.7420</td>\n","      <td>-0.5979</td>\n","      <td>-1.0240</td>\n","      <td>0.7268</td>\n","      <td>0.1590</td>\n","      <td>-1.9730</td>\n","      <td>1.1340</td>\n","      <td>-2.5720</td>\n","      <td>0.2068</td>\n","      <td>0.9992</td>\n","      <td>-0.1958</td>\n","      <td>0.2262</td>\n","      <td>1.0140</td>\n","      <td>...</td>\n","      <td>0.8142</td>\n","      <td>1.0990</td>\n","      <td>1.0860</td>\n","      <td>0.4011</td>\n","      <td>-0.1342</td>\n","      <td>0.4653</td>\n","      <td>-0.1104</td>\n","      <td>0.3935</td>\n","      <td>1.2370</td>\n","      <td>-0.5072</td>\n","      <td>0.0351</td>\n","      <td>0.5084</td>\n","      <td>-0.1248</td>\n","      <td>0.4351</td>\n","      <td>0.1389</td>\n","      <td>0.6726</td>\n","      <td>0.6070</td>\n","      <td>0.3431</td>\n","      <td>-0.4116</td>\n","      <td>0.1194</td>\n","      <td>0.3420</td>\n","      <td>0.1331</td>\n","      <td>0.8541</td>\n","      <td>0.6282</td>\n","      <td>0.3230</td>\n","      <td>-0.4140</td>\n","      <td>0.2532</td>\n","      <td>0.0513</td>\n","      <td>0.8600</td>\n","      <td>1.4250</td>\n","      <td>0.6633</td>\n","      <td>0.4562</td>\n","      <td>-0.9622</td>\n","      <td>0.0260</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>8</th>\n","      <td>id_00224bf20</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>952b76dfc</td>\n","      <td>-0.3014</td>\n","      <td>0.5545</td>\n","      <td>-0.2576</td>\n","      <td>-0.1390</td>\n","      <td>-0.6487</td>\n","      <td>-0.6057</td>\n","      <td>-0.7549</td>\n","      <td>0.0896</td>\n","      <td>-0.0946</td>\n","      <td>1.3950</td>\n","      <td>0.5803</td>\n","      <td>0.0350</td>\n","      <td>0.3887</td>\n","      <td>0.8024</td>\n","      <td>-1.2810</td>\n","      <td>0.4403</td>\n","      <td>-0.5125</td>\n","      <td>0.4421</td>\n","      <td>0.0573</td>\n","      <td>-0.3632</td>\n","      <td>-0.7767</td>\n","      <td>0.4234</td>\n","      <td>-0.4403</td>\n","      <td>0.0000</td>\n","      <td>-0.7262</td>\n","      <td>-0.3586</td>\n","      <td>0.6236</td>\n","      <td>0.7060</td>\n","      <td>-0.3461</td>\n","      <td>-0.8389</td>\n","      <td>0.4151</td>\n","      <td>-0.6344</td>\n","      <td>-0.3171</td>\n","      <td>-0.3250</td>\n","      <td>-0.9373</td>\n","      <td>...</td>\n","      <td>0.5141</td>\n","      <td>-0.2704</td>\n","      <td>-1.1490</td>\n","      <td>-0.8242</td>\n","      <td>-0.6872</td>\n","      <td>-1.0260</td>\n","      <td>-0.8389</td>\n","      <td>-0.3815</td>\n","      <td>0.2002</td>\n","      <td>-0.7580</td>\n","      <td>0.0525</td>\n","      <td>-0.8299</td>\n","      <td>0.1164</td>\n","      <td>-0.0231</td>\n","      <td>0.2644</td>\n","      <td>0.0663</td>\n","      <td>-0.3794</td>\n","      <td>-0.3130</td>\n","      <td>-0.3167</td>\n","      <td>-0.0090</td>\n","      <td>-0.5243</td>\n","      <td>-0.7220</td>\n","      <td>-0.7501</td>\n","      <td>0.3808</td>\n","      <td>-1.6470</td>\n","      <td>0.2863</td>\n","      <td>1.1070</td>\n","      <td>-0.7735</td>\n","      <td>-1.0280</td>\n","      <td>-1.3070</td>\n","      <td>-0.1167</td>\n","      <td>-0.1241</td>\n","      <td>-0.6420</td>\n","      <td>0.5543</td>\n","      <td>0</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>9</th>\n","      <td>id_0023f063e</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>de7583071</td>\n","      <td>-0.0630</td>\n","      <td>0.2564</td>\n","      <td>-0.5279</td>\n","      <td>-0.2541</td>\n","      <td>-0.0182</td>\n","      <td>-1.5370</td>\n","      <td>-0.2180</td>\n","      <td>-0.0430</td>\n","      <td>-0.0116</td>\n","      <td>0.6565</td>\n","      <td>-0.1618</td>\n","      <td>-0.6742</td>\n","      <td>0.7260</td>\n","      <td>-0.8124</td>\n","      <td>0.3477</td>\n","      <td>0.2425</td>\n","      <td>1.2030</td>\n","      <td>-0.4435</td>\n","      <td>0.8795</td>\n","      <td>-0.2243</td>\n","      <td>-0.1423</td>\n","      <td>0.3758</td>\n","      <td>-0.6869</td>\n","      <td>0.2382</td>\n","      <td>-0.8178</td>\n","      <td>-0.7586</td>\n","      <td>1.2330</td>\n","      <td>1.0770</td>\n","      <td>0.3447</td>\n","      <td>-0.3917</td>\n","      <td>0.3276</td>\n","      <td>2.2610</td>\n","      <td>-0.1933</td>\n","      <td>0.2296</td>\n","      <td>-0.1599</td>\n","      <td>...</td>\n","      <td>-0.5881</td>\n","      <td>-0.8408</td>\n","      <td>-0.1703</td>\n","      <td>-0.0097</td>\n","      <td>0.1205</td>\n","      <td>-0.5683</td>\n","      <td>-0.5235</td>\n","      <td>-0.8461</td>\n","      <td>-0.8039</td>\n","      <td>-1.1390</td>\n","      <td>-0.3498</td>\n","      <td>-0.2183</td>\n","      <td>-0.3053</td>\n","      <td>-0.6116</td>\n","      <td>-0.1504</td>\n","      <td>-0.5320</td>\n","      <td>-1.1000</td>\n","      <td>-0.2852</td>\n","      <td>-0.5361</td>\n","      <td>-0.3377</td>\n","      <td>-0.2916</td>\n","      <td>-1.4360</td>\n","      <td>0.3119</td>\n","      <td>-1.0490</td>\n","      <td>0.2201</td>\n","      <td>0.5601</td>\n","      <td>-0.3501</td>\n","      <td>-1.4070</td>\n","      <td>-0.1717</td>\n","      <td>-1.1160</td>\n","      <td>-0.8745</td>\n","      <td>-0.2716</td>\n","      <td>0.0189</td>\n","      <td>-2.0000</td>\n","      <td>1</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>10 rows × 883 columns</p>\n","</div>"],"text/plain":["             id tratamento  tempo  ... tempo_24 tempo_48  tempo_72\n","0  id_000644bb2  com_droga     24  ...     True    False     False\n","1  id_000779bfc  com_droga     72  ...    False    False      True\n","2  id_000a6266a  com_droga     48  ...    False     True     False\n","3  id_0015fd391  com_droga     48  ...    False     True     False\n","4  id_001626bd3  com_droga     72  ...    False    False      True\n","5  id_001762a82  com_droga     24  ...     True    False     False\n","6  id_001bd861f  com_droga     24  ...     True    False     False\n","7  id_0020d0484  com_droga     48  ...    False     True     False\n","8  id_00224bf20  com_droga     48  ...    False     True     False\n","9  id_0023f063e  com_droga     48  ...    False     True     False\n","\n","[10 rows x 883 columns]"]},"metadata":{"tags":[]},"execution_count":32}]},{"cell_type":"code","metadata":{"id":"9BpyGog1_gT3","executionInfo":{"status":"ok","timestamp":1620339239901,"user_tz":180,"elapsed":11940,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["# Se errou alguma coisa kkkkkkk\n","#dados_combinados.rename(columns={'tempo_42': 'tempo_48'}, inplace = True)\n","#dados_combinados.drop(['tempo_24'], axis= 1)\n","#dados_combinados.pop('tempo_72')\n","#dados_combinados"],"execution_count":33,"outputs":[]},{"cell_type":"code","metadata":{"id":"GS0iqWuqACqV","executionInfo":{"status":"ok","timestamp":1620339239902,"user_tz":180,"elapsed":11939,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":[""],"execution_count":33,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"xVA3LTDODapH"},"source":["# Desafio 4:"]},{"cell_type":"markdown","metadata":{"id":"jU6UqYF7D7AK"},"source":["No link indicado temos Merge, join, concatenate e compare.\n","\n","Apos a leitura da página temos o seguinte resumo:\n","\n","### 1 - concat() \n","A concat(): função que faz todo o trabalho pesado de realizar operações de concatenação ao longo de um eixo enquanto executa a lógica de conjunto opcional (união ou interseção) dos índices (se houver) nos outros eixos. É possivel haver apenas um único eixo de concatenação, para Séries.\n","\n","\n","### 2 - merge()\n","O pandas possui operações de junção in-memory full-features e de alto desempenho , idonologicamente muito semelhantes a bancos de dados relacionais como SQL. Esses métodos têm um desempenho significativamente melhor (em alguns casos, bem acima de uma ordem de magnitude melhor) do que outras implementações de código aberto (como base::merge.data.frame em R). A razão para isso é o design algorítmico cuidadoso e o layout interno dos dados em DataFrame.\n","\n","Veja o livro de receitas para algumas estratégias avançadas.\n","\n","Os usuários familiarizados com o SQL, mas novos no pandas, podem se interessar por uma comparação com o SQL .\n","\n","O pandas fornece uma única função, merge()como ponto de entrada para todas as operações padrão de junção de banco de dados entre objetos DataFramenomeados ou Series.\n","\n","### 3 - join()\n","O join()método relacionado é usado merge internamente para a junção índice no índice (por padrão) e coluna (s) no índice. Se você está ingressando no índice apenas, pode desejar usar o DataFrame.joinpara economizar um pouco de digitação.\n","\n","DataFrame.join()é um método conveniente para combinar as colunas de dois potencialmente indexados de forma diferente DataFramesem um único resultado DataFrame. Aqui está um exemplo muito básico\n","\n","### 4 - compare()\n","\n","Os métodos compare() permitem comparar dois DataFrame ou Series, respectivamente, e resumir suas diferenças.\n","\n","Este recurso foi adicionado na V1.1.0 ."]},{"cell_type":"code","metadata":{"id":"99bIwlZ7DeEg","executionInfo":{"status":"ok","timestamp":1620339239902,"user_tz":180,"elapsed":11936,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":[""],"execution_count":33,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"tC0kNerFGT06"},"source":["# Desafio 5:"]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"diilDteQGVXh","executionInfo":{"status":"ok","timestamp":1620339239907,"user_tz":180,"elapsed":11918,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"cbaac76c-32f5-4d62-9059-0b1b3f9e1ecb"},"source":["dados_combinados['composto'].value_counts()"],"execution_count":34,"outputs":[{"output_type":"execute_result","data":{"text/plain":["cacb2b860    1866\n","87d714366     718\n","9f80f3f77     246\n","8b87a7a83     203\n","5628cb3ee     202\n","             ... \n","828099693       1\n","ba08ac4bc       1\n","57f5932fb       1\n","4d7280c91       1\n","42feaa183       1\n","Name: composto, Length: 3289, dtype: int64"]},"metadata":{"tags":[]},"execution_count":34}]},{"cell_type":"markdown","metadata":{"id":"KiwsRF5rHaWM"},"source":["Para analisar mais detalhadamente vamos usar o composto com maior frequencia (exeto o controle)."]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"KbOlLNWyGvSt","executionInfo":{"status":"ok","timestamp":1620339239909,"user_tz":180,"elapsed":11907,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"2ff59369-a734-43c0-dcbe-fa6ebf95c4ea"},"source":["dados_combinados.query('composto == \"87d714366\"' )['ativo_moa'].value_counts()"],"execution_count":35,"outputs":[{"output_type":"execute_result","data":{"text/plain":["True    718\n","Name: ativo_moa, dtype: int64"]},"metadata":{"tags":[]},"execution_count":35}]},{"cell_type":"markdown","metadata":{"id":"O198vCGvIJOM"},"source":["O primeiro ponto que vimos é que em todos os casos o composto \"87d714366\" ativou o MOA."]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"Z4V3Qo3zH04E","executionInfo":{"status":"ok","timestamp":1620339621784,"user_tz":180,"elapsed":663,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"897eee26-e3c0-4c5b-849a-a7b90f3aea74"},"source":["selecao_24 = (dados_combinados['composto'] == '87d714366') & (dados_combinados['tempo_24'] == True)\n","selecao_24.value_counts()"],"execution_count":37,"outputs":[{"output_type":"execute_result","data":{"text/plain":["False    23579\n","True       235\n","dtype: int64"]},"metadata":{"tags":[]},"execution_count":37}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":419},"id":"zjoZbvBrJz4u","executionInfo":{"status":"ok","timestamp":1620339623156,"user_tz":180,"elapsed":688,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"b357b59d-8364-4945-8352-0c6f6ba561ee"},"source":["dados_combinados_d24 = dados_combinados[selecao_24]\n","dados_combinados_d24"],"execution_count":38,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","      <th>tratamento_controle</th>\n","      <th>tempo_24</th>\n","      <th>tempo_48</th>\n","      <th>tempo_72</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>218</th>\n","      <td>id_024a52260</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>2.119</td>\n","      <td>0.1098</td>\n","      <td>1.1040</td>\n","      <td>5.062</td>\n","      <td>-0.7427</td>\n","      <td>-0.3564</td>\n","      <td>-0.8253</td>\n","      <td>-3.6180</td>\n","      <td>-1.127</td>\n","      <td>-2.1360</td>\n","      <td>-3.371</td>\n","      <td>5.4820</td>\n","      <td>0.0537</td>\n","      <td>8.094</td>\n","      <td>-1.3650</td>\n","      <td>-1.4740</td>\n","      <td>-4.1950</td>\n","      <td>0.0338</td>\n","      <td>-0.2759</td>\n","      <td>0.3821</td>\n","      <td>-0.6859</td>\n","      <td>-2.6870</td>\n","      <td>0.1784</td>\n","      <td>-1.0710</td>\n","      <td>-4.1710</td>\n","      <td>1.5710</td>\n","      <td>-1.9490</td>\n","      <td>-1.0180</td>\n","      <td>-4.7910</td>\n","      <td>-5.3540</td>\n","      <td>-5.922</td>\n","      <td>2.569</td>\n","      <td>-1.5100</td>\n","      <td>-2.7960</td>\n","      <td>3.0740</td>\n","      <td>...</td>\n","      <td>-6.681</td>\n","      <td>-7.150</td>\n","      <td>-6.109</td>\n","      <td>-4.503</td>\n","      <td>-10.000</td>\n","      <td>-5.367</td>\n","      <td>-5.762</td>\n","      <td>-5.173</td>\n","      <td>-1.988</td>\n","      <td>-7.265</td>\n","      <td>-6.1890</td>\n","      <td>-5.044</td>\n","      <td>-8.035</td>\n","      <td>-4.652</td>\n","      <td>-4.068</td>\n","      <td>-6.564</td>\n","      <td>-5.805</td>\n","      <td>-8.420</td>\n","      <td>-5.524</td>\n","      <td>-6.696</td>\n","      <td>-2.777</td>\n","      <td>-3.348</td>\n","      <td>-4.720</td>\n","      <td>-5.357</td>\n","      <td>-8.619</td>\n","      <td>-7.332</td>\n","      <td>-7.828</td>\n","      <td>-9.679</td>\n","      <td>-8.439</td>\n","      <td>-2.047</td>\n","      <td>-7.430</td>\n","      <td>-5.861</td>\n","      <td>-4.591</td>\n","      <td>-3.533</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>359</th>\n","      <td>id_03dd91d6c</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>3.864</td>\n","      <td>1.1390</td>\n","      <td>0.8857</td>\n","      <td>1.861</td>\n","      <td>0.5814</td>\n","      <td>-0.0786</td>\n","      <td>-0.5178</td>\n","      <td>-4.6610</td>\n","      <td>-1.757</td>\n","      <td>-1.0630</td>\n","      <td>-4.651</td>\n","      <td>1.6890</td>\n","      <td>-1.1690</td>\n","      <td>4.438</td>\n","      <td>-0.3474</td>\n","      <td>-3.2670</td>\n","      <td>-1.8940</td>\n","      <td>-1.5800</td>\n","      <td>-0.2045</td>\n","      <td>0.2008</td>\n","      <td>-3.1790</td>\n","      <td>-0.0727</td>\n","      <td>-0.4256</td>\n","      <td>-0.6506</td>\n","      <td>-2.5680</td>\n","      <td>0.9283</td>\n","      <td>-2.5590</td>\n","      <td>-0.7336</td>\n","      <td>-2.3840</td>\n","      <td>-3.0690</td>\n","      <td>-3.477</td>\n","      <td>2.880</td>\n","      <td>-0.1036</td>\n","      <td>-2.6860</td>\n","      <td>3.0860</td>\n","      <td>...</td>\n","      <td>-6.335</td>\n","      <td>-8.364</td>\n","      <td>-6.093</td>\n","      <td>-3.696</td>\n","      <td>-9.982</td>\n","      <td>-5.198</td>\n","      <td>-9.425</td>\n","      <td>-6.172</td>\n","      <td>-2.158</td>\n","      <td>-7.849</td>\n","      <td>-5.6160</td>\n","      <td>-7.463</td>\n","      <td>-8.466</td>\n","      <td>-3.690</td>\n","      <td>-5.178</td>\n","      <td>-6.502</td>\n","      <td>-7.211</td>\n","      <td>-9.223</td>\n","      <td>-3.834</td>\n","      <td>-8.287</td>\n","      <td>-2.944</td>\n","      <td>-3.220</td>\n","      <td>-5.733</td>\n","      <td>-5.411</td>\n","      <td>-9.682</td>\n","      <td>-8.465</td>\n","      <td>-8.265</td>\n","      <td>-10.000</td>\n","      <td>-7.994</td>\n","      <td>-2.828</td>\n","      <td>-8.393</td>\n","      <td>-6.245</td>\n","      <td>-4.745</td>\n","      <td>-3.879</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>428</th>\n","      <td>id_0481e7f4b</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>4.242</td>\n","      <td>0.8118</td>\n","      <td>0.0284</td>\n","      <td>1.994</td>\n","      <td>0.7662</td>\n","      <td>0.2544</td>\n","      <td>2.7680</td>\n","      <td>-4.5760</td>\n","      <td>0.000</td>\n","      <td>-3.6820</td>\n","      <td>-3.651</td>\n","      <td>2.3990</td>\n","      <td>3.0720</td>\n","      <td>5.641</td>\n","      <td>-0.9804</td>\n","      <td>-1.7450</td>\n","      <td>-5.9060</td>\n","      <td>1.5820</td>\n","      <td>-0.1410</td>\n","      <td>1.4290</td>\n","      <td>-3.1510</td>\n","      <td>0.1125</td>\n","      <td>-2.7350</td>\n","      <td>-1.5550</td>\n","      <td>-8.3640</td>\n","      <td>-1.8160</td>\n","      <td>-4.3200</td>\n","      <td>1.7400</td>\n","      <td>-4.7180</td>\n","      <td>-4.2250</td>\n","      <td>-7.353</td>\n","      <td>10.000</td>\n","      <td>0.0448</td>\n","      <td>-3.6350</td>\n","      <td>-0.3961</td>\n","      <td>...</td>\n","      <td>-6.038</td>\n","      <td>-8.927</td>\n","      <td>-7.009</td>\n","      <td>-4.340</td>\n","      <td>-10.000</td>\n","      <td>-4.705</td>\n","      <td>-5.746</td>\n","      <td>-6.833</td>\n","      <td>-2.362</td>\n","      <td>-7.422</td>\n","      <td>-5.3260</td>\n","      <td>-3.280</td>\n","      <td>-8.735</td>\n","      <td>-3.586</td>\n","      <td>-6.341</td>\n","      <td>-7.249</td>\n","      <td>-6.793</td>\n","      <td>-7.806</td>\n","      <td>-5.646</td>\n","      <td>-5.612</td>\n","      <td>-4.512</td>\n","      <td>-2.913</td>\n","      <td>-4.930</td>\n","      <td>-4.634</td>\n","      <td>-8.727</td>\n","      <td>-9.347</td>\n","      <td>-7.327</td>\n","      <td>-9.002</td>\n","      <td>-9.361</td>\n","      <td>-3.357</td>\n","      <td>-8.400</td>\n","      <td>-6.582</td>\n","      <td>-4.998</td>\n","      <td>-3.371</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>622</th>\n","      <td>id_065985006</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>2.887</td>\n","      <td>-0.0221</td>\n","      <td>1.6920</td>\n","      <td>5.052</td>\n","      <td>-0.5128</td>\n","      <td>-0.8011</td>\n","      <td>1.5600</td>\n","      <td>-3.1920</td>\n","      <td>-3.489</td>\n","      <td>-3.1050</td>\n","      <td>-3.580</td>\n","      <td>5.6660</td>\n","      <td>4.0070</td>\n","      <td>7.102</td>\n","      <td>-1.2980</td>\n","      <td>-0.3544</td>\n","      <td>-3.1250</td>\n","      <td>-3.4260</td>\n","      <td>0.7480</td>\n","      <td>2.3310</td>\n","      <td>-0.4135</td>\n","      <td>-3.2280</td>\n","      <td>-0.9854</td>\n","      <td>-0.7886</td>\n","      <td>-4.9210</td>\n","      <td>0.2621</td>\n","      <td>-3.7960</td>\n","      <td>-1.1950</td>\n","      <td>-3.6170</td>\n","      <td>-2.2720</td>\n","      <td>-4.189</td>\n","      <td>6.323</td>\n","      <td>-2.0560</td>\n","      <td>-2.3020</td>\n","      <td>3.0100</td>\n","      <td>...</td>\n","      <td>-5.723</td>\n","      <td>-7.621</td>\n","      <td>-4.974</td>\n","      <td>-3.544</td>\n","      <td>-9.795</td>\n","      <td>-5.147</td>\n","      <td>-7.417</td>\n","      <td>-4.926</td>\n","      <td>-3.133</td>\n","      <td>-7.282</td>\n","      <td>-6.6480</td>\n","      <td>-5.249</td>\n","      <td>-7.361</td>\n","      <td>-4.096</td>\n","      <td>-6.330</td>\n","      <td>-6.011</td>\n","      <td>-3.347</td>\n","      <td>-6.779</td>\n","      <td>-4.615</td>\n","      <td>-6.266</td>\n","      <td>-3.048</td>\n","      <td>-2.616</td>\n","      <td>-4.463</td>\n","      <td>-6.417</td>\n","      <td>-9.236</td>\n","      <td>-8.122</td>\n","      <td>-6.528</td>\n","      <td>-9.988</td>\n","      <td>-7.887</td>\n","      <td>-2.669</td>\n","      <td>-7.663</td>\n","      <td>-5.696</td>\n","      <td>-4.980</td>\n","      <td>-3.989</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>670</th>\n","      <td>id_06c151919</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>1.288</td>\n","      <td>-1.1120</td>\n","      <td>8.2570</td>\n","      <td>4.508</td>\n","      <td>-0.3912</td>\n","      <td>-1.4320</td>\n","      <td>-1.5580</td>\n","      <td>-2.8290</td>\n","      <td>-1.031</td>\n","      <td>-0.2956</td>\n","      <td>-1.533</td>\n","      <td>4.8700</td>\n","      <td>2.6820</td>\n","      <td>4.839</td>\n","      <td>1.4860</td>\n","      <td>-1.4020</td>\n","      <td>-1.9010</td>\n","      <td>0.2710</td>\n","      <td>0.3217</td>\n","      <td>0.3774</td>\n","      <td>-2.0380</td>\n","      <td>-3.3270</td>\n","      <td>0.3184</td>\n","      <td>-4.0420</td>\n","      <td>-3.1180</td>\n","      <td>0.5215</td>\n","      <td>-0.2539</td>\n","      <td>0.1617</td>\n","      <td>-4.5130</td>\n","      <td>-4.2500</td>\n","      <td>-3.091</td>\n","      <td>3.696</td>\n","      <td>-1.1590</td>\n","      <td>-3.8800</td>\n","      <td>1.7200</td>\n","      <td>...</td>\n","      <td>-5.421</td>\n","      <td>-5.714</td>\n","      <td>-6.650</td>\n","      <td>-4.000</td>\n","      <td>-9.740</td>\n","      <td>-5.474</td>\n","      <td>-7.212</td>\n","      <td>-5.040</td>\n","      <td>-2.381</td>\n","      <td>-6.468</td>\n","      <td>-4.6720</td>\n","      <td>-6.070</td>\n","      <td>-6.791</td>\n","      <td>-3.403</td>\n","      <td>-6.297</td>\n","      <td>-4.449</td>\n","      <td>-5.432</td>\n","      <td>-7.762</td>\n","      <td>-3.929</td>\n","      <td>-5.018</td>\n","      <td>-1.621</td>\n","      <td>-3.206</td>\n","      <td>-3.621</td>\n","      <td>-6.230</td>\n","      <td>-10.000</td>\n","      <td>-7.476</td>\n","      <td>-7.122</td>\n","      <td>-8.872</td>\n","      <td>-6.709</td>\n","      <td>-3.219</td>\n","      <td>-9.208</td>\n","      <td>-5.505</td>\n","      <td>-3.954</td>\n","      <td>-3.234</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>...</th>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      <td>...</td>\n","      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<td>1.0660</td>\n","      <td>-3.6130</td>\n","      <td>-2.104</td>\n","      <td>-4.4690</td>\n","      <td>-5.284</td>\n","      <td>1.3990</td>\n","      <td>-0.1906</td>\n","      <td>6.753</td>\n","      <td>-0.1104</td>\n","      <td>-0.5587</td>\n","      <td>-0.6843</td>\n","      <td>-6.1210</td>\n","      <td>-0.0439</td>\n","      <td>0.3555</td>\n","      <td>0.7403</td>\n","      <td>0.5085</td>\n","      <td>-1.2910</td>\n","      <td>-2.6080</td>\n","      <td>-4.2000</td>\n","      <td>0.8594</td>\n","      <td>-3.4270</td>\n","      <td>-2.6460</td>\n","      <td>-0.8448</td>\n","      <td>-3.3060</td>\n","      <td>-1.485</td>\n","      <td>1.715</td>\n","      <td>-1.7000</td>\n","      <td>-0.7383</td>\n","      <td>1.6890</td>\n","      <td>...</td>\n","      <td>-4.676</td>\n","      <td>-4.406</td>\n","      <td>-5.369</td>\n","      <td>-3.450</td>\n","      <td>-9.453</td>\n","      <td>-3.922</td>\n","      <td>-4.475</td>\n","      <td>-3.607</td>\n","      <td>-1.376</td>\n","      <td>-5.660</td>\n","      <td>-0.9186</td>\n","      <td>-7.305</td>\n","      <td>-5.939</td>\n","      <td>-2.619</td>\n","      <td>-3.133</td>\n","      <td>-3.005</td>\n","      <td>-4.270</td>\n","      <td>-7.449</td>\n","      <td>-2.280</td>\n","      <td>-4.650</td>\n","      <td>-2.538</td>\n","      <td>-2.678</td>\n","      <td>-4.237</td>\n","      <td>-4.940</td>\n","      <td>-6.989</td>\n","      <td>-6.034</td>\n","      <td>-5.799</td>\n","      <td>-8.629</td>\n","      <td>-6.783</td>\n","      <td>-1.277</td>\n","      <td>-7.015</td>\n","      <td>-3.712</td>\n","      <td>-3.509</td>\n","      <td>-1.965</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23433</th>\n","      <td>id_fbdc2d91a</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>3.032</td>\n","      <td>1.0770</td>\n","      <td>0.8468</td>\n","      <td>1.608</td>\n","      <td>0.9535</td>\n","      <td>-0.7703</td>\n","      <td>-0.8554</td>\n","      <td>-6.9960</td>\n","      <td>-1.438</td>\n","      <td>-4.8190</td>\n","      <td>-4.414</td>\n","      <td>1.8520</td>\n","      <td>-0.8877</td>\n","      <td>2.779</td>\n","      <td>-1.8350</td>\n","      <td>-0.6954</td>\n","      <td>-4.3640</td>\n","      <td>-1.7740</td>\n","      <td>-0.3143</td>\n","      <td>-2.5860</td>\n","      <td>-1.5400</td>\n","      <td>-1.5570</td>\n","      <td>-2.4730</td>\n","      <td>-1.8100</td>\n","      <td>-1.6770</td>\n","      <td>1.0960</td>\n","      <td>-2.7190</td>\n","      <td>-2.3380</td>\n","      <td>-3.3250</td>\n","      <td>-0.1435</td>\n","      <td>-2.168</td>\n","      <td>2.300</td>\n","      <td>-2.7010</td>\n","      <td>-2.3150</td>\n","      <td>-1.4600</td>\n","      <td>...</td>\n","      <td>-6.205</td>\n","      <td>-8.997</td>\n","      <td>-7.322</td>\n","      <td>-3.000</td>\n","      <td>-9.963</td>\n","      <td>-4.796</td>\n","      <td>-6.554</td>\n","      <td>-6.739</td>\n","      <td>-1.621</td>\n","      <td>-5.581</td>\n","      <td>-5.4660</td>\n","      <td>-6.705</td>\n","      <td>-8.171</td>\n","      <td>-4.133</td>\n","      <td>-7.216</td>\n","      <td>-5.572</td>\n","      <td>-7.294</td>\n","      <td>-6.656</td>\n","      <td>-2.768</td>\n","      <td>-7.238</td>\n","      <td>-2.443</td>\n","      <td>-3.133</td>\n","      <td>-2.351</td>\n","      <td>-3.810</td>\n","      <td>-8.261</td>\n","      <td>-7.394</td>\n","      <td>-8.914</td>\n","      <td>-10.000</td>\n","      <td>-9.986</td>\n","      <td>-3.539</td>\n","      <td>-7.511</td>\n","      <td>-4.983</td>\n","      <td>-5.403</td>\n","      <td>-3.242</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23727</th>\n","      <td>id_ff1d43f96</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>3.263</td>\n","      <td>1.4620</td>\n","      <td>0.2311</td>\n","      <td>3.359</td>\n","      <td>1.7250</td>\n","      <td>0.4117</td>\n","      <td>-0.4033</td>\n","      <td>-0.6053</td>\n","      <td>-3.445</td>\n","      <td>-1.5280</td>\n","      <td>-3.771</td>\n","      <td>6.1560</td>\n","      <td>1.4140</td>\n","      <td>6.352</td>\n","      <td>0.2650</td>\n","      <td>-1.3610</td>\n","      <td>-4.6420</td>\n","      <td>-2.8910</td>\n","      <td>0.6158</td>\n","      <td>1.5470</td>\n","      <td>-3.2930</td>\n","      <td>0.3337</td>\n","      <td>-0.6316</td>\n","      <td>-2.0770</td>\n","      <td>0.7569</td>\n","      <td>0.7684</td>\n","      <td>-3.0640</td>\n","      <td>-1.4090</td>\n","      <td>-4.2140</td>\n","      <td>-5.5860</td>\n","  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<td>-4.139</td>\n","      <td>-3.271</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23776</th>\n","      <td>id_ff9d0a022</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>1.227</td>\n","      <td>0.3781</td>\n","      <td>2.8860</td>\n","      <td>7.147</td>\n","      <td>-0.4875</td>\n","      <td>-1.2070</td>\n","      <td>0.7124</td>\n","      <td>-2.9770</td>\n","      <td>-2.879</td>\n","      <td>0.8712</td>\n","      <td>10.000</td>\n","      <td>5.5150</td>\n","      <td>-1.9930</td>\n","      <td>5.193</td>\n","      <td>-0.6509</td>\n","      <td>-1.5610</td>\n","      <td>-1.1370</td>\n","      <td>-1.4880</td>\n","      <td>0.2867</td>\n","      <td>0.2786</td>\n","      <td>-0.9956</td>\n","      <td>-1.3100</td>\n","      <td>-0.6124</td>\n","      <td>-1.4480</td>\n","      <td>-3.2240</td>\n","      <td>1.0280</td>\n","      <td>-1.4230</td>\n","      <td>-2.7110</td>\n","      <td>-4.1830</td>\n","      <td>-3.8860</td>\n","      <td>-5.463</td>\n","      <td>3.662</td>\n","      <td>-1.1530</td>\n","      <td>-1.2060</td>\n","      <td>3.5390</td>\n","      <td>...</td>\n","      <td>-7.526</td>\n","      <td>-9.182</td>\n","      <td>-6.765</td>\n","      <td>-5.493</td>\n","      <td>-9.657</td>\n","      <td>-5.448</td>\n","      <td>-8.192</td>\n","      <td>-5.703</td>\n","      <td>-2.689</td>\n","      <td>-7.787</td>\n","      <td>-7.4160</td>\n","      <td>-4.585</td>\n","      <td>-8.108</td>\n","      <td>-4.620</td>\n","      <td>-7.661</td>\n","      <td>-8.309</td>\n","      <td>-6.302</td>\n","      <td>-9.355</td>\n","      <td>-5.185</td>\n","      <td>-8.082</td>\n","      <td>-3.078</td>\n","      <td>-3.840</td>\n","      <td>-5.908</td>\n","      <td>-5.867</td>\n","      <td>-10.000</td>\n","      <td>-9.328</td>\n","      <td>-7.380</td>\n","      <td>-10.000</td>\n","      <td>-8.754</td>\n","      <td>-1.938</td>\n","      <td>-7.529</td>\n","      <td>-6.318</td>\n","      <td>-5.701</td>\n","      <td>-3.561</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23802</th>\n","      <td>id_fff3976bd</td>\n","      <td>com_droga</td>\n","      <td>24</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>3.289</td>\n","      <td>2.1270</td>\n","      <td>0.9770</td>\n","      <td>2.049</td>\n","      <td>2.3170</td>\n","      <td>-0.5355</td>\n","      <td>-0.6357</td>\n","      <td>-6.9060</td>\n","      <td>-4.483</td>\n","      <td>-2.8400</td>\n","      <td>-5.331</td>\n","      <td>0.6547</td>\n","      <td>-2.2080</td>\n","      <td>3.603</td>\n","      <td>0.6380</td>\n","      <td>-2.1280</td>\n","      <td>-3.1680</td>\n","      <td>-4.2180</td>\n","      <td>-0.3170</td>\n","      <td>0.2140</td>\n","      <td>-1.7660</td>\n","      <td>-1.9700</td>\n","      <td>-1.4820</td>\n","      <td>-1.3710</td>\n","      <td>-0.2628</td>\n","      <td>-0.5276</td>\n","      <td>-2.4160</td>\n","      <td>-0.4638</td>\n","      <td>-3.8630</td>\n","      <td>-0.8880</td>\n","      <td>-1.985</td>\n","      <td>2.053</td>\n","      <td>-1.4700</td>\n","      <td>-3.3220</td>\n","      <td>1.8800</td>\n","      <td>...</td>\n","      <td>-5.750</td>\n","      <td>-8.476</td>\n","      <td>-6.947</td>\n","      <td>-4.765</td>\n","      <td>-9.769</td>\n","      <td>-5.790</td>\n","      <td>-9.917</td>\n","      <td>-5.745</td>\n","      <td>-2.357</td>\n","      <td>-9.119</td>\n","      <td>-4.5980</td>\n","      <td>-8.776</td>\n","      <td>-7.798</td>\n","      <td>-4.162</td>\n","      <td>-6.151</td>\n","      <td>-5.740</td>\n","      <td>-6.870</td>\n","      <td>-9.100</td>\n","      <td>-3.336</td>\n","      <td>-6.642</td>\n","      <td>-2.275</td>\n","      <td>-3.472</td>\n","      <td>-6.267</td>\n","      <td>-6.398</td>\n","      <td>-8.630</td>\n","      <td>-8.149</td>\n","      <td>-6.290</td>\n","      <td>-8.097</td>\n","      <td>-8.733</td>\n","      <td>-2.378</td>\n","      <td>-8.448</td>\n","      <td>-4.455</td>\n","      <td>-5.793</td>\n","      <td>-3.700</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>235 rows × 883 columns</p>\n","</div>"],"text/plain":["                 id tratamento  tempo  ... tempo_24 tempo_48  tempo_72\n","218    id_024a52260  com_droga     24  ...     True    False     False\n","359    id_03dd91d6c  com_droga     24  ...     True    False     False\n","428    id_0481e7f4b  com_droga     24  ...     True    False     False\n","622    id_065985006  com_droga     24  ...     True    False     False\n","670    id_06c151919  com_droga     24  ...     True    False     False\n","...             ...        ...    ...  ...      ...      ...       ...\n","23386  id_fb57829c1  com_droga     24  ...     True    False     False\n","23433  id_fbdc2d91a  com_droga     24  ...     True    False     False\n","23727  id_ff1d43f96  com_droga     24  ...     True    False     False\n","23776  id_ff9d0a022  com_droga     24  ...     True    False     False\n","23802  id_fff3976bd  com_droga     24  ...     True    False     False\n","\n","[235 rows x 883 columns]"]},"metadata":{"tags":[]},"execution_count":38}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":515},"id":"Go5xH90mKs5B","executionInfo":{"status":"ok","timestamp":1620339624802,"user_tz":180,"elapsed":1135,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"b7df75e3-6840-4aa3-d8ed-30b295d8074b"},"source":["composto_principal_d = dados_combinados_d24['composto'].value_counts().index[:]\n","plt.figure(figsize=(12,8))\n","sns.boxplot(data = dados_combinados_d24.query('composto in @composto_principal_d'), y= 'g-0', x='composto', hue='ativo_moa')"],"execution_count":39,"outputs":[{"output_type":"execute_result","data":{"text/plain":["<matplotlib.axes._subplots.AxesSubplot at 0x7fb124323850>"]},"metadata":{"tags":[]},"execution_count":39},{"output_type":"display_data","data":{"image/png":"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\n","text/plain":["<Figure size 864x576 with 1 Axes>"]},"metadata":{"tags":[],"needs_background":"light"}}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"rUK6ne_8JXFA","executionInfo":{"status":"ok","timestamp":1620339629738,"user_tz":180,"elapsed":747,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"aaaf36b8-c49a-4adc-f8af-4d49cb3421a2"},"source":["selecao_48 = (dados_combinados['composto'] == '87d714366') & (dados_combinados['tempo_48'] == True)\n","selecao_48.value_counts()"],"execution_count":40,"outputs":[{"output_type":"execute_result","data":{"text/plain":["False    23567\n","True       247\n","dtype: int64"]},"metadata":{"tags":[]},"execution_count":40}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":419},"id":"wMDqGrLHMX2_","executionInfo":{"status":"ok","timestamp":1620339630056,"user_tz":180,"elapsed":716,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"ed9b0eaa-88d0-4e8c-fdb2-0692a55e9ee2"},"source":["dados_combinados_d48 = dados_combinados[selecao_48]\n","dados_combinados_d48"],"execution_count":41,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","      <th>tratamento_controle</th>\n","      <th>tempo_24</th>\n","      <th>tempo_48</th>\n","      <th>tempo_72</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>16</th>\n","      <td>id_002fb9c19</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>8.738</td>\n","      <td>0.1914</td>\n","      <td>2.4380</td>\n","      <td>-0.2930</td>\n","      <td>3.2010</td>\n","      <td>1.4910</td>\n","      <td>5.3920</td>\n","      <td>-1.0420</td>\n","      <td>-8.486</td>\n","      <td>-2.5790</td>\n","      <td>-6.747</td>\n","      <td>3.6150</td>\n","      <td>-1.451</td>\n","      <td>0.6909</td>\n","      <td>-0.7623</td>\n","      <td>-2.9400</td>\n","      <td>-9.285</td>\n","      <td>-6.7110</td>\n","      <td>-0.4195</td>\n","      <td>1.1600</td>\n","      <td>-1.318</td>\n","      <td>1.3660</td>\n","      <td>-1.4020</td>\n","      <td>-2.6220</td>\n","      <td>0.7204</td>\n","      <td>-2.593</td>\n","      <td>-4.063</td>\n","      <td>-0.8282</td>\n","      <td>-3.500</td>\n","      <td>0.9206</td>\n","      <td>-5.1450</td>\n","      <td>9.804</td>\n","      <td>-2.6840</td>\n","      <td>-2.4390</td>\n","      <td>-0.1427</td>\n","      <td>...</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-8.887</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-4.902</td>\n","      <td>-9.984</td>\n","      <td>-5.552</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.796</td>\n","      <td>-8.177</td>\n","      <td>-9.899</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-9.984</td>\n","      <td>-6.784</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>76</th>\n","      <td>id_00cf039a7</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>4.546</td>\n","      <td>0.4257</td>\n","      <td>0.7670</td>\n","      <td>2.1950</td>\n","      <td>2.5960</td>\n","      <td>0.3677</td>\n","      <td>-0.3854</td>\n","      <td>-1.1590</td>\n","      <td>-8.180</td>\n","      <td>-2.1310</td>\n","      <td>-4.168</td>\n","      <td>2.5630</td>\n","      <td>-1.341</td>\n","      <td>5.2610</td>\n","      <td>-2.5680</td>\n","      <td>1.0840</td>\n","      <td>-3.835</td>\n","      <td>-4.8440</td>\n","      <td>0.8522</td>\n","      <td>0.2435</td>\n","      <td>-2.609</td>\n","      <td>0.3067</td>\n","      <td>0.9733</td>\n","      <td>-1.6080</td>\n","      <td>-2.9210</td>\n","      <td>-1.957</td>\n","      <td>-2.644</td>\n","      <td>2.4030</td>\n","      <td>-3.036</td>\n","      <td>-6.4520</td>\n","      <td>-3.2580</td>\n","      <td>4.355</td>\n","      <td>-0.7562</td>\n","      <td>0.9930</td>\n","      <td>-0.2854</td>\n","      <td>...</td>\n","      <td>-8.504</td>\n","      <td>-8.528</td>\n","      <td>-9.995</td>\n","      <td>-6.254</td>\n","      <td>-9.995</td>\n","      <td>-6.955</td>\n","      <td>-9.995</td>\n","      <td>-9.743</td>\n","      <td>-3.457</td>\n","      <td>-8.712</td>\n","      <td>-3.972</td>\n","      <td>-8.709</td>\n","      <td>-10.000</td>\n","      <td>-8.461</td>\n","      <td>-9.347</td>\n","      <td>-8.698</td>\n","      <td>-9.807</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-5.657</td>\n","      <td>-5.513</td>\n","      <td>-8.284</td>\n","      <td>-9.490</td>\n","      <td>-8.729</td>\n","      <td>-10.000</td>\n","      <td>-7.834</td>\n","      <td>-9.538</td>\n","      <td>-10.000</td>\n","      <td>-8.520</td>\n","      <td>-10.000</td>\n","      <td>-7.436</td>\n","      <td>-6.918</td>\n","      <td>-5.235</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>246</th>\n","      <td>id_028b6d60d</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>6.783</td>\n","      <td>-0.0079</td>\n","      <td>1.1780</td>\n","      <td>1.2530</td>\n","      <td>2.9560</td>\n","      <td>-0.5525</td>\n","      <td>0.5921</td>\n","      <td>-3.8070</td>\n","      <td>-5.900</td>\n","      <td>-1.9590</td>\n","      <td>-7.095</td>\n","      <td>-0.5689</td>\n","      <td>-2.731</td>\n","      <td>7.2450</td>\n","      <td>-5.3630</td>\n","      <td>-0.0345</td>\n","      <td>-3.151</td>\n","      <td>-3.4490</td>\n","      <td>0.4162</td>\n","      <td>-0.6517</td>\n","      <td>-2.406</td>\n","      <td>-1.0190</td>\n","      <td>0.9068</td>\n","      <td>0.1723</td>\n","      <td>-7.3540</td>\n","      <td>-1.459</td>\n","      <td>-2.339</td>\n","      <td>2.0580</td>\n","      <td>-1.441</td>\n","      <td>-3.6410</td>\n","      <td>-4.0160</td>\n","      <td>5.085</td>\n","      <td>-1.4470</td>\n","      <td>-2.2580</td>\n","      <td>-1.1850</td>\n","      <td>...</td>\n","      <td>-9.630</td>\n","      <td>-9.654</td>\n","      <td>-10.000</td>\n","      <td>-7.280</td>\n","      <td>-10.000</td>\n","      <td>-8.786</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-4.037</td>\n","      <td>-10.000</td>\n","      <td>-7.514</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-9.127</td>\n","      <td>-10.000</td>\n","    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<td>-2.753</td>\n","      <td>-1.5760</td>\n","      <td>0.4411</td>\n","      <td>0.9585</td>\n","      <td>-4.9960</td>\n","      <td>-2.936</td>\n","      <td>-2.224</td>\n","      <td>2.3880</td>\n","      <td>-6.106</td>\n","      <td>-6.8830</td>\n","      <td>-4.0350</td>\n","      <td>6.917</td>\n","      <td>-0.6220</td>\n","      <td>-0.8008</td>\n","      <td>0.0226</td>\n","      <td>...</td>\n","      <td>-8.531</td>\n","      <td>-9.958</td>\n","      <td>-10.000</td>\n","      <td>-6.078</td>\n","      <td>-10.000</td>\n","      <td>-8.291</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-3.233</td>\n","      <td>-9.283</td>\n","      <td>-6.457</td>\n","      <td>-7.103</td>\n","      <td>-10.000</td>\n","      <td>-8.481</td>\n","      <td>-10.000</td>\n","      <td>-8.310</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-6.732</td>\n","      <td>-5.412</td>\n","      <td>-10.000</td>\n","      <td>-9.518</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-8.010</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-9.710</td>\n","      <td>-10.000</td>\n","      <td>-7.339</td>\n","      <td>-8.709</td>\n","      <td>-6.461</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23456</th>\n","      <td>id_fc221071a</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>4.542</td>\n","      <td>-0.4749</td>\n","      <td>0.4048</td>\n","      <td>-2.0310</td>\n","      <td>2.3000</td>\n","      <td>2.4300</td>\n","      <td>2.0680</td>\n","      <td>-0.0401</td>\n","      <td>-6.038</td>\n","      <td>-3.2470</td>\n","      <td>-3.630</td>\n","      <td>1.3970</td>\n","      <td>-2.957</td>\n","      <td>1.2800</td>\n","      <td>-0.6070</td>\n","      <td>-0.0621</td>\n","      <td>-3.294</td>\n","      <td>-1.3600</td>\n","      <td>1.5980</td>\n","      <td>-0.4779</td>\n","      <td>-2.943</td>\n","      <td>1.9970</td>\n","      <td>-0.6465</td>\n","      <td>0.2144</td>\n","      <td>-3.1910</td>\n","      <td>-2.025</td>\n","      <td>-3.685</td>\n","      <td>4.1330</td>\n","      <td>-3.081</td>\n","      <td>-4.8830</td>\n","      <td>-4.6190</td>\n","      <td>6.976</td>\n","      <td>0.9983</td>\n","      <td>-2.2610</td>\n","      <td>-3.1010</td>\n","      <td>...</td>\n","      <td>-6.962</td>\n","      <td>-7.653</td>\n","      <td>-9.133</td>\n","      <td>-5.350</td>\n","      <td>-8.082</td>\n","      <td>-6.969</td>\n","      <td>-8.737</td>\n","      <td>-10.000</td>\n","      <td>-3.159</td>\n","      <td>-7.185</td>\n","      <td>-3.874</td>\n","      <td>-6.410</td>\n","      <td>-9.213</td>\n","      <td>-6.106</td>\n","      <td>-9.168</td>\n","      <td>-7.977</td>\n","      <td>-7.207</td>\n","      <td>-8.604</td>\n","      <td>-8.846</td>\n","      <td>-8.648</td>\n","      <td>-6.062</td>\n","      <td>-6.307</td>\n","      <td>-7.319</td>\n","      <td>-6.589</td>\n","      <td>-6.501</td>\n","      <td>-9.132</td>\n","      <td>-6.024</td>\n","      <td>-9.814</td>\n","      <td>-10.000</td>\n","      <td>-5.263</td>\n","      <td>-9.681</td>\n","      <td>-6.370</td>\n","      <td>-5.974</td>\n","      <td>-4.701</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","    <tr>\n","      <th>23514</th>\n","      <td>id_fcc6036c1</td>\n","      <td>com_droga</td>\n","      <td>48</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>9.597</td>\n","      <td>1.3650</td>\n","      <td>0.3937</td>\n","      <td>0.0000</td>\n","      <td>0.6638</td>\n","      <td>-1.2910</td>\n","      <td>1.7180</td>\n","      <td>-2.0580</td>\n","      <td>-8.410</td>\n","      <td>-2.8330</td>\n","      <td>-7.744</td>\n","      <td>-0.8739</td>\n","      <td>-3.611</td>\n","      <td>6.1380</td>\n","      <td>-4.6870</td>\n","      <td>-0.9470</td>\n","      <td>-1.656</td>\n","      <td>-1.7880</td>\n","      <td>-1.2070</td>\n","      <td>-2.4460</td>\n","      <td>-2.137</td>\n","      <td>-0.2988</td>\n","      <td>1.0130</td>\n","      <td>0.9760</td>\n","      <td>-6.7640</td>\n","      <td>-2.027</td>\n","      <td>-2.981</td>\n","      <td>2.7170</td>\n","      <td>-4.155</td>\n","      <td>-1.1390</td>\n","      <td>-1.9500</td>\n","      <td>6.704</td>\n","      <td>0.8312</td>\n","      <td>0.0427</td>\n","      <td>-1.8930</td>\n","      <td>...</td>\n","      <td>-7.646</td>\n","      <td>-9.249</td>\n","      <td>-10.000</td>\n","      <td>-6.582</td>\n","      <td>-10.000</td>\n","      <td>-6.726</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-2.932</td>\n","      <td>-8.696</td>\n","      <td>-4.436</td>\n","      <td>-9.991</td>\n","      <td>-9.991</td>\n","      <td>-6.350</td>\n","      <td>-8.786</td>\n","      <td>-9.009</td>\n","      <td>-9.991</td>\n","      <td>-9.991</td>\n","      <td>-9.115</td>\n","      <td>-9.688</td>\n","      <td>-9.065</td>\n","      <td>-5.977</td>\n","      <td>-7.085</td>\n","      <td>-8.997</td>\n","      <td>-7.248</td>\n","      <td>-9.991</td>\n","      <td>-7.387</td>\n","      <td>-9.991</td>\n","      <td>-9.991</td>\n","      <td>-5.709</td>\n","      <td>-9.991</td>\n","      <td>-5.089</td>\n","      <td>-6.021</td>\n","      <td>-4.349</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","      <td>False</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>247 rows × 883 columns</p>\n","</div>"],"text/plain":["                 id tratamento  tempo  ... tempo_24 tempo_48  tempo_72\n","16     id_002fb9c19  com_droga     48  ...    False     True     False\n","76     id_00cf039a7  com_droga     48  ...    False     True     False\n","246    id_028b6d60d  com_droga     48  ...    False     True     False\n","249    id_0290cfd3b  com_droga     48  ...    False     True     False\n","336    id_039ec0a59  com_droga     48  ...    False     True     False\n","...             ...        ...    ...  ...      ...      ...       ...\n","23309  id_fa6ea2aee  com_droga     48  ...    False     True     False\n","23361  id_fb12fd265  com_droga     48  ...    False     True     False\n","23420  id_fbc00d756  com_droga     48  ...    False     True     False\n","23456  id_fc221071a  com_droga     48  ...    False     True     False\n","23514  id_fcc6036c1  com_droga     48  ...    False     True     False\n","\n","[247 rows x 883 columns]"]},"metadata":{"tags":[]},"execution_count":41}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":515},"id":"YU1TJboxMjro","executionInfo":{"status":"ok","timestamp":1620339630770,"user_tz":180,"elapsed":1114,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"3de57d46-940c-47cc-c08a-91256f06afec"},"source":["composto_principal_d2 = dados_combinados_d48['composto'].value_counts().index[:]\n","plt.figure(figsize=(12,8))\n","sns.boxplot(data = dados_combinados_d48.query('composto in @composto_principal_d2'), y= 'g-0', x='composto', hue='ativo_moa')"],"execution_count":42,"outputs":[{"output_type":"execute_result","data":{"text/plain":["<matplotlib.axes._subplots.AxesSubplot at 0x7fb124153d10>"]},"metadata":{"tags":[]},"execution_count":42},{"output_type":"display_data","data":{"image/png":"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\n","text/plain":["<Figure size 864x576 with 1 Axes>"]},"metadata":{"tags":[],"needs_background":"light"}}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"mW61iyVcJXj3","executionInfo":{"status":"ok","timestamp":1620339630771,"user_tz":180,"elapsed":885,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"241450ae-d630-425c-83e2-2dc579ace698"},"source":["selecao_72 = (dados_combinados['composto'] == '87d714366') & (dados_combinados['tempo_72'] == True)\n","selecao_72.value_counts()"],"execution_count":43,"outputs":[{"output_type":"execute_result","data":{"text/plain":["False    23578\n","True       236\n","dtype: int64"]},"metadata":{"tags":[]},"execution_count":43}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":419},"id":"D7QQDDeRMcGt","executionInfo":{"status":"ok","timestamp":1620339631058,"user_tz":180,"elapsed":630,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"2710cdc0-796a-41d6-f84f-93b534949baf"},"source":["dados_combinados_d72 = dados_combinados[selecao_72]\n","dados_combinados_d72"],"execution_count":44,"outputs":[{"output_type":"execute_result","data":{"text/html":["<div>\n","<style scoped>\n","    .dataframe tbody tr th:only-of-type {\n","        vertical-align: middle;\n","    }\n","\n","    .dataframe tbody tr th {\n","        vertical-align: top;\n","    }\n","\n","    .dataframe thead th {\n","        text-align: right;\n","    }\n","</style>\n","<table border=\"1\" class=\"dataframe\">\n","  <thead>\n","    <tr style=\"text-align: right;\">\n","      <th></th>\n","      <th>id</th>\n","      <th>tratamento</th>\n","      <th>tempo</th>\n","      <th>dose</th>\n","      <th>composto</th>\n","      <th>g-0</th>\n","      <th>g-1</th>\n","      <th>g-2</th>\n","      <th>g-3</th>\n","      <th>g-4</th>\n","      <th>g-5</th>\n","      <th>g-6</th>\n","      <th>g-7</th>\n","      <th>g-8</th>\n","      <th>g-9</th>\n","      <th>g-10</th>\n","      <th>g-11</th>\n","      <th>g-12</th>\n","      <th>g-13</th>\n","      <th>g-14</th>\n","      <th>g-15</th>\n","      <th>g-16</th>\n","      <th>g-17</th>\n","      <th>g-18</th>\n","      <th>g-19</th>\n","      <th>g-20</th>\n","      <th>g-21</th>\n","      <th>g-22</th>\n","      <th>g-23</th>\n","      <th>g-24</th>\n","      <th>g-25</th>\n","      <th>g-26</th>\n","      <th>g-27</th>\n","      <th>g-28</th>\n","      <th>g-29</th>\n","      <th>g-30</th>\n","      <th>g-31</th>\n","      <th>g-32</th>\n","      <th>g-33</th>\n","      <th>g-34</th>\n","      <th>...</th>\n","      <th>c-66</th>\n","      <th>c-67</th>\n","      <th>c-68</th>\n","      <th>c-69</th>\n","      <th>c-70</th>\n","      <th>c-71</th>\n","      <th>c-72</th>\n","      <th>c-73</th>\n","      <th>c-74</th>\n","      <th>c-75</th>\n","      <th>c-76</th>\n","      <th>c-77</th>\n","      <th>c-78</th>\n","      <th>c-79</th>\n","      <th>c-80</th>\n","      <th>c-81</th>\n","      <th>c-82</th>\n","      <th>c-83</th>\n","      <th>c-84</th>\n","      <th>c-85</th>\n","      <th>c-86</th>\n","      <th>c-87</th>\n","      <th>c-88</th>\n","      <th>c-89</th>\n","      <th>c-90</th>\n","      <th>c-91</th>\n","      <th>c-92</th>\n","      <th>c-93</th>\n","      <th>c-94</th>\n","      <th>c-95</th>\n","      <th>c-96</th>\n","      <th>c-97</th>\n","      <th>c-98</th>\n","      <th>c-99</th>\n","      <th>n_moa</th>\n","      <th>ativo_moa</th>\n","      <th>tratamento_controle</th>\n","      <th>tempo_24</th>\n","      <th>tempo_48</th>\n","      <th>tempo_72</th>\n","    </tr>\n","  </thead>\n","  <tbody>\n","    <tr>\n","      <th>119</th>\n","      <td>id_01534c4ee</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>10.000</td>\n","      <td>-1.2200</td>\n","      <td>1.5150</td>\n","      <td>-2.1910</td>\n","      <td>4.353</td>\n","      <td>-0.9594</td>\n","      <td>2.5600</td>\n","      <td>-3.3120</td>\n","      <td>-9.507</td>\n","      <td>-3.393</td>\n","      <td>-4.160</td>\n","      <td>-2.9320</td>\n","      <td>0.0000</td>\n","      <td>2.2650</td>\n","      <td>-6.256</td>\n","      <td>0.1147</td>\n","      <td>-4.209</td>\n","      <td>-3.558</td>\n","      <td>3.2920</td>\n","      <td>0.1551</td>\n","      <td>-3.720</td>\n","      <td>0.1069</td>\n","      <td>1.3000</td>\n","      <td>1.9710</td>\n","      <td>-9.9350</td>\n","      <td>-1.8340</td>\n","      <td>-1.072</td>\n","  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<td>0.5886</td>\n","      <td>-1.1490</td>\n","      <td>-7.976</td>\n","      <td>-2.872</td>\n","      <td>-4.562</td>\n","      <td>0.9842</td>\n","      <td>-1.3720</td>\n","      <td>4.5980</td>\n","      <td>-2.196</td>\n","      <td>1.5180</td>\n","      <td>-3.378</td>\n","      <td>-5.756</td>\n","      <td>-1.4690</td>\n","      <td>0.0882</td>\n","      <td>-4.476</td>\n","      <td>-1.2940</td>\n","      <td>-0.6524</td>\n","      <td>-3.0650</td>\n","      <td>-2.4300</td>\n","      <td>-1.7920</td>\n","      <td>-1.740</td>\n","      <td>-1.0010</td>\n","      <td>-3.096</td>\n","      <td>-2.8180</td>\n","      <td>-4.776</td>\n","      <td>5.715</td>\n","      <td>0.3260</td>\n","      <td>2.6240</td>\n","      <td>-1.3550</td>\n","      <td>...</td>\n","      <td>-9.955</td>\n","      <td>-9.955</td>\n","      <td>-9.955</td>\n","      <td>-7.544</td>\n","      <td>-9.955</td>\n","      <td>-9.955</td>\n","      <td>-9.955</td>\n","      <td>-9.955</td>\n","      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<td>id_fbe76bd40</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>2.488</td>\n","      <td>1.8250</td>\n","      <td>0.7779</td>\n","      <td>0.0931</td>\n","      <td>3.977</td>\n","      <td>-4.4900</td>\n","      <td>-1.1290</td>\n","      <td>0.5557</td>\n","      <td>-10.000</td>\n","      <td>-1.631</td>\n","      <td>-2.523</td>\n","      <td>-0.3697</td>\n","      <td>-1.0060</td>\n","      <td>0.0605</td>\n","      <td>-1.945</td>\n","      <td>0.9234</td>\n","      <td>-5.450</td>\n","      <td>-9.182</td>\n","      <td>-1.0140</td>\n","      <td>-0.9146</td>\n","      <td>-6.350</td>\n","      <td>1.5060</td>\n","      <td>2.1770</td>\n","      <td>-2.3590</td>\n","      <td>-1.1210</td>\n","      <td>-1.5420</td>\n","      <td>-1.812</td>\n","      <td>-0.6745</td>\n","      <td>-4.038</td>\n","      <td>-5.9190</td>\n","      <td>-4.329</td>\n","      <td>10.000</td>\n","      <td>1.8110</td>\n","      <td>0.6676</td>\n","      <td>-0.5084</td>\n","      <td>...</td>\n","      <td>-9.797</td>\n","      <td>-8.547</td>\n","      <td>-10.000</td>\n","      <td>-6.155</td>\n","      <td>-10.000</td>\n","      <td>-9.256</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-4.887</td>\n","      <td>-9.899</td>\n","      <td>-4.937</td>\n","      <td>-6.766</td>\n","      <td>-9.899</td>\n","      <td>-7.537</td>\n","      <td>-9.899</td>\n","      <td>-9.899</td>\n","      <td>-9.899</td>\n","      <td>-9.899</td>\n","      <td>-9.899</td>\n","      <td>-9.899</td>\n","      <td>-6.383</td>\n","      <td>-7.559</td>\n","      <td>-9.870</td>\n","      <td>-8.476</td>\n","      <td>-9.855</td>\n","      <td>-9.899</td>\n","      <td>-7.814</td>\n","      <td>-9.721</td>\n","      <td>-9.899</td>\n","      <td>-8.222</td>\n","      <td>-9.899</td>\n","      <td>-8.802</td>\n","      <td>-8.136</td>\n","      <td>-5.727</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>23483</th>\n","      <td>id_fc6d80a5d</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>5.866</td>\n","      <td>-0.5645</td>\n","      <td>1.2710</td>\n","      <td>-1.5900</td>\n","      <td>1.903</td>\n","      <td>-1.6510</td>\n","      <td>4.0190</td>\n","      <td>-1.5270</td>\n","      <td>-5.996</td>\n","      <td>-1.565</td>\n","      <td>-3.783</td>\n","      <td>0.9746</td>\n","      <td>-3.3840</td>\n","      <td>3.9660</td>\n","      <td>-1.951</td>\n","      <td>-1.4050</td>\n","      <td>-3.693</td>\n","      <td>-2.994</td>\n","      <td>-0.7234</td>\n","      <td>-1.5250</td>\n","      <td>-2.099</td>\n","      <td>0.8069</td>\n","      <td>-1.2540</td>\n","      <td>-1.1570</td>\n","      <td>1.4840</td>\n","      <td>-1.3450</td>\n","      <td>-3.287</td>\n","      <td>3.9210</td>\n","      <td>-1.698</td>\n","      <td>-0.6033</td>\n","      <td>-2.027</td>\n","      <td>5.727</td>\n","      <td>0.4748</td>\n","      <td>1.6230</td>\n","      <td>-3.1120</td>\n","      <td>...</td>\n","      <td>-9.898</td>\n","      <td>-9.770</td>\n","      <td>-9.985</td>\n","      <td>-7.455</td>\n","      <td>-9.985</td>\n","      <td>-9.804</td>\n","      <td>-9.985</td>\n","      <td>-9.985</td>\n","      <td>-4.524</td>\n","      <td>-9.733</td>\n","      <td>-5.485</td>\n","      <td>-9.227</td>\n","      <td>-9.960</td>\n","      <td>-9.117</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.137</td>\n","      <td>-9.393</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-9.867</td>\n","      <td>-9.960</td>\n","      <td>-9.960</td>\n","      <td>-7.070</td>\n","      <td>-9.960</td>\n","      <td>-8.273</td>\n","      <td>-8.266</td>\n","      <td>-5.749</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>23634</th>\n","      <td>id_fdf33871a</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>7.577</td>\n","      <td>-1.0380</td>\n","      <td>1.2930</td>\n","      <td>-0.4958</td>\n","      <td>3.759</td>\n","      <td>-2.2040</td>\n","      <td>3.3530</td>\n","      <td>-4.3680</td>\n","      <td>-10.000</td>\n","      <td>-3.230</td>\n","      <td>-5.840</td>\n","      <td>0.8245</td>\n","      <td>-5.5000</td>\n","      <td>6.9460</td>\n","      <td>-4.637</td>\n","      <td>-0.2418</td>\n","      <td>-4.816</td>\n","      <td>-4.700</td>\n","      <td>-1.6600</td>\n","      <td>-3.1140</td>\n","      <td>-4.431</td>\n","      <td>1.3710</td>\n","      <td>-3.0000</td>\n","      <td>-0.7707</td>\n","      <td>-0.0429</td>\n","      <td>-4.0730</td>\n","      <td>-4.240</td>\n","      <td>1.4320</td>\n","      <td>-3.644</td>\n","      <td>-1.6370</td>\n","      <td>-5.229</td>\n","      <td>6.625</td>\n","      <td>-2.2040</td>\n","      <td>4.3410</td>\n","      <td>-2.6100</td>\n","      <td>...</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-8.732</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-5.423</td>\n","      <td>-9.946</td>\n","      <td>-4.971</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-9.946</td>\n","      <td>-8.977</td>\n","      <td>-9.946</td>\n","      <td>-9.581</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>23680</th>\n","      <td>id_fe8abffe0</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D1</td>\n","      <td>87d714366</td>\n","      <td>6.649</td>\n","      <td>-0.4462</td>\n","      <td>1.7370</td>\n","      <td>0.0553</td>\n","      <td>3.033</td>\n","      <td>-2.7360</td>\n","      <td>0.4016</td>\n","      <td>-4.5340</td>\n","      <td>-9.746</td>\n","      <td>-3.116</td>\n","      <td>-5.381</td>\n","      <td>2.1980</td>\n","      <td>-1.4490</td>\n","      <td>6.8380</td>\n","      <td>-5.019</td>\n","      <td>0.7382</td>\n","      <td>-4.690</td>\n","      <td>-4.576</td>\n","      <td>-1.5880</td>\n","      <td>-3.1120</td>\n","      <td>-5.509</td>\n","      <td>-1.4490</td>\n","      <td>-2.2670</td>\n","      <td>-1.7240</td>\n","      <td>-1.2190</td>\n","      <td>-2.5050</td>\n","      <td>-5.049</td>\n","      <td>0.9918</td>\n","      <td>-4.635</td>\n","      <td>-1.8910</td>\n","      <td>-3.750</td>\n","      <td>4.339</td>\n","      <td>-0.5515</td>\n","      <td>7.0970</td>\n","      <td>-2.5690</td>\n","      <td>...</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-8.596</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-5.098</td>\n","      <td>-9.910</td>\n","      <td>-5.222</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-8.969</td>\n","      <td>-9.910</td>\n","      <td>-9.152</td>\n","      <td>-9.432</td>\n","      <td>-8.110</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-9.910</td>\n","      <td>-8.830</td>\n","      <td>-9.910</td>\n","      <td>-7.807</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","    <tr>\n","      <th>23791</th>\n","      <td>id_ffd1fd119</td>\n","      <td>com_droga</td>\n","      <td>72</td>\n","      <td>D2</td>\n","      <td>87d714366</td>\n","      <td>5.312</td>\n","      <td>0.4505</td>\n","      <td>1.5320</td>\n","      <td>0.8226</td>\n","      <td>3.025</td>\n","      <td>-0.4502</td>\n","      <td>-0.8196</td>\n","      <td>-1.7550</td>\n","      <td>-9.205</td>\n","      <td>-2.489</td>\n","      <td>-2.743</td>\n","      <td>0.3039</td>\n","      <td>-3.1820</td>\n","      <td>3.7120</td>\n","      <td>-3.519</td>\n","      <td>1.3900</td>\n","      <td>-2.796</td>\n","      <td>-4.367</td>\n","      <td>-1.6070</td>\n","      <td>0.6094</td>\n","      <td>-5.006</td>\n","      <td>-0.6930</td>\n","      <td>1.2240</td>\n","      <td>0.5679</td>\n","      <td>-3.9940</td>\n","      <td>-3.0080</td>\n","      <td>-1.883</td>\n","      <td>3.5390</td>\n","      <td>-2.899</td>\n","      <td>-9.0610</td>\n","      <td>-5.198</td>\n","      <td>5.802</td>\n","      <td>1.3620</td>\n","      <td>0.8115</td>\n","      <td>-2.0090</td>\n","      <td>...</td>\n","      <td>-10.000</td>\n","      <td>-9.436</td>\n","      <td>-9.918</td>\n","      <td>-7.790</td>\n","      <td>-10.000</td>\n","      <td>-9.802</td>\n","      <td>-10.000</td>\n","      <td>-10.000</td>\n","      <td>-5.340</td>\n","      <td>-9.852</td>\n","      <td>-8.071</td>\n","      <td>-8.019</td>\n","      <td>-9.966</td>\n","      <td>-9.410</td>\n","      <td>-9.966</td>\n","      <td>-9.817</td>\n","      <td>-9.966</td>\n","      <td>-9.966</td>\n","      <td>-9.966</td>\n","      <td>-9.966</td>\n","      <td>-8.638</td>\n","      <td>-8.966</td>\n","      <td>-9.171</td>\n","      <td>-8.631</td>\n","      <td>-9.966</td>\n","      <td>-9.966</td>\n","      <td>-9.220</td>\n","      <td>-9.373</td>\n","      <td>-9.966</td>\n","      <td>-9.362</td>\n","      <td>-9.966</td>\n","      <td>-8.642</td>\n","      <td>-9.966</td>\n","      <td>-4.605</td>\n","      <td>2</td>\n","      <td>True</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>False</td>\n","      <td>True</td>\n","    </tr>\n","  </tbody>\n","</table>\n","<p>236 rows × 883 columns</p>\n","</div>"],"text/plain":["                 id tratamento  tempo  ... tempo_24 tempo_48  tempo_72\n","119    id_01534c4ee  com_droga     72  ...    False    False      True\n","209    id_0236e3425  com_droga     72  ...    False    False      True\n","289    id_03033f263  com_droga     72  ...    False    False      True\n","348    id_03bdbab43  com_droga     72  ...    False    False      True\n","397    id_04372d73c  com_droga     72  ...    False    False      True\n","...             ...        ...    ...  ...      ...      ...       ...\n","23434  id_fbe76bd40  com_droga     72  ...    False    False      True\n","23483  id_fc6d80a5d  com_droga     72  ...    False    False      True\n","23634  id_fdf33871a  com_droga     72  ...    False    False      True\n","23680  id_fe8abffe0  com_droga     72  ...    False    False      True\n","23791  id_ffd1fd119  com_droga     72  ...    False    False      True\n","\n","[236 rows x 883 columns]"]},"metadata":{"tags":[]},"execution_count":44}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":515},"id":"4xXkkWGhMf9r","executionInfo":{"status":"ok","timestamp":1620339633635,"user_tz":180,"elapsed":915,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"f64fe6cd-324b-4b75-9eeb-2b20014e8cb0"},"source":["composto_principal_d3 = dados_combinados_d72['composto'].value_counts().index[:]\n","plt.figure(figsize=(12,8))\n","sns.boxplot(data = dados_combinados_d72.query('composto in @composto_principal_d3'), y= 'g-0', x='composto', hue='ativo_moa')"],"execution_count":45,"outputs":[{"output_type":"execute_result","data":{"text/plain":["<matplotlib.axes._subplots.AxesSubplot at 0x7fb1241a5710>"]},"metadata":{"tags":[]},"execution_count":45},{"output_type":"display_data","data":{"image/png":"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\n","text/plain":["<Figure size 864x576 with 1 Axes>"]},"metadata":{"tags":[],"needs_background":"light"}}]},{"cell_type":"code","metadata":{"id":"17ikScwZMxHF","executionInfo":{"status":"ok","timestamp":1620341717577,"user_tz":180,"elapsed":670,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["composto = dados_combinados[dados_combinados['composto']=='87d714366']\n","controle = dados_combinados[dados_combinados['tratamento']=='com_controle']"],"execution_count":56,"outputs":[]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/","height":531},"id":"jEbWR5XO5IKy","executionInfo":{"status":"ok","timestamp":1620341728762,"user_tz":180,"elapsed":1126,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"e1a1f0dd-356a-4516-ccbf-e007cecf368d"},"source":["fig, axs = plt.subplots(1,2,figsize=(20,8))\n","\n","sns.boxplot(data=composto,y='g-0', x='tempo', hue='dose',ax=axs[0])\n","axs[0].set_title('Composto 87d714366')\n","sns.boxplot(data=controle,y='g-0', x='tempo', hue='dose',ax=axs[1])\n","axs[1].set_title('Controle')"],"execution_count":57,"outputs":[{"output_type":"execute_result","data":{"text/plain":["Text(0.5, 1.0, 'Controle')"]},"metadata":{"tags":[]},"execution_count":57},{"output_type":"display_data","data":{"image/png":"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\n","text/plain":["<Figure size 1440x576 with 2 Axes>"]},"metadata":{"tags":[],"needs_background":"light"}}]},{"cell_type":"markdown","metadata":{"id":"w4WzpX4OM2Th"},"source":["# Desafio 6:"]},{"cell_type":"markdown","metadata":{"id":"HtHbe5pH2TJD"},"source":["Para esse desafio vamos usar a função nunique(). ela retorna series com número de observações distintas. Em outras palavras, se a mesma droga tem uma variação com o numero de MOA nessa função ela vai retornar com um valor diferente de 1.\n","\n","ref 1: https://pandas.pydata.org/docs/reference/api/pandas.DataFrame.nunique.html\n","\n","\n","ref2: https://github.com/gnserafim/ImersaoDados_Alura/blob/main/Aula_04_GabrielSerafim.ipynb"]},{"cell_type":"code","metadata":{"id":"OIpKLAk5M4yf","colab":{"base_uri":"https://localhost:8080/"},"executionInfo":{"status":"ok","timestamp":1620343212125,"user_tz":180,"elapsed":545,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"279a1192-6eb1-49ee-d44e-b4447ed14cd3"},"source":["selecao_moa_nunique = dados_combinados.groupby(by='composto')['ativo_moa'].nunique()\n","selecao_moa_nunique"],"execution_count":65,"outputs":[{"output_type":"execute_result","data":{"text/plain":["composto\n","00199ff52    1\n","00251fc41    1\n","00321ea80    1\n","0034c0847    1\n","0060e686f    1\n","            ..\n","ff9565933    1\n","ffd66e220    1\n","ffe357f8f    1\n","ffed8e1c9    1\n","fff7d208d    1\n","Name: ativo_moa, Length: 3289, dtype: int64"]},"metadata":{"tags":[]},"execution_count":65}]},{"cell_type":"markdown","metadata":{"id":"xM4VzHOP8cbw"},"source":["Feito essa seleção agora precisamos varrer a selecao para saber se temos valores diferente de 1."]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"ND-AueDH3LXw","executionInfo":{"status":"ok","timestamp":1620343212394,"user_tz":180,"elapsed":804,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"6cbe6dd8-2498-49b6-dc7d-f4c48027cdd8"},"source":["aux = 0\n","for i in range(len(selecao_moa_nunique)):\n","  if selecao_moa_nunique[i] != 1:\n","    aux += 1\n","    print(selecao_moa_nunique[i].index)\n","if aux == 0:\n","  print('Não houve variação na ativação do MOA alterando as variaveis para uma mesma droga/composto')\n"],"execution_count":66,"outputs":[{"output_type":"stream","text":["Não houve variação na ativação do MOA alterando as variaveis para uma mesma droga/composto\n"],"name":"stdout"}]},{"cell_type":"code","metadata":{"id":"toVaTrwO2iRZ","executionInfo":{"status":"ok","timestamp":1620343212394,"user_tz":180,"elapsed":802,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}}},"source":["\n"],"execution_count":66,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"JT4xq15492fT"},"source":["# Desafio 7:"]},{"cell_type":"markdown","metadata":{"id":"UrHH_5cz9_mg"},"source":["Aqui vamos usar a mesma ideia do item anterios. Porém o parametro para analise agora é o n_moa.\n","\n","Um detalhe é que eu isolei no desafio 5 uma droga, a cara que apareceu foi os mesmo MOA e ativação. Então crio a hipotese de que isso seria pra todas as drogas. Será?"]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"luu8m-Uc94L2","executionInfo":{"status":"ok","timestamp":1620343209316,"user_tz":180,"elapsed":698,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"d5db483c-671d-4d2b-a193-ac5bf64cafaf"},"source":["selecao_moa2_nunique = dados_combinados.groupby(by='composto')['n_moa'].nunique()\n","selecao_moa2_nunique"],"execution_count":64,"outputs":[{"output_type":"execute_result","data":{"text/plain":["composto\n","00199ff52    1\n","00251fc41    1\n","00321ea80    1\n","0034c0847    1\n","0060e686f    1\n","            ..\n","ff9565933    1\n","ffd66e220    1\n","ffe357f8f    1\n","ffed8e1c9    1\n","fff7d208d    1\n","Name: n_moa, Length: 3289, dtype: int64"]},"metadata":{"tags":[]},"execution_count":64}]},{"cell_type":"code","metadata":{"colab":{"base_uri":"https://localhost:8080/"},"id":"OHcbqcU7-2rS","executionInfo":{"status":"ok","timestamp":1620343262693,"user_tz":180,"elapsed":665,"user":{"displayName":"Italo Alves","photoUrl":"https://lh3.googleusercontent.com/a-/AOh14GjN_--uX1AHIM2IBNU09Hb4CqzUlfXAHZR60rP7kA=s64","userId":"09696316357588203068"}},"outputId":"6236cd09-3f32-49d0-d5f2-ceb781f27ef0"},"source":["aux = 0\n","for i in range(len(selecao_moa2_nunique)):\n","  if selecao_moa2_nunique[i] != 1:\n","    aux += 1\n","    print(selecao_moa2_nunique[i].index)\n","if aux == 0:\n","  print('Não houve variação do MOA alterando as variaveis para uma mesma droga/composto')"],"execution_count":67,"outputs":[{"output_type":"stream","text":["Não houve variação do MOA alterando as variaveis para uma mesma droga/composto\n"],"name":"stdout"}]},{"cell_type":"markdown","metadata":{"id":"zqxE5-N-95V8"},"source":["Concluimos que independente das variaveis o MOA e sua ativação será a mesma."]},{"cell_type":"code","metadata":{"id":"Lnef-ThQ_IuQ"},"source":[""],"execution_count":null,"outputs":[]},{"cell_type":"markdown","metadata":{"id":"4ebA0guS_JUn"},"source":[""]},{"cell_type":"markdown","metadata":{"id":"oe0okI4JAF1M"},"source":["# Desafio 08:"]},{"cell_type":"markdown","metadata":{"id":"I7Mwdx7OCb4C"},"source":["Na aula 4 nós começamos a analisar os dados de resultado, outra base de dados. Importamos e analisamos essa base de dados. Ela se trata de dados com os tipos de influencias que a droga fez em certo gene ou célula. Para melhor analise criamos novas colunas e mesclamos essas colunas com a base de dados que já estávamos trabalhando. Agora temos informações mais completas. Então fizemos analises com o numero MOA e sua ativação."]},{"cell_type":"code","metadata":{"id":"HFe5f7nTAIej"},"source":[""],"execution_count":null,"outputs":[]}]}