diff --git a/src/background/modules/AutoRemoteFollow.js b/src/background/modules/AutoRemoteFollow.js
index efba3bf..b06a5be 100644
--- a/src/background/modules/AutoRemoteFollow.js
+++ b/src/background/modules/AutoRemoteFollow.js
@@ -155,8 +155,8 @@ async function onTabUpdate(tabId, changeInfo) {
     const ownMastodon = await AddonSettings.get("ownMastodon");
     const currentURL = new URL(changeInfo.url);
     if (ownMastodon.server !== currentURL.hostname){
-        browser.tabs.executeScript({
-            file: "/content_script/mastodonInject.js"
+        browser.tabs.executeScript(tabId, {
+            file: "/content_script/mastodonInject.js",
         });
     }
 }
diff --git a/src/content_script/mastodonInject.js b/src/content_script/mastodonInject.js
index ee1c5d7..64a3572 100644
--- a/src/content_script/mastodonInject.js
+++ b/src/content_script/mastodonInject.js
@@ -1,7 +1,5 @@
 "use strict";
 
-const TIMEOUT_DURATION = 20000;
-
 /**
  * Replacement onClick handler for Follow button.
  * 
@@ -26,10 +24,14 @@ function onClickInteract(event) {
     event.stopPropagation();
     event.preventDefault();
     const articleElement = event.target.closest("article[data-id]");
+    const getId = () => {
+        const rawId = articleElement.getAttribute("data-id");
+        return rawId.slice(0, 2) === "f-" ? rawId.slice(2) : rawId;
+    };
     const tootId = (
         articleElement === null
             ? window.location.pathname.split("/").slice(-1)[0]
-            : articleElement.getAttribute("data-id")
+            : getId()
     );
     // activate AutoRemoteFollow
     window.open(`/interact/${tootId}`, "_blank");
@@ -40,12 +42,12 @@ function onClickInteract(event) {
  * 
  * @param {string} selector
  * @param {boolean} [multiple=false]
- * @param {number} timeoutDuration
+ * @param {number} [timeoutDuration=200000]
  * @see {@link https://github.com/storybookjs/test-runner/blob/6d41927154e8dd1e4c9e7493122e24e2739a7a0f/src/setup-page.ts#L134}
  *  from which this was adapted
  * @returns {Promise}
  */
-function waitForElement(selector, multiple = false, timeoutDuration) {
+function waitForElement(selector, multiple = false, timeoutDuration = 200000) {
     return new Promise((resolve, reject) => {
         const getElement = () => (
             multiple
@@ -59,14 +61,14 @@ function waitForElement(selector, multiple = false, timeoutDuration) {
         }, timeoutDuration);
 
         const element = getElement();
-        if (isElementFound(element)){
+        if (isElementFound(element)) {
             window.clearTimeout(timeout);
             return resolve(element);
         }
 
         const observer = new MutationObserver(() => {
             const element = getElement();
-            if (isElementFound(element)){
+            if (isElementFound(element)) {
                 window.clearTimeout(timeout);
                 resolve(element);
                 observer.disconnect();
@@ -79,7 +81,7 @@ function waitForElement(selector, multiple = false, timeoutDuration) {
         });
 
         return null;
-    }); 
+    });
 }
 
 /**
@@ -89,7 +91,7 @@ function waitForElement(selector, multiple = false, timeoutDuration) {
  */
 async function injectFollowButton() {
     try {
-        const followButton = await waitForElement("#mastodon .account__header__tabs__buttons button:first-of-type", false, TIMEOUT_DURATION);
+        const followButton = await waitForElement("#mastodon .account__header__tabs__buttons button:first-of-type", false);
         followButton.addEventListener("click", onClickFollow);
     } catch (error) {
         // Follow button failed to appear
@@ -103,22 +105,30 @@ async function injectFollowButton() {
  */
 async function injectInteractionButtons() {
     const INJECTED_REPLY_CLASS = "mastodon-simplified-federation-injected-interaction";
-    const replyButtons = await waitForElement(
-        "#mastodon .item-list[role='feed'] article[data-id] .status__action-bar button," +
-        "#mastodon .detailed-status__wrapper .detailed-status__action-bar button",
-        true,
-        TIMEOUT_DURATION,
-    );
-    replyButtons.forEach((button) => {
-        try {
-            if (!button.classList.contains(INJECTED_REPLY_CLASS)){
-                button.addEventListener("click", onClickInteract);
-                button.classList.add(INJECTED_REPLY_CLASS);
+    const TIMELINE_SELECTOR = "#mastodon .item-list[role='feed'] article[data-id] .status__action-bar button"; // timeline / user profile
+    const STATUS_NO_REPLIES_SELECTOR = "#mastodon .detailed-status__wrapper .detailed-status__action-bar button"; // status with no replies
+    const STATUS_WITH_REPLIES_SELECTOR = "#mastodon .status__wrapper .status__action-bar button"; // status with replies
+    try {
+        const replyButtons = await waitForElement([
+            TIMELINE_SELECTOR,
+            STATUS_NO_REPLIES_SELECTOR,
+            STATUS_WITH_REPLIES_SELECTOR,
+        ].join(","), true,);
+        replyButtons.forEach((button) => {
+            try {
+                if (!button.classList.contains(INJECTED_REPLY_CLASS)) {
+                    button.addEventListener("click", onClickInteract);
+                    button.classList.add(INJECTED_REPLY_CLASS);
+                }
+            } catch (error) {
+                // Failed to inject interaction buttons
             }
-        } catch (error) {
-            // Interaction buttons failed to appear
-        }
-    });
+        });
+    } catch (error) {
+        // Interaction buttons failed to appear
+    }
+
+
 }
 
 /**
@@ -126,23 +136,40 @@ async function injectInteractionButtons() {
  * 
  * @returns {void}
  */
+function initInjections() {
+    injectFollowButton().catch(console.error);
+    injectInteractionButtons().catch(console.error);
+}
+
+/**
+ * Initialise script and re-run if there are changes.
+ * 
+ * @returns {void}
+ */
 async function init() {
-    injectFollowButton();
+    const MASTODON_INJECTED_CLASS = "mastodon-simplified-federation-injected";
+
+    if (document.body.classList.contains(MASTODON_INJECTED_CLASS)) {
+        // init has already run
+        return;
+    }
+
+    document.body.classList.add(MASTODON_INJECTED_CLASS);
+    initInjections();
 
     const observer = new MutationObserver(() => {
-        Promise.allSettled([
-            injectInteractionButtons(),
-        ]);
+        initInjections();
     });
 
-    const feedElement = await waitForElement(
-        "#mastodon .item-list[role='feed']",
+    // monitor only the main column in the Mastodon UI
+    const mainColumn = await waitForElement(
+        "#mastodon .ui",
         false,
-        TIMEOUT_DURATION
     );
-    observer.observe(feedElement, {
-        childList: true, subtree: true,
+    observer.observe(mainColumn, {
+        childList: true,
+        subtree: true,
     });
 }
 
-init();
\ No newline at end of file
+init().catch(console.error);
\ No newline at end of file