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lxw391 authored Mar 14, 2022
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Expand Up @@ -6,7 +6,7 @@ Tiago C. Silva, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Xi Chen, Ed

This github repository includes scripts used for the analyses in the above manuscript.

In this work, we performed a sex-specific meta-analysis of two large independent blood-based epigenome-wide association studies, the ADNI and AIBL studies, with a total of 1284 whole blood samples (633 female samples and 651 male samples). Furthermore, to identify blood-based DNA methylation markers that also change with underlying neuropathology in the brain, we next performed a cross-tissue meta-analysis by combining these blood DNA methylation datasets with four additional DNA methylation datasets, which included a total of 1,030 prefrontal cortex brain samples (642 female samples and 388 male samples). Our findings provide a useful resource for future biomarker studies in AD.
In this work, we performed a sex-specific meta-analysis of two large independent blood-based epigenome-wide association studies, the ADNI and AIBL studies (see references below), with a total of 1284 whole blood samples (633 female samples and 651 male samples). Furthermore, to identify blood-based DNA methylation markers that also change with underlying neuropathology in the brain, we next performed a cross-tissue meta-analysis by combining these blood DNA methylation datasets with four additional DNA methylation datasets, which included a total of 1,030 prefrontal cortex brain samples (642 female samples and 388 male samples). Our findings provide a useful resource for future biomarker studies in AD.

### 1. Study cohorts, Preprocessing of DNA methylation data, Single Cohort analysis

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