diff --git a/__tests__/application/respond.js b/__tests__/application/respond.js
index ccc57e269..db1af4543 100644
--- a/__tests__/application/respond.js
+++ b/__tests__/application/respond.js
@@ -570,6 +570,93 @@ describe('app.respond', () => {
     })
   })
 
+  describe('when .body is a Blob', () => {
+    it('should respond', async () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Blob(['Hello'])
+      })
+
+      const expectedBlob = new Blob(['Hello'])
+
+      const server = app.listen()
+
+      const res = await request(server)
+        .get('/')
+        .expect(200)
+
+      assert.deepStrictEqual(res.body, Buffer.from(await expectedBlob.arrayBuffer()))
+    })
+
+    it('should keep Blob headers', async () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Blob(['hello world'])
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+        .expect('content-length', '11')
+    })
+  })
+
+  describe('when .body is a ReadableStream', () => {
+    it('should respond', async () => {
+      const app = new Koa()
+
+      app.use(async ctx => {
+        ctx.body = new ReadableStream()
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+    })
+  })
+
+  describe('when .body is a Response', () => {
+    it('should keep Response headers', () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Response(null, { status: 201, statusText: 'OK', headers: { 'Content-Type': 'text/plain' } })
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(201)
+        .expect('content-type', 'text/plain')
+        .expect('content-length', '2')
+    })
+
+    it('should default to octet-stream', () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Response(null, { status: 200, statusText: 'OK' })
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+        .expect('content-length', '2')
+    })
+  })
+
   describe('when .body is a Stream', () => {
     it('should respond', async () => {
       const app = new Koa()
diff --git a/__tests__/response/body.js b/__tests__/response/body.js
index 5af050786..41c97a6db 100644
--- a/__tests__/response/body.js
+++ b/__tests__/response/body.js
@@ -141,4 +141,48 @@ describe('res.body=', () => {
       assert.strictEqual('application/json; charset=utf-8', res.header['content-type'])
     })
   })
+
+  describe('when a ReadableStream is given', () => {
+    it('should default to an octet stream', () => {
+      const res = response()
+      res.body = new ReadableStream()
+      assert.strictEqual('application/octet-stream', res.header['content-type'])
+    })
+  })
+
+  describe('when a Blob is given', () => {
+    it('should default to an octet stream', () => {
+      const res = response()
+      res.body = new Blob([new Uint8Array([1, 2, 3])], { type: 'application/octet-stream' })
+      assert.strictEqual('application/octet-stream', res.header['content-type'])
+    })
+
+    it('should set length', () => {
+      const res = response()
+      res.body = new Blob([new Uint8Array([1, 2, 3])], { type: 'application/octet-stream' })
+      assert.strictEqual('3', res.header['content-length'])
+    })
+  })
+
+  describe('when a response is given', () => {
+    it('should set the status', () => {
+      const res = response()
+      res.body = new Response(null, { status: 201 })
+      assert.strictEqual(201, res.status)
+    })
+
+    it('should set headers', () => {
+      const res = response()
+      res.body = new Response(null, { status: 200, headers: { 'x-fizz': 'buzz', 'x-foo': 'bar' } })
+      assert.strictEqual('buzz', res.header['x-fizz'])
+      assert.strictEqual('bar', res.header['x-foo'])
+    })
+
+    it('should redirect', () => {
+      const res = response()
+      res.body = Response.redirect('https://www.example.com/', 301)
+      assert.strictEqual(301, res.status)
+      assert.strictEqual('https://www.example.com/', res.header.location)
+    })
+  })
 })
diff --git a/lib/application.js b/lib/application.js
index ec7524dac..0ba1c8907 100644
--- a/lib/application.js
+++ b/lib/application.js
@@ -300,9 +300,13 @@ function respond (ctx) {
   }
 
   // responses
+
   if (Buffer.isBuffer(body)) return res.end(body)
   if (typeof body === 'string') return res.end(body)
   if (body instanceof Stream) return body.pipe(res)
+  if (body instanceof Blob) return Stream.Readable.from(body.stream()).pipe(res)
+  if (body instanceof ReadableStream) return Stream.Readable.from(body).pipe(res)
+  if (body instanceof Response) return Stream.Readable.from(body?.body).pipe(res)
 
   // body: json
   body = JSON.stringify(body)
diff --git a/lib/response.js b/lib/response.js
index e6601569c..3dcd6e65e 100644
--- a/lib/response.js
+++ b/lib/response.js
@@ -126,15 +126,15 @@ module.exports = {
   /**
    * Set response body.
    *
-   * @param {String|Buffer|Object|Stream} val
+   * @param {String|Buffer|Object|Stream|ReadableStream|Blob|Response} val
    * @api public
    */
 
   set body (val) {
     const original = this._body
     this._body = val
-
     // no content
+
     if (val == null) {
       if (!statuses.empty[this.status]) {
         if (this.type === 'application/json') {
@@ -183,6 +183,34 @@ module.exports = {
       return
     }
 
+    // ReadableStream
+    if (val instanceof ReadableStream) {
+      if (setType) this.type = 'bin'
+      return
+    }
+
+    // blob
+    if (val instanceof Blob) {
+      if (setType) this.type = 'bin'
+      this.length = val.size
+      return
+    }
+
+    // Response
+    if (val instanceof Response) {
+      this.status = val.status
+      if (setType) this.type = 'bin'
+      const headers = val.headers
+      for (const key of headers.keys()) {
+        this.set(key, headers.get(key))
+      }
+
+      if (val.redirected) {
+        this.redirect(val.url)
+      }
+      return
+    }
+
     // json
     this.remove('Content-Length')
     this.type = 'json'