bnf.json

{"FUSIDIC ACID": {"name": "FUSIDIC ACID", "doses": ["See under preparation below"]}, "SODIUM VALPROATE": {"name": "SODIUM VALPROATE", "doses": ["epilepsy, adult and child, as above, total daily dose given in 2\u20134 divided\r\ndoses"]}, "DESMOPRESSIN": {"name": "DESMOPRESSIN", "doses": ["By mouth (as desmopressin acetate)", "Diabetes insipidus, treatment, adult and child initially 300\u00a0micrograms\r\ndaily (in 3 divided doses); maintenance, 300\u2013600\u00a0micrograms daily\r\nin 3 divided doses; range 0.2\u20131.2\u00a0mg daily", "Primary nocturnal enuresis, adult (under\r\n65 years) and child over 5 years 200\u00a0micrograms\r\nat bedtime, only increased to 400\u00a0micrograms if lower dose not effective\r\n(important: see also Cautions); withdraw for at least\r\n1 week for reassessment after 3 months", "Postoperative polyuria or polydipsia, adjust dose according\r\nto urine osmolality", "Sublingually (as desmopressin base)", "Diabetes insipidus, treatment, adult and child initially 180\u00a0micrograms\r\ndaily in 3 divided doses; range 120\u2013720\u00a0micrograms daily", "Primary nocturnal enuresis, adult (under 65 years) and child over 5\r\nyears 120\u00a0micrograms at bedtime, only increased to 240\u00a0micrograms\r\nif lower dose not effective (important: see also\r\nCautions); withdraw for at least 1 week for reassessment after 3 months", "Polyuria or polydipsia after hypophysectomy, adjust dose according\r\nto urine osmolality", "Intranasally (as desmopressin acetate)", "Diabetes insipidus, diagnosis, adult and child 20\u00a0micrograms (limit fluid\r\nintake to 500\u00a0mL from 1 hour before to 8 hours after administration)", "Diabetes insipidus, treatment, adult 10\u201340\u00a0micrograms daily (in 1\u20132 divided doses); child 5\u201320\u00a0micrograms daily; infants may require lower doses", "Nocturia associated with multiple sclerosis (when other treatments\r\nhave failed), adult (under 65 years)\r\n10\u201320\u00a0micrograms at bedtime (important: see also\r\nCautions), dose not to be repeated within 24 hours", "Renal function testing (empty bladder at time of administration\r\nand limit fluid intake to 500\u00a0mL from 1 hour before until 8 hours\r\nafter administration), adult 40\u00a0micrograms; infant under 1 year 10\u00a0micrograms (restrict fluid\r\nintake to 50% at next 2 feeds to avoid fluid overload), child 1\u201315\u00a0years 20\u00a0micrograms", "Mild to moderate haemophilia and von Willebrand\u2019s disease, adult 300\u00a0micrograms (one 150-microgram spray into\r\neach nostril) 30 minutes before surgery or when bleeding; may be repeated\r\nat intervals of 12 hours (or at intervals of at least 3 days if self-administered)", "Fibrinolytic response testing, adult 300\u00a0micrograms (one 150-microgram spray into each nostril); blood\r\nsampled after 1 hour for fibrinolytic activity", "By injection (as desmopressin acetate)", "Diabetes insipidus, diagnosis (subcutaneous or intramuscular), adult and child 2\u00a0micrograms (limit fluid\r\nintake to 500\u00a0mL from 1 hour before to 8 hours after administration)", "Diabetes insipidus, treatment (subcutaneous, intramuscular or intravenous), adult 1\u20134\u00a0micrograms daily; infant and child 400\u00a0nanograms", "Renal function testing (empty bladder at time of administration\r\nand limit fluid intake to 500\u00a0mL from 1 hour before until 8 hours\r\nafter administration) (subcutaneous or intramuscular), adult and child 2\u00a0micrograms; infant 400\u00a0nanograms (restrict fluid intake to 50%\r\nat next 2 feeds)", "Mild to moderate haemophilia and  von Willebrand\u2019s disease, (subcutaneous or intravenous), adult and child over 1 month 300\u00a0nanograms/kg as a single dose immediately before\r\nsurgery or after trauma; may be repeated at intervals of 12 hours", "Fibrinolytic response testing, (subcutaneous or intravenous), adult and child 300\u00a0nanograms/kg; blood\r\nsampled after 20 minutes for fibrinolytic activity", "Lumbar-puncture-associated headache, consult product literature"]}, "CLONAZEPAM": {"name": "CLONAZEPAM", "doses": ["1\u00a0mg (elderly 500\u00a0micrograms)\r\ninitially at night for 4 nights, increased according to response over\r\n2\u20134 weeks to usual maintenance dose of 4\u20138\u00a0mg usually at night (may\r\nbe given in 3\u20134 divided doses if necessary); child up to 1 year, initially 250\u00a0micrograms increased as above to usual\r\nmaintenance dose of 0.5\u20131\u00a0mg, 1\u20135 years, initially 250\u00a0micrograms\r\nincreased as above to 1\u20133\u00a0mg, 5\u201312 years, initially 500\u00a0micrograms\r\nincreased as above to 3\u20136\u00a0mg", "Clonazepam doses in BNF may differ from those\r\nin product literature"]}, "PALIFERMIN": {"name": "PALIFERMIN", "doses": ["By intravenous injection, 60\u00a0micrograms/kg\r\nonce daily for 3 doses (third dose given 24\u201348 hours before myeloablative\r\ntherapy) then 3 further doses at least 24 hours after myeloablative\r\ntherapy, and more than 4 days after most recent palifermin\r\ninjection, starting on same day as (but after) stem-cell infusion; child not recommended"]}, "CO-BENELDOPA": {"name": "CO-BENELDOPA", "doses": ["Expressed as levodopa, initially 50\u00a0mg\r\n3\u20134 times daily (100\u00a0mg 3 times daily in advanced disease), increased\r\nby 100\u00a0mg daily once or twice weekly according to response; usual\r\nmaintenance dose 400\u2013800\u00a0mg daily in divided doses; elderly initially 50\u00a0mg once or twice daily, increased\r\nby 50\u00a0mg daily every 3\u20134 days according to response", "When transferring patients from another levodopa/dopa-decarboxylase\r\ninhibitor preparation, the previous preparation should be discontinued\r\n12 hours before (although interval can be shorter)", "When administered as an adjunct to other\r\nantiparkinsonian drugs, once therapeutic effect apparent, the other\r\ndrugs may be reduced or withdrawn", "When switching from modified-release levodopa\r\nto dispersible co-beneldopa, reduce dose by approx. 30%"]}, "BUPROPION HYDROCHLORIDE": {"name": "BUPROPION HYDROCHLORIDE", "doses": ["adult over 18 years, start\r\n1\u20132 weeks before target stop date, initially 150\u00a0mg daily for 6 days\r\nthen 150\u00a0mg twice daily (max. single dose 150\u00a0mg, max. daily dose\r\n300\u00a0mg; minimum 8 hours between doses); period of treatment 7\u20139 weeks;\r\ndiscontinue if abstinence not achieved at 7 weeks; consider max. 150\u00a0mg\r\ndaily in patients with risk factors for seizures; elderly max. 150\u00a0mg daily"]}, "SALBUTAMOL": {"name": "SALBUTAMOL", "doses": ["By intravenous infusion, initially 10\u00a0micrograms/minute,\r\nrate increased gradually according to response at 10-minute intervals\r\nuntil contractions diminish then increase rate slowly until contractions\r\ncease (max. rate 45\u00a0micrograms/minute); maintain rate for 1\u00a0hour after\r\ncontractions have stopped, then gradually reduce by 50% every 6\u00a0hours;\r\nthen by mouth (but see notes above), 4\u00a0mg every 6\u20138\u00a0hours"]}, "PARACETAMOL": {"name": "PARACETAMOL", "doses": ["2 tablets not more often than every 6 hours; max. 8 tablets\r\ndaily; child under 12 years not recommended"]}, "SODIUM FUSIDATE": {"name": "SODIUM FUSIDATE", "doses": ["as fusidic acid, adult 750\u00a0mg every 8 hours; child up to\r\n1 year 50\u00a0mg/kg daily (in 3 divided doses), 1\u20135 years 250\u00a0mg every\r\n8 hours, 5\u201312 years 500\u00a0mg every 8 hours"]}, "DEXAMETHASONE": {"name": "DEXAMETHASONE", "doses": ["adult and child over 2 years, apply 1 metered\r\nspray 3 times daily"]}}