UniDec Version 4.1.0

Version 4.1.0 UniDec.

Please cite Marty et al. Anal. Chem. 2015. DOI: 10.1021/acs.analchem.5b00140 if you use UniDec in publications.

Check out a video tutorial: https://www.youtube.com/watch?v=e33JxgY6CJY

Installation Instructions: Download the zip file and extract it to a convenient location. Click on "GUI_UniDec.exe". The software should then run with no additional installation. It is a self-contained package. Note, this compiled version will only run on Windows.

It is possible to build and run UniDec on Linux and Mac, but you will need to compile the binary from the C code and run the GUI with Python.

Note: We rely on help from the community to find issues and suggest improvements. If you encounter a bug, first try downloading the latest version if available. If that doesn't fix it, please send an email to [email protected]. Thanks for your continued help.

Change Log:

Introduced UniScore. This will automatically score the quality of your peaks and the overall deconvolution. Various experimental features were also added with this to visualize and filter the scores. Some updates to the scoring algorithm from Version 4.0.2 to improve it.

A full description of the UniScore can be found in this preprint: https://doi.org/10.26434/chemrxiv.10278041

A good heuristic for UniScore and DScore values is:

80-100: A (Excellent)

60-80: B (Good)

40-60: C (Fair)

20-40: D (Poor)

0-20: F (Almost certainly noise)

Added Calculator for getting masses from Protein/Peptide or RNA sequences. This can be launched stand alone from the Experimental Menu or by right clicking on the Oligomer and Mass Tools Oligomer Builder box.

Fixed bug to now allow protein-protein oligomerization KD values to be measured with the Data Collector. Find out more on the UniDec Wiki Page.