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starts organization process
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raywray committed Oct 23, 2024
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3 changes: 3 additions & 0 deletions .gitmodules
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[submodule "statMix"]
path = statMix
url = https://github.com/raywray/statMix.git
[submodule "evolutionary_history/supercomputer_scripts"]
path = evolutionary_history/supercomputer_scripts
url = https://github.com/raywray/supercomputer_scripts.git
18 changes: 1 addition & 17 deletions README.md
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This is the pipeline used in the hops paper (citation).

First, we created a reusable pipeline that generates several summary statistics (statMix) and fed our *hops* `vcf` data through the pipeline. The summary statistics and analysis results we generated for *hops* are as follows:
- Hardy Weinberg Equilibrium
- Full population structure analysis using admixture
- SFS based on the population structure results
- tajima's D
- windowed weir Fst
- weir Fst
- site pi
- site pi per population (from population structure analysis)
- windowed pi
- windowed pi per population (from population structure analysis)
- Fit
- Fis
- allele frequency
- SFS(s) compatible for fastsimcoal analyses

Next, the pipeline uses the SFS(s) created for fastsimcoal analyses, as well as a user-generated parameter `yaml` file, to feed into a fastsimcoal wrapper (citation here) that generates thousands of random coalescent models. This was run on a cluster. The wrapper identified the best model and parameters, ran a bootstrap analysis, and generated images. The results of the best model are included here in the `results/fastsimcoal` folder.
We have created different folders for the different analyses performed. Each folder has its own README.md.
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