diff --git a/compiler/defer.go b/compiler/defer.go
index df8686957a..677df8f2a1 100644
--- a/compiler/defer.go
+++ b/compiler/defer.go
@@ -16,6 +16,7 @@ package compiler
 import (
 	"go/types"
 	"strconv"
+	"strings"
 
 	"github.com/tinygo-org/tinygo/compiler/llvmutil"
 	"golang.org/x/tools/go/ssa"
@@ -198,7 +199,13 @@ jal 1f
 addiu $$ra, 8
 sw $$ra, 4($$5)
 .set at`
-		constraints = "={$4},{$5},~{$1},~{$2},~{$3},~{$5},~{$6},~{$7},~{$8},~{$9},~{$10},~{$11},~{$12},~{$13},~{$14},~{$15},~{$16},~{$17},~{$18},~{$19},~{$20},~{$21},~{$22},~{$23},~{$24},~{$25},~{$26},~{$27},~{$28},~{$29},~{$30},~{$31},~{$f0},~{$f1},~{$f2},~{$f3},~{$f4},~{$f5},~{$f6},~{$f7},~{$f8},~{$f9},~{$f10},~{$f11},~{$f12},~{$f13},~{$f14},~{$f15},~{$f16},~{$f17},~{$f18},~{$f19},~{$f20},~{$f21},~{$f22},~{$f23},~{$f24},~{$f25},~{$f26},~{$f27},~{$f28},~{$f29},~{$f30},~{$f31},~{memory}"
+		constraints = "={$4},{$5},~{$1},~{$2},~{$3},~{$5},~{$6},~{$7},~{$8},~{$9},~{$10},~{$11},~{$12},~{$13},~{$14},~{$15},~{$16},~{$17},~{$18},~{$19},~{$20},~{$21},~{$22},~{$23},~{$24},~{$25},~{$26},~{$27},~{$28},~{$29},~{$30},~{$31},~{memory}"
+		if !strings.Contains(b.Features, "+soft-float") {
+			// Using floating point registers together with GOMIPS=softfloat
+			// results in a crash: "This value type is not natively supported!"
+			// So only add them when using hardfloat.
+			constraints += ",~{$f0},~{$f1},~{$f2},~{$f3},~{$f4},~{$f5},~{$f6},~{$f7},~{$f8},~{$f9},~{$f10},~{$f11},~{$f12},~{$f13},~{$f14},~{$f15},~{$f16},~{$f17},~{$f18},~{$f19},~{$f20},~{$f21},~{$f22},~{$f23},~{$f24},~{$f25},~{$f26},~{$f27},~{$f28},~{$f29},~{$f30},~{$f31}"
+		}
 	case "riscv32":
 		asmString = `
 la a2, 1f