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mitochondrial disulfide relay system (GO:0160203) #8

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ValWood opened this issue Nov 4, 2024 · 1 comment
Open

mitochondrial disulfide relay system (GO:0160203) #8

ValWood opened this issue Nov 4, 2024 · 1 comment

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@ValWood
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ValWood commented Nov 4, 2024

Aif1 currently "conserved unknown" (I can't find the evidence for this?)
erv1 (only has protein folding) (Asked SGD to make more specific for ISS)

https://www.uniprot.org/uniprotkb/O95831/entry is over-annotated

@hattrill
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For D.mel we have the MITOCHONDRIAL DISULFIDE RELAY SYTEM gene group:

FBgn0031392 Apoptosis inducing factor AIF
FBgn0031068 Augmenter of liver regeneration Alr
FBgn0260468 Mitochondrial intermembrane space Import and Assembly 40 Mia40

Curated from PMID: 32936885 "AIF is a component of the MIA disulfide relay-dependent import pathway (Meyer et al., 2015; Hangen et al., 2015; Modjtahedi and Kroemer, 2016). Other primary components of this pathway are the oxidoreductase Mia40/CHCHD4 and the sulfhydryl oxidase Erv1/ALR (Hell, 2008). Drosophila orthologues of Mia40 and Erv1 are CG7950 and CG12534"

Fly Human cerevisiae pombe
Alr GFER ERV1 erv1
AIF AIFM1 AIF1 aif1
Mia40 CHCHD4 MIA40 tim40

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