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authors.yml
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Thomas Morrison:
suffix: PhD
links:
publications: https://scholar.google.com/citations?user=ljkm0eMAAAAJ&hl=en&oi=ao
website: https://medschool.cuanschutz.edu/immunology-and-microbiology/immu-micro-labs/morrison-lab
email: mailto:[email protected]
project: project-1
bio: My laboratory investigates mechanisms of infectious disease pathogenesis and
immunity. We use genetic, molecular, cellular, and immunological approaches to
define molecular mechanisms of pathogenesis, to elucidate immunological mechanisms
that dictate viral clearance, including antibodies and B cells, and to evaluate
novel therapeutic interventions. My laboratory has developed mouse models of chikungunya
virus (CHIKV) and Ross River virus (RRV)-induced rheumatic disease that recapitulate
important aspects of acute and chronic CHIKV and RRV disease in humans. In addition,
we also investigate mechanisms of neurological disease associated with neurotropic
viruses such as Venezuelan equine encephalitis virus (VEEV), West Nile virus,
and Zika virus. I also have extensive experience working with human coronaviruses
and other highly pathogenic respiratory viruses.
image: /images/thomas-morrison.png
Beth Tamburini:
suffix: PhD
links:
publications: https://orcid.org/0000-0003-1991-231X
website: https://medschool.cuanschutz.edu/gastroenterology/research/research-laboratories/beth-jiron-tamburini-lab
email: mailto:[email protected]
project:
- project-2
bio: The overarching goal of my research program is to understand how the lymphatic
stroma recognize and react to stimuli within the lymph to guide the immune response.
My initial studies of lymphatic stroma were focused on understanding the mechanisms
by which lymphatic endothelial cells acquire and retain antigens as well as recruit
and interact with immune cells in different organs. Currently my research program
is focused on understanding the immunologic consequence of interaction between
lymphatic stroma and components of the immune system within different organ systems.
We have been working to dissect how the lymphatics respond to stimuli such as
proteins, small molecules, fat, cholesterol, alcohol, infectious material and
cytokine. We have experience with a number of techniques including flow cytometry,
immunohistochemistry, immunofluorescence, live molecular imaging, and a number
of therapeutic treatments to target and identify lymphatic endothelial cells as
well as experience in several mouse models and assays. In addition, my expertise
and the expertise of a wide range of collaborators at the University of Colorado
in the fields of Gastroenterology, Hepatology and Immunology have been critical
in developing this research program. This collaborative research program as proven
to be well suited for the training and success of the graduate students and post-docs
in my laboratory.
image: /images/beth-tamburini.jpg
Jay Hesselberth:
suffix: PhD
links:
publications: https://scholar.google.com/citations?user=EnOmNEYAAAAJ
website: https://hesselberthlab.org/
email: mailto:[email protected]
project:
- project-3
- core-c
bio: I am an RNA biochemist and computational biologist with extensive experience
in developing new high- throughput methods and associated bioinformatic analysis
software. My RNA biology program spans classical and modern approaches to address
outstanding questions in RNA damage and repair. Over the past ten years my group
has developed new sequencing approaches to identify damaged RNAs and new model
systems with which to understand the causes and consequences of RNA damage. Our
studies have led to new concepts in post-transcriptional regulation that have
broad implications for understanding the role of RNA damage in biology. Recently
we have been focused on understanding how RNA damage and repair events are coupled
to control RNA fate after stress-induced RNA cleavage.
More recently, we have applied nanopore RNA sequencing to characterize
the landscape of RNA repair events in budding yeast.
image: /images/jay-hesselberth.png
Ryan Sheridan:
suffix: PhD
links:
publications: https://orcid.org/0000-0003-4012-3147
website: https://github.com/sheridar
email: mailto:[email protected]
project: core-c
Jennifer Matsuda:
suffix: PhD
links:
publications: https://scholar.google.com/citations?user=xNd-F7YAAAAJ
email: mailto:[email protected]
project: core-b
bio: 'In 2008, following my graduate studies and post-doctoral training, I became
the Director of the Mouse Genetics Core Facility at National Jewish Health. Given
my years at the bench, it was critical to me that the facility I established enabled
all investigators, regardless of prior experience, with the support necessary
to make mouse models. To this end, in addition to classic services like ES cell
targeting, blastocyst and pronuclear microinjections, embryo and sperm cryopreservation,
in vitro fertilization, and rederivation, we have developed additional areas of
expertise. We generate complex DNA constructs, using BAC recombineering, markerless
recombineering, and classic cloning methodologies. We also train graduate students
and post-doctoral fellows in our laboratory to make their own constructs. We have
also gained the expertise to identify homologous recombinant ES cell clones by
Loss of Allele (LOA). In addition, we successfully use engineered nucleases (ZFNs,
TALENs, and more recently CRISPR/Cas9) to generate knockout mice by NHEJ as well
as relying upon homology directed repair (HDR) to introduce genetic modifications.
This technology has been further improved upon by our capacity to make mouse models
directly on a variety of backgrounds by using IVF, including but not limited to:
C57BL/6, FVB, NOD, 129S4, and NSGS backgrounds as well genetically modified strains
of mice. Due to the core''s consistently high quality of work, we have recently
been designated as the Regional Mouse Genetics Core Facility to support investigators
at the University of Colorado Denver, in addition to the investigators at NJH.'
image: /images/jennifer-matsuda.jpeg
Frances Li:
links:
publications: https://orcid.org/0000-0001-8798-8290
Erin Lucas:
links:
publications: http://orcid.org/0000-0001-7705-2069
Shannon Walsh: []
Thu Doan: []
Brian Ware: []
Johnathon Schafer: []
Rui Fu: []
Matthew Burchill: []
Ross Kedl: []
Robin Lindsay: []
Jeffrey Finlon: []
Rachel Friedman: []
Kathryn Carpentier: []
Cormac Lucas: []
Bennett Davenport: []
Mary McCarthy: []
Glennys Reynoso: []
Nicholas May: []
Heather Hickman: []
Tadg Forward: []
Aspen Martin: []
Susan Elmore: []
Tonya Colpitts: []
Austin Gillen: []
Michael Kriss: []
Kent Riemondy: []
Ronald Schuyler: []
Hugo Rosen: []
Madison Kraus: []
Ira Fleming: []
Aspen Uecker-Martin: []
Ju-Sim Kim: []
Lin Liu: []
Sashi Kant: []
David Orlicky: []
Siva Uppalapati: []
Alyssa Margolis: []
Michael McClelland: []
Jessica Jones-Carson: []
Andres Vazquez-Torres: []