Radmeth Merge DMR Criterion

[SDeans0]

Hi,

Thanks for making such an approachable tool.

I was wondering about the exact criteria for calling a DMR in radmeth merge. I noticed in the code that at least one of the sites in the DMR is required to have been significant at the set FDR cutoff level before adjustment and multiple test correction. I was wondering if you could tell me more about the rationale for this - I can see that it would be more stringent, but I don't really get what the properties of this are.

Relatedly, are there other DMR-calling criteria that you have tried on radmeth regression output with FDR correction?