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White2016.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version3" level="2" version="3">
<model id="base">
<listOfCompartments>
<compartment id="cell" size="1" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="EGF" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="NGF" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="freeEGFReceptor" compartment="cell" boundaryCondition="false"/>
<species id="boundEGFReceptor" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="freeNGFReceptor" compartment="cell" boundaryCondition="false"/>
<species id="boundNGFReceptor" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="SosInactive" compartment="cell" boundaryCondition="false"/>
<species id="SosActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="P90RskInactive" compartment="cell" boundaryCondition="false"/>
<species id="P90RskActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RasInactive" compartment="cell" boundaryCondition="false"/>
<species id="RasActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RasGapActive" compartment="cell" boundaryCondition="false"/>
<species id="Raf1Inactive" compartment="cell" boundaryCondition="false"/>
<species id="Raf1Active" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="BRafInactive" compartment="cell" boundaryCondition="false"/>
<species id="BRafActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="MekInactive" compartment="cell" boundaryCondition="false"/>
<species id="MekActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="ErkInactive" compartment="cell" boundaryCondition="false"/>
<species id="ErkActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="PI3KInactive" compartment="cell" boundaryCondition="false"/>
<species id="PI3KActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="AktInactive" compartment="cell" boundaryCondition="false"/>
<species id="AktActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="C3GInactive" compartment="cell" boundaryCondition="false"/>
<species id="C3GActive" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="Rap1Inactive" compartment="cell" boundaryCondition="false"/>
<species id="Rap1Active" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RapGapActive" compartment="cell" boundaryCondition="false"/>
<species id="PP2AActive" compartment="cell" boundaryCondition="false"/>
<species id="Raf1PPtase" compartment="cell" boundaryCondition="false"/>
<species id="RasPI3K" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="Raf1PPtaseRaf1" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="BRafMek" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="boundNGFReceptorC3G" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="P90RskSos" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="Raf1PPtaseBRaf" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RasGapRas" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="ErkP90Rsk" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RasRaf1" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="MekErk" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="RapGapRap1" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="AktRaf1" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="C3GRap1" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="Raf1Mek" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="SosRas" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="boundEGFReceptorPI3K" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="boundEGFReceptorSos" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="boundNGFReceptorSos" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="Rap1BRaf" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="PP2AMek" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="PP2AErk" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
<species id="PI3KAkt" compartment="cell" initialConcentration="0" boundaryCondition="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="RasGapTotal" value="1" constant="true"/>
<parameter id="RapGapTotal" value="1" constant="true"/>
<parameter id="PP2ATotal" value="1" constant="true"/>
<parameter id="Raf1PPtaseTotal" value="1" constant="true"/>
<parameter id="EGF_IC" value="1" constant="true"/>
<parameter id="NGF_IC" value="1" constant="true"/>
<parameter id="Total_EGFReceptor" value="1" constant="true"/>
<parameter id="Total_NGFReceptor" value="1" constant="true"/>
<parameter id="Total_Sos" value="1" constant="true"/>
<parameter id="Total_P90Rsk" value="1" constant="true"/>
<parameter id="Total_Ras" value="1" constant="true"/>
<parameter id="Total_Raf1" value="1" constant="true"/>
<parameter id="Total_BRaf" value="1" constant="true"/>
<parameter id="Total_Mek" value="1" constant="true"/>
<parameter id="Total_Erk" value="1" constant="true"/>
<parameter id="Total_PI3K" value="1" constant="true"/>
<parameter id="Total_Akt" value="1" constant="true"/>
<parameter id="Total_C3G" value="1" constant="true"/>
<parameter id="Total_Rap1" value="1" constant="true"/>
<parameter id="k00f" value="1" constant="true"/>
<parameter id="k00b" value="1" constant="true"/>
<parameter id="k01f" value="1" constant="true"/>
<parameter id="k01b" value="1" constant="true"/>
<parameter id="k02f" value="1" constant="true"/>
<parameter id="k02b" value="1" constant="true"/>
<parameter id="k03f" value="1" constant="true"/>
<parameter id="k04f" value="1" constant="true"/>
<parameter id="k04b" value="1" constant="true"/>
<parameter id="k05f" value="1" constant="true"/>
<parameter id="k06f" value="1" constant="true"/>
<parameter id="k06b" value="1" constant="true"/>
<parameter id="k07f" value="1" constant="true"/>
<parameter id="k08f" value="1" constant="true"/>
<parameter id="k08b" value="1" constant="true"/>
<parameter id="k09f" value="1" constant="true"/>
<parameter id="k10f" value="1" constant="true"/>
<parameter id="k10b" value="1" constant="true"/>
<parameter id="k11f" value="1" constant="true"/>
<parameter id="k12f" value="1" constant="true"/>
<parameter id="k12b" value="1" constant="true"/>
<parameter id="k13f" value="1" constant="true"/>
<parameter id="k14f" value="1" constant="true"/>
<parameter id="k14b" value="1" constant="true"/>
<parameter id="k15f" value="1" constant="true"/>
<parameter id="k16f" value="1" constant="true"/>
<parameter id="k16b" value="1" constant="true"/>
<parameter id="k17f" value="1" constant="true"/>
<parameter id="k18f" value="1" constant="true"/>
<parameter id="k18b" value="1" constant="true"/>
<parameter id="k19f" value="1" constant="true"/>
<parameter id="k20f" value="1" constant="true"/>
<parameter id="k20b" value="1" constant="true"/>
<parameter id="k21f" value="1" constant="true"/>
<parameter id="k22f" value="1" constant="true"/>
<parameter id="k22b" value="1" constant="true"/>
<parameter id="k23f" value="1" constant="true"/>
<parameter id="k24f" value="1" constant="true"/>
<parameter id="k24b" value="1" constant="true"/>
<parameter id="k25f" value="1" constant="true"/>
<parameter id="k26f" value="1" constant="true"/>
<parameter id="k26b" value="1" constant="true"/>
<parameter id="k27f" value="1" constant="true"/>
<parameter id="k28f" value="1" constant="true"/>
<parameter id="k28b" value="1" constant="true"/>
<parameter id="k29f" value="1" constant="true"/>
<parameter id="k30f" value="1" constant="true"/>
<parameter id="k30b" value="1" constant="true"/>
<parameter id="k31f" value="1" constant="true"/>
<parameter id="k42f" value="1" constant="true"/>
<parameter id="k42b" value="1" constant="true"/>
<parameter id="k43f" value="1" constant="true"/>
<parameter id="k44f" value="1" constant="true"/>
<parameter id="k44b" value="1" constant="true"/>
<parameter id="k45f" value="1" constant="true"/>
</listOfParameters>
<listOfReactions>
<reaction id="EGFBindingReaction">
<listOfReactants>
<speciesReference species="EGF" stoichiometry="1"/>
<speciesReference species="freeEGFReceptor" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundEGFReceptor" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k00f </ci>
<ci> EGF </ci>
<ci> freeEGFReceptor </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="EGFUnbindingReaction">
<listOfReactants>
<speciesReference species="boundEGFReceptor" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGF" stoichiometry="1"/>
<speciesReference species="freeEGFReceptor" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k00b </ci>
<ci> boundEGFReceptor </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="NGFBindingReaction">
<listOfReactants>
<speciesReference species="NGF" stoichiometry="1"/>
<speciesReference species="freeNGFReceptor" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundNGFReceptor" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k01f </ci>
<ci> NGF </ci>
<ci> freeNGFReceptor </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="NGFUnbindingReaction">
<listOfReactants>
<speciesReference species="boundNGFReceptor" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="NGF" stoichiometry="1"/>
<speciesReference species="freeNGFReceptor" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k01b </ci>
<ci> boundNGFReceptor </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="boundEGFReceptorSosBindingReaction">
<listOfReactants>
<speciesReference species="boundEGFReceptor" stoichiometry="1"/>
<speciesReference species="SosInactive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundEGFReceptorSos" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k02f </ci>
<ci> boundEGFReceptor </ci>
<ci> SosInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="boundEGFReceptorSosUnbindingReaction">
<listOfReactants>
<speciesReference species="boundEGFReceptorSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundEGFReceptor" stoichiometry="1"/>
<speciesReference species="SosInactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k02b </ci>
<ci> boundEGFReceptorSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="SosActivationByEGFReaction">
<listOfReactants>
<speciesReference species="boundEGFReceptorSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundEGFReceptor" stoichiometry="1"/>
<speciesReference species="SosActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k03f </ci>
<ci> boundEGFReceptorSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="boundNGFReceptorSosBindingReaction">
<listOfReactants>
<speciesReference species="boundNGFReceptor" stoichiometry="1"/>
<speciesReference species="SosInactive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundNGFReceptorSos" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k04f </ci>
<ci> boundNGFReceptor </ci>
<ci> SosInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="boundNGFReceptorSosUnbindingReaction">
<listOfReactants>
<speciesReference species="boundNGFReceptorSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundNGFReceptor" stoichiometry="1"/>
<speciesReference species="SosInactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k04b </ci>
<ci> boundNGFReceptorSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="SosActivationByNGFReaction">
<listOfReactants>
<speciesReference species="boundNGFReceptorSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="boundNGFReceptor" stoichiometry="1"/>
<speciesReference species="SosActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k05f </ci>
<ci> boundNGFReceptorSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="P90RskSosBindingReaction">
<listOfReactants>
<speciesReference species="SosActive" stoichiometry="1"/>
<speciesReference species="P90RskActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="P90RskSos" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k06f </ci>
<ci> P90RskActive </ci>
<ci> SosActive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="P90RskSosUnbindingReaction">
<listOfReactants>
<speciesReference species="P90RskSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="SosActive" stoichiometry="1"/>
<speciesReference species="P90RskActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k06b </ci>
<ci> P90RskSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="SosInactivationByP90RskReaction">
<listOfReactants>
<speciesReference species="P90RskSos" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="SosInactive" stoichiometry="1"/>
<speciesReference species="P90RskActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k07f </ci>
<ci> P90RskSos </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="ErkP90RskBindingReaction">
<listOfReactants>
<speciesReference species="ErkActive" stoichiometry="1"/>
<speciesReference species="P90RskInactive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="ErkP90Rsk" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k08f </ci>
<ci> ErkActive </ci>
<ci> P90RskInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="ErkP90RskUnbindingReaction">
<listOfReactants>
<speciesReference species="ErkP90Rsk" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="ErkActive" stoichiometry="1"/>
<speciesReference species="P90RskInactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k08b </ci>
<ci> ErkP90Rsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="P90RskActivationByErkReaction">
<listOfReactants>
<speciesReference species="ErkP90Rsk" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="ErkActive" stoichiometry="1"/>
<speciesReference species="P90RskActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k09f </ci>
<ci> ErkP90Rsk </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="SosRasBindingReaction">
<listOfReactants>
<speciesReference species="RasInactive" stoichiometry="1"/>
<speciesReference species="SosActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="SosRas" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k10f </ci>
<ci> SosActive </ci>
<ci> RasInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="SosRasUnbindingReaction">
<listOfReactants>
<speciesReference species="SosRas" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasInactive" stoichiometry="1"/>
<speciesReference species="SosActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k10b </ci>
<ci> SosRas </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasActivationBySosReaction">
<listOfReactants>
<speciesReference species="SosRas" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasActive" stoichiometry="1"/>
<speciesReference species="SosActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k11f </ci>
<ci> SosRas </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasGapRasBindingReaction">
<listOfReactants>
<speciesReference species="RasGapActive" stoichiometry="1"/>
<speciesReference species="RasActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasGapRas" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k12f </ci>
<ci> RasGapActive </ci>
<ci> RasActive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasGapRasUnbindingReaction">
<listOfReactants>
<speciesReference species="RasGapRas" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasGapActive" stoichiometry="1"/>
<speciesReference species="RasActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k12b </ci>
<ci> RasGapRas </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasInactivationByRasGapReaction">
<listOfReactants>
<speciesReference species="RasGapRas" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasGapActive" stoichiometry="1"/>
<speciesReference species="RasInactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k13f </ci>
<ci> RasGapRas </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasRaf1BindingReaction">
<listOfReactants>
<speciesReference species="RasActive" stoichiometry="1"/>
<speciesReference species="Raf1Inactive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasRaf1" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k14f </ci>
<ci> RasActive </ci>
<ci> Raf1Inactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="RasRaf1UnbindingReaction">
<listOfReactants>
<speciesReference species="RasRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="RasActive" stoichiometry="1"/>
<speciesReference species="Raf1Inactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k14b </ci>
<ci> RasRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1ActivationByRasReaction">
<listOfReactants>
<speciesReference species="RasRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1Active" stoichiometry="1"/>
<speciesReference species="RasActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k15f </ci>
<ci> RasRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1PPtaseRaf1BindingReaction">
<listOfReactants>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1PPtaseRaf1" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k16f </ci>
<ci> Raf1PPtase </ci>
<ci> Raf1Active </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1PPtaseRaf1UnbindingReaction">
<listOfReactants>
<speciesReference species="Raf1PPtaseRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k16b </ci>
<ci> Raf1PPtaseRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1InactivationByRaf1PPtaseReaction">
<listOfReactants>
<speciesReference species="Raf1PPtaseRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
<speciesReference species="Raf1Inactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k17f </ci>
<ci> Raf1PPtaseRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="AktRaf1BindingReaction">
<listOfReactants>
<speciesReference species="AktActive" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="AktRaf1" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k18f </ci>
<ci> AktActive </ci>
<ci> Raf1Active </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="AktRaf1UnbindingReaction">
<listOfReactants>
<speciesReference species="AktRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="AktActive" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k18b </ci>
<ci> AktRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1InactivationByAktReaction">
<listOfReactants>
<speciesReference species="AktRaf1" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="AktActive" stoichiometry="1"/>
<speciesReference species="Raf1Inactive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k19f </ci>
<ci> AktRaf1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Rap1BRafBindingReaction">
<listOfReactants>
<speciesReference species="BRafInactive" stoichiometry="1"/>
<speciesReference species="Rap1Active" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Rap1BRaf" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k20f </ci>
<ci> Rap1Active </ci>
<ci> BRafInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Rap1BRafUnbindingReaction">
<listOfReactants>
<speciesReference species="Rap1BRaf" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="BRafInactive" stoichiometry="1"/>
<speciesReference species="Rap1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k20b </ci>
<ci> Rap1BRaf </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="BRafActivationByRap1Reaction">
<listOfReactants>
<speciesReference species="Rap1BRaf" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="BRafActive" stoichiometry="1"/>
<speciesReference species="Rap1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k21f </ci>
<ci> Rap1BRaf </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1PPtaseBRafBindingReaction">
<listOfReactants>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
<speciesReference species="BRafActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1PPtaseBRaf" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k22f </ci>
<ci> Raf1PPtase </ci>
<ci> BRafActive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1PPtaseBRafUnbindingReaction">
<listOfReactants>
<speciesReference species="Raf1PPtaseBRaf" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
<speciesReference species="BRafActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k22b </ci>
<ci> Raf1PPtaseBRaf </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="BRafInactivationByRaf1PPtaseReaction">
<listOfReactants>
<speciesReference species="Raf1PPtaseBRaf" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="BRafInactive" stoichiometry="1"/>
<speciesReference species="Raf1PPtase" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k23f </ci>
<ci> Raf1PPtaseBRaf </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1MekBindingReaction">
<listOfReactants>
<speciesReference species="MekInactive" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Raf1Mek" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k24f </ci>
<ci> Raf1Active </ci>
<ci> MekInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="Raf1MekUnbindingReaction">
<listOfReactants>
<speciesReference species="Raf1Mek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekInactive" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k24b </ci>
<ci> Raf1Mek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="MekActivationByRaf1Reaction">
<listOfReactants>
<speciesReference species="Raf1Mek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekActive" stoichiometry="1"/>
<speciesReference species="Raf1Active" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k25f </ci>
<ci> Raf1Mek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="BRafMekBindingReaction">
<listOfReactants>
<speciesReference species="MekInactive" stoichiometry="1"/>
<speciesReference species="BRafActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="BRafMek" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k26f </ci>
<ci> BRafActive </ci>
<ci> MekInactive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="BRafMekUnbindingReaction">
<listOfReactants>
<speciesReference species="BRafMek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekInactive" stoichiometry="1"/>
<speciesReference species="BRafActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k26b </ci>
<ci> BRafMek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="MekActivationByBRafReaction">
<listOfReactants>
<speciesReference species="BRafMek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekActive" stoichiometry="1"/>
<speciesReference species="BRafActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k27f </ci>
<ci> BRafMek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="PP2AMekBindingReaction">
<listOfReactants>
<speciesReference species="MekActive" stoichiometry="1"/>
<speciesReference species="PP2AActive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="PP2AMek" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k28f </ci>
<ci> PP2AActive </ci>
<ci> MekActive </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="PP2AMekUnbindingReaction">
<listOfReactants>
<speciesReference species="PP2AMek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekActive" stoichiometry="1"/>
<speciesReference species="PP2AActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k28b </ci>
<ci> PP2AMek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="MekInactivationByPP2AReaction">
<listOfReactants>
<speciesReference species="PP2AMek" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekInactive" stoichiometry="1"/>
<speciesReference species="PP2AActive" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k29f </ci>
<ci> PP2AMek </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="MekErkBindingReaction">
<listOfReactants>
<speciesReference species="MekActive" stoichiometry="1"/>
<speciesReference species="ErkInactive" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MekErk" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> k30f </ci>
<ci> MekActive </ci>
<ci> ErkInactive </ci>
</apply>
</math>