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Novel Diagnostic Model in Rheumatoid Arthritis

Collabrated with Peking University People's Hospital, we built diagnostic model for Rheumatoid Arthritis (RA) based on protein array. With 44 selected autoantibodies as markers, the model has achieved high accuracy (AUC=0.86, Specificity=0.9, Sensitivity=0.68). Here, we provided the model and script for RA prediction.

Dependencies

  • python3
  • numpy
  • sklearn
  • pickle
  • pandas

Usage

git clone https://github.com/gao-lab/RA_prediction.git

python RA_prediction.py example.txt output.txt

*Both input file and output file are REQUIRED.

Input

See example.txt. The first row is the patient IDs and should be started with "#". The first column is the IDs of the autoantibody markers (RFE.select.ids). Note that the autoantibody expression value in protein array shoulde be with the same rank with RFE.select.ids.

Contact

Yu-Jian Kang <[email protected]>

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Model for RA prediction

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