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Analyses were conducted using the R Statistical language (version 3.6.3; R Core Team, 2020) on macOS 10.16, using the packages voronoiTreemap (version 0.2.1; Alexander Kowarik et al., 2021), cowplot (version 1.1.1; Claus Wilke, 2020), ggsignif (version 0.6.1; Constantin Ahlmann-Eltze and Indrajeet Patil, 2021), igraph (version 1.2.6; Csardi G, Nepusz T: The igraph software package for complex network research, InterJournal, Complex Systems 1695. 2006. https://igraph.org), hexbin (version 1.28.2; Dan Carr et al., 2021), RColorBrewer (version 1.1.2; Erich Neuwirth, 2014), S4Vectors (version 0.24.4; Pagès, Lawrence and Aboyoun, 2020), ggplot2 (version 3.3.3; Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016.), reshape2 (version 1.4.4; Hadley Wickham, 2007), stringr (version 1.4.0; Hadley Wickham, 2019), tidyr (version 1.1.2; Hadley Wickham, 2020), forcats (version 0.5.1; Hadley Wickham, 2021), scales (version 1.1.1; Hadley Wickham and Dana Seidel, 2020), readr (version 1.4.0; Hadley Wickham and Jim Hester, 2020), dplyr (version 1.0.4; Hadley Wickham et al., 2021), AnnotationDbi (version 1.48.0; Hervé Pagès et al., 2019), ggforestplot (version 0.1.0; Ilari Scheinin et al., 2021), rmarkdown (version 2.7; JJ Allaire and Yihui Xie and Jonathan McPherson and Javier Luraschi and Kevin Ushey and Aron Atkins and Hadley Wickham and Joe Cheng and Winston Chang and Richard Iannone, 2021), ggrepel (version 0.9.1; Kamil Slowikowski, 2021), tibble (version 3.1.0; Kirill Müller and Hadley Wickham, 2021), IRanges (version 2.20.2; Lawrence M et al., 2013), purrr (version 0.3.4; Lionel Henry and Hadley Wickham, 2020), report (version 0.3.0; Makowski et al., 2020), org.Hs.eg.db (version 3.10.0; Marc Carlson, 2019), treemap (version 2.4.2; Martijn Tennekes, 2017), Biobase (version 2.46.0; Orchestrating high-throughput genomic analysis with Bioconductor. Huber, V.Carey, Gentleman, ..., Morgan Nature Methods, 2015:12, 115.), BiocGenerics (version 0.32.0; Orchestrating high-throughput genomic analysis with Bioconductor. Huber, V.Carey, Gentleman, ..., Morgan Nature Methods, 2015:12, 115.), ggstatsplot (version 0.7.0; Patil, 2018), pacman (version 0.5.1; Rinker et al., 2017), ggforce (version 0.3.2; Thomas Lin Pedersen, 2020), ggraph (version 2.0.4; Thomas Lin Pedersen, 2020), patchwork (version 1.1.1; Thomas Lin Pedersen, 2020), tidygraph (version 1.2.0; Thomas Lin Pedersen, 2020), MASS (version 7.3.53; Venables et al., 2002), tidyverse (version 1.3.0; Wickham et al., 2019), pROC (version 1.17.0.1; Xavier Robin et al., 2011) and knitr (version 1.31; Yihui Xie, 2021).

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