diff --git a/.github/workflows/backend.yml b/.github/workflows/backend.yml
index c46dbec7f9..90e0bbc4ca 100644
--- a/.github/workflows/backend.yml
+++ b/.github/workflows/backend.yml
@@ -35,24 +35,21 @@ jobs:
         options: --health-cmd pg_isready --health-interval 10s --health-timeout 5s --health-retries 5
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - name: Set up uv
+        uses: astral-sh/setup-uv@v2
         with:
-          python-version: '3.11'
-          cache: pip
-          cache-dependency-path: |
-            requirements/default.txt
-            requirements/dev.txt
-            requirements/lint.txt
-            requirements/test.txt
+          enable-cache: true
+      - name: Install Python
+        run: uv python install 3.11
       - run: >
-          pip install
+          uv pip install
           -r requirements/default.txt
           -r requirements/dev.txt
           -r requirements/test.txt
           -r requirements/lint.txt
 
       # Set environment variables
-      - run: pip install pytest-dotenv
+      - run: uv pip install pytest-dotenv
       - run: >
           sed
           -e 's#^DATABASE_URL=.*#DATABASE_URL=postgres://pontoon:pontoon@localhost/pontoon#'
diff --git a/.github/workflows/py-lint.yml b/.github/workflows/py-lint.yml
index 6a798ab9e4..8a8f07b830 100644
--- a/.github/workflows/py-lint.yml
+++ b/.github/workflows/py-lint.yml
@@ -22,13 +22,16 @@ jobs:
     runs-on: ubuntu-latest
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - name: Set up uv
+        uses: astral-sh/setup-uv@v2
         with:
-          python-version: '3.11'
+          enable-cache: true
+      - name: Install Python
+        run: uv python install 3.11
       - name: Install Dependencies
         run: |
-          pip install -U pip
-          pip install -r requirements/lint.txt
+          uv pip install -U pip
+          uv pip install -r requirements/lint.txt
       - name: ruff lint
         run: ruff check pontoon
       - name: ruff format
diff --git a/.gitignore b/.gitignore
index c50f800d38..af6c68f97c 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,7 +1,6 @@
 *.py[co]
 *.sw[po]
 /pontoon/coverage.xml
-pip-log.txt
 docs/_gh-pages
 build.py
 build
diff --git a/CONTRIBUTING.rst b/CONTRIBUTING.rst
index 2caf47e1ae..e103bee2d1 100644
--- a/CONTRIBUTING.rst
+++ b/CONTRIBUTING.rst
@@ -225,10 +225,12 @@ Direct dependencies for Pontoon are distributed across four files:
 3. ``requirements/test.in``: Testing
 4. ``requirements/lint.in``:  Linting
 
-In order to pin and hash the direct and indirect dependencies, we use `pip-compile <https://pypi.org/project/pip-tools/>`_,
-which yields corresponding ``*.txt`` files. These ``*.txt`` files contain all direct and indirect dependencies,
-and can be used for installation with ``pip``. After any change to the ``*.in`` files,
-you should run the following command to update all ``requirements/*.txt`` files.
+In order to pin and hash the direct and indirect dependencies, we use
+`uv pip compile <https://docs.astral.sh/uv/#the-pip-interface>`_, which yields
+corresponding ``*.txt`` files. These ``*.txt`` files contain all direct and
+indirect dependencies, and can be used for installation with ``uv pip``. After any
+change to the ``*.in`` files, you should run the following command to update all
+``requirements/*.txt`` files.
 
 .. code-block:: shell
 
@@ -247,7 +249,7 @@ Once you are done adding, removing or updating requirements, rebuild your docker
 If there are problems, it'll tell you.
 
 To upgrade existing dependencies within the given constraints of the input
-files, you can pass options through to the ``pip-compile`` invocations, i.e.
+files, you can pass options through to the ``uv pip compile`` invocations, i.e.
 
 .. code-block:: shell
 
@@ -265,9 +267,9 @@ a virtualenv to build docs, do this:
 .. code-block:: shell
 
     $ cd docs/
-    $ virtualenv venv
-    $ source venv/bin/activate
-    $ pip install --require-hashes -r requirements.txt
+    $ uv venv
+    $ source .venv/bin/activate
+    $ uv pip install -r requirements.txt
 
 Then, to build the docs, run this:
 
@@ -378,7 +380,7 @@ steps, as they don't affect your setup if nothing has changed:
    git pull origin main
 
    # Install new dependencies or update existing ones.
-   pip install -U --force --require-hashes -r requirements/default.txt
+   uv pip install -U --force -r requirements/default.txt
 
    # Run database migrations.
    python manage.py migrate
diff --git a/Makefile b/Makefile
index 7d38e87475..cf8a5744a8 100644
--- a/Makefile
+++ b/Makefile
@@ -40,7 +40,7 @@ help:
 	@echo "  dumpdb           Create a postgres database dump with timestamp used as file name"
 	@echo "  loaddb           Load a database dump into postgres, file name in DB_DUMP_FILE"
 	@echo "  sync-projects    Runs the synchronization task on all projects"
-	@echo "  requirements     Compiles all requirements files with pip-compile\n"
+	@echo "  requirements     Compiles all requirements files with uv pip compile\n"
 
 translate/dist:
 	make build-translate
@@ -143,5 +143,5 @@ sync-projects:
 
 requirements:
 	# Pass --upgrade to upgrade all dependencies
-	# The arguments are passed through to pip-compile
+	# The arguments are passed through to `uv pip compile`
 	"${DC}" run --rm server //app/docker/compile_requirements.sh ${opts}
diff --git a/bin/post_compile b/bin/post_compile
index 4fb89cc470..8165a1723e 100644
--- a/bin/post_compile
+++ b/bin/post_compile
@@ -3,7 +3,7 @@
 # Install requirements/dev.txt on staging
 if [ "$DJANGO_STAGE" = True ]; then
     echo "Installing dev requirements..."
-    pip install --require-hashes -r requirements/dev.txt
+    uv pip install requirements/dev.txt
 fi
 
 # Compile static assets
diff --git a/docker/Dockerfile b/docker/Dockerfile
index 9d5bcbfe2d..172e1ef213 100644
--- a/docker/Dockerfile
+++ b/docker/Dockerfile
@@ -33,8 +33,8 @@ WORKDIR /app
 
 # Install Pontoon Python requirements
 COPY requirements/* /app/requirements/
-RUN pip install -U 'pip>=8' && \
-    pip install --no-cache-dir --require-hashes -r requirements/default.txt -r requirements/dev.txt -r requirements/test.txt -r requirements/lint.txt
+RUN uv pip install -U 'pip>=8' && \
+    uv pip install --no-cache-dir --require-hashes -r requirements/default.txt -r requirements/dev.txt -r requirements/test.txt -r requirements/lint.txt
 
 # Create the app user
 RUN groupadd -r --gid=${GROUP_ID} pontoon && useradd --uid=${USER_ID} --no-log-init -r -m -g pontoon pontoon
diff --git a/docker/compile_requirements.sh b/docker/compile_requirements.sh
index ff566f0970..f1af912601 100755
--- a/docker/compile_requirements.sh
+++ b/docker/compile_requirements.sh
@@ -1,11 +1,11 @@
 #!/bin/bash
 
-# This compiles all requirements files with pip-compile.
+# This compiles all requirements files with uv pip compile.
 # You should always use this script, because dev.txt and test.txt depend on default.txt.
 
 export CUSTOM_COMPILE_COMMAND="./docker/compile_requirements.sh"
 
-pip-compile --generate-hashes --resolver=backtracking $@ requirements/default.in
-pip-compile --generate-hashes --resolver=backtracking $@ requirements/dev.in
-pip-compile --generate-hashes --resolver=backtracking $@ requirements/lint.in
-pip-compile --generate-hashes --resolver=backtracking $@ requirements/test.in
+uv pip compile --generate-hashes --resolver=backtracking $@ requirements/default.in
+uv pip compile --generate-hashes --resolver=backtracking $@ requirements/dev.in
+uv pip compile --generate-hashes --resolver=backtracking $@ requirements/lint.in
+uv pip compile --generate-hashes --resolver=backtracking $@ requirements/test.in
diff --git a/requirements/dev.in b/requirements/dev.in
index e6148ef303..124e0fceb6 100644
--- a/requirements/dev.in
+++ b/requirements/dev.in
@@ -20,4 +20,3 @@
 django-debug-toolbar==4.3.0
 django-extensions==3.2.3
 django-sslserver==0.22
-pip-tools==7.4.1
diff --git a/requirements/dev.txt b/requirements/dev.txt
index ba9a8f15bd..29cb174c36 100644
--- a/requirements/dev.txt
+++ b/requirements/dev.txt
@@ -10,16 +10,6 @@ asgiref==3.8.1 \
     # via
     #   -c requirements/default.txt
     #   django
-build==1.2.1 \
-    --hash=sha256:526263f4870c26f26c433545579475377b2b7588b6f1eac76a001e873ae3e19d \
-    --hash=sha256:75e10f767a433d9a86e50d83f418e83efc18ede923ee5ff7df93b6cb0306c5d4
-    # via pip-tools
-click==8.1.7 \
-    --hash=sha256:ae74fb96c20a0277a1d615f1e4d73c8414f5a98db8b799a7931d1582f3390c28 \
-    --hash=sha256:ca9853ad459e787e2192211578cc907e7594e294c7ccc834310722b41b9ca6de
-    # via
-    #   -c requirements/default.txt
-    #   pip-tools
 django==4.2.11 \
     --hash=sha256:6e6ff3db2d8dd0c986b4eec8554c8e4f919b5c1ff62a5b4390c17aff2ed6e5c4 \
     --hash=sha256:ddc24a0a8280a0430baa37aff11f28574720af05888c62b7cfe71d219f4599d3
@@ -39,20 +29,6 @@ django-extensions==3.2.3 \
 django-sslserver==0.22 \
     --hash=sha256:c598a363d2ccdc2421c08ddb3d8b0973f80e8e47a3a5b74e4a2896f21c2947c5
     # via -r requirements/dev.in
-packaging==24.0 \
-    --hash=sha256:2ddfb553fdf02fb784c234c7ba6ccc288296ceabec964ad2eae3777778130bc5 \
-    --hash=sha256:eb82c5e3e56209074766e6885bb04b8c38a0c015d0a30036ebe7ece34c9989e9
-    # via build
-pip-tools==7.4.1 \
-    --hash=sha256:4c690e5fbae2f21e87843e89c26191f0d9454f362d8acdbd695716493ec8b3a9 \
-    --hash=sha256:864826f5073864450e24dbeeb85ce3920cdfb09848a3d69ebf537b521f14bcc9
-    # via -r requirements/dev.in
-pyproject-hooks==1.0.0 \
-    --hash=sha256:283c11acd6b928d2f6a7c73fa0d01cb2bdc5f07c57a2eeb6e83d5e56b97976f8 \
-    --hash=sha256:f271b298b97f5955d53fb12b72c1fb1948c22c1a6b70b315c54cedaca0264ef5
-    # via
-    #   build
-    #   pip-tools
 sqlparse==0.4.4 \
     --hash=sha256:5430a4fe2ac7d0f93e66f1efc6e1338a41884b7ddf2a350cedd20ccc4d9d28f3 \
     --hash=sha256:d446183e84b8349fa3061f0fe7f06ca94ba65b426946ffebe6e3e8295332420c
@@ -60,13 +36,3 @@ sqlparse==0.4.4 \
     #   -c requirements/default.txt
     #   django
     #   django-debug-toolbar
-wheel==0.43.0 \
-    --hash=sha256:465ef92c69fa5c5da2d1cf8ac40559a8c940886afcef87dcf14b9470862f1d85 \
-    --hash=sha256:55c570405f142630c6b9f72fe09d9b67cf1477fcf543ae5b8dcb1f5b7377da81
-    # via pip-tools
-
-# WARNING: The following packages were not pinned, but pip requires them to be
-# pinned when the requirements file includes hashes and the requirement is not
-# satisfied by a package already installed. Consider using the --allow-unsafe flag.
-# pip
-# setuptools
diff --git a/requirements/lint.in b/requirements/lint.in
index 5a507e99e6..fbc491416c 100644
--- a/requirements/lint.in
+++ b/requirements/lint.in
@@ -14,4 +14,4 @@
 # The dependencies are sorted by alphabetical order.
 # Dependencies that do not come from pypi (eg. eggs from github) are listed at the end of the list.
 # -------------------------------------------------------------------------------------------------
-ruff==0.4.6
+ruff==0.6.4
diff --git a/requirements/lint.txt b/requirements/lint.txt
index 91050b92a4..ec2dd749db 100644
--- a/requirements/lint.txt
+++ b/requirements/lint.txt
@@ -4,22 +4,23 @@
 #
 #    ./docker/compile_requirements.sh
 #
-ruff==0.4.6 \
-    --hash=sha256:04a80acfc862e0e1630c8b738e70dcca03f350bad9e106968a8108379e12b31f \
-    --hash=sha256:0cf5cc02d3ae52dfb0c8a946eb7a1d6ffe4d91846ffc8ce388baa8f627e3bd50 \
-    --hash=sha256:1fa8561489fadf483ffbb091ea94b9c39a00ed63efacd426aae2f197a45e67fc \
-    --hash=sha256:1ff930d6e05f444090a0139e4e13e1e2e1f02bd51bb4547734823c760c621e79 \
-    --hash=sha256:3a6a0a4f4b5f54fff7c860010ab3dd81425445e37d35701a965c0248819dde7a \
-    --hash=sha256:3f9ced5cbb7510fd7525448eeb204e0a22cabb6e99a3cb160272262817d49786 \
-    --hash=sha256:4d5b914818d8047270308fe3e85d9d7f4a31ec86c6475c9f418fbd1624d198e0 \
-    --hash=sha256:4f02284335c766678778475e7698b7ab83abaf2f9ff0554a07b6f28df3b5c259 \
-    --hash=sha256:602ebd7ad909eab6e7da65d3c091547781bb06f5f826974a53dbe563d357e53c \
-    --hash=sha256:735a16407a1a8f58e4c5b913ad6102722e80b562dd17acb88887685ff6f20cf6 \
-    --hash=sha256:9018bf59b3aa8ad4fba2b1dc0299a6e4e60a4c3bc62bbeaea222679865453062 \
-    --hash=sha256:a769ae07ac74ff1a019d6bd529426427c3e30d75bdf1e08bb3d46ac8f417326a \
-    --hash=sha256:a797a87da50603f71e6d0765282098245aca6e3b94b7c17473115167d8dfb0b7 \
-    --hash=sha256:be47700ecb004dfa3fd4dcdddf7322d4e632de3c06cd05329d69c45c0280e618 \
-    --hash=sha256:ea3424793c29906407e3cf417f28fc33f689dacbbadfb52b7e9a809dd535dcef \
-    --hash=sha256:ef995583a038cd4a7edf1422c9e19118e2511b8ba0b015861b4abd26ec5367c5 \
-    --hash=sha256:f13410aabd3b5776f9c5699f42b37a3a348d65498c4310589bc6e5c548dc8a2f
+ruff==0.6.4 \
+    --hash=sha256:0308610470fcc82969082fc83c76c0d362f562e2f0cdab0586516f03a4e06ec6 \
+    --hash=sha256:0b52387d3289ccd227b62102c24714ed75fbba0b16ecc69a923a37e3b5e0aaaa \
+    --hash=sha256:0ea086601b22dc5e7693a78f3fcfc460cceabfdf3bdc36dc898792aba48fbad6 \
+    --hash=sha256:34d5efad480193c046c86608dbba2bccdc1c5fd11950fb271f8086e0c763a5d1 \
+    --hash=sha256:50e30b437cebef547bd5c3edf9ce81343e5dd7c737cb36ccb4fe83573f3d392e \
+    --hash=sha256:549daccee5227282289390b0222d0fbee0275d1db6d514550d65420053021a58 \
+    --hash=sha256:66dbfea86b663baab8fcae56c59f190caba9398df1488164e2df53e216248baa \
+    --hash=sha256:7862f42fc1a4aca1ea3ffe8a11f67819d183a5693b228f0bb3a531f5e40336fc \
+    --hash=sha256:803b96dea21795a6c9d5bfa9e96127cc9c31a1987802ca68f35e5c95aed3fc0d \
+    --hash=sha256:932063a03bac394866683e15710c25b8690ccdca1cf192b9a98260332ca93408 \
+    --hash=sha256:ac3b5bfbee99973f80aa1b7cbd1c9cbce200883bdd067300c22a6cc1c7fba212 \
+    --hash=sha256:ac4b75e898ed189b3708c9ab3fc70b79a433219e1e87193b4f2b77251d058d14 \
+    --hash=sha256:bedff9e4f004dad5f7f76a9d39c4ca98af526c9b1695068198b3bda8c085ef60 \
+    --hash=sha256:c44536df7b93a587de690e124b89bd47306fddd59398a0fb12afd6133c7b3818 \
+    --hash=sha256:c4b153fc152af51855458e79e835fb6b933032921756cec9af7d0ba2aa01a258 \
+    --hash=sha256:d02a4127a86de23002e694d7ff19f905c51e338c72d8e09b56bfb60e1681724f \
+    --hash=sha256:eebe4ff1967c838a1a9618a5a59a3b0a00406f8d7eefee97c70411fefc353617 \
+    --hash=sha256:f0f8968feea5ce3777c0d8365653d5e91c40c31a81d95824ba61d871a11b8523
     # via -r requirements/lint.in