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Literature: ACE2

Jakke Neiro edited this page Apr 5, 2020 · 6 revisions

Add here literature on ACE2 and your summary of it:

1. SARS-CoV-2 and ACE2 interaction

1.1 Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(Biochemical and Biophysical Research Communications, 19 March)

  • ACE2 is expressed in lung, liver, stomach, ileum, kidney and colon.
  • ANPEP, DPP4 and ENPEP were identified as the candidate co-receptors, showing the most similar expression patterns with ACE2
  • Methods: single cell gene expression atlas including 119 cell types of 13 human tissues: GEO or Human Cell Atlas
  • Analyzed 51 reported RNA virus receptors
  • ANPEP and DPP4 known receptors for human CoVs

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3. ACE2 expression

3.1 ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy